Faculty

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Nerses Sanossian, MD
Associate Professor of Neurology (Clinical Scholar)
Director, Roxanna Todd Hodges Stroke Program
Neurology
CHP 209C 1540 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 7793

Overview

My primary clinical research interest is in emergency evaluation and treatment of stroke focusing on the prehospital arena. Other research interests include imaging of stroke and transient ischemic attack as well as stroke prevention in the underserved. I am currently Associate Professor of Neurology (Clinical Scholar), and associate director of the Division of Neurocritical Care & Stroke at the University of Southern California. Administratively I serve as stroke fellowship director, medical director of Stroke Centers at LAC+USC Medical Center and USC Verdugo Hills Hospital and the Roxana Todd Hodges (RTH) Comprehensive Stroke Clinic. My experience in prehospital care includes serving in the leadership of the NIH-funded Field Administration of Stroke Therapy Magnesium (FAST-MAG) clinical trial as well a serving as a commissioner of Emergency Medical Services for Los Angeles County since 2012. In addition to Neurology and Vascular Neurology, I am board-certified in Neuroimaging through the United Council for Neurologic Subspecialties.

Publications

Ramirez L, Kim-Tenser MA, Sanossian N, Cen S, Wen G, He S, Mack WJ, Towfighi A. Trends in Acute Ischemic Stroke Hospitalizations in the United States. J Am Heart Assoc. 2016; 5(5). View in: PubMed

Kim DH, Saver JL, Starkman S, Liebeskind DS, Ali LK, Restrepo L, Kim-Tenser M, Valdes-Sueiras M, Eckstein M, Pratt F, Stratton S, Hamilton S, Conwit R, Sanossian N. Enrollment Yield and Reasons for Screen Failure in a Large Prehospital Stroke Trial. Stroke. 2016 Jan; 47(1):232-5. View in: PubMed

Sheth SA, Sanossian N, Hao Q, Starkman S, Ali LK, Kim D, Gonzalez NR, Tateshima S, Jahan R, Duckwiler GR, Saver JL, Vinuela F, Liebeskind DS. Collateral flow as causative of good outcomes in endovascular stroke therapy. J Neurointerv Surg. 2016 Jan; 8(1):2-7. View in: PubMed

Dorhout Mees SM, Algra A, Wong GK, Poon WS, Bradford CM, Saver JL, Starkman S, Rinkel GJ, van den Bergh WM. Early Magnesium Treatment After Aneurysmal Subarachnoid Hemorrhage: Individual Patient Data Meta-Analysis. Stroke. 2015 Nov; 46(11):3190-3. View in: PubMed

Sanossian N, Liebeskind DS, Eckstein M, Starkman S, Stratton S, Pratt FD, Koenig W, Hamilton S, Kim-Tenser M, Conwit R, Saver JL. Routing Ambulances to Designated Centers Increases Access to Stroke Center Care and Enrollment in Prehospital Research. Stroke. 2015 Oct; 46(10):2886-90. View in: PubMed

Lin MP, Sanossian N, Liebeskind DS. Imaging of prehospital stroke therapeutics. Expert Rev Cardiovasc Ther. 2015 Sep; 13(9):1001-15. View in: PubMed

Dimitrov N, Koenig W, Bosson N, Song S, Saver JL, Mack WJ, Sanossian N. Variability in Criteria for Emergency Medical Services Routing of Acute Stroke Patients to Designated Stroke Center Hospitals. West J Emerg Med. 2015 Sep; 16(5):743-6. View in: PubMed

Ramirez L, Krug A, Nhoung H, Kazaryan S, Gasparian G, Perese J, Razmara A, Liebeskind DS, Majersik JJ, Sanossian N. Vascular Neurologists as Directors of Stroke Centers in the United States. Stroke. 2015 Sep; 46(9):2654-6. View in: PubMed

Attenello FJ, Ng A, Wen T, Cen SY, Sanossian N, Amar AP, Zada G, Krieger MD, McComb JG, Mack WJ. Racial and socioeconomic disparities in outcomes following pediatric cerebrospinal fluid shunt procedures. J Neurosurg Pediatr. 2015 Jun; 15(6):560-6. View in: PubMed

Gasparian GG, Sanossian N, Shiroishi MS, Liebeskind DS. Imaging of occlusive thrombi in acute ischemic stroke. Int J Stroke. 2015 Apr; 10(3):298-305. View in: PubMed

