Faculty

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Randall Bruce Widelitz, PhD
Associate Professor of Research Pathology
Pathology
HMR 305D Off Campus Los Angeles
+1 323 442 1158

Overview

When organs are damaged due to injury they can be repaired or regenerated. Repair produces scars which do not offer complete functionality. In contrast, regeneration restores complete functionality. We have been trying to understand why in some tissues, repair is the primary response and in others regeneration is the primary response to injury. In particular, we have been studying the role of adult progenitor cells in tissue regeneration using ectodermal organs (hairs, feathers, and teeth) as models. Our focus has been on molecular and cellular aspects stem cell activation and how cells are guided for proper morphogenesis.

Publications

Chen CC, Plikus MV, Tang PC, Widelitz RB, Chuong CM. The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration. J Mol Biol. 2016 Apr 10; 428(7):1423-40. View in: PubMed

Wu P, Ng CS, Yan J, Lai YC, Chen CK, Lai YT, Wu SM, Chen JJ, Luo W, Widelitz RB, Li WH, Chuong CM. Topographical mapping of a- and ß-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives. Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49):E6770-9. View in: PubMed

Bai X, Lei M, Shi J, Yu Y, Qiu W, Lai X, Liu Y, Yang T, Yang L, Widelitz RB, Chuong CM, Lian X. Roles of GasderminA3 in Catagen-Telogen Transition During Hair Cycling. J Invest Dermatol. 2015 Sep; 135(9):2162-72. View in: PubMed

Li A, Lai YC, Figueroa S, Yang T, Widelitz RB, Kobielak K, Nie Q, Chuong CM. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument. Dev Dyn. 2015 Aug; 244(8):905-20. View in: PubMed

Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell. 2015 Apr 9; 161(2):277-90. View in: PubMed

Chen CF, Foley J, Tang PC, Li A, Jiang TX, Wu P, Widelitz RB, Chuong CM. Development, regeneration, and evolution of feathers. Annu Rev Anim Biosci. 2015 Feb 16; 3:169-95. View in: PubMed

Chuong CM, Bhat R, Widelitz RB, Bissell MJ. SnapShot: Branching Morphogenesis. Cell. 2014 Aug 28; 158(5):1212-1212. e1. View in: PubMed

Chen CC, Murray PJ, Jiang TX, Plikus MV, Chang YT, Lee OK, Widelitz RB, Chuong CM. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J Invest Dermatol. 2014 Aug; 134(8):2086-96. View in: PubMed

Lei M, Guo H, Qiu W, Lai X, Yang T, Widelitz RB, Chuong CM, Lian X, Yang L. Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration. Exp Dermatol. 2014 Jun; 23(6):407-13. View in: PubMed

Chu Q, Cai L, Fu Y, Chen X, Yan Z, Lin X, Zhou G, Han H, Widelitz RB, Chuong CM, Wu W, Yue Z. Dkk2/Frzb in the dermal papillae regulates feather regeneration. Dev Biol. 2014 Mar 15; 387(2):167-78. View in: PubMed

Ng CS, Wu P, Fan WL, Yan J, Chen CK, Lai YT, Wu SM, Mao CT, Chen JJ, Lu MY, Ho MR, Widelitz RB, Chen CF, Chuong CM, Li WH. Genomic Organization, Transcriptomic Analysis, and Functional Characterization of Avian a- and ß-Keratins in Diverse Feather Forms. Genome Biol Evol. 2014; 6(9):2258-73. View in: PubMed

Hughes MW, Jiang TX, Lin SJ, Leung Y, Kobielak K, Widelitz RB, Chuong CM. Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis. J Invest Dermatol. 2014 Jan; 134(1):24-32. View in: PubMed

Wu P, Wu X, Jiang TX, Elsey RM, Temple BL, Divers SJ, Glenn TC, Yuan K, Chen MH, Widelitz RB, Chuong CM. Specialized stem cell niche enables repetitive renewal of alligator teeth. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E2009-18. View in: PubMed

Lei MX, Chuong CM, Widelitz RB. Tuning Wnt signals for more or fewer hairs. J Invest Dermatol. 2013 Jan; 133(1):7-9. View in: PubMed

Li J, Jiang TX, Hughes MW, Wu P, Yu J, Widelitz RB, Fan G, Chuong CM. Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol. 2012 Dec; 132(12):2681-90. View in: PubMed

Yue Z, Jiang TX, Wu P, Widelitz RB, Chuong CM. Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae. Dev Biol. 2012 Dec 1; 372(1):45-54. View in: PubMed

Ng CS, Wu P, Foley J, Foley A, McDonald ML, Juan WT, Huang CJ, Lai YT, Lo WS, Chen CF, Leal SM, Zhang H, Widelitz RB, Patel PI, Li WH, Chuong CM. The Chicken Frizzle Feather Is Due to an a-Keratin (KRT75) Mutation That Causes a Defective Rachis. PLoS Genet. 2012 Jul; 8(7):e1002748. View in: PubMed

