Faculty

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Ramen H. Chmait, MD
Associate Professor of Obstetrics & Gynecology (Clinical Scholar)
Director of Fetal Surgery Program
Obstetrics & Gynecology
IRD 206 Off Campus Los Angeles
+1 323 226 3306

Overview

Ramen Chmait, MD is Assistant Professor of Clinical Obstetrics and Gynecology, Pediatrics, and Surgery at the University of Southern California’s Keck School of Medicine. Dr. Chmait has served as director of Los Angeles Fetal Therapy since 2006. The Los Angeles Fetal Therapy is a program within the CHLA-USC Institute for Maternal-Fetal Health. In this capacity he has provided surgical treatment to hundreds of unborn children. Dr. Chmait also directs a research program devoted to understanding fetal disease and investigating potential treatment modalities.

Awards

U.S. News Top Doctors

Fetal Hope: Light of Hope Award, 2008

UCSD Department of Reproductive Medicine: Fellows Teaching Award, 2003

Kaiser Permanente Los Angeles Medical Center : Resident Research Award, 2000

Publications

Vascular limb occlusion in twin-twin transfusion syndrome (TTTS): case series and literature review. Am J Obstet Gynecol. 2012 Aug; 207(2):131. e1-131. e10. View in: PubMed

Endoscopic surgery for the antenatal treatment of myelomeningocele: the CECAM trial. Am J Obstet Gynecol. 2016 Jan; 214(1):111. e1-111. e11. View in: PubMed

Recipient Twin Circular Shunt Physiology Before Fetal Laser Surgery: Survival and Risks for Postnatal Right Ventricular Outflow Tract Obstruction. J Ultrasound Med. 2017 Apr 03. View in: PubMed

The impact of laser surgery on angiogenic and anti-angiogenic factors in twin-twin transfusion syndrome: a prospective study. J Matern Fetal Neonatal Med. 2017 Mar 20; 1-21. View in: PubMed

Design and Testing of a Transcutaneous RF Recharging System for a Fetal Micropacemaker. IEEE Trans Biomed Circuits Syst. 2017 Feb 13. View in: PubMed

Analytical Modeling for Computing Lead Stress in a Novel Epicardial Micropacemaker. Cardiovasc Eng Technol. 2017 Jan 09. View in: PubMed

Minimally invasive implantable fetal micropacemaker: mechanical testing and technical refinements. Med Biol Eng Comput. 2016 Dec; 54(12):1819-1830. View in: PubMed

Fetal Serum ß2-Microglobulin and Postnatal Renal Function in Lower Urinary Tract Obstruction Treated with Vesicoamniotic Shunt. Fetal Diagn Ther. 2016 Sep 08. View in: PubMed

Amniotic fluid levels of phospholipase A2 in fetal rats with retinoic acid induced myelomeningocele: the potential "second hit" in neurologic damage. J Matern Fetal Neonatal Med. 2016 Sep; 29(18):3003-8. View in: PubMed

Umbilical Cord Occlusion via Laser Coagulation in Monochorionic Multifetal Gestations before and after 20 Weeks of Gestation. Fetal Diagn Ther. 2016 Aug 31. View in: PubMed

Amniopatch treatment of iatrogenic preterm premature rupture of membranes (iPPROM) after fetoscopic laser surgery for twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2016 Aug 10; 1-6. View in: PubMed

Fetoscopic repair of spina bifida: safer and better? Ultrasound Obstet Gynecol. Fetoscopic repair of spina bifida: safer and better? Ultrasound Obstet Gynecol. 2016 Aug; 48(2):141-7. View in: PubMed

Twin-to-Twin Transfusion Syndrome: Definition, Staging, and Ultrasound Assessment. Twin Res Hum Genet. 2016 Jun; 19(3):175-83. View in: PubMed

Laser Treatment of Twin-to-Twin Transfusion Syndrome. Twin Res Hum Genet. 2016 Jun; 19(3):197-206. View in: PubMed

Generalized Arterial Calcification in a Recipient Twin: Discordant Fetal Hemodynamics Result in Differing Phenotypes in Monozygotic Twins with an ABCC6 Mutation. Fetal Diagn Ther. 2016 Mar 17. View in: PubMed

Fetal brain-sparing after laser surgery for twin-twin transfusion syndrome appears associated with two-year neurodevelopmental outcomes. Prenat Diagn. 2016 Jan; 36(1):63-7. View in: PubMed

