Faculty

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Preet M Chaudhary, MD, PhD
Chief, Jane Anne Nohl Division of Hematolody and Center For The Study of Blood Diseases Professor, Department of Medicine Associate Director For Translational Research Co Leader, Leukemia Lymphoma Program
Medicine
NOR 3468 Health Sciences Campus Los Angeles
+1 323 865 3950

Overview

Preet M. Chaudhary, M.D., Ph.D. is chief of the Jane Anne Nohl Division of Hematology and Center for the study of Blood Diseases in the Department of Medicine, and coleader of the Molecular Genetics Program at the USC Norris Comprehensive Cancer Center. He is also Professor of Medicine, Ronald H. Bloom Family Chair in Lymphoma Research, and Program Director of the USC/Norris Blood and Marrow Transplant Program.

As a physician-scientist dedicated to hematologic oncology, Dr. Chaudhary has research interests in several areas of cancer, including AIDS-associated cancers, cancer drug resistance, biology of normal and leukemic hematopoietic stem cells, programmed cell death and cellular signaling. He is also interested in molecularly targeted and cellular therapies for leukemias, lymphomas, multiple myeloma and solid tumors. Current work in Dr. Chaudhary's laboratory is focused on developing novel strategies to improve the outcome of stem cell transplantation and the use of chimeric antigen receptor modified T cells for the treatment of cancer.

Dr. Chaudhary holds six U.S. patents and has published in some of the top scientific journals, including Cell, Immunity, JNCI, PNAS and Blood. He has served as a peer-reviewer for several national and international cancer research funding agencies and has been elected to the prestigious American Society for Clinical Investigations, an honor society of the top physician-scientists in the country.

Awards

Leukemia Lymphoma Society: Translational Research Award, 2005-2008

Leukemia Lymphoma Society: Translational Research Award, 2008-2011

Multiple Myeloma Research Foundation: Senior Research Award, 2005-2006

American Society for Clinical Investigations

Leukemia Research Foundation: New Investigator Award, 1999-2000

Howard Hughes Institutes: New Faculty Start-Up Award, 1998-2001

Damon Runyon-Walter Winchell Foundation: Postdoctoral Fellowship, 1995-1998

March of Dimes Birth Defects Foundation: Pre-doctoral Fellowship, 1990-1992

Second Prize in Ophthalmology

Gold Medal in Surgery

Second Prize in Pathology

Distinctions in Anatomy, Physiology Biochemistry and Pharmacology

Honors in First Professional M.B.B.S

Pre-Medical University Merit Certificate (First Rank in the College)

National Talent Search Scholarship

Publications

Liu CC, Tseng YT, Li W, Wu CY, Mayzus I, Rzhetsky A, Sun F, Waterman M, Chen JJ, Chaudhary PM, Loscalzo J, Crandall E, Zhou XJ. DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections. Nucleic Acids Res. 2014 Jul; 42(Web Server issue):W137-46. View in: PubMed

Tolani B, Matta H, Gopalakrishnan R, Punj V, Chaudhary PM. NEMO Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Encoded vFLIP K13-Induced Gene Expression and Protection against Death Receptor-Induced Cell Death, and Its N-Terminal 251 Residues Are Sufficient for This Process. J Virol. 2014 Jun; 88(11):6345-54. View in: PubMed

Gopalakrishnan R, Matta H, Chaudhary PM. A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-? B. Clin Cancer Res. 2013 Sep 15; 19(18):5016-26. View in: PubMed

Graham C, Matta H, Yang Y, Yi H, Suo Y, Tolani B, Chaudhary PM. Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-? B activation. J Virol. 2013 Feb; 87(4):2242-52. View in: PubMed

Punj V, Matta H, Chaudhary PM. A Computational Profiling of Changes in Gene Expression and Transcription Factors Induced by vFLIP K13 in Primary Effusion Lymphoma. PLoS One. 2012; 7(5):e37498. View in: PubMed

Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM. Kaposi's Sarcoma Associated Herpesvirus Encoded Viral FLICE Inhibitory Protein K13 Activates NF-?B Pathway Independent of TRAF6, TAK1 and LUBAC. PLoS One. 2012; 7(5):e36601. View in: PubMed

Yang Y, Groshong JS, Matta H, Gopalakrishnan R, Yi H, Chaudhary PM. Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells. J Biol Chem. 2011 Aug 12; 286(32):27988-97. View in: PubMed

Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM. A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner. J Biol Chem. 2011 Jun 17; 286(24):21555-64. View in: PubMed

Ahmad A, Groshong JS, Matta H, Schamus S, Punj V, Robinson LJ, Gill PS, Chaudhary PM. Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice. Cancer Biol Ther. 2010 Nov; 10(10):1033-40. View in: PubMed

Lee HR, Lee S, Chaudhary PM, Gill P, Jung JU. Immune evasion by Kaposi's sarcoma-associated herpesvirus. Future Microbiol. 2010 Sep; 5(9):1349-65. View in: PubMed

Liu R, Gong M, Li X, Zhou Y, Gao W, Tulpule A, Chaudhary PM, Jung J, Gill PS. Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma. Blood. 2010 Jul 15; 116(2):297-305. View in: PubMed

Tolstov YL, Arora R, Scudiere SC, Busam K, Chaudhary PM, Chang Y, Moore PS. Lack of evidence for direct involvement of Merkel cell polyomavirus (MCV) in chronic lymphocytic leukemia (CLL). Blood. 2010 Jun 10; 115(23):4973-4. View in: PubMed

