Faculty

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Neil Kaplowitz, MD
Professor of Medicine
Usc Associates/Thomas H. Brem Chair in Medicine
Chief, Division of Gastroenterology and Liver Diseases
Medicine
HMR 101 Health Sciences Campus Los Angeles
+1 323 442 5576

Overview

Dr. Kaplowtiz's research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

NIH: Merit Award, 1992

Department of Veterans Affairs : William S. Middleton Award, 1993

Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006

American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005

American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Association of American Physicians: Member, 1988

Western Gastroenterology : Research Prize, 1986

American Liver Foundation: Greater Los Angeles Medical Honoree, 2000

New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994

Western Society of Clinical Investigation: Mayo Soley Award, 2007

American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006

Publications

Han D, Johnson HS, Rao MP, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Casian JG, Cadenas E, Kaplowitz N. Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radic Biol Med. 2016 Nov 17. View in: PubMed

Dara L, Liu ZX, Kaplowitz N. A murder mystery in the liver: who done it and how? J Clin Invest. 2016 Nov 1; 126(11):4068-4071. View in: PubMed

Dara L, Kaplowitz N. The many faces of RIPK3: What about NASH? Hepatology. 2016 Nov; 64(5):1411-1413. View in: PubMed

Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N, Liu ZX. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-? B. J Immunol. 2016 Oct 15; 197(8):3120-3129. View in: PubMed

Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2016 Oct 11. View in: PubMed

Medina-Caliz I, Robles-Diaz M, Garcia-Muñoz B, Stephens C, Ortega-Alonso A, Garcia-Cortes M, González-Jimenez A, Sanabria-Cabrera JA, Moreno I, Fernandez MC, Romero-Gomez M, Navarro JM, Barriocanal AM, Montane E, Hallal H, Blanco S, Soriano G, Roman EM, Gómez-Dominguez E, Castiella A, Zapata EM, Jimenez-Perez M, Moreno JM, Aldea-Perona A, Hernández-Guerra M, Prieto M, Zoubek ME, Kaplowitz N, Lucena MI, Andrade RJ. Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury. J Hepatol. 2016 Sep; 65(3):532-42. View in: PubMed

Dara L, Kaplowitz N. Reply. Hepatology. 2016 Jul; 64(1):308-9. View in: PubMed

Dara L, Kaplowitz N. Reply. Hepatology. 2016 Jul; 64(1):312-3. View in: PubMed

Robles-Diaz M, Andrade RJ, Kaplowitz N. Is Sensitivity the Key Measure to Predict Acute Liver Failure in Drug-Induced Liver Injury Patients? Clin Gastroenterol Hepatol. 2016 Jun; 14(6):918. View in: PubMed

Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 Jun; 63(6):1987-2003. View in: PubMed

Xu CF, Johnson T, Wang X, Carpenter C, Graves AP, Warren L, Xue Z, King KS, Fraser DJ, Stinnett S, Briley LP, Mitrica I, Spraggs CF, Nelson MR, Tada H, du Bois A, Powles T, Kaplowitz N, Pandite LN. HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer. Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. View in: PubMed

Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. View in: PubMed

Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. View in: PubMed

Uetrecht J, Kaplowitz N. Inhibition of immune tolerance unmasks drug-induced allergic hepatitis. Hepatology. 2015 Aug; 62(2):346-8. View in: PubMed

Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. View in: PubMed

Powles T, Bracarda S, Chen M, Norry E, Compton N, Heise M, Hutson T, Harter P, Carpenter C, Pandite L, Kaplowitz N. Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients. Eur J Cancer. 2015 Jul; 51(10):1293-302. View in: PubMed

Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. View in: PubMed

Robles-Diaz M, Kaplowitz N, Stephens C, Andrade RJ, Lucena MI. Reply. Gastroenterology. 2015 Feb; 148(2):452-3. View in: PubMed

Garcia-Ruiz C, Mato JM, Vance D, Kaplowitz N, Fernández-Checa JC. Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways. J Hepatol. 2015 Jan; 62(1):219-33. View in: PubMed

Baulies A, Ribas V, Núñez S, Torres S, Alarcón-Vila C, Martínez L, Suda J, Ybanez MD, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy. Sci Rep. 2015; 5:18017. View in: PubMed

Robles-Diaz M, Kaplowitz N, Stephens C, Andrade RJ, Lucena MI. Reply. Gastroenterology. 2014 Dec; 147(6):1442. View in: PubMed

Than TA, Win S, Kaplowitz N. In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. View in: PubMed

Fucho R, Martínez L, Baulies A, Torres S, Tarrats N, Fernandez A, Ribas V, Astudillo AM, Balsinde J, Garcia-Rovés P, Elena M, Bergheim I, Lotersztajn S, Trautwein C, Appelqvist H, Paton AW, Paton JC, Czaja MJ, Kaplowitz N, Fernandez-Checa JC, García-Ruiz C. ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. J Hepatol. 2014 Nov; 61(5):1126-34. View in: PubMed

Watkins PB, Merz M, Avigan MI, Kaplowitz N, Regev A, Senior JR. The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf. 2014 Nov; 37 Suppl 1:1-7. View in: PubMed

Kullak-Ublick GA, Merz M, Griffel L, Kaplowitz N, Watkins PB. Liver safety assessment in special populations (hepatitis B, C, and oncology trials). Drug Saf. 2014 Nov; 37 Suppl 1:57-62. View in: PubMed

Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology. 2014 Oct; 147(4):765-783. e4. View in: PubMed

Robles-Diaz M, Lucena MI, Kaplowitz N, Stephens C, Medina-Cáliz I, González-Jimenez A, Ulzurrun E, Gonzalez AF, Fernandez MC, Romero-Gómez M, Jimenez-Perez M, Bruguera M, Prieto M, Bessone F, Hernandez N, Arrese M, Andrade RJ. Use of Hy's Law and a New Composite Algorithm to Predict Acute Liver Failure in Patients With Drug-Induced Liver Injury. Gastroenterology. 2014 Jul; 147(1):109-118. e5. View in: PubMed

Chang AH, Sancheti H, Garcia J, Kaplowitz N, Cadenas E, Han D. Respiratory Substrates Regulate S-Nitrosylation of Mitochondrial Proteins through a Thiol-Dependent Pathway. Chem Res Toxicol. 2014 May 19; 27(5):794-804. View in: PubMed

Saberi B, Ybanez MD, Johnson HS, Gaarde WA, Han D, Kaplowitz N. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways. Hepatology. 2014 Apr; 59(4):1543-54. View in: PubMed

Win S, Than TA, Fernandez-Checa JC, Kaplowitz N. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014; 5:e989. View in: PubMed

Yuan L, Kaplowitz N. Mechanisms of drug-induced liver injury. Clin Liver Dis. 2013 Nov; 17(4):507-18, vii. View in: PubMed

Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol. 2013 Oct; 59(4):805-13. View in: PubMed

García-Ruiz C, Kaplowitz N, Fernandez-Checa JC. Role of Mitochondria in Alcoholic Liver Disease. Curr Pathobiol Rep. 2013 Sep 1; 1(3):159-168. View in: PubMed

Kaplowitz N. Avoiding idiosyncratic DILI: two is better than one. Hepatology. 2013 Jul; 58(1):15-7. View in: PubMed

Marí M, Morales A, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; 1830(5):3317-28. View in: PubMed

Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. View in: PubMed

Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 7; 287(50):42165-79. View in: PubMed

Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, Watkins PB, Albassam M, Liu B, Stancic S, Suter L, Bortolini M. Current challenges and controversies in drug-induced liver injury. Drug Saf. 2012 Dec 1; 35(12):1099-117. View in: PubMed

Gika HG, Ji C, Theodoridis GA, Michopoulos F, Kaplowitz N, Wilson ID. Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling. J Chromatogr A. 2012 Oct 12; 1259:128-37. View in: PubMed

Montfort Cv, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. View in: PubMed

Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology. 2012 Jul; 56(1):130-9. View in: PubMed

Kaplowitz N. Dealing with stress. Hepatology. 2012 Jan; 55(1):3-13. View in: PubMed

Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 7; 286(40):35071-8. View in: PubMed

Lucena MI, Kaplowitz N, Hallal H, Castiella A, García-Bengoechea M, Otazua P, Berenguer M, Fernandez MC, Planas R, Andrade RJ. Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J Hepatol. 2011 Oct; 55(4):820-7. View in: PubMed

Gilsanz V, Chung SA, Kaplowitz N. Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep; 41(9):1146-53. View in: PubMed

Ji C, Kaplowitz N, Lau MY, Kao E, Petrovic LM, Lee AS. Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice. Hepatology. 2011 Jul; 54(1):229-39. View in: PubMed

Lee JS, Wang J, Martin M, Germer S, Kenwright A, Benayed R, Spleiss O, Platt A, Pilson R, Hemmings A, Weinblatt ME, Kaplowitz N, Krasnow J. Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. View in: PubMed

Than TA, Lou H, Ji C, Win S, Kaplowitz N. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. View in: PubMed

Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H, Hunt CM, Wilke RA, Avigan M, Kaplowitz N, Bjornsson E, Daly AK. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011 Jun; 89(6):806-15. View in: PubMed

Dara L, Ji C, Kaplowitz N. The contribution of endoplasmic reticulum stress to liver diseases. Hepatology. 2011 May; 53(5):1752-63. View in: PubMed

Loftus N, Barnes A, Ashton S, Michopoulos F, Theodoridis G, Wilson I, Ji C, Kaplowitz N. Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res. 2011 Feb 4; 10(2):705-13. View in: PubMed

Garcia J, Han D, Sancheti H, Yap LP, Kaplowitz N, Cadenas E. Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem. 2010 Dec 17; 285(51):39646-54. View in: PubMed

Jones DP, Lemasters JJ, Han D, Boelsterli UA, Kaplowitz N. Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv. 2010 Apr; 10(2):98-111. View in: PubMed

Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. View in: PubMed

Shinohara M, Ji C, Kaplowitz N. Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology. 2010 Mar; 51(3):796-805. View in: PubMed

Han D, Shinohara M, Ybanez MD, Saberi B, Kaplowitz N. Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol. 2010; (196):267-310. View in: PubMed

Verma S, Kaplowitz N. Diagnosis, management and prevention of drug-induced liver injury. Gut. 2009 Nov; 58(11):1555-64. View in: PubMed

Han D, Ybanez MD, Ahmadi S, Yeh K, Kaplowitz N. Redox regulation of tumor necrosis factor signaling. Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. View in: PubMed

Lucena MI, Andrade RJ, Kaplowitz N, García-Cortes M, Fernández MC, Romero-Gomez M, Bruguera M, Hallal H, Robles-Diaz M, Rodriguez-González JF, Navarro JM, Salmeron J, Martinez-Odriozola P, Pérez-Alvarez R, Borraz Y, Hidalgo R. Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex. Hepatology. 2009 Jun; 49(6):2001-9. View in: PubMed

Roberts KE, Fallon MB, Krowka MJ, Brown RS, Trotter JF, Peter I, Tighiouart H, Knowles JA, Rabinowitz D, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Kawut SM. Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease. Am J Respir Crit Care Med. 2009 May 1; 179(9):835-42. View in: PubMed

Yuan L, Kaplowitz N. Glutathione in liver diseases and hepatotoxicity. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. View in: PubMed

Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, Shah VH, Kaplowitz N, Forman L, Wille K, Kawut SM. Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008 Oct; 135(4):1168-75. View in: PubMed

Kaplowitz N, Shinohara M, Liu ZX, Han D. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. View in: PubMed

Saberi B, Shinohara M, Ybanez MD, Hanawa N, Gaarde WA, Kaplowitz N, Han D. Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C50-63. View in: PubMed

Kawut SM, Krowka MJ, Trotter JF, Roberts KE, Benza RL, Badesch DB, Taichman DB, Horn EM, Zacks S, Kaplowitz N, Brown RS, Fallon MB. Clinical risk factors for portopulmonary hypertension. Hepatology. 2008 Jul; 48(1):196-203. View in: PubMed

Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. View in: PubMed

Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem. 2008 May 16; 283(20):13565-77. View in: PubMed

Kaplowitz N, Than TA, Shinohara M, Ji C. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 Nov; 27(4):367-77. View in: PubMed

Ji C, Shinohara M, Kuhlenkamp J, Chan C, Kaplowitz N. Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology. 2007 Nov; 46(5):1586-96. View in: PubMed

Lou H, Kaplowitz N. Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem. 2007 Oct 5; 282(40):29470-81. View in: PubMed

Gunawan BK, Kaplowitz N. Mechanisms of drug-induced liver disease. Clin Liver Dis. 2007 Aug; 11(3):459-75, v. View in: PubMed

Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr. 2007 Jul; 86(1):14-24. View in: PubMed

Abboud G, Kaplowitz N. Drug-induced liver injury. Drug Saf. 2007; 30(4):277-94. View in: PubMed

Andrade RJ, Lucena MI, Kaplowitz N, García-Munoz B, Borraz Y, Pachkoria K, García-Cortés M, Fernández MC, Pelaez G, Rodrigo L, Durán JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Munoz-Yagüe T, Salmerón J, Hidalgo R. Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology. 2006 Dec; 44(6):1581-8. View in: PubMed

Rongey C, Kaplowitz N. Current concepts and controversies in the treatment of alcoholic hepatitis. World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. View in: PubMed

Ji C, Chan C, Kaplowitz N. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol. 2006 Nov; 45(5):717-24. View in: PubMed

Kaplowitz N, Ji C. Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. View in: PubMed

Han D, Hanawa N, Saberi B, Kaplowitz N. Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. View in: PubMed

Ji C, Kaplowitz N. ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33. View in: PubMed

Liu ZX, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. View in: PubMed

Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006 Jul 5; 296(1):87-93. View in: PubMed

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. View in: PubMed

Han D, Hanawa N, Saberi B, Kaplowitz N. Mechanisms of liver injury. III. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. View in: PubMed

Liu ZX, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. View in: PubMed

Nathwani RA, Kaplowitz N. Drug hepatotoxicity. Clin Liver Dis. 2006 May; 10(2):207-17, vii. View in: PubMed

Kaplowitz N. Rules and laws of drug hepatotoxicity. Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. View in: PubMed

Kaplowitz N. Liver biology and pathobiology. Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. View in: PubMed

Ji C, Mehrian-Shai R, Chan C, Hsu YH, Kaplowitz N. Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. View in: PubMed

Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. View in: PubMed

Fernandez-Checa JC, Kaplowitz N. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol. 2005 May 1; 204(3):263-73. View in: PubMed

Nathwani RA, Pais S, Reynolds TB, Kaplowitz N. Serum alanine aminotransferase in skeletal muscle diseases. Hepatology. 2005 Feb; 41(2):380-2. View in: PubMed

Nathwani RA, Kumar SR, Reynolds TB, Kaplowitz N. Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis. Am J Gastroenterol. 2005 Feb; 100(2):295-8. View in: PubMed

Liu ZX, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. View in: PubMed

Neff GW, Reddy KR, Durazo FA, Meyer D, Marrero R, Kaplowitz N. Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid. J Hepatol. 2004 Dec; 41(6):1062-4. View in: PubMed

Kaplowitz N. Statin-induced hepatotoxicity. Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. View in: PubMed

Francis GS, Kaplowitz N, Alteri E. Liver injury associated with the beta-interferons for MS. Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. View in: PubMed

Ji C, Deng Q, Kaplowitz N. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology. 2004 Aug; 40(2):442-51. View in: PubMed

Kaplowitz N. Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6. View in: PubMed

Ji C, Kaplowitz N. Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. View in: PubMed

Gunawan B, Kaplowitz N. Clinical perspectives on xenobiotic-induced hepatotoxicity. Drug Metab Rev. 2004 May; 36(2):301-12. View in: PubMed

Kaplowitz N. Drug-induced liver injury. Clin Infect Dis. 2004 Mar 1; 38 Suppl 2:S44-8. View in: PubMed

