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Parviz Minoo, PhD
Professor of Pediatrics
Director of Research Program
GLB 1-G1 1801 Marengo Street Off Campus Los Angeles
+1 323 226 3406


Li A, Lee RH, Felix JC, Minoo P, Goodwin TM. Alteration of secretory leukocyte protease inhibitor in human myometrium during labor. Am J Obstet Gynecol. 2009 Mar; 200(3):311. e1-311. e10. View in: PubMed

Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED. Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):395-406. View in: PubMed

Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z. p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. View in: PubMed

Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B. GRP78 Regulates ER Homeostasis and Distal Epithelial Cell Survival During Lung Development. Am J Respir Cell Mol Biol. 2016 Jan 27. View in: PubMed

Liebler JM, Marconett CN, Juul N, Wang H, Liu Y, Flodby P, Laird-Offringa IA, Minoo P, Zhou B. Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. View in: PubMed

Li A, Ma S, Smith SM, Lee MK, Fischer A, Borok Z, Bellusci S, Li C, Minoo P. Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016; 14(1):19. View in: PubMed

Xing Y, Wang R, Li C, Minoo P. PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway. Dev Biol. 2015 Dec 1; 408(1):56-65. View in: PubMed

Al Alam D, El Agha E, Sakurai R, Kheirollahi V, Moiseenko A, Danopoulos S, Shrestha A, Schmoldt C, Quantius J, Herold S, Chao CM, Tiozzo C, De Langhe S, Plikus MV, Thornton M, Grubbs B, Minoo P, Rehan VK, Bellusci S. Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 1; 142(23):4139-50. View in: PubMed

Li C, Bellusci S, Borok Z, Minoo P. Non-canonical WNT signalling in the lung. J Biochem. 2015 Nov; 158(5):355-65. View in: PubMed

Yang CY, Lien R, Fu RH, Chu SM, Hsu JF, Lai JY, Minoo P, Chiang MC. Prognostic factors and concomitant anomalies in neonatal gastric perforation. J Pediatr Surg. 2015 Aug; 50(8):1278-82. View in: PubMed

Li C, Li M, Li S, Xing Y, Yang CY, Li A, Borok Z, De Langhe S, Minoo P. Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. Stem Cells. 2015 Mar; 33(3):999-1012. View in: PubMed

Chao CM, El Agha E, Tiozzo C, Minoo P, Bellusci S. A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia. Front Med (Lausanne). 2015; 2:27. View in: PubMed

Sureshbabu A, Syed MA, Boddupalli CS, Dhodapkar MV, Homer RJ, Minoo P, Bhandari V. Conditional overexpression of TGFß1 promotes pulmonary inflammation, apoptosis and mortality via TGFßR2 in the developing mouse lung. Respir Res. 2015; 16(1):4. View in: PubMed

Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. View in: PubMed

Lee MK, Smith SM, Murray S, Pham LD, Minoo P, Nielsen HC. Dihydrotestosterone Potentiates EGF-Induced ERK Activation by Inducing SRC in Fetal Lung Fibroblasts. Am J Respir Cell Mol Biol. 2014 Jul; 51(1):114-24. View in: PubMed

Lee MK, Smith SM, Banerjee MM, Li C, Minoo P, Volpe MV, Nielsen HC. The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2014 Feb; 306(4):L316-25. View in: PubMed

El Agha E, Herold S, Alam DA, Quantius J, Mackenzie B, Carraro G, Moiseenko A, Chao CM, Minoo P, Seeger W, Bellusci S. Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development. 2014 Jan; 141(2):296-306. View in: PubMed

Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013 Sep; 140(18):3731-42. View in: PubMed

Li C, Li A, Xing Y, Li M, Chan B, Ouyang R, Taketo MM, Kucherlapati R, Borok Z, Minoo P. Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2. 1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1; 378(1):13-24. View in: PubMed

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. View in: PubMed

Minoo P, Wolkenhauer O, Guttentag S. Systems biology and pediatric research. Pediatr Res. 2013 Apr; 73(4 Pt 2):499-501. View in: PubMed

Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Borok Z, Li C, Minoo P. Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS One. 2013; 8(4):e62215. View in: PubMed

Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P. Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1; 122(11):3862-72. View in: PubMed