Punj V, Matta H, Chaudhary PM. X-linked ectodermal dysplasia receptor is downregulated in breast cancer via promoter methylation. Clin Cancer Res. 2010 Feb 15; 16(4):1140-8. View in: PubMed

Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS. KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood. 2010 Jan 28; 115(4):887-95. View in: PubMed

Shuda M, Arora R, Kwun HJ, Feng H, Sarid R, Fernández-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary PM, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer. 2009 Sep 15; 125(6):1243-9. View in: PubMed

Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary PM. Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation. Blood. 2009 May 28; 113(22):5660-8. View in: PubMed

Punj V, Matta H, Schamus S, Chaudhary PM. Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells. BMC Med Genomics. 2009; 2:50. View in: PubMed

Moschos SJ, Chaudhary PM, Kirkwood JM. Resolving "kinks" of chemotherapy in melanoma. J Natl Cancer Inst. 2008 Jun 18; 100(12):833-5. View in: PubMed

Lu G, Punj V, Chaudhary PM. Proteasome inhibitor Bortezomib induces cell cycle arrest and apoptosis in cell lines derived from Ewing's sarcoma family of tumors and synergizes with TRAIL. Cancer Biol Ther. 2008 Apr; 7(4):603-8. View in: PubMed

Matta H, Mazzacurati L, Schamus S, Yang T, Sun Q, Chaudhary PM. Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation. J Biol Chem. 2007 Aug 24; 282(34):24858-65. View in: PubMed

Lacoste V, Nicot C, Gessain A, Valensi F, Gabarre J, Matta H, Chaudhary PM, Mahieux R. In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle. Br J Haematol. 2007 Aug; 138(4):487-501. View in: PubMed

Chugh P, Matta H, Schamus S, Zachariah S, Kumar A, Richardson JA, Smith AL, Chaudhary PM. Constitutive NF-kappaB activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice. Proc Natl Acad Sci U S A. 2005 Sep 6; 102(36):12885-90. View in: PubMed

Matta H, Chaudhary PM. The proteasome inhibitor bortezomib (PS-341) inhibits growth and induces apoptosis in primary effusion lymphoma cells. Cancer Biol Ther. 2005 Jan; 4(1):77-82. View in: PubMed

Sun Q, Matta H, Chaudhary PM. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat. Retrovirology. 2005; 2:9. View in: PubMed

Rathore N, Matta H, Chaudhary PM. An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha. J Biol Chem. 2004 Sep 17; 279(38):39358-65. View in: PubMed

Matta H, Chaudhary PM. Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP). Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9399-404. View in: PubMed

Shivapurkar N, Toyooka S, Toyooka KO, Reddy J, Miyajima K, Suzuki M, Shigematsu H, Takahashi T, Parikh G, Pass HI, Chaudhary PM, Gazdar AF. Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types. Int J Cancer. 2004 May 1; 109(5):786-92. View in: PubMed

Shindo M, Chaudhary PM. The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation. Biochem Biophys Res Commun. 2004 Feb 27; 315(1):73-8. View in: PubMed

Sun Q, Zachariah S, Chaudhary PM. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52437-45. View in: PubMed

Matta H, Sun Q, Moses G, Chaudhary PM. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation. J Biol Chem. 2003 Dec 26; 278(52):52406-11. View in: PubMed

Tomar RS, Matta H, Chaudhary PM. Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene. 2003 Aug 28; 22(36):5712-5. View in: PubMed

Kauppila S, Maaty WS, Chen P, Tomar RS, Eby MT, Chapo J, Chew S, Rathore N, Zachariah S, Sinha SK, Abrams JM, Chaudhary PM. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene. 2003 Jul 31; 22(31):4860-7. View in: PubMed

Sun Q, Matta H, Chaudhary PM. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood. 2003 Mar 1; 101(5):1956-61. View in: PubMed

Matta H, Hozayev B, Tomar R, Chugh P, Chaudhary PM. Use of lentiviral vectors for delivery of small interfering RNA. Cancer Biol Ther. 2003 Mar-Apr; 2(2):206-10. View in: PubMed

Shivapurkar N, Reddy J, Matta H, Sathyanarayana UG, Huang CX, Toyooka S, Minna JD, Chaudhary PM, Gazdar AF. Loss of expression of death-inducing signaling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Oncogene. 2002 Dec 5; 21(55):8510-4. View in: PubMed

Sinha SK, Zachariah S, Quiñones HI, Shindo M, Chaudhary PM. Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor. J Biol Chem. 2002 Nov 22; 277(47):44953-61. View in: PubMed

Matta H, Eby MT, Gazdar AF, Chaudhary PM. Role of MRIT/cFLIP in protection against chemotherapy-induced apoptosis. Cancer Biol Ther. 2002 Nov-Dec; 1(6):652-60. View in: PubMed

Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy JL, Matta H, Miyajima K, Timmons CF, Tomlinson GE, Mastrangelo D, Hay RJ, Chaudhary PM, Gazdar AF. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res. 2002 Oct 15; 62(20):5897-901. View in: PubMed

Liu L, Eby MT, Rathore N, Sinha SK, Kumar A, Chaudhary PM. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem. 2002 Apr 19; 277(16):13745-51. View in: PubMed

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