Faculty

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Randall C. Wetzel, MD
Professor of Pediatrics
Pediatrics
CHL Mail Stop 12 Off Campus Los Angeles
+1 323 361 2557

Overview

Dr. Randall Wetzel is the Chairman of the Department of Anesthesiology Critical Care Medicine at Children’s Hospital Los Angeles, Professor (Tenured) of Anesthesiology and Pediatrics, Keck School of Medicine, University of Southern California, and the Director of The Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit (VPICU) at Children’s Hospital Los Angeles. Prior to coming to CHLA, Dr. Wetzel held various faculty appointments in Anesthesiology and Critical Care Medicine at Johns Hopkins Hospital and University from 1981-1997.

After completing his undergraduate studies at Durham University in England, he went on to receive his medical degree from the Medical College of St. Bartholomew’s Hospital, London University, England. He moved stateside for his pediatric residency, then fellowship training in Critical Care and Pediatric Cardiology at Rainbow Babies and Children’s Hospital at University Hospitals in Cleveland, Ohio. He was subsequently a fellow in Pediatric Critical Care and Resident/Chief Resident in Anesthesiology/Critical Care Medicine at Johns Hopkins Hospital in Baltimore. Dr. Wetzel returned to England for a fellowship in Pediatric Anesthesia and Critical Care Medicine at the Hospital for Sick Children and Guy’s Hospital in London. In addition, he earned a Master of Science in Business (Medicine) from Johns Hopkins University (1997). He moved to Los Angeles in 1997.

His current interests in medical informatics led him to develop the VPICU; a Southern California Critical Care Telemedicine Network; he is CEO and Chair of VPS, LLC a Quality Improvement and Data management company with over 120 hospital clients; and he leads a complex big data research team developing data extraction, management, architecture and advanced analytic techniques for highly granular Pediatric Critical Care Data. He has received over $18 million in federal and private foundation grant funding for these projects. He has served as a board member for The American Board of Pediatrics (2000-2003); Editor-in-Chief, the Society for Pediatric Anesthesia (1988-1995). He has authored 94 peer-reviewed articles and 45 book chapters, he is editor of Roger’s Critical Care Medicine and Critical Heart Disease in Infants and Children; and has presented over 100 abstracts at various symposia.

Dr. Wetzel and his wife Ann have been married 34 years and currently reside in La Cañada, California. They have four wonderful daughters.

Publications

Gall C, Wetzel R, Kolker A, Kanter RK, Toltzis P. Pediatric Triage in a Severe Pandemic: Maximizing Survival by Establishing Triage Thresholds. Crit Care Med. 2016 Sep; 44(9):1762-8. View in: PubMed

Gupta P, Rettiganti M, Jeffries HE, Scanlon MC, Ghanayem NS, Daufeldt J, Rice TB, Wetzel RC. Risk factors and outcomes of in-hospital cardiac arrest following pediatric heart operations of varying complexity. Resuscitation. 2016 Aug; 105:1-7. View in: PubMed

Ross PA, Newth CJ, Leung D, Wetzel RC, Khemani RG. Obesity and Mortality Risk in Critically Ill Children. Pediatrics. 2016 Mar; 137(3):1-8. View in: PubMed

Gupta P, Rettiganti M, Gossett JM, Yeh JC, Jeffries HE, Rice TB, Wetzel RC. Risk factors for mechanical ventilation and reintubation after pediatric heart surgery. J Thorac Cardiovasc Surg. 2016 Feb; 151(2):451-458. e3. View in: PubMed

Gupta P, Tang X, Rettiganti M, Lauer C, Kacmarek RM, Rice TB, Markovitz BP, Wetzel RC. Association of house staff training with mortality in children with critical illness. Acta Paediatr. 2016 Feb; 105(2):e60-6. View in: PubMed

Jeffries HE, Soto-Campos G, Katch A, Gall C, Rice TB, Wetzel R. Pediatric Index of Cardiac Surgical Intensive Care Mortality Risk Score for Pediatric Cardiac Critical Care. Pediatr Crit Care Med. 2015 Nov; 16(9):846-52. View in: PubMed

Toltzis P, Soto-Campos G, Kuhn EM, Hahn R, Kanter RK, Wetzel RC. Evidence-Based Pediatric Outcome Predictors to Guide the Allocation of Critical Care Resources in a Mass Casualty Event. Pediatr Crit Care Med. 2015 Sep; 16(7):e207-16. View in: PubMed

Gupta P, Tang X, Gossett JM, Gall CM, Lauer C, Rice TB, Wetzel RC. Variation of ventilation practices with center volume after pediatric heart surgery. Clin Cardiol. 2015 Mar; 38(3):178-84. View in: PubMed

Fackler J, Lehmann HP, Wetzel RC. Critical Care for Rare Diseases (and Procedures): Redux*. Pediatr Crit Care Med. 2015 Mar; 16(3):297-9. View in: PubMed

Kale DC, Che Z, Bahadori MT, Li W, Liu Y, Wetzel R. Causal Phenotype Discovery via Deep Networks. AMIA Annu Symp Proc. 2015; 2015:677-86. View in: PubMed

Gupta P, Tang X, Gall CM, Lauer C, Rice TB, Wetzel RC. Epidemiology and outcomes of in-hospital cardiac arrest in critically ill children across hospitals of varied center volume: A multi-center analysis. Resuscitation. 2014 Nov; 85(11):1473-9. View in: PubMed