Selective Reduction Using Intravascular Potassium Chloride Injection after Laser Surgery for Twin-Twin Transfusion Syndrome. Fetal Diagn Ther. 2016; 39(4):306-10. View in: PubMed

Decreased Total Placental Mass Found in Twin-Twin Transfusion Syndrome Gestations with Selective Growth Restriction. Fetal Diagn Ther. 2016; 40(2):116-22. View in: PubMed

Donor catch-up growth after laser surgery for twin-twin transfusion syndrome. Early Hum Dev. 2015 Dec; 91(12):751-4. View in: PubMed

Blood pressure evaluation in children treated with laser surgery for twin-twin transfusion syndrome at 2-year follow-up. Am J Obstet Gynecol. 2015 Sep; 213(3):417. e1-7. View in: PubMed

Perinatal survival in cases of twin-twin transfusion syndrome complicated by selective intrauterine growth restriction. J Matern Fetal Neonatal Med. 2015 Sep; 28(13):1549-53. View in: PubMed

Which twin is which? A proposed solution for the labeling of twins at birth. Am J Obstet Gynecol. 2015 Aug; 213(2):245-6. View in: PubMed

International Fetal Cardiac Intervention Registry: A Worldwide Collaborative Description and Preliminary Outcomes. J Am Coll Cardiol. 2015 Jul 28; 66(4):388-99. View in: PubMed

Preclinical testing and optimization of a novel fetal micropacemaker. Heart Rhythm. 2015 Jul; 12(7):1683-90. View in: PubMed

Treatment of alpha(0)-thalassemia (--(SEA)/--(SEA)) via serial fetal and post-natal transfusions: Can early fetal intervention improve outcomes? Hematology. Treatment of alpha(0)-thalassemia (--(SEA)/--(SEA)) via serial fetal and post-natal transfusions: Can early fetal intervention improve outcomes? Hematology. 2015 May; 20(4):217-22. View in: PubMed

Abnormal umbilical artery Doppler findings in the recipient twin before laser surgery for twin-twin transfusion syndrome. J Ultrasound Med. 2015 May; 34(5):843-6. View in: PubMed

Identification of essential steps in laser procedure for twin-twin transfusion syndrome using the Delphi methodology: SILICONE study. Ultrasound Obstet Gynecol. 2015 Apr; 45(4):439-46. View in: PubMed

Chlorhexidine gluconate versus povidone iodine at cesarean delivery: a randomized controlled trial. J Matern Fetal Neonatal Med. 2015 Mar; 28(5):573-7. View in: PubMed

Giant Chorioangioma Treated In Utero via Laser of Feeding Vessels with Subsequent Development of Multifocal Infantile Hemangiomas. Fetal Pediatr Pathol. 2015 Feb; 34(1):1-8. View in: PubMed

Treatment of Complicated Spontaneous Twin Anemia-Polycythemia Sequence via Fetoscopic Laser Ablation of the Vascular Communications. Fetal Diagn Ther. 2015; 38(3):233-7. View in: PubMed

Pre-Operative Twin Anemia/Polycythemia in the Setting of Twin-Twin Transfusion Syndrome (TTTS). Fetal Diagn Ther. 2015; 37(4):274-80. View in: PubMed

Fetoscopic single-layer repair of open spina bifida using a cellulose patch: preliminary clinical experience. J Matern Fetal Neonatal Med. 2014 Nov; 27(16):1613-9. View in: PubMed

Predictors of 2-year cognitive performance after laser surgery for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2014 Oct; 211(4):388. e1-7. View in: PubMed

Midtrimester isolated polyhydramnios in monochorionic diamniotic multiple gestations. Am J Obstet Gynecol. 2014 Sep; 211(3):303. e1-5. View in: PubMed

Sequential laser surgery for twin-twin transfusion syndrome. Am J Perinatol. 2014 Sep; 31 Suppl 1:S13-8. View in: PubMed

Dual twin survival after laser surgery for twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2014 Aug; 44(2):244. View in: PubMed

A percutaneously implantable fetal pacemaker. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug; 2014:4459-63. View in: PubMed

Chorioamniotic membrane separation over the cervical os ("moon sign") in twin-twin transfusion syndrome. J Ultrasound Med. 2014 Jul; 33(7):1147-54. View in: PubMed

Term Vaginal Delivery following Fetoscopic Laser Photocoagulation of Type II Vasa Previa. Fetal Diagn Ther. 2014; 35(1):62-4. View in: PubMed