Attenello FJ, Reid P, Wen T, Cen S, Kim-Tenser M, Sanossian N, Russin J, Amar A, Giannotta S, Mack WJ, Tenser M. Evaluation of time to aneurysm treatment following subarachnoid hemorrhage: comparison of patients treated with clipping versus coiling. J Neurointerv Surg. 2015 Mar 12. View in: PubMed

Saver JL, Starkman S, Eckstein M, Stratton SJ, Pratt FD, Hamilton S, Conwit R, Liebeskind DS, Sung G, Kramer I, Moreau G, Goldweber R, Sanossian N. Prehospital use of magnesium sulfate as neuroprotection in acute stroke. N Engl J Med. 2015 Feb 5; 372(6):528-36. View in: PubMed

Lin MP, Sanossian N. Reperfusion therapy in the acute management of ischemic stroke. Cardiol Clin. 2015 Feb; 33(1):99-109. View in: PubMed

Fu KA, Nguyen PL, Sanossian N. Basilar artery territory stroke secondary to invasive fungal sphenoid sinusitis: a case report and review of the literature. Case Rep Neurol. 2015 Jan-Apr; 7(1):51-8. View in: PubMed

Yu S, Liebeskind DS, Dua S, Wilhalme H, Elashoff D, Qiao XJ, Alger JR, Sanossian N, Starkman S, Ali LK, Scalzo F, Lou X, Yoo B, Saver JL, Salamon N, Wang DJ. Postischemic hyperperfusion on arterial spin labeled perfusion MRI is linked to hemorrhagic transformation in stroke. J Cereb Blood Flow Metab. 2015; 35:630-7. View in: PubMed

Attenello FJ, Wen T, Cen SY, Ng A, Kim-Tenser M, Sanossian N, Amar AP, Mack WJ. Incidence of "never events" among weekend admissions versus weekday admissions to US hospitals: national analysis. BMJ. 2015; 350:h1460. View in: PubMed

McDonald CM, Cen S, Ramirez L, Song S, Saver JL, Mack WJ, Sanossian N. Hospital and demographic characteristics associated with advanced primary stroke center designation. Stroke. 2014 Dec; 45(12):3717-9. View in: PubMed

Attenello FJ, Wang K, Wen T, Cen SY, Kim-Tenser M, Amar AP, Sanossian N, Giannotta SL, Mack WJ. Health disparities in time to aneurysm clipping/coiling among aneurysmal subarachnoid hemorrhage patients: a national study. World Neurosurg. 2014 Dec; 82(6):1071-6. View in: PubMed

Wen T, He S, Attenello F, Cen SY, Kim-Tenser M, Adamczyk P, Amar AP, Sanossian N, Mack WJ. The impact of patient age and comorbidities on the occurrence of "never events" in cerebrovascular surgery: an analysis of the Nationwide Inpatient Sample. J Neurosurg. 2014 Sep; 121(3):580-6. View in: PubMed

Hanks N, Wen G, He S, Song S, Saver JL, Cen S, Kim-Tenser M, Mack W, Sanossian N. Expansion of u. s. Emergency medical service routing for stroke care: 2000-2010. West J Emerg Med. 2014 Jul; 15(4):499-503. View in: PubMed

Wen T, Attenello FJ, He S, Cen Y, Kim-Tenser MA, Sanossian N, Amar AP, Mack WJ. Racial and socioeconomic disparities in incidence of hospital-acquired complications following cerebrovascular procedures. Neurosurgery. 2014 Jul; 75(1):43-50. View in: PubMed

Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui HC, Weiner MW, Jagust WJ. Vascular risk and Aß interact to reduce cortical thickness in AD vulnerable brain regions. Neurology. 2014 Jul 1; 83(1):40-7. View in: PubMed

Saver JL, Starkman S, Eckstein M, Stratton S, Pratt F, Hamilton S, Conwit R, Liebeskind DS, Sung G, Sanossian N. Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 1 - rationale and general methods. Int J Stroke. 2014 Feb; 9(2):215-9. View in: PubMed

Saver JL, Starkman S, Eckstein M, Stratton S, Pratt F, Hamilton S, Conwit R, Liebeskind DS, Sung G, Sanossian N. Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: Part 2 - prehospital study methods. Int J Stroke. 2014 Feb; 9(2):220-5. View in: PubMed

Attenello FJ, Adamczyk P, Wen G, He S, Zhang K, Russin JJ, Sanossian N, Amar AP, Mack WJ. Racial and socioeconomic disparities in access to mechanical revascularization procedures for acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Feb; 23(2):327-34. View in: PubMed