Chuong CM, Randall VA, Widelitz RB, Wu P, Jiang TX. Physiological regeneration of skin appendages and implications for regenerative medicine. Physiology (Bethesda). 2012 Apr; 27(2):61-72. View in: PubMed

Jiang TX, Tuan TL, Wu P, Widelitz RB, Chuong CM. From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis. Differentiation. 2011 Jun; 81(5):307-14. View in: PubMed

Hughes MW, Wu P, Jiang TX, Lin SJ, Dong CY, Li A, Hsieh FJ, Widelitz RB, Chuong CM. In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages. Integr Biol (Camb). 2011 Apr; 3(4):388-407. View in: PubMed

Lin CM, Jiang TX, Baker RE, Maini PK, Widelitz RB, Chuong CM. Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation. Dev Biol. 2009 Oct 15; 334(2):369-82. View in: PubMed

Chuong CM, Widelitz RB. The river of stem cells. Cell Stem Cell. 2009 Feb 6; 4(2):100-2. View in: PubMed

Plikus MV, Widelitz RB, Maxson R, Chuong CM. Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity. Int J Dev Biol. 2009; 53(5-6):857-68. View in: PubMed

Widelitz RB. Wnt signaling in skin organogenesis. Organogenesis. 2008 Apr; 4(2):123-33. View in: PubMed

Widelitz RB, Veltmaat JM, Mayer JA, Foley J, Chuong CM. Mammary glands and feathers: comparing two skin appendages which help define novel classes during vertebrate evolution. Semin Cell Dev Biol. 2007 Apr; 18(2):255-66. View in: PubMed

Lin CM, Jiang TX, Widelitz RB, Chuong CM. Molecular signaling in feather morphogenesis. Curr Opin Cell Biol. 2006 Dec; 18(6):730-41. View in: PubMed

Widelitz RB, Baker RE, Plikus M, Lin CM, Maini PK, Paus R, Chuong CM. Distinct mechanisms underlie pattern formation in the skin and skin appendages. Birth Defects Res C Embryo Today. 2006 Sep; 78(3):280-91. View in: PubMed

Wu P, Jiang TX, Shen JY, Widelitz RB, Chuong CM. Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution. Dev Dyn. 2006 May; 235(5):1400-12. View in: PubMed

Yue Z, Jiang TX, Widelitz RB, Chuong CM. Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):951-5. View in: PubMed

Yue Z, Jiang TX, Widelitz RB, Chuong CM. Mapping stem cell activities in the feather follicle. Nature. 2005 Dec 15; 438(7070):1026-9. View in: PubMed

Wu P, Jiang TX, Suksaweang S, Widelitz RB, Chuong CM. Molecular shaping of the beak. Science. 2004 Sep 3; 305(5689):1465-6. View in: PubMed

Widelitz RB. Regulating the regulators: routing the Wnt-beta-catenin--Lef signals. J Invest Dermatol. 2004 Aug; 123(2):VIII-X. View in: PubMed

Chang CH, Yu M, Wu P, Jiang TX, Yu HS, Widelitz RB, Chuong CM. Sculpting skin appendages out of epidermal layers via temporally and spatially regulated apoptotic events. J Invest Dermatol. 2004 Jun; 122(6):1348-55. View in: PubMed

Suksaweang S, Lin CM, Jiang TX, Hughes MW, Widelitz RB, Chuong CM. Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation. Dev Biol. 2004 Feb 1; 266(1):109-22. View in: PubMed

Jiang TX, Widelitz RB, Shen WM, Will P, Wu DY, Lin CM, Jung HS, Chuong CM. Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models. Int J Dev Biol. 2004; 48(2-3):117-35. View in: PubMed

Yu M, Yue Z, Wu P, Wu DY, Mayer JA, Medina M, Widelitz RB, Jiang TX, Chuong CM. The biology of feather follicles. Int J Dev Biol. 2004; 48(2-3):181-91. View in: PubMed

Widelitz RB, Jiang TX, Yu M, Shen T, Shen JY, Wu P, Yu Z, Chuong CM. Molecular biology of feather morphogenesis: a testable model for evo-devo research. J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):109-22. View in: PubMed

Chuong CM, Wu P, Zhang FC, Xu X, Yu M, Widelitz RB, Jiang TX, Hou L. Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories. J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):42-56. View in: PubMed

Chodankar R, Chang CH, Yue Z, Jiang TX, Suksaweang S, Burrus L, Chuong CM, Widelitz R. Shift of localized growth zones contributes to skin appendage morphogenesis: role of the Wnt/beta-catenin pathway. J Invest Dermatol. 2003 Jan; 120(1):20-6. View in: PubMed

Yu M, Wu P, Widelitz RB, Chuong CM. The morphogenesis of feathers. Nature. 2002 Nov 21; 420(6913):308-12. View in: PubMed

Koh SS, Li H, Lee YH, Widelitz RB, Chuong CM, Stallcup MR. Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem. 2002 Jul 19; 277(29):26031-5. View in: PubMed

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