Xing Y, Li A, Borok Z, Li C, Minoo P. NOTCH1 Is Required for Regeneration of Clara Cells During Repair of Airway Injury. Stem Cells. 2012 May; 30(5):946-55. View in: PubMed

Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Virender R, De Langhe S, Di Cristofano A, Bellusci S, Minoo P. Embryonic epithelial Pten deletion through Nkx2. 1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-22. View in: PubMed

Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. Interactions Between ß-Catenin and Transforming Growth Factor-ß Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP). J Biol Chem. 2012 Mar 2; 287(10):7026-38. View in: PubMed

Demaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z. Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. View in: PubMed

Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z. Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. View in: PubMed

Londhe VA, Maisonet TM, Lopez B, Jeng JM, Li C, Minoo P. A subset of epithelial cells with CCSP promoter activity participates in alveolar development. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):804-12. View in: PubMed

Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan 4; 121(1):277-87. View in: PubMed

Londhe VA, Maisonet TM, Lopez B, Jeng JM, Xiao J, Li C, Minoo P. Conditional deletion of epithelial IKKß impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011; 12:134. View in: PubMed

Li A, Xing Y, Chan B, Heisterkamp N, Groffen J, Borok Z, Minoo P, Li C. Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010 Aug; 239(8):2288-97. View in: PubMed

Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. View in: PubMed

Minoo P, Li C. Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease. Int J Biochem Cell Biol. 2010 Jun; 42(6):809-12. View in: PubMed

Xing Y, Li C, Li A, Sridurongrit S, Tiozzo C, Bellusci S, Borok Z, Kaartinen V, Minoo P. Signaling via Alk5 controls the ontogeny of lung Clara cells. Development. 2010 Mar; 137(5):825-33. View in: PubMed

Cunnick JM, Schmidhuber S, Chen G, Yu M, Yi SJ, Cho YJ, Kaartinen V, Minoo P, Warburton D, Groffen J, Heisterkamp N. Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009 Nov; 29(21):5742-50. View in: PubMed

Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P. Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. View in: PubMed

Li C, Li A, Li M, Xing Y, Chen H, Hu L, Tiozzo C, Anderson S, Taketo MM, Minoo P. Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis. Dev Biol. 2009 Oct 1; 334(1):97-108. View in: PubMed

Tiozzo C, De Langhe S, Carraro G, Alam DA, Nagy A, Wigfall C, Hajihosseini MK, Warburton D, Minoo P, Bellusci S. Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res. 2009 Oct; 66(4):386-90. View in: PubMed

Tai CC, Sala FG, Ford HR, Wang KS, Li C, Minoo P, Grikscheit TC, Bellusci S. Wnt5a knock-out mouse as a new model of anorectal malformation. J Surg Res. 2009 Oct; 156(2):278-82. View in: PubMed

Gupte VV, Ramasamy SK, Reddy R, Lee J, Weinreb PH, Violette SM, Guenther A, Warburton D, Driscoll B, Minoo P, Bellusci S. Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):424-36. View in: PubMed

Li M, Li C, Liu YH, Xing Y, Hu L, Borok Z, Kwong KY, Minoo P. Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J Biol Chem. 2008 Dec 26; 283(52):36257-64. View in: PubMed

Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. View in: PubMed

Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z. GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. View in: PubMed

Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P. Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2. 1 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. View in: PubMed

Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z. Rat aquaporin-5 4. 3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. View in: PubMed

Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. Foxp2 inhibits Nkx2. 1-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. View in: PubMed

Kweon SM, Cho YJ, Minoo P, Groffen J, Heisterkamp N. Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. J Biol Chem. 2008 Feb 8; 283(6):3023-30. View in: PubMed

Londhe VA, Nguyen HT, Jeng JM, Li X, Li C, Tiozzo C, Zhu N, Minoo P. NF-kB induces lung maturation during mouse lung morphogenesis. Dev Dyn. 2008 Feb; 237(2):328-38. View in: PubMed

Minoo P, Hu L, Zhu N, Borok Z, Bellusci S, Groffen J, Kardassis D, Li C. SMAD3 prevents binding of NKX2. 1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains. Nucleic Acids Res. 2008 Jan; 36(1):179-88. View in: PubMed

De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S. Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008; 3(1):e1516. View in: PubMed

Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol. 2008; 9:11. View in: PubMed

Cayabyab RG, Kwong K, Jones C, Minoo P, Durand M. Lung inflammation and pulmonary function in infants with meconium aspiration syndrome. Pediatr Pulmonol. 2007 Oct; 42(10):898-905. View in: PubMed