Fu KA, DiNorcia J, Sher L, Velani SA, Akhtar S, Kalayjian LA, Sanossian N. Predictive factors of neurological complications and one-month mortality after liver transplantation. Front Neurol. 2014; 5:275. View in: PubMed

Ramirez L, D'Auria A, Popalzai A, Sanossian N. Bilateral Vision Loss Secondary to Pachymeningitis in a Patient with IgG4-Related Disease. Front Neurol. 2014; 5:192. View in: PubMed

Chang JJ, Mack WJ, Saver JL, Sanossian N. Magnesium: potential roles in neurovascular disease. Front Neurol. 2014; 5:52. View in: PubMed

Schuberg S, Song S, Saver JL, Mack WJ, Cen SY, Sanossian N. Impact of emergency medical services stroke routing protocols on primary stroke center certification in california. Stroke. 2013 Dec; 44(12):3584-6. View in: PubMed

Flint AC, Xiang B, Gupta R, Nogueira RG, Lutsep HL, Jovin TG, Albers GW, Liebeskind DS, Sanossian N, Smith WS. THRIVE Score Predicts Outcomes With a Third-Generation Endovascular Stroke Treatment Device in the TREVO-2 Trial. Stroke. 2013 Dec; 44(12):3370-5. View in: PubMed

Adamczyk P, Attenello F, Wen G, He S, Russin J, Sanossian N, Amar AP, Mack WJ. Mechanical thrombectomy in acute stroke: utilization variances and impact of procedural volume on inpatient mortality. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1263-9. View in: PubMed

Sanossian N, Djabiras C, Mack WJ, Ovbiagele B. Trends in cancer diagnoses among inpatients hospitalized with stroke. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):1146-50. View in: PubMed

Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ. The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction. JAMA Neurol. 2013 Apr; 70(4):488-95. View in: PubMed

Chao LL, Decarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack WJ, Chui HC, Weiner MW. Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One. 2013; 8(6):e65175. View in: PubMed

Liebeskind DS, Sanossian N, Sapo ML, Saver JL. Cerebral microbleeds after use of extracorporeal membrane oxygenation in children. J Neuroimaging. 2013 Jan; 23(1):75-8. View in: PubMed

Sanossian N, Shatzmiller RA, Djabiras C, Liebeskind DS. FLAIR vascular hyperintensity preceding stroke in cryptococcal meningitis. J Neuroimaging. 2013 Jan; 23(1):126-8. View in: PubMed

Sanossian N, Merino JG. Blogging about stroke: a new chapter for the journal. Stroke. 2012 Dec; 43(12):3157. View in: PubMed

Cardenas VA, Reed B, Chao LL, Chui H, Sanossian N, Decarli CC, Mack W, Kramer J, Hodis HN, Yan M, Buonocore MH, Carmichael O, Jagust WJ, Weiner MW. Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults. Stroke. 2012 Nov; 43(11):2865-70. View in: PubMed

Liebeskind DS, Sanossian N. How well do blood flow imaging and collaterals on angiography predict brain at risk? Neurology. 2012 Sep 25; 79(13 Suppl 1):S105-9. View in: PubMed

Nguyen TN, Zaidat OO, Edgell RC, Janjua N, Yavagal DR, Xavier AR, Kirmani JF, Liebeskind DS, Nogueira RG, Vora NA, Sims JR, Lynch JR, Fitzsimmons BF, Wolfe TJ, Chen M, Badruddin A, Zahuranec DB, McDonagh DL, Janardhan V, Bastan B, Madden JA, Sanossian N, Gupta R, Lazzaro MA, Jovin TG, Abou-Chebl A, Linfante I, Hussain SI. Vascular neurologists and neurointerventionalists on endovascular stroke care: Polling results. Neurology. 2012 Sep 25; 79(13 Suppl 1):S5-S15. View in: PubMed

Mittal A, Mittal G, Partikian A, Liebeskind D, Sanossian N. Benefits of hemicraniectomy seen many years after malignant stroke in a young patient. Front Neurol. 2012; 3:123. View in: PubMed

Azizyan A, Sanossian N, Mogensen MA, Liebeskind DS. Fluid-attenuated inversion recovery vascular hyperintensities: an important imaging marker for cerebrovascular disease. AJNR Am J Neuroradiol. 2011 Nov; 32(10):1771-5. View in: PubMed

Sanossian N, Hao Q, Liebeskind DS. The thrombus and discontinuity of FLAIR vascular hyperintensity. Arch Neurol. 2011 Jul; 68(7):950-1. View in: PubMed