Han D, Matsumaru K, Rettori D, Kaplowitz N. Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. Biochem Pharmacol. 2004 Feb 1; 67(3):439-51. View in: PubMed

Lou H, Ookhtens M, Stolz A, Kaplowitz N. Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells. Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. View in: PubMed

Han D, Canali R, Rettori D, Kaplowitz N. Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria. Mol Pharmacol. 2003 Nov; 64(5):1136-44. View in: PubMed

Coll O, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology. 2003 Sep; 38(3):692-702. View in: PubMed

Matsumaru K, Ji C, Kaplowitz N. Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology. 2003 Jun; 37(6):1425-34. View in: PubMed

Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003 May; 124(5):1488-99. View in: PubMed

Lluis JM, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology. 2003 Mar; 124(3):708-24. View in: PubMed

Kaplowitz N, Lewis JH, Watkins PB. Did this drug cause my patient's hepatitis? Ann Intern Med. 2003 Jan 21; 138(2):159-60; author reply 159-60. View in: PubMed

Francis GS, Grumser Y, Alteri E, Micaleff A, O'Brien F, Alsop J, Stam Moraga M, Kaplowitz N. Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf. 2003; 26(11):815-27. View in: PubMed

Liu ZX, Kaplowitz N. Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. View in: PubMed

Nagai H, Matsumaru K, Feng G, Kaplowitz N. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology. 2002 Jul; 36(1):55-64. View in: PubMed

Feng G, Kaplowitz N. Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G825-34. View in: PubMed

Mittur A, Wolkoff AW, Kaplowitz N. The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane. Mol Pharmacol. 2002 Feb; 61(2):425-35. View in: PubMed

Kaplowitz N. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 2002; 22(2):137-44. View in: PubMed

Colell A, Coll O, García-Ruiz C, París R, Tiribelli C, Kaplowitz N, Fernández-Checa JC. Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology. 2001 Nov; 34(5):964-71. View in: PubMed

Tsukamoto H, Takei Y, McClain CJ, Joshi-Barve S, Hill D, Schmidt J, Deaciuc I, Barve S, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC, Yokoyama H, Okamura Y, Nakamura Y, Ishii H, Chawla RK, Barve S, Joshi-Barve S, Watson W, Nelson W, Lin M, Ohata M, Motomura K, Enomoto N, Ikejima K, Kitamura T, Oide H, Hirose M, Bradford BU, Rivera CA, Kono H, Peter S, Yamashina S, Konno A, Ishikawa M, Shimizu H, Sato N, Thurman R. How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):171S-181S. View in: PubMed

Kannan R, Ouyang B, Wawrousek E, Kaplowitz N, Andley UP. Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses. Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):409-16. View in: PubMed

Kaplowitz N. Causality assessment versus guilt-by-association in drug hepatotoxicity. Hepatology. 2001 Jan; 33(1):308-10. View in: PubMed

Kaplowitz N. Drug-induced liver disorders: implications for drug development and regulation. Drug Saf. 2001; 24(7):483-90. View in: PubMed

Mittur AV, Kaplowitz N, Kempner ES, Ookhtens M. Radiation inactivation studies of hepatic sinusoidal reduced glutathione transport system. Biochim Biophys Acta. 2000 Apr 5; 1464(2):207-18. View in: PubMed

Kaplowitz N. Cell death at the millennium. Implications for liver diseases. Clin Liver Dis. 2000 Feb; 4(1):1-23, v. View in: PubMed

Feng G, Kaplowitz N. Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. J Clin Invest. 2000 Feb; 105(3):329-39. View in: PubMed

Kannan R, Chakrabarti R, Tang D, Kim KJ, Kaplowitz N. GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC. Brain Res. 2000 Jan 10; 852(2):374-82. View in: PubMed

Kaplowitz N. Mechanisms of liver cell injury. J Hepatol. 2000; 32(1 Suppl):39-47. View in: PubMed

Kaplowitz N. Avoiding hepatic injury from drugs. Gastroenterology. 1999 Oct; 117(4):759. View in: PubMed

Kannan R, Mittur A, Bao Y, Tsuruo T, Kaplowitz N. GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter. J Neurochem. 1999 Jul; 73(1):390-9. View in: PubMed

Kannan R, Bao Y, Wang Y, Sarthy VP, Kaplowitz N. Protection from oxidant injury by sodium-dependent GSH uptake in retinal Müller cells. Exp Eye Res. 1999 May; 68(5):609-16. View in: PubMed

Selim K, Kaplowitz N. Hepatotoxicity of psychotropic drugs. Hepatology. 1999 May; 29(5):1347-51. View in: PubMed

Colell A, García-Ruiz C, Miranda M, Ardite E, Marí M, Morales A, Corrales F, Kaplowitz N, Fernández-Checa JC. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 1998 Dec; 115(6):1541-51. View in: PubMed

Kannan R, Bao Y, Mittur A, Andley UP, Kaplowitz N. Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes. Invest Ophthalmol Vis Sci. 1998 Jul; 39(8):1379-86. View in: PubMed

Mittur AV, Kaplowitz N, Kempner ES, Ookhtens M. Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation. Am J Physiol. 1998 May; 274(5 Pt 1):G923-30. View in: PubMed

Ookhtens M, Kaplowitz N. Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine. Semin Liver Dis. 1998; 18(4):313-29. View in: PubMed