Gupta P, Kacmarek RM, Wetzel RC. It is too early to declare early or late rescue high-frequency oscillatory ventilation dead-reply. JAMA Pediatr. 2014 Sep 1; 168(9):863. View in: PubMed

Khemani RG, Celikkaya EB, Shelton CR, Kale D, Ross PA, Wetzel RC, Newth CJ. Algorithms to estimate PaCO2 and pH using noninvasive parameters for children with hypoxemic respiratory failure. Respir Care. 2014 Aug; 59(8):1248-57. View in: PubMed

Gupta P, Tang X, Gossett JM, Gall CM, Lauer C, Rice TB, Carroll CL, Kacmarek RM, Wetzel RC. Association of center volume with outcomes in critically ill children with acute asthma. Ann Allergy Asthma Immunol. 2014 Jul; 113(1):42-7. View in: PubMed

Gupta P, Green JW, Tang X, Gall CM, Gossett JM, Rice TB, Kacmarek RM, Wetzel RC. Comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. JAMA Pediatr. 2014 Mar 1; 168(3):243-9. View in: PubMed

Marcin JP, Wetzel RC. The parsimonious pediatric index of mortality*. Pediatr Crit Care Med. 2013 Sep; 14(7):718-9. View in: PubMed

Burke RV, Berg BM, Vee P, Morton I, Nager A, Neches R, Wetzel R, Upperman JS. Using robotic telecommunications to triage pediatric disaster victims. J Pediatr Surg. 2012 Jan; 47(1):221-4. View in: PubMed

Wetzel RC, Sachedeva R, Rice TB. Are all ICUs the same? Paediatr Anaesth. 2011 Jul; 21(7):787-93. View in: PubMed

Wetzel RC. Who is doing what to whom: a large prospective study of propofol anesthesia in children. Anesth Analg. 2009 Mar; 108(3):695-8. View in: PubMed

Gorman M, Sachdeva R, Rice T, Wetzel R. Support for PICUs and the PRISM scoring algorithms. Pediatr Crit Care Med. 2009 Jan; 10(1):143-4. View in: PubMed

LaRovere JM, Jeffries HE, Sachdeva RC, Rice TB, Wetzel RC, Cooper DS, Bird GL, Ghanayem NS, Checchia PA, Chang AC, Wessel DL. Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease--the perspective of critical care. Cardiol Young. 2008 Dec; 18 Suppl 2:130-6. View in: PubMed

Wetzel RC. Calcium: a double-edged sword. Pediatr Crit Care Med. 2007 May; 8(3):300-1. View in: PubMed

Graham AS, Chandrashekharaiah G, Citak A, Wetzel RC, Newth CJ. Positive end-expiratory pressure and pressure support in peripheral airways obstruction : work of breathing in intubated children. Intensive Care Med. 2007 Jan; 33(1):120-7. View in: PubMed

Wetzel RC. Don't confuse the anesthetic with the anesthesiologist! Anesth Analg. 2006 Oct; 103(4):859-62. View in: PubMed

Baden HP, Berger J, Brilli RI, Burns JP, Checchia PA, Dalton HJ, Nadkarni V, Pollack M, Wetzel RC, Zimmerman JJ. Pediatric cardiac critical care patients should be cared for by intensivists. J Am Coll Cardiol. 2006 Jul 4; 48(1):221-2; author reply 222-3. View in: PubMed

Wetzel RC. Precise use of medical terminology. Crit Care Med. 2006 Jun; 34(6):1854; author reply 1854-5. View in: PubMed

Baden HP, Zimmerman JJ, Brilli RJ, Wong H, Wetzel RC, Burns JP, Nadkarni V, Checchia PA, Dalton HJ, Berger J, Pollack M, Notterman D, Green TP, Blumer J, Dean M. Intensivist-led team approach to critical care of children with heart disease. Pediatrics. 2006 May; 117(5):1854-6; author reply 1856-7. View in: PubMed

Jeffries HE, Wells WJ, Starnes VA, Wetzel RC, Moromisato DY. Gastrointestinal morbidity after Norwood palliation for hypoplastic left heart syndrome. Ann Thorac Surg. 2006 Mar; 81(3):982-7. View in: PubMed

Willis BC, Graham AS, Yoon E, Wetzel RC, Newth CJ. Pressure-rate products and phase angles in children on minimal support ventilation and after extubation. Intensive Care Med. 2005 Dec; 31(12):1700-5. View in: PubMed

Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov; 6(6):642-7. View in: PubMed

Baker LC, Wetzel RC. Telemedicine: basic technical considerations. J Intensive Care Med. 2004 Sep-Oct; 19(5):297-8. View in: PubMed

Willis BC, Graham AS, Wetzel R, L Newth CJ. Respiratory inductance plethysmography used to diagnose bilateral diaphragmatic paralysis: a case report. Pediatr Crit Care Med. 2004 Jul; 5(4):399-402. View in: PubMed

Wetzel RC. Telemedicine and intensive care: are we ready and willing? J Intensive Care Med. 2004 Mar-Apr; 19(2):117-8. View in: PubMed

Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27; 288(20):2561-8. View in: PubMed

Wetzel RC, Burns RC. Multiple trauma in children: critical care overview. Crit Care Med. 2002 Nov; 30(11 Suppl):S468-77. View in: PubMed

Fackler JC, Wetzel RC. Critical care for rare diseases. Pediatr Crit Care Med. 2002 Jan; 3(1):89-90. View in: PubMed

Wetzel RC. The virtual pediatric intensive care unit. Practice in the new millennium. Pediatr Clin North Am. 2001 Jun; 48(3):795-814. View in: PubMed

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