Perioperative characteristics associated with preterm birth in twin-twin transfusion syndrome treated by laser surgery. Am J Obstet Gynecol. 2013 Sep; 209(3):264. e1-8. View in: PubMed

Laser treatment of twin-twin transfusion syndrome: what do the data really show? Am J Obstet Gynecol. Laser treatment of twin-twin transfusion syndrome: what do the data really show? Am J Obstet Gynecol. 2013 Aug; 209(2):157-8. View in: PubMed

Chimerism in monochorionic dizygotic twins: case study and review. Am J Med Genet A. 2013 Jul; 161A(7):1817-24. View in: PubMed

The observed vs. expected lung-to-head ratio does not correct for the effect of gestational age on the lung-to-head ratio. J Matern Fetal Neonatal Med. 2013 Apr; 26(6):552-7. View in: PubMed

Mutation in an mtDNA protein-coding gene: prenatal diagnosis aided by fetal muscle biopsy. J Child Neurol. 2013 Feb; 28(2):264-8. View in: PubMed

Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmune thrombocytopenia. Obstet Gynecol. 2013 Feb; 121(2 Pt 2 Suppl 1):471-3. View in: PubMed

Middle cerebral artery Doppler and hemoglobin changes immediately following fetal transfusion. J Matern Fetal Neonatal Med. 2013 Jan; 26(2):155-7. View in: PubMed

Design and testing of a percutaneously implantable fetal pacemaker. Ann Biomed Eng. 2013 Jan; 41(1):17-27. View in: PubMed

Intraluminal tracheal occlusion using a modified 8-mm Z-stent in a sheep model of left-sided congenital diaphragmatic hernia. J Matern Fetal Neonatal Med. 2012 Nov; 25(11):2346-53. View in: PubMed

Prevalence and risk factors of cerebral lesions in neonates after laser surgery for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2012 Oct; 207(4):320. e1-6. View in: PubMed

Incidental fetoscopy during laparoscopy in pregnancy: management of perforation of the gravid uterus. Surg Laparosc Endosc Percutan Tech. 2012 Apr; 22(2):e76-8. View in: PubMed

Prevalence of noncardiac structural anomalies in twin-twin transfusion syndrome. J Ultrasound Med. 2012 Apr; 31(4):555-60. View in: PubMed

In Utero Release of Constriction Amniotic Bands via Blunt Dissection. Fetal Pediatr Pathol. 2012 Feb; 31(1):25-9. View in: PubMed

Percutaneously injectable fetal pacemaker: electronics, pacing thresholds, and power budget. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:5730-3. View in: PubMed

Fetoscopic Laser Photocoagulation of Feeding Vessels to a Large Placental Chorioangioma following Fetal Deterioration after Amnioreduction. Fetal Diagn Ther. 2012; 31(3):191-5. View in: PubMed

Percutaneously injectable fetal pacemaker: electrodes, mechanical design and implantation. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:6600-3. View in: PubMed

Treatment of Congenital Pulmonary Airway Malformation Induced Hydrops Fetalis via Percutaneous Sclerotherapy. Fetal Diagn Ther. 2012; 31(4):264-8. View in: PubMed

The quantitative lung index (QLI): a gestational age-independent sonographic predictor of fetal lung growth. Am J Obstet Gynecol. 2011 Dec; 205(6):544. e1-8. View in: PubMed

Neurodevelopmental outcomes after laser therapy for twin-twin transfusion syndrome: a systematic review and meta-analysis. Obstet Gynecol. 2011 Nov; 118(5):1145-50. View in: PubMed

Fetoscopic documentation of meconium passage at 19 weeks' gestation. Clin Gastroenterol Hepatol. 2011 Nov; 9(11):e120. View in: PubMed

Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors. Prenat Diagn. 2011 Oct; 31(10):973-7. View in: PubMed

Role of low placental share in twin-twin transfusion syndrome complicated by intrauterine growth restriction. Placenta. 2011 Aug; 32(8):616-8. View in: PubMed

Duplicity: Sonography suggested a twin gestation was dichorionic-and monochorionic. Am J Obstet Gynecol. 2011 Jul; 205(1):87. e1-2. View in: PubMed

Fetal middle cerebral artery Doppler fluctuations after laser surgery for twin-twin transfusion syndrome. J Perinatol. 2011 May; 31(5):368-72. View in: PubMed