Fernández-Checa JC, Kaplowitz N, García-Ruiz C, Colell A. Mitochondrial glutathione: importance and transport. Semin Liver Dis. 1998; 18(4):389-401. View in: PubMed

Huang ZZ, Li H, Cai J, Kuhlenkamp J, Kaplowitz N, Lu SC. Changes in glutathione homeostasis during liver regeneration in the rat. Hepatology. 1998 Jan; 27(1):147-53. View in: PubMed

Kaplowitz N. Hepatotoxicity of herbal remedies: insights into the intricacies of plant-animal warfare and cell death. Gastroenterology. 1997 Oct; 113(4):1408-12. View in: PubMed

Colell A, García-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodés J, Kaplowitz N, Fernández-Checa JC. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology. 1997 Sep; 26(3):699-708. View in: PubMed

Fernández-Checa JC, Kaplowitz N, García-Ruiz C, Colell A, Miranda M, Marí M, Ardite E, Morales A. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol. 1997 Jul; 273(1 Pt 1):G7-17. View in: PubMed

DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 9; 53(9):1339-45. View in: PubMed

Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. View in: PubMed

Lu SC, Kuhlenkamp J, Wu H, Sun WM, Stone L, Kaplowitz N. Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats. Am J Physiol. 1997 Feb; 272(2 Pt 1):G374-82. View in: PubMed

Fernández-Checa JC, Kaplowitz N, Colell A, García-Ruiz C. Oxidative stress and alcoholic liver disease. Alcohol Health Res World. 1997; 21(4):321-4. View in: PubMed

Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. View in: PubMed

Lu SC, Cai J, Kuhlenkamp J, Sun WM, Takikawa H, Takenaka O, Horie T, Yi J, Kaplowitz N. Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats. Hepatology. 1996 Jul; 24(1):253-8. View in: PubMed

Takikawa H, Sugiyama Y, Fernandez-Checa JC, Kuhlenkamp J, Ookhtens M, Kaplowitz N. Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats. Hepatology. 1996 Jun; 23(6):1642-9. View in: PubMed

Fernández-Checa JC, García-Ruiz C, Colell A, Yi JR, Kaplowitz N. Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics. Am J Physiol. 1996 Jun; 270(6 Pt 1):G969-75. View in: PubMed

Kaplowitz N, Fernández-Checa JC, Kannan R, Garcia-Ruiz C, Ookhtens M, Yi JR. GSH transporters: molecular characterization and role in GSH homeostasis. Biol Chem Hoppe Seyler. 1996 May; 377(5):267-73. View in: PubMed

Fernández-Checa JC, Yi JR, García Ruiz C, Ookhtens M, Kaplowitz N. Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis. 1996 May; 16(2):147-58. View in: PubMed

Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. View in: PubMed

Lu SC, Sun WM, Yi J, Ookhtens M, Sze G, Kaplowitz N. Role of two recently cloned rat liver GSH transporters in the ubiquitous transport of GSH in mammalian cells. J Clin Invest. 1996 Mar 15; 97(6):1488-96. View in: PubMed

DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. View in: PubMed

Kaplowitz N, Tsukamoto H. Oxidative stress and liver disease. Prog Liver Dis. 1996; 14:131-59. View in: PubMed

Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. View in: PubMed

DeLeve LD, Kaplowitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. View in: PubMed

García-Ruiz C, Colell A, Morales A, Kaplowitz N, Fernández-Checa JC. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol Pharmacol. 1995 Nov; 48(5):825-34. View in: PubMed

Runnegar M, Berndt N, Kaplowitz N. Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol Appl Pharmacol. 1995 Oct; 134(2):264-72. View in: PubMed

Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. View in: PubMed

García-Ruiz C, Morales A, Colell A, Rodés J, Yi JR, Kaplowitz N, Fernández-Checa JC. Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes. J Biol Chem. 1995 Jul 7; 270(27):15946-9. View in: PubMed

Yi JR, Lu S, Fernández-Checa J, Kaplowitz N. Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1495-9. View in: PubMed

García-Ruiz C, Morales A, Colell A, Ballesta A, Rodés J, Kaplowitz N, Fernández-Checa JC. Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology. 1995 Jan; 21(1):207-14. View in: PubMed

Lu SC, Kuhlenkamp J, Ge JL, Sun WM, Kaplowitz N. Specificity and directionality of thiol effects on sinusoidal glutathione transport in rat liver. Mol Pharmacol. 1994 Sep; 46(3):578-85. View in: PubMed

García-Ruiz C, Morales A, Ballesta A, Rodés J, Kaplowitz N, Fernández-Checa JC. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest. 1994 Jul; 94(1):193-201. View in: PubMed

Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. View in: PubMed

Torres AM, Kaplowitz N, Tiribelli C. Role of BSP/bilirubin binding protein and bilitranslocase in glutathione uptake in rat basolateral liver plasma membrane vesicles. Biochem Biophys Res Commun. 1994 Apr 29; 200(2):1079-85. View in: PubMed

Yamamuro W, Stolz A, Takikawa H, Sugimoto M, Kaplowitz N. Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits. J Gastroenterol. 1994 Apr; 29(2):115-9. View in: PubMed

Yi JR, Lu S, Fernandez-Checa J, Kaplowitz N. Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics. J Clin Invest. 1994 Apr; 93(4):1841-5. View in: PubMed

Sze G, Kaplowitz N, Ookhtens M, Lu SC. Bidirectional membrane transport of intact glutathione in Hep G2 cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):G1128-34. View in: PubMed