Ding W, Shi W, Bellusci S, Groffen J, Heisterkamp N, Minoo P, Warburton D. Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. View in: PubMed

Ramasamy SK, Mailleux AA, Gupte VV, Mata F, Sala FG, Veltmaat JM, Del Moral PM, De Langhe S, Parsa S, Kelly LK, Kelly R, Shia W, Keshet E, Minoo P, Warburton D, Bellusci S. Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol. 2007 Jul 15; 307(2):237-47. View in: PubMed

Li A, Felix JC, Yang W, Xiong DW, Minoo P, Jain JK. Effect of mifepristone on endometrial matrix metalloproteinase expression and leukocyte abundance in new medroxyprogesterone acetate users. Contraception. 2007 Jul; 76(1):57-65. View in: PubMed

Zhu NL, Li C, Huang HH, Sebald M, Londhe VA, Heisterkamp N, Warburton D, Bellusci S, Minoo P. TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. View in: PubMed

Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z. Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. View in: PubMed

Zhou B, Ann DK, Li X, Kim KJ, Lin H, Minoo P, Crandall ED, Borok Z. Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. View in: PubMed

Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol. 2007 Apr; 27(8):3131-42. View in: PubMed

Minoo P, Hu L, Xing Y, Zhu NL, Chen H, Li M, Borok Z, Li C. Physical and functional interactions between homeodomain NKX2. 1 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol. 2007 Mar; 27(6):2155-65. View in: PubMed

Garingo A, Tesoriero L, Cayabyab R, Durand M, Blahnik M, Sardesai S, Ramanathan R, Jones C, Kwong K, Li C, Minoo P. Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia. Pediatr Res. 2007 Feb; 61(2):197-202. View in: PubMed

Jain JK, Li A, Yang W, Minoo P, Felix JC. Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate. Fertil Steril. 2007 Jan; 87(1):8-23. View in: PubMed

Borok Z, Li C, Liebler J, Aghamohammadi N, Londhe VA, Minoo P. Developmental pathways and specification of intrapulmonary stem cells. Pediatr Res. 2006 Apr; 59(4 Pt 2):84R-93R. View in: PubMed

Jain JK, Li A, Yang W, Minoo P, Felix JC. Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate. Hum Reprod. 2006 Mar; 21(3):798-809. View in: PubMed

Li C, Hu L, Xiao J, Chen H, Li JT, Bellusci S, Delanghe S, Minoo P. Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol. 2005 Nov 1; 287(1):86-97. View in: PubMed

Jain JK, Li A, Nucatola DL, Minoo P, Felix JC. Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways. Biol Reprod. 2005 Aug; 73(2):382-8. View in: PubMed

Li A, Felix JC, Minoo P, Amezcua CA, Jain JK. Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells. Fertil Steril. 2005 Jul; 84(1):202-11. View in: PubMed

Jain JK, Li A, Minoo P, Nucatola DL, Felix JC. The effect of nonoxynol-9 on human endometrium. Contraception. 2005 Feb; 71(2):137-42. View in: PubMed

Kang Y, Hebron H, Ozbun L, Mariano J, Minoo P, Jakowlew SB. Nkx2. 1 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis. Mol Carcinog. 2004 Aug; 40(4):212-31. View in: PubMed

Pan Q, Li C, Xiao J, Kimura S, Rubenstein J, Puelles L, Minoo P. In vivo characterization of the Nkx2. 1 promoter/enhancer elements in transgenic mice. Gene. 2004 Apr 28; 331:73-82. View in: PubMed

Zhu NL, Li C, Xiao J, Minoo P. NKX2. 1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells. Gene. 2004 Feb 18; 327(1):25-36. View in: PubMed

Xiao J, Li C, Zhu NL, Borok Z, Minoo P. Timeless in lung morphogenesis. Dev Dyn. 2003 Sep; 228(1):82-94. View in: PubMed

Li C, Zhu NL, Tan RC, Ballard PL, Derynck R, Minoo P. Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2. 1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. View in: PubMed

Li C, Xiao J, Hormi K, Borok Z, Minoo P. Wnt5a participates in distal lung morphogenesis. Dev Biol. 2002 Aug 1; 248(1):68-81. View in: PubMed

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