Stage-based outcomes of 682 consecutive cases of twin-twin transfusion syndrome treated with laser surgery: the USFetus experience. Am J Obstet Gynecol. 2011 May; 204(5):393. e1-6. View in: PubMed

Neonatal outcomes of twins according to birth order, presentation and mode of delivery: a systematic review and meta-analysis. BJOG. 2011 Apr; 118(5):523-32. View in: PubMed

Twin-to-twin transfusion syndrome (TTTS). J Perinat Med. 2011 Mar; 39(2):107-12. View in: PubMed

Spontaneous twin anemia-polycythemia sequence complicated by recipient placental vascular thrombosis and hydrops fetalis. J Matern Fetal Neonatal Med. 2011 Mar; 24(3):549-52. View in: PubMed

Normalization of amniotic fluid levels after fetoscopic laser surgery for twin-twin transfusion syndrome. J Ultrasound Med. 2010 Oct; 29(10):1431-6. View in: PubMed

Discordant blood chimerism in dizygotic monochorionic laser-treated twin-twin transfusion syndrome. Obstet Gynecol. 2010 Aug; 116 Suppl 2:483-5. View in: PubMed

In utero management of fetal lower urinary tract obstruction with a novel shunt: a landmark development in fetal therapy. J Matern Fetal Neonatal Med. 2010 Aug; 23(8):806-12. View in: PubMed

Residual vascular communications in twin-twin transfusion syndrome treated with sequential laser surgery: frequency and clinical implications. Placenta. 2010 Jul; 31(7):611-4. View in: PubMed

Third trimester fetoscopic laser ablation of type II vasa previa. J Matern Fetal Neonatal Med. 2010 May; 23(5):459-62. View in: PubMed

Triplets with feto-fetal transfusion syndrome treated with laser ablation: the USFetus experience. J Matern Fetal Neonatal Med. 2010 May; 23(5):361-5. View in: PubMed

Trocar-assisted selective laser photocoagulation of communicating vessels: a technique for the laser treatment of patients with twin-twin transfusion syndrome with inaccessible anterior placentas. J Matern Fetal Neonatal Med. 2010 Apr; 23(4):330-4. View in: PubMed

Emergency postpartum hysterectomy for uncontrolled postpartum bleeding: a systematic review. Obstet Gynecol. 2010 Mar; 115(3):637-44. View in: PubMed

Fetal heart rate changes associated with sequential selective laser surgery for twin-twin transfusion syndrome. J Perinatol. 2010 Mar; 30(3):188-91. View in: PubMed

Twin-twin transfusion syndrome in a dichorionic-monozygotic twin pregnancy: The end of a paradigm? Fetal Pediatr Pathol. Twin-twin transfusion syndrome in a dichorionic-monozygotic twin pregnancy: The end of a paradigm? Fetal Pediatr Pathol. 2010 Jan; 29(2):81-8. View in: PubMed

Perinatal survival following preferential sequential selective laser surgery for twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2010 Jan; 23(1):10-6. View in: PubMed

Postoperative middle cerebral artery peak systolic velocity changes confirm physiological principles of the sequential laser technique for twin-twin transfusion syndrome. Fetal Diagn Ther. 2010; 28(3):140-4. View in: PubMed

Amniopatch as a treatment for rupture of membranes following laser surgery for twin-twin transfusion syndrome. Fetal Diagn Ther. 2010; 27(3):134-7. View in: PubMed

Fetoscopic management of complicated monochorionic twins. Clin Obstet Gynecol. 2009 Dec; 52(4):647-53. View in: PubMed

Umbilical artery hypoplasia in twin-twin transfusion syndrome complicated by discordant umbilical artery Doppler findings in the donor twin: a diagnostic dilemma. J Ultrasound Med. 2009 Aug; 28(8):1107-10. View in: PubMed

Complete right heart flow reversal: pathognomonic recipient twin circular shunt in twin-twin transfusion syndrome. J Ultrasound Med. 2009 Aug; 28(8):1101-6. View in: PubMed

Are patients with twin-twin transfusion syndrome and a very short cervix candidates for laser surgery? J Ultrasound Med. Are patients with twin-twin transfusion syndrome and a very short cervix candidates for laser surgery? J Ultrasound Med. 2009 May; 28(5):633-9. View in: PubMed

Prenatal diagnosis of spontaneous septostomy of the dividing membranes in complicated monochorionic diamniotic multiple gestations. J Ultrasound Med. 2009 May; 28(5):663-8. View in: PubMed

The con trial. Am J Obstet Gynecol. 2009 Mar; 200(3):e14-5; author reply e15. View in: PubMed

In utero fetal oximetry via visible light spectroscopy in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2008 Dec; 199(6):639. e1-4. View in: PubMed

Complementary roles of sonography and magnetic resonance imaging in the assessment of fetal urinary tract anomalies. J Ultrasound Med. 2008 Nov; 27(11):1563-9. View in: PubMed

Fetal growth after laser therapy for twin-twin transfusion syndrome. Am J Obstet Gynecol. 2008 Jul; 199(1):47. e1-6. View in: PubMed

Operative fetoscopy in complicated monochorionic twins: current status and future direction. Curr Opin Obstet Gynecol. 2008 Apr; 20(2):169-74. View in: PubMed

Sequential selective laser photocoagulation of communicating vessels in twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2007 Oct; 20(10):763-8. View in: PubMed

Percent absent end-diastolic velocity in the umbilical artery waveform as a predictor of intrauterine fetal demise of the donor twin after selective laser photocoagulation of communicating vessels in twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2007 Jul; 30(1):35-9. View in: PubMed

Paradoxical scalloped placenta with polyhydramnios in twin-twin transfusion syndrome. J Matern Fetal Neonatal Med. 2007 Jan; 20(1):29-32. View in: PubMed

The role of laser surgery in dissecting the etiology of absent or reverse end-diastolic velocity in the umbilical artery of the donor twin in twin-twin transfusion syndrome. Am J Obstet Gynecol. 2006 Aug; 195(2):478-83. View in: PubMed

Surgical management of twin reversed arterial perfusion sequence. Am J Obstet Gynecol. 2006 Apr; 194(4):982-91. View in: PubMed

Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero. Ultrasound Obstet Gynecol. 2006 Feb; 27(2):173-6. View in: PubMed

Management of twin-twin transfusion syndrome in pregnancies with iatrogenic detachment of membranes following therapeutic amniocentesis and the role of interim amniopatch. Ultrasound Obstet Gynecol. 2005 Nov; 26(6):628-33. View in: PubMed

In utero cardiac fetal surgery: laser atrial septotomy in the treatment of hypoplastic left heart syndrome with intact atrial septum. Am J Obstet Gynecol. 2005 Oct; 193(4):1424-8. View in: PubMed

Prospective observational study to establish predictors of glyburide success in women with gestational diabetes mellitus. J Perinatol. 2004 Oct; 24(10):617-22. View in: PubMed

Ultrasound assessment of venous blood flow before and after laser therapy: approach to understanding the pathophysiology of twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2004 Aug; 24(2):164-8. View in: PubMed

Intra-amniotic Doppler measurement of blood flow in placental vascular anastomoses in twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2004 Jul; 24(1):102-3. View in: PubMed

Umbilical cord occlusion of the donor versus recipient fetus in twin-twin transfusion syndrome. Ultrasound Obstet Gynecol. 2004 May; 23(5):446-50. View in: PubMed

The cocoon sign: a potential sonographic pitfall in the diagnosis of twin - twin transfusion syndrome. Ultrasound Obstet Gynecol. 2004 Jan; 23(1):38-41. View in: PubMed

Preterm premature rupture of membranes: vascular endothelial growth factor and its association with histologic chorioamnionitis. Am J Obstet Gynecol. 2002 Nov; 187(5):1131-6. View in: PubMed

Prenatal evaluation of facial clefts with two-dimensional and adjunctive three-dimensional ultrasonography: a prospective trial. Am J Obstet Gynecol. 2002 Oct; 187(4):946-9. View in: PubMed

Nasal glioma. Ultrasound Obstet Gynecol. 2002 Oct; 20(4):417-8. View in: PubMed

Protease inhibitors and decreased birth weight in HIV-infected pregnant women with impaired glucose tolerance. J Perinatol. 2002 Jul-Aug; 22(5):370-3. View in: PubMed

Doppler ultrasonographic evaluation of twins discordant for Rh alloimmunization. Am J Obstet Gynecol. 2002 Jul; 187(1):250-1. View in: PubMed

Placental pathology casebook. Unusually large acardiac twin pregnancy at term. J Perinatol. 2001 Mar; 21(2):150-2. View in: PubMed

Hemophagocytic syndrome in pregnancy. Obstet Gynecol. 2000 Jun; 95(6 Pt 2):1022-4. View in: PubMed

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