Fernández-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol. 1993 Nov-Dec; 10(6):469-75. View in: PubMed

Kuhlenkamp J, Ronk M, Yusin M, Stolz A, Kaplowitz N. Identification and purification of a human liver cytosolic tocopherol binding protein. Protein Expr Purif. 1993 Oct; 4(5):382-9. View in: PubMed

Lu SC, Ge JL, Huang HY, Kuhlenkamp J, Kaplowitz N. Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers. J Clin Invest. 1993 Sep; 92(3):1188-97. View in: PubMed

Fernández-Checa JC, Ookhtens M, Kaplowitz N. Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles. J Biol Chem. 1993 May 25; 268(15):10836-41. View in: PubMed

Fernández-Checa JC, Yi JR, Garcia-Ruiz C, Knezic Z, Tahara SM, Kaplowitz N. Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes. J Biol Chem. 1993 Feb 5; 268(4):2324-8. View in: PubMed

Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 1992 Dec; 16(6):1423-7. View in: PubMed

Kannan R, Kuhlenkamp JF, Ookhtens M, Kaplowitz N. Transport of glutathione at blood-brain barrier of the rat: inhibition by glutathione analogs and age-dependence. J Pharmacol Exp Ther. 1992 Dec; 263(3):964-70. View in: PubMed

García-Ruiz C, Fernández-Checa JC, Kaplowitz N. Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles. J Biol Chem. 1992 Nov 5; 267(31):22256-64. View in: PubMed

Lu SC, Ge JL, Kuhlenkamp J, Kaplowitz N. Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo. J Clin Invest. 1992 Aug; 90(2):524-32. View in: PubMed

Yoshida H, Kuronuma Y, Iijima M, Harada T, Kuhlenkamp J, Kaplowitz N. The relationship between biliary secretion of bilirubin and glutathione in the rat. Gastroenterol Jpn. 1992 Jun; 27(3):369-73. View in: PubMed

Komatsu H, Koo A, Ghadishah E, Zeng H, Kuhlenkamp JF, Inoue M, Guth PH, Kaplowitz N. Neutrophil accumulation in ischemic reperfused rat liver: evidence for a role for superoxide free radicals. Am J Physiol. 1992 Apr; 262(4 Pt 1):G669-76. View in: PubMed

Koo A, Komatsu H, Tao G, Inoue M, Guth PH, Kaplowitz N. Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion. Hepatology. 1992 Mar; 15(3):507-14. View in: PubMed

Yoshida H, Yusin M, Ren I, Kuhlenkamp J, Hirano T, Stolz A, Kaplowitz N. Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. J Lipid Res. 1992 Mar; 33(3):343-50. View in: PubMed

Fernández-Checa JC, Takikawa H, Horie T, Ookhtens M, Kaplowitz N. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem. 1992 Jan 25; 267(3):1667-73. View in: PubMed

Saiki H, Chan ET, Wong E, Yamamuro W, Ookhtens M, Kaplowitz N. Zonal distribution of cysteine uptake in the perfused rat liver. J Biol Chem. 1992 Jan 5; 267(1):192-6. View in: PubMed

DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991 Dec; 52(3):287-305. View in: PubMed

Takikawa H, Fernandez-Checa JC, Kuhlenkamp J, Stolz A, Ookhtens M, Kaplowitz N. Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver. Biochim Biophys Acta. 1991 Jul 30; 1084(3):247-50. View in: PubMed

Lu SC, Kuhlenkamp J, Garcia-Ruiz C, Kaplowitz N. Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat. J Clin Invest. 1991 Jul; 88(1):260-9. View in: PubMed

Fernández-Checa JC, García-Ruiz C, Ookhtens M, Kaplowitz N. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest. 1991 Feb; 87(2):397-405. View in: PubMed

DeLeve LD, Kaplowitz N. Importance and regulation of hepatic glutathione. Semin Liver Dis. 1990 Nov; 10(4):251-66. View in: PubMed

Fernández-Checa JC, Kaplowitz N. The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal Biochem. 1990 Nov 1; 190(2):212-9. View in: PubMed

Lu SC, Garcia-Ruiz C, Kuhlenkamp J, Ookhtens M, Salas-Prato M, Kaplowitz N. Hormonal regulation of glutathione efflux. J Biol Chem. 1990 Sep 25; 265(27):16088-95. View in: PubMed

Kannan R, Kuhlenkamp JF, Jeandidier E, Trinh H, Ookhtens M, Kaplowitz N. Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat. J Clin Invest. 1990 Jun; 85(6):2009-13. View in: PubMed

Fernandez-Checa JC, Maddatu T, Ookhtens M, Kaplowitz N. Inhibition of GSH efflux from rat liver by methionine: effects of GSH synthesis in cells and perfused organ. Am J Physiol. 1990 Jun; 258(6 Pt 1):G967-73. View in: PubMed

Takikawa H, Stolz A, Kuroki S, Kaplowitz N. Oxidation and reduction of bile acid precursors by rat hepatic 3 alpha-hydroxysteroid dehydrogenase and inhibition by bile acids and indomethacin. Biochim Biophys Acta. 1990 Apr 2; 1043(2):153-6. View in: PubMed

Takikawa H, Stolz A, Sugiyama Y, Yoshida H, Yamanaka M, Kaplowitz N. Relationship between the newly identified bile acid binder and bile acid oxidoreductases in human liver. J Biol Chem. 1990 Feb 5; 265(4):2132-6. View in: PubMed

