Faculty

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Raymond D Mosteller, PhD
Associate Professor of Biochemistry & Molecular Biology
Director of The Computer Curriculum, Educational Affairs
Biochemistry and Molecular Biology
BMT B11 E 1333 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1588

Overview

CURRENT RESEARCH INTERESTS:
Dr. Mosteller's research interests are in the area of guanine nucleotide binding proteins (G-proteins) including the Ras proteins (e.g. k-ras) from eucaryotic organisms including yeast (Saccharomyces cerevisiae) and humans. His most recent research has involved studies of the interactions of G-proteins with other regulatory molecules in the cell such as the guanine nucleotide exchange factor (GNEF) and Vav. He is also interested in the membrane phosphoinositides, PIP2 and PIP3, and the PI-3-kinase signalling pathway.

PREVIOUS RESEARCH INTERESTS:
His previous research interests include the following: regulation of expression of the tryptophan operon in Escherichia coli; interaction of the alpha and beta subunits of tryptophan synthase from Escherichia coli; protein metabolism and turnover in Escherichia coli; interaction of transducin protein with rhodopsin in photoreceptor cells; the mechanism of protein synthesis in vitro on polyribosomes from rabbit reticulocytes.

EDUCATION AND TRAINING:
Dr. Mosteller received his B.A. and Ph.D. degrees from the University of Texas in Austin. As an undergraduate, he was elected into the Phi Eta Sigma and Phi Beta Kappa honor societies. His Ph.D. work was with Dr. Boyd Hardesty studying protein synthesis in vitro on polyribosomes from rabbit reticulocytes. He completed his postdoctoral studies at Stanford University working with Dr. Charles Yanofsky on the regulation of expression of the tryptophan operon in Escherichia coli. Dr. Mosteller also spent a one year sabbatical with Dr. Melvin Simon at the California Institute of Technology (Caltech) studying the interaction of the protein transducin with rhodopsin in photoreceptor cells. After his sabbatical, Dr. Mosteller collaborated for 10 years with Dr. Daniel Broek in the USC Norris Comprehensive Cancer Center studying various aspects of Ras and G-protein regulation in yeast (Saccharomyces cerevisiae) and humans.

Publications

Wu W, Mosteller RD, Broek D. Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis. Mol Cell Biol. 2004 Sep; 24(17):7359-69. View in: PubMed

Wu W, Shu X, Hovsepyan H, Mosteller RD, Broek D. VEGF receptor expression and signaling in human bladder tumors. Oncogene. 2003 May 29; 22(22):3361-70. View in: PubMed

Shu X, Wu W, Mosteller RD, Broek D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol Cell Biol. 2002 Nov; 22(22):7758-68. View in: PubMed

Mosteller RD, Goldstein BE. A mathematical model that applies to protein degradation and post-translational processing of proteins and to analogous processes for other molecules in non-growing and exponentially growing cells. J Theor Biol. 1984 Jun 21; 108(4):597-621. View in: PubMed

Mosteller RD, Goldstein RV. Post-translational modification of a tryptophan biosynthetic enzyme. Precursor-product relationships in vivo and carbon-energy source dependence. J Biol Chem. 1983 Nov 10; 258(21):12793-6. View in: PubMed

Mosteller RD, Nishimoto KR, Bush PR, Golstein RV. Energy-dependent inactivation and modification of a tryptophan biosynthetic enzyme in Escherichia coli. J Biol Chem. 1982 Sep 10; 257(17):10184-90. View in: PubMed

Mosteller RD, Goldstein RV, Nishimoto KR. Metabolism of individual proteins in exponentially growing Escherichia coli. J Biol Chem. 1980 Mar 25; 255(6):2524-32. View in: PubMed

Simonian MH, Goldstein RV, Mosteller RD. Genetic and segregation analysis of Escherichia coli strains containing a tandem duplication of the trpD-purB region of the chromosome. J Bacteriol. 1978 Feb; 133(2):650-60. View in: PubMed

Mosteller RD. Evidence that glucose starvation-sensitive mutants are altered in the relB locus. J Bacteriol. 1978 Feb; 133(2):1034-7. View in: PubMed

Katze JR, Simonian MH, Mosteller RD. Role of methionine in the synthesis of nucleoside Q in Escherichia coli transfer ribonucleic acid. J Bacteriol. 1977 Oct; 132(1):174-9. View in: PubMed

Mosteller RD, Goldstein RV, Nishimoto KR. Interactions of tryptophan synthetase subunits in Escherichia coli containing mutationally altered beta2 subunits. J Biol Chem. 1977 Jul 10; 252(13):4527-32. View in: PubMed

Mosteller RD, Nishimoto KR, Goldstein RV. Inactivation and partial degradation of phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase in nongrowing cultures of Escherichia coli. J Bacteriol. 1977 Jul; 131(1):153-62. View in: PubMed

Mosteller RD, Kwan SF. Isolation of relaxed-control mutants of escherichia coli K-12 which are sensitive to glucose starvation. Biochem Biophys Res Commun. 1976 Mar 22; 69(2):325-32. View in: PubMed

Katze JR, Mosteller RD. Inhibition of nucleoside Q formation in transfer ribonucleic acid during methionine starvation of relaxed-control Escherichia coli. J Bacteriol. 1976 Jan; 125(1):205-10. View in: PubMed

Simonian MH, Mosteller RD. Increased loss of duplicated genes in streptomycin-resistant (strA) mutants of Escherichia coli k-12. J Bacteriol. 1976 Jan; 125(1):382-4. View in: PubMed

Mosteller RD, Goldstein RV. Unusual sensitivity of Escherichia coli to adenine or adenine plus histidine. J Bacteriol. 1975 Aug; 123(2):750-1. View in: PubMed

Mosteller RD, Yanofsky C. Evidence that tryptophanyl transfer ribonucleic acid is not the corepressor of the tryptophan operon of Escherichia coli. J Bacteriol. 1971 Jan; 105(1):268-75. View in: PubMed

Rose JK, Mosteller RD, Yanofsky C. Tryptophan messenger ribonucleic acid elongation rates and steady-state levels of tryptophan operon enzymes under various growth conditions. J Mol Biol. 1970 Aug; 51(3):541-50. View in: PubMed

Mosteller RD, Yanofsky C. Transcription of the tryptophan operon in Escherichia coli: rifampicin as an inhibitor of initiation. J Mol Biol. 1970 Mar; 48(3):525-31. View in: PubMed

Morse DE, Mosteller RD, Yanofsky C. Dynamics of synthesis, translation, and degradation of trp operon messenger RNA in E. coli. Cold Spring Harb Symp Quant Biol. 1969; 34:725-40. View in: PubMed

Mosteller RD, Culp WJ, Hardesty B. Deacylated transfer ribonucleic acid as a factor for peptide chain initiation in rabbit reticulocyte systems. J Biol Chem. 1968 Dec 25; 243(24):6343-52. View in: PubMed

Culp WJ, Mosteller RD, Hardesty B. Involvement of transfer ribonucleic acid in early reactions of polyphenylalanine synthesis. Arch Biochem Biophys. 1968 May; 125(2):658-70. View in: PubMed

Mosteller RD, Culp WJ, Hardesty B. The requirement for tRNA for the shift in the optimum Mg++ concentration during the synthesis of polyphenylalanine. Biochem Biophys Res Commun. 1968 Mar 27; 30(6):631-6. View in: PubMed

Mosteller RD, Culp WJ, Hardesty B. A reaction associated with nonenzymatic binding in the reticulocyte transfer system. Proc Natl Acad Sci U S A. 1967 Jun; 57(6):1817-24. View in: PubMed

Lin SY, Mosteller RD, Hardesty B. The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte system. J Mol Biol. 1966 Oct 28; 21(1):51-69. View in: PubMed

Ravel JM, Mosteller RD, Hardesty B. