Faculty

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Paul K Pattengale, MD
Professor of Pathology
Pediatrics
CHL MailStop32 Off Campus Los Angeles
+1 323 361 5608

Publications

Xiao Y, Fu X, Pattengale P, Dien Bard J, Xu YK, O'Gorman MR. A sensitive LC-MS/MS method for the quantification of urinary 8-iso-prostaglandin F2a (8-iso-PGF2a) including pediatric reference interval. Clin Chim Acta. 2016 Sep 1; 460:128-34. View in: PubMed

Moschiano E, Raca G, Fu C, Pattengale PK, Oberley MJ. Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia. Leuk Res Rep. 2016; 6:29-32. View in: PubMed

Zhou S, Parham DM, Yung E, Pattengale P, Wang L. Quantification of Glypican 3, Beta-catenin and Claudin-1 Protein Expression in Hepatoblastoma and Pediatric Hepatocellular Carcinoma by Color Deconvolution. Histopathology. 2015 May 4. View in: PubMed

Acree SC, Tovar JP, Pattengale PK, Wang LL, Church JA, Gaynon PS, Cassarino DS. Subcutaneous Panniculitis-like T-cell lymphoma in two pediatric patients: an HIV-positive adolescent and a 4-month-old infant. Fetal Pediatr Pathol. 2013 Jun; 32(3):175-83. View in: PubMed

Fu X, Xu YK, Chan P, Pattengale PK. Simple, Fast, and Simultaneous Detection of Plasma Total Homocysteine, Methylmalonic Acid, Methionine, and 2-Methylcitric Acid Using Liquid Chromatography and Mass Spectrometry (LC/MS/MS). JIMD Rep. 2013; 10:69-78. View in: PubMed

Nachman JB, Sposto R, Herzog P, Gilchrist GS, Wolden SL, Thomson J, Kadin ME, Pattengale P, Davis PC, Hutchinson RJ, White K. Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin's disease who achieve a complete response to chemotherapy. J Clin Oncol. 2002 Sep 15; 20(18):3765-71. View in: PubMed

Morse HC, Anver MR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Jaffe ES, Kogan SC, MacLennan IC, Pattengale PK, Ward JM. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood. 2002 Jul 1; 100(1):246-58. View in: PubMed

Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002 Jul 1; 100(1):238-45. View in: PubMed

Hemmeryckx B, Reichert A, Watanabe M, Kaartinen V, de Jong R, Pattengale PK, Groffen J, Heisterkamp N. BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene. 2002 May 9; 21(20):3225-31. View in: PubMed

Carlton WW, Boitnott JK, Dungworth DL, Ernst H, Hayashi Y, Mohr U, Parodi AL, Pattengale PK, Rittinghausen S, Ward JM. Assessment of the morphology and significance of the lymph nodal and hepatic lesions produced in rats by the feeding of certain mineral oils and waxes. Proceedings of a pathology workshop held at the Fraunhofer Institute of Toxicology and Aerosol Research Hannover, Germany, May 7-9, 2001. Exp Toxicol Pathol. 2001 Sep; 53(4):247-55. View in: PubMed

Heisterkamp N, Voncken JW, Senadheera D, Hemmeryckx B, Gonzalez-Gomez I, Reichert A, Pattengale PK, Groffen J. The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice. Int J Mol Med. 2001 Apr; 7(4):351-7. View in: PubMed

Hemmeryckx B, van Wijk A, Reichert A, Kaartinen V, de Jong R, Pattengale PK, Gonzalez-Gomez I, Groffen J, Heisterkamp N. Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice. Cancer Res. 2001 Feb 15; 61(4):1398-405. View in: PubMed

Deng P, Wang YL, Shahbazian VL, Pattengale PK. Biological characterization of uncleavable plasma membrane-anchored human macrophage colony-stimulating factor. Biochem Biophys Res Commun. 2000 Sep 16; 276(1):304-11. View in: PubMed

Heisterkamp N, Voncken JW, Senadheera D, Gonzalez-Gomez I, Reichert A, Haataja L, Reinikainen A, Pattengale PK, Groffen J. Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants. Blood. 2000 Sep 15; 96(6):2226-32. View in: PubMed

Stripecke R, Skelton DC, Pattengale PK, Shimada H, Kohn DB. Combination of CD80 and granulocyte-macrophage colony-stimulating factor coexpression by a leukemia cell vaccine: preclinical studies in a murine model recapitulating Philadelphia chromosome-positive acute lymphoblastic leukemia. Hum Gene Ther. 1999 Sep 1; 10(13):2109-22. View in: PubMed

Crooks GM, Fuller J, Petersen D, Izadi P, Malik P, Pattengale PK, Kohn DB, Gasson JC. Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. Blood. 1999 Jul 15; 94(2):519-28. View in: PubMed

Kundu RK, Sangiorgi F, Wu LY, Pattengale PK, Hinton DR, Gill PS, Maxson R. Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma. Blood. 1999 Jul 1; 94(1):275-82. View in: PubMed

Deng P, Wang YL, Haga Y, Pattengale PK. Multiple factors determine the selection of the ectodomain cleavage site of human cell surface macrophage colony-stimulating factor. Biochemistry. 1998 Dec 22; 37(51):17898-904. View in: PubMed

Stripecke R, Skelton DC, Gruber T, Afar D, Pattengale PK, Witte ON, Kohn DB. Immune response to Philadelphia chromosome-positive acute lymphoblastic leukemia induced by expression of CD80, interleukin 2, and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther. 1998 Sep 20; 9(14):2049-62. View in: PubMed

Pattengale PK. Role of interleukin-6 in the pathogenesis of murine plasmacytoma and human multiple myeloma. Am J Pathol. 1997 Sep; 151(3):647-9. View in: PubMed