Sanossian N, Ovbiagele B, Saver JL, Alger JR, Starkman S, Kim D, Ohanian AG, Buck BH, Ali LK, Duckwiler GR, Jahan R, Viñuela F, Liebeskind DS. Leukoaraiosis and collaterals in acute ischemic stroke. J Neuroimaging. 2011 Jul; 21(3):232-5. View in: PubMed

Sanossian N, Gatto NM, Ovbiagele B. Subpar utilization of dental care among Americans with a history of stroke. J Stroke Cerebrovasc Dis. 2011 May-Jun; 20(3):255-9. View in: PubMed

Liebeskind DS, Sanossian N, Yong WH, Starkman S, Tsang MP, Moya AL, Zheng DD, Abolian AM, Kim D, Ali LK, Shah SH, Towfighi A, Ovbiagele B, Kidwell CS, Tateshima S, Jahan R, Duckwiler GR, Viñuela F, Salamon N, Villablanca JP, Vinters HV, Marder VJ, Saver JL. CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke. 2011 May; 42(5):1237-43. View in: PubMed

Cheng EM, Cunningham WE, Towfighi A, Sanossian N, Bryg RJ, Anderson TL, Guterman JJ, Gross-Schulman SG, Beanes S, Jones AS, Liu H, Ettner SL, Saver JL, Vickrey BG. Randomized, controlled trial of an intervention to enable stroke survivors throughout the Los Angeles County safety net to "stay with the guidelines". Circ Cardiovasc Qual Outcomes. 2011 Mar; 4(2):229-34. View in: PubMed

Sanossian N, Starkman S, Eckstein M, Stratton S, Pratt F, Conwit R, Saver JL. Intercontinental elicitation of informed consent for enrollment in stroke research. Cerebrovasc Dis. 2010 Aug; 30(3):323-4. View in: PubMed

Kuo I, Long T, Nguyen N, Chaudry B, Karp M, Sanossian N. Ruptured intracranial mycotic aneurysm in infective endocarditis: a natural history. Case Report Med. 2010; 2010. View in: PubMed

Sanossian N, Ovbiagele B. Prevention and management of stroke in very elderly patients. Lancet Neurol. 2009 Nov; 8(11):1031-41. View in: PubMed

Sanossian N, Saver JL, Alger JR, Kim D, Duckwiler GR, Jahan R, Vinuela F, Ovbiagele B, Liebeskind DS. Angiography reveals that fluid-attenuated inversion recovery vascular hyperintensities are due to slow flow, not thrombus. AJNR Am J Neuroradiol. 2009 Mar; 30(3):564-8. View in: PubMed

Sanossian N, Starkman S, Liebeskind DS, Ali LK, Restrepo L, Hamilton S, Conwit R, Saver JL. Simultaneous ring voice-over-Internet phone system enables rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials. Cerebrovasc Dis. 2009; 28(6):539-44. View in: PubMed

Ovbiagele B, Sanossian N, Liebeskind DS, Kim D, Ali LK, Pineda S, Saver JL. Indices of kidney dysfunction and discharge outcomes in hospitalized stroke patients without known renal disease. Cerebrovasc Dis. 2009; 28(6):582-8. View in: PubMed

Sanossian N, Gatto NM, Ovbiagele B. Patterns of influenza vaccination among stroke survivors. Neuroepidemiology. 2009; 32(3):165-70. View in: PubMed

Sanossian N, Wu J, Azen SP, Varma R. Prevalence and risk factors for cerebrovascular disease in community-dwelling Latinos. Clin Neurol Neurosurg. 2008 Dec; 110(10):985-7. View in: PubMed

Sanossian N, Ovbiagele B. Probing racial and regional disparities in stroke mortality: same problem, different solutions? Ann Neurol. 2008 Nov; 64(5):483-4. View in: PubMed

Nazliel B, Starkman S, Liebeskind DS, Ovbiagele B, Kim D, Sanossian N, Ali L, Buck B, Villablanca P, Vinuela F, Duckwiler G, Jahan R, Saver JL. A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions. Stroke. 2008 Aug; 39(8):2264-7. View in: PubMed

Sanossian N, Ovbiagele B. The risk of stroke within a week of minor stroke or transient ischemic attack. Expert Opin Pharmacother. 2008 Aug; 9(12):2069-76. View in: PubMed

