Faculty

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Nyam Osor Chimge, PhD
Assistant Professor of Research Medicine
Medicine
CSA 210 Health Sciences Campus Los Angeles
+1 323 442 3914

Awards

Joint Mongolian Academy of Sciences and Third World Academy of Sciences (TWAS): Award for Scientific Excellence, 2000

Publications

Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 May 19; 62(4):507-19. View in: PubMed

Morimoto E, Li M, Khalid AB, Krum SA, Chimge NO, Frenkel B. Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation. J Cell Physiol. 2016 Apr 6. View in: PubMed

Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016; 7:10751. View in: PubMed

Martin A, Xiong J, Koromila T, Ji JS, Chang S, Song YS, Miller JL, Han CY, Kostenuik P, Krum SA, Chimge NO, Gabet Y, Frenkel B. Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. Bone. 2015 Jun; 75:96-104. View in: PubMed

Little GH, Baniwal SK, Adisetiyo H, Groshen S, Chimge NO, Kim SY, Khalid O, Hawes D, Jones JO, Pinski J, Schones DE, Frenkel B. Differential Effects of RUNX2 on the Androgen Receptor in Prostate Cancer: Synergistic Stimulation of a Gene Set Exemplified by SNAI2 and Subsequent Invasiveness. Cancer Res. 2014 May 15; 74(10):2857-68. View in: PubMed

Chimge NO, Frenkel B. The RUNX family in breast cancer: relationships with estrogen signaling. Oncogene. 2013 Apr 25; 32(17):2121-30. View in: PubMed

Baniwal SK, Chimge NO, Jordan VC, Tripathy D, Frenkel B. Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner. PLoS One. 2013; 8(6):e62361. View in: PubMed

Baniwal SK, Little GH, Chimge NO, Frenkel B. Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation. J Cell Physiol. 2012 May; 227(5):2276-82. View in: PubMed

Chimge NO, Makeyev AV, Waigel SJ, Enkhmandakh B, Bayarsaihan D. PI3K/Akt-dependent functions of TFII-I transcription factors in mouse embryonic stem cells. J Cell Biochem. 2012 Apr; 113(4):1122-31. View in: PubMed

Chimge NO, Baniwal SK, Luo J, Coetzee S, Khalid O, Berman BP, Tripathy D, Ellis MJ, Frenkel B. Opposing effects of runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness. Clin Cancer Res. 2012 Feb 1; 18(3):901-11. View in: PubMed

Chimge NO, Baniwal SK, Little GH, Chen YB, Kahn M, Tripathy D, Borok Z, Frenkel B. Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011 Dec; 13(6):R127. View in: PubMed

Pramanik S, Cui X, Wang HY, Chimge NO, Hu G, Shen L, Gao R, Li H. Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region. BMC Genomics. 2011; 12:78. View in: PubMed

Chimge NO, Bayarsaihan D. Generation of neural crest progenitors from human embryonic stem cells. J Exp Zool B Mol Dev Evol. 2010 Mar 15; 314(2):95-103. View in: PubMed

Enkhmandakh B, Makeyev AV, Erdenechimeg L, Ruddle FH, Chimge NO, Tussie-Luna MI, Roy AL, Bayarsaihan D. Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development. Proc Natl Acad Sci U S A. 2009 Jan 6; 106(1):181-6. View in: PubMed

Chimge NO, Makeyev AV, Ruddle FH, Bayarsaihan D. Identification of the TFII-I family target genes in the vertebrate genome. Proc Natl Acad Sci U S A. 2008 Jul 1; 105(26):9006-10. View in: PubMed

Hirayasu K, Ohashi J, Tanaka H, Kashiwase K, Ogawa A, Takanashi M, Satake M, Jia GJ, Chimge NO, Sideltseva EW, Tokunaga K, Yabe T. Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians. Am J Hum Genet. 2008 May; 82(5):1075-83. View in: PubMed

Chimge NO, Mungunsukh O, Ruddle F, Bayarsaihan D. Expression profiling of BEN regulated genes in mouse embryonic fibroblasts. J Exp Zool B Mol Dev Evol. 2007 May 15; 308(3):209-24. View in: PubMed

Chimge NO, Mungunsukh O, Ruddle F, Bayarsaihan D. Gene expression analysis of TFII-I modulated genes in mouse embryonic fibroblasts. J Exp Zool B Mol Dev Evol. 2007 May 15; 308(3):225-35. View in: PubMed

Chimge NO, Ruddle F, Bayarsaihan D. Laser-assisted microdissection (LAM) in developmental biology. J Exp Zool B Mol Dev Evol. 2007 Mar 15; 308(2):113-8. View in: PubMed

Greenawalt DM, Cui X, Wu Y, Lin Y, Wang HY, Luo M, Tereshchenko IV, Hu G, Li JY, Chu Y, Azaro MA, Decoste CJ, Chimge NO, Gao R, Shen L, Shih WJ, Lange K, Li H. Strong correlation between meiotic crossovers and haplotype structure in a 2. 5-Mb region on the long arm of chromosome 21. Genome Res. 2006 Feb; 16(2):208-14. View in: PubMed

Li H, Cui X, Pramanik S, Chimge NO. Genetic diversity of the human immunoglobulin heavy chain VH region. Immunol Rev. 2002 Dec; 190:53-68. View in: PubMed

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