Deng P, Rettenmier CW, Pattengale PK. Structural requirements for the ectodomain cleavage of human cell surface macrophage colony-stimulating factor. J Biol Chem. 1996 Jul 5; 271(27):16338-43. View in: PubMed

Voncken JW, Kaartinen V, Pattengale PK, Germeraad WT, Groffen J, Heisterkamp N. BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice. Blood. 1995 Dec 15; 86(12):4603-11. View in: PubMed

Voncken JW, van Schaick H, Kaartinen V, Deemer K, Coates T, Landing B, Pattengale P, Dorseuil O, Bokoch GM, Groffen J, et al. Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995 Mar 10; 80(5):719-28. View in: PubMed

Suchman EL, Pattengale PK, Fan H. Leukaemogenesis by the delta Mo + SV Moloney murine leukaemia virus (M-MuLV) variant in E mu pim-1 transgenic mice: high frequency of recombination with a solo endogenous M-MuLV LTR in vivo. J Gen Virol. 1995 Feb; 76 ( Pt 2):347-56. View in: PubMed

Pattengale PK. Tumours of the lymphohaematopoietic system. IARC Sci Publ. 1994; (111):651-70. View in: PubMed

Umiel T, Rettenmier CW, Siegel S, Ota S, Shimada H, Tran TW, Pattengale PK. Establishment and characterization of a human mixed-lineage, T-lymphoid/myeloid cell line (USP-91). Blood. 1993 Sep 15; 82(6):1829-37. View in: PubMed

Gersuk GM, Carmel R, Pattamakom S, Challita PM, Rabinowitz AP, Pattengale PK. Quantitative and functional studies of impaired natural killer (NK) cells in patients with myelofibrosis, essential thrombocythemia, and polycythemia vera. I. A potential role for platelet-derived growth factor in defective NK cytotoxicity. Nat Immun. 1993 May-Jun; 12(3):136-51. View in: PubMed

Cardiff RD, Leder A, Kuo A, Pattengale PK, Leder P. Multiple tumor types appear in a transgenic mouse with the ras oncogene. Am J Pathol. 1993 Apr; 142(4):1199-207. View in: PubMed

Umiel T, Pattengale P, Weinberg K. Recombination activating gene-1 (RAG-1) expression in all differentiation stages of B-lineage precursor acute lymphoblastic leukemia. Leukemia. 1993 Mar; 7(3):435-40. View in: PubMed

Voncken JW, Griffiths S, Greaves MF, Pattengale PK, Heisterkamp N, Groffen J. Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Cancer Res. 1992 Aug 15; 52(16):4534-9. View in: PubMed

Voncken JW, Morris C, Pattengale P, Dennert G, Kikly C, Groffen J, Heisterkamp N. Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice. Blood. 1992 Feb 15; 79(4):1029-36. View in: PubMed

Heisterkamp N, Jenster G, Kioussis D, Pattengale PK, Groffen J. Human bcr-abl gene has a lethal effect on embryogenesis. Transgenic Res. 1991 Dec; 1(1):45-53. View in: PubMed

Gersuk GM, Westermark B, Mohabeer AJ, Challita PM, Pattamakom S, Pattengale PK. Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF). III. Membrane binding studies and differential biological effect of recombinant PDGF isoforms. Scand J Immunol. 1991 May; 33(5):521-32. View in: PubMed

Heisterkamp N, Jenster G, ten Hoeve J, Zovich D, Pattengale PK, Groffen J. Acute leukaemia in bcr/abl transgenic mice. Nature. 1990 Mar 15; 344(6263):251-3. View in: PubMed

Ellison DJ, Hu E, Zovich D, Pinter-Brown L, Pattengale PK. Immunogenetic analysis of bone marrow aspirates in patients with non-Hodgkin lymphomas. Am J Hematol. 1990 Mar; 33(3):160-6. View in: PubMed

Gersuk GM, Carmel R, Pattengale PK. Platelet-derived growth factor concentrations in platelet-poor plasma and urine from patients with myeloproliferative disorders. Blood. 1989 Nov 15; 74(7):2330-4. View in: PubMed

Pattengale PK, Stewart TA, Leder A, Sinn E, Muller W, Tepler I, Schmidt E, Leder P. Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes. Am J Pathol. 1989 Jul; 135(1):39-61. View in: PubMed

Chang WC, Fujimiya Y, Casteel N, Pattengale P. Natural killer cell immunodeficiency in patients with chronic myelogenous leukemia. III. Defective interleukin-2 production by T-helper and natural killer cells. Int J Cancer. 1989 Apr 15; 43(4):591-7. View in: PubMed

Gersuk GM, Chang WC, Pattengale PK. Inhibition of human natural killer cell activity by platelet-derived growth factor. II. Membrane binding studies, effects of recombinant IFN-alpha and IL-2, and lack of effect on T cell and antibody-dependent cellular cytotoxicity. J Immunol. 1988 Dec 1; 141(11):4031-8. View in: PubMed

Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988 Jul 1; 54(1):105-15. View in: PubMed

Pattengale PK, Frith CH. Contributions of recent research to the classification of spontaneous lymphoid cell neoplasms in mice. Crit Rev Toxicol. 1986; 16(3):185-212. View in: PubMed

Fredrickson TN, Morse HC, Yetter RA, Rowe WP, Hartley JW, Pattengale PK. Multiparameter analyses of spontaneous nonthymic lymphomas occurring in NFS/N mice congenic for ecotropic murine leukemia viruses. Am J Pathol. 1985 Nov; 121(2):349-60. View in: PubMed

Pattengale PK, Taylor CR. Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias. Am J Pathol. 1983 Nov; 113(2):237-65. View in: PubMed

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