Ookhtens M, Kaplowitz N. The use of isolated perfused liver in studies of biological transport processes. Methods Enzymol. 1990; 192:485-95. View in: PubMed

Fernandez-Checa JC, Ookhtens M, Kaplowitz N. Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest. 1989 Apr; 83(4):1247-52. View in: PubMed

Stolz A, Takikawa H, Ookhtens M, Kaplowitz N. The role of cytoplasmic proteins in hepatic bile acid transport. Annu Rev Physiol. 1989; 51:161-76. View in: PubMed

Kaplowitz N, Yoshida H, Kuhlenkamp J, Slitsky B, Ren I, Stolz A. Tocopherol-binding proteins of hepatic cytosol. Ann N Y Acad Sci. 1989; 570:85-94. View in: PubMed

Lu SC, Kuhlenkamp J, Robert A, Kaplowitz N. Role of glutathione status in protection against ethanol-induced gastric lesions. Pharmacology. 1989; 38(1):57-60. View in: PubMed

Fernandez-Checa JC, Ren C, Aw TY, Ookhtens M, Kaplowitz N. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8. View in: PubMed

Ookhtens M, Lyon I, Fernandez-Checa J, Kaplowitz N. Inhibition of glutathione efflux in the perfused rat liver and isolated hepatocytes by organic anions and bilirubin. Kinetics, sidedness, and molecular forms. J Clin Invest. 1988 Aug; 82(2):608-16. View in: PubMed

Takikawa H, Sugiyama Y, Kaplowitz N. Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases. Biochim Biophys Acta. 1988 Apr 28; 954(1):37-43. View in: PubMed

Takikawa H, Kaplowitz N. Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids. J Lipid Res. 1988 Mar; 29(3):279-86. View in: PubMed

Ookhtens M, Lyon I, Kaplowitz N. Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver. Biochem Pharmacol. 1987 Nov 15; 36(22):4015-7. View in: PubMed

Takikawa H, Ookhtens M, Stolz A, Kaplowitz N. Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenase. II. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):861-6. View in: PubMed

Takikawa H, Stolz A, Kaplowitz N. Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenase. I. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):852-60. View in: PubMed

Fernandez-Checa JC, Ookhtens M, Kaplowitz N. Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol. J Clin Invest. 1987 Jul; 80(1):57-62. View in: PubMed

Aw TY, Ookhtens M, Kuhlenkamp JF, Kaplowitz N. Trans-stimulation and driving forces for GSH transport in sinusoidal membrane vesicles from rat liver. Biochem Biophys Res Commun. 1987 Feb 27; 143(1):377-82. View in: PubMed

Stolz A, Takikawa H, Sugiyama Y, Kuhlenkamp J, Kaplowitz N. 3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosol. Identification, kinetics, and physiologic significance. J Clin Invest. 1987 Feb; 79(2):427-34. View in: PubMed

Sugimoto M, Takikawa H, Stolz A, Kaplowitz N. Subunit heterogeneity of cationic human hepatic glutathione S-transferases. Pharmacology. 1987; 35(2):65-78. View in: PubMed

Takikawa H, Stolz A, Kaplowitz N. Purification of a 32. 5 kDa monomeric sulfotransferase from rat liver with activity for bile acids and phenolic steroids. FEBS Lett. 1986 Oct 27; 207(2):193-7. View in: PubMed

Aw TY, Ookhtens M, Kaplowitz N. Mechanism of inhibition of glutathione efflux by methionine from isolated rat hepatocytes. Am J Physiol. 1986 Sep; 251(3 Pt 1):G354-61. View in: PubMed

Kaplowitz N, Aw TY, Simon FR, Stolz A. Drug-induced hepatotoxicity. Ann Intern Med. 1986 Jun; 104(6):826-39. View in: PubMed

Takikawa H, Stolz A, Sugimoto M, Sugiyama Y, Kaplowitz N. Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids. J Lipid Res. 1986 Jun; 27(6):652-7. View in: PubMed

Stolz A, Sugiyama Y, Kuhlenkamp J, Osadchey B, Yamada T, Belknap W, Balistreri W, Kaplowitz N. Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution. Hepatology. 1986 May-Jun; 6(3):433-9. View in: PubMed

Aw TY, Ookhtens M, Ren C, Kaplowitz N. Kinetics of glutathione efflux from isolated rat hepatocytes. Am J Physiol. 1986 Feb; 250(2 Pt 1):G236-43. View in: PubMed

Takikawa H, Sugiyama Y, Stolz A, Sugimoto M, Kaplowitz N. Organic anion-binding by human hepatic GSH S-transferases. Biochem Pharmacol. 1986 Jan 15; 35(2):354-6. View in: PubMed

Sugimoto M, Kuhlenkamp J, Ookhtens M, Aw TY, Reeve J, Kaplowitz N. Gamma-glutamylcysteine: a substrate for glutathione S-transferases. Biochem Pharmacol. 1985 Oct 15; 34(20):3643-7. View in: PubMed

Kaplowitz N, Aw TY, Ookhtens M. The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol. 1985; 25:715-44. View in: PubMed

Ookhtens M, Hobdy K, Corvasce MC, Aw TY, Kaplowitz N. Sinusoidal efflux of glutathione in the perfused rat liver. Evidence for a carrier-mediated process. J Clin Invest. 1985 Jan; 75(1):258-65. View in: PubMed

