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Radha Kalluri, PhD

Assistant Professor of Otolaryngology-Head & Neck Surgery

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Phone +1 323 442 4820
Email radha@usc.edu
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Overview

Dr. Radha Kalluri heads the Physiology of the Inner Ear Laboratory whose focus is to understand the physical and physiological mechanisms underlying sensory transduction in the inner ear, with the ultimate goal of understanding how disease and injury impair function. The lab. studies sensory transduction in the auditory and vestibular systems both at the cellular and system level using electrophysiology and biophysical modeling. Our work relies heavily on the interplay between quantitative analysis, theoretical modeling and experimental neuroscience.

Otolaryngology

Publications

  • Nuclear Translocation Triggered at the Onset of Hearing in Cochlear Inner Hair Cells of Rats and Mice J Assoc Res Otolaryngol. 2023 06; 24(3):291-303. . View in PubMed
  • Muscarinic Acetylcholine Receptors Modulate HCN Channel Properties in Vestibular Ganglion Neurons J Neurosci. 2023 02 08; 43(6):902-917. . View in PubMed
  • Isolating and Culturing Vestibular and Spiral Ganglion Somata from Neonatal Rodents for Patch-Clamp Recordings J Vis Exp. 2023 04 21; (194). . View in PubMed
  • Patch-clamp Recordings and Single Fiber Labeling from Spiral Ganglion Somata in Acutely Prepared Semi-intact Cochleae from Neonatal Rats Bio Protoc. 2022 Jan 05; 12(1):e4281. . View in PubMed
  • Similarities in the Biophysical Properties of Spiral-Ganglion and Vestibular-Ganglion Neurons in Neonatal Rats Front Neurosci. 2021; 15:710275. . View in PubMed
  • Generation of inner ear hair cells by direct lineage conversion of primary somatic cells Elife. 2020 06 30; 9. . View in PubMed
  • Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells Elife. 2020 07 08; 9. . View in PubMed
  • Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons J Neurosci. 2019 04 10; 39(15):2860-2876. . View in PubMed
  • Spatial Gradients in the Size of Inner Hair Cell Ribbons Emerge Before the Onset of Hearing in Rats J Assoc Res Otolaryngol. 2017 Jun; 18(3):399-413. . View in PubMed
  • Towards a joint reflection-distortion otoacoustic emission profile: Results in normal and impaired ears J Acoust Soc Am. 2017 08; 142(2):812. . View in PubMed
  • A biophysical model examining the role of low-voltage-activated potassium currents in shaping the responses of vestibular ganglion neurons J Neurophysiol. 2016 08 01; 116(2):503-21. . View in PubMed
  • Stimulus-frequency otoacoustic emissions in human newborns J Acoust Soc Am. 2015 Jan; 137(1):EL78-84. . View in PubMed
  • Exploiting Dual Otoacoustic Emission Sources AIP Conf Proc. 2015; 1703. . View in PubMed
  • Measuring stimulus-frequency otoacoustic emissions using swept tones J Acoust Soc Am. 2013 Jul; 134(1):356-68. . View in PubMed
  • Frequency selectivity in Old-World monkeys corroborates sharp cochlear tuning in humans Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17516-20. . View in PubMed
  • Level dependence of distortion product otoacoustic emission phase is attributed to component mixing J Acoust Soc Am. 2011 May; 129(5):3123-33. . View in PubMed
  • Deviations from Scaling Symmetry in the Apical Half of the Human Cochlea AIP Conf Proc. 2011; 1403:483-488. . View in PubMed
  • Otoacoustic Estimates of Cochlear Tuning: Testing Predictions in Macaque AIP Conf Proc. 2011; 1403:286-292. . View in PubMed
  • Ion channels set spike timing regularity of mammalian vestibular afferent neurons J Neurophysiol. 2010 Oct; 104(4):2034-51. . View in PubMed
  • Ion channels in mammalian vestibular afferents may set regularity of firing J Exp Biol. 2008 Jun; 211(Pt 11):1764-74. . View in PubMed
  • Comparing stimulus-frequency otoacoustic emissions measured by compression, suppression, and spectral smoothing J Acoust Soc Am. 2007 Dec; 122(6):3562-75. . View in PubMed
  • Near equivalence of human click-evoked and stimulus-frequency otoacoustic emissions J Acoust Soc Am. 2007 Apr; 121(4):2097-110. . View in PubMed

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