Sanossian N, Tarlov NE. HDL-C and LDL-C: their role in stroke pathogenesis and implications for treatment. Curr Treat Options Cardiovasc Med. 2008 Jun; 10(3):195-206. View in: PubMed

Patel N, Shatzmiller R, Sanossian N, Sahai-Srivastava S. Cryptogenic stroke in the setting of intravaginal prostaglandin therapy for elective abortion. Clin Neurol Neurosurg. 2008 May; 110(5):529-31. View in: PubMed

Sanossian N, Ovbiagele B. Drug insight: translating evidence on statin therapy into clinical benefits. Nat Clin Pract Neurol. 2008 Jan; 4(1):43-9. View in: PubMed

Keener A, Sanossian N. Niacin for stroke prevention: evidence and rationale. CNS Neurosci Ther. 2008; 14(4):287-94. View in: PubMed

Sanossian N, Ances BM, Shah SH, Kim D, Saver JL, Liebeskind DS. FLAIR vascular hyperintensity may predict stroke after TIA. Clin Neurol Neurosurg. 2007 Sep; 109(7):617-9. View in: PubMed

Bang OY, Buck BH, Saver JL, Alger JR, Yoon SR, Starkman S, Ovbiagele B, Kim D, Ali LK, Sanossian N, Jahan R, Duckwiler GR, Viñuela F, Salamon N, Villablanca JP, Liebeskind DS. Prediction of hemorrhagic transformation after recanalization therapy using T2*-permeability magnetic resonance imaging. Ann Neurol. 2007 Aug; 62(2):170-6. View in: PubMed

Sanossian N, Saver JL, Navab M, Ovbiagele B. High-density lipoprotein cholesterol: an emerging target for stroke treatment. Stroke. 2007 Mar; 38(3):1104-9. View in: PubMed

Sanossian N, Saver JL, Ovbiagele B. Aspirin and stroke severity. Stroke. 2006 Nov; 37(11):2660; author reply 2661. View in: PubMed

Sanossian N, Ohanian AG, Saver JL, Kim LI, Ovbiagele B. Frequency and determinants of nonpublication of research in the stroke literature. Stroke. 2006 Oct; 37(10):2588-92. View in: PubMed

Sanossian N, Saver JL, Kim D, Razinia T, Ovbiagele B. Do high-density lipoprotein cholesterol levels influence stroke severity? J Stroke Cerebrovasc Dis. 2006 Sep-Oct; 15(5):187-9. View in: PubMed

Marder VJ, Chute DJ, Starkman S, Abolian AM, Kidwell C, Liebeskind D, Ovbiagele B, Vinuela F, Duckwiler G, Jahan R, Vespa PM, Selco S, Rajajee V, Kim D, Sanossian N, Saver JL. Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke. Stroke. 2006 Aug; 37(8):2086-93. View in: PubMed

Sanossian N, Saver JL, Liebeskind DS, Kim D, Razinia T, Ovbiagele B. Achieving target cholesterol goals after stroke: is in-hospital statin initiation the key? Arch Neurol. 2006 Aug; 63(8):1081-3. View in: PubMed

Ovbiagele B, Liebeskind DS, Starkman S, Sanossian N, Kim D, Razinia T, Saver JL. Are elevated admission calcium levels associated with better outcomes after ischemic stroke? Neurology. 2006 Jul 11; 67(1):170-3. View in: PubMed

Shah SH, Liebeskind DS, Saver JL, Starkman S, Vinuela F, Duckwiler G, Jahan R, Kim D, Sanossian N, Vespa P, Ovbiagele B. Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke. Neurology. 2006 Jun 13; 66(11):1745-6. View in: PubMed

Sanossian N, Saver JL, Rajajee V, Selco SL, Kim D, Razinia T, Ovbiagele B. Premorbid antiplatelet use and ischemic stroke outcomes. Neurology. 2006 Feb 14; 66(3):319-23. View in: PubMed

Ovbiagele B, Saver JL, Sanossian N, Salamon N, Villablanca P, Alger JR, Razinia T, Kim D, Liebeskind DS. Predictors of cerebral microbleeds in acute ischemic stroke and TIA patients. Cerebrovasc Dis. 2006; 22(5-6):378-83. View in: PubMed

Sanossian N, Ovbiagele B. Multimodality stroke prevention. Neurologist. 2006 Jan; 12(1):14-31. View in: PubMed

Sanossian N, Haut S. Chronic diarrhea associated with vagal nerve stimulation. Neurology. 2002 Jan 22; 58(2):330. View in: PubMed

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