Sugiyama Y, Stolz A, Sugimoto M, Kuhlenkamp J, Yamada T, Kaplowitz N. Identification and partial purification of a unique phenolic steroid sulphotransferase in rat liver cytosol. Biochem J. 1984 Dec 15; 224(3):947-53. View in: PubMed

Stolz A, Sugiyama Y, Kuhlenkamp J, Kaplowitz N. Identification and purification of a 36 kDa bile acid binder in human hepatic cytosol. FEBS Lett. 1984 Nov 5; 177(1):31-5. View in: PubMed

Sugiyama Y, Stolz A, Sugimoto M, Kaplowitz N. Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin. J Lipid Res. 1984 Nov; 25(11):1177-83. View in: PubMed

Sugiyama Y, Sugimoto M, Stolz A, Kaplowitz N. Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin. Biochem Pharmacol. 1984 Nov 1; 33(21):3511-3. View in: PubMed

Sugiyama Y, Stolz A, Hershman JM, Kaplowitz N. Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins. Biochim Biophys Acta. 1984 Sep 28; 801(2):184-8. View in: PubMed

Aw TY, Ookhtens M, Kaplowitz N. Inhibition of glutathione efflux from isolated rat hepatocytes by methionine. J Biol Chem. 1984 Aug 10; 259(15):9355-8. View in: PubMed

Stolz A, Yamada T, Sugiyama Y, Belknap W, Kaplowitz N. Quantitation and characterization of a newly described organic anion binder by radioimmunoassay. Biochim Biophys Acta. 1984 Jul 30; 800(2):171-7. View in: PubMed

Kaplowitz N, Eberle DE, Petrini J, Touloukian J, Corvasce MC, Kuhlenkamp J. Factors influencing the efflux of hepatic glutathione into bile in rats. J Pharmacol Exp Ther. 1983 Jan; 224(1):141-7. View in: PubMed

Sugiyama Y, Yamada T, Kaplowitz N. Newly identified organic anion-binding proteins in rat liver cytosol. Biochim Biophys Acta. 1982 Dec 20; 709(2):342-52. View in: PubMed

Kaplowitz N. Propylthiouracil treatment for alcoholic hepatitis: should it and does it work? Gastroenterology. 1982 Jun; 82(6):1468-71. View in: PubMed

Touloukian J, Kaplowitz N. Halothane-induced hepatic disease. Semin Liver Dis. 1981 May; 1(2):134-42. View in: PubMed

Yamada T, Ludwig S, Kuhlenkamp J, Kaplowitz N. Direct protection against acetaminophen hepatotoxicity by propylthiouracil. In vivo and in vitro studies in rats and mice. J Clin Invest. 1981 Mar; 67(3):688-95. View in: PubMed

Melmed S, Nelson M, Kaplowitz N, Yamada T, Hershman JM. Glutathione-dependent thyroxine 5'-monodeiodination modulates growth hormone production by cultured nonthyrotropic rat pituitary cells. Endocrinology. 1981 Mar; 108(3):970-6. View in: PubMed

Ludwig S, Kaplowitz N. Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat. Gastroenterology. 1980 Sep; 79(3):545-9. View in: PubMed

Reeve J, Kuhlenkamp J, Kaplowitz N. Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine. J Chromatogr. 1980 Jun 27; 194(3):424-8. View in: PubMed

von Bahr C, Glaumann H, Gudas J, Kaplowitz N. Inhibition of hepatic metabolism of azathioprine by furosemide in human liver in vitro. Biochem Pharmacol. 1980 May 15; 29(10):1439-41. View in: PubMed

Kaplowitz N, Kuhlenkamp J, Goldstein L, Reeve J. Effect of salicylates and phenobarbital on hepatic glutathione in the rat. J Pharmacol Exp Ther. 1980 Feb; 212(2):240-5. View in: PubMed

Kaplowitz N, Spina C, Graham M, Kuhlenkamp J. Glutathione S-transferase in human lymphoid cell lines and fractionated peripheral leucocytes. Biochem J. 1978 Mar 1; 169(3):465-70. View in: PubMed

Kaplowitz N, Kuhlenkamp J. Inhibition of hepatic metabolism of azathioprine in vivo. Gastroenterology. 1978 Jan; 74(1):90-2. View in: PubMed

Kaplowitz N. Enzymatic thiolysis of azathioprine in vitro. Biochem Pharmacol. 1976 Nov 1; 25(21):2421-6. View in: PubMed

Kaplowitz N, Clifton G, Kuhlenkamp J, Wallin JD. Comparison of renal and hepatic glutathione S-transferases in the rat. Biochem J. 1976 Aug 15; 158(2):243-8. View in: PubMed

Clifton G, Kaplowitz N, Wallin JD, Kuhlenkamp J. Drug induction and sex differences of renal glutathione S-transferases in the rat. Biochem J. 1975 Aug; 150(2):259-62. View in: PubMed

Kaplowitz N, Kuhlenkamp J, Clifton G. Hepatic glutathione S-transferases: identification by gel filtration and in vitro inhibition by organic anions. Proc Soc Exp Biol Med. 1975 May; 149(1):234-7. View in: PubMed

Kaplowitz N, Kok E, Javitt NB. Postprandial serum bile acid for the detection of hepatobiliary disease. JAMA. 1973 Jul 16; 225(3):292-3. View in: PubMed

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