Faculty

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Parviz Minoo, PhD
Professor of Pediatrics
Director of Research Program
Pediatrics
GLB 1-G1 1801 Marengo Street Off Campus Los Angeles
+1 323 226 3406

Publications

Alteration of secretory leukocyte protease inhibitor in human myometrium during labor. Am J Obstet Gynecol. 2009 Mar; 200(3):311. e1-311. e10. View in: PubMed

Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development. Stem Cells. 2017 Apr 03. View in: PubMed

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 Sep; 55(3):395-406. View in: PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. View in: PubMed

GRP78 Regulates ER Homeostasis and Distal Epithelial Cell Survival During Lung Development. Am J Respir Cell Mol Biol. 2016 Jan 27. View in: PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. View in: PubMed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016; 14(1):19. View in: PubMed

PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway. Dev Biol. 2015 Dec 1; 408(1):56-65. View in: PubMed

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 1; 142(23):4139-50. View in: PubMed

Non-canonical WNT signalling in the lung. J Biochem. 2015 Nov; 158(5):355-65. View in: PubMed

Prognostic factors and concomitant anomalies in neonatal gastric perforation. J Pediatr Surg. 2015 Aug; 50(8):1278-82. View in: PubMed

Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. Stem Cells. 2015 Mar; 33(3):999-1012. View in: PubMed

A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia. Front Med (Lausanne). 2015; 2:27. View in: PubMed

Conditional overexpression of TGFß1 promotes pulmonary inflammation, apoptosis and mortality via TGFßR2 in the developing mouse lung. Respir Res. 2015; 16(1):4. View in: PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. View in: PubMed

Dihydrotestosterone Potentiates EGF-Induced ERK Activation by Inducing SRC in Fetal Lung Fibroblasts. Am J Respir Cell Mol Biol. 2014 Jul; 51(1):114-24. View in: PubMed

The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2014 Feb; 306(4):L316-25. View in: PubMed

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development. 2014 Jan; 141(2):296-306. View in: PubMed

Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013 Sep; 140(18):3731-42. View in: PubMed

Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2. 1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 1; 378(1):13-24. View in: PubMed

Molecular determinants of lung development. Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. View in: PubMed

Systems biology and pediatric research. Pediatr Res. 2013 Apr; 73(4 Pt 2):499-501. View in: PubMed

Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS One. 2013; 8(4):e62215. View in: PubMed

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1; 122(11):3862-72. View in: PubMed

NOTCH1 Is Required for Regeneration of Clara Cells During Repair of Airway Injury. Stem Cells. 2012 May; 30(5):946-55. View in: PubMed

Embryonic epithelial Pten deletion through Nkx2. 1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-22. View in: PubMed

Interactions Between ß-Catenin and Transforming Growth Factor-ß Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP). J Biol Chem. 2012 Mar 2; 287(10):7026-38. View in: PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. View in: PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. View in: PubMed

A subset of epithelial cells with CCSP promoter activity participates in alveolar development. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):804-12. View in: PubMed

Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan 4; 121(1):277-87. View in: PubMed

Conditional deletion of epithelial IKKß impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis. Respir Res. 2011; 12:134. View in: PubMed

Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. View in: PubMed

Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010 Aug; 239(8):2288-97. View in: PubMed

Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease. Int J Biochem Cell Biol. 2010 Jun; 42(6):809-12. View in: PubMed

Signaling via Alk5 controls the ontogeny of lung Clara cells. Development. 2010 Mar; 137(5):825-33. View in: PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009 Nov; 29(21):5742-50. View in: PubMed

Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. View in: PubMed

Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis. Dev Biol. 2009 Oct 1; 334(1):97-108. View in: PubMed

Wnt5a knock-out mouse as a new model of anorectal malformation. J Surg Res. 2009 Oct; 156(2):278-82. View in: PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res. 2009 Oct; 66(4):386-90. View in: PubMed

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):424-36. View in: PubMed

Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J Biol Chem. 2008 Dec 26; 283(52):36257-64. View in: PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. View in: PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. View in: PubMed

Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2. 1 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. View in: PubMed

Rat aquaporin-5 4. 3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. View in: PubMed

Foxp2 inhibits Nkx2. 1-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. View in: PubMed

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. J Biol Chem. 2008 Feb 8; 283(6):3023-30. View in: PubMed

NF-kB induces lung maturation during mouse lung morphogenesis. Dev Dyn. 2008 Feb; 237(2):328-38. View in: PubMed

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol. 2008; 9:11. View in: PubMed

SMAD3 prevents binding of NKX2. 1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains. Nucleic Acids Res. 2008 Jan; 36(1):179-88. View in: PubMed

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008; 3(1):e1516. View in: PubMed

Lung inflammation and pulmonary function in infants with meconium aspiration syndrome. Pediatr Pulmonol. 2007 Oct; 42(10):898-905. View in: PubMed

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. View in: PubMed

Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol. 2007 Jul 15; 307(2):237-47. View in: PubMed

Effect of mifepristone on endometrial matrix metalloproteinase expression and leukocyte abundance in new medroxyprogesterone acetate users. Contraception. 2007 Jul; 76(1):57-65. View in: PubMed

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. View in: PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. View in: PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. View in: PubMed

The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol. 2007 Apr; 27(8):3131-42. View in: PubMed

Physical and functional interactions between homeodomain NKX2. 1 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol. 2007 Mar; 27(6):2155-65. View in: PubMed

Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia. Pediatr Res. 2007 Feb; 61(2):197-202. View in: PubMed

Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate. Fertil Steril. 2007 Jan; 87(1):8-23. View in: PubMed

Developmental pathways and specification of intrapulmonary stem cells. Pediatr Res. 2006 Apr; 59(4 Pt 2):84R-93R. View in: PubMed

Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate. Hum Reprod. 2006 Mar; 21(3):798-809. View in: PubMed

Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol. 2005 Nov 1; 287(1):86-97. View in: PubMed

Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways. Biol Reprod. 2005 Aug; 73(2):382-8. View in: PubMed

Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells. Fertil Steril. 2005 Jul; 84(1):202-11. View in: PubMed

The effect of nonoxynol-9 on human endometrium. Contraception. 2005 Feb; 71(2):137-42. View in: PubMed

Nkx2. 1 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis. Mol Carcinog. 2004 Aug; 40(4):212-31. View in: PubMed

In vivo characterization of the Nkx2. 1 promoter/enhancer elements in transgenic mice. Gene. 2004 Apr 28; 331:73-82. View in: PubMed

NKX2. 1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells. Gene. 2004 Feb 18; 327(1):25-36. View in: PubMed

Timeless in lung morphogenesis. Dev Dyn. 2003 Sep; 228(1):82-94. View in: PubMed

Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2. 1 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. View in: PubMed

Wnt5a participates in distal lung morphogenesis. Dev Biol. 2002 Aug 1; 248(1):68-81. View in: PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 18; ajplung. 00005. 2015. View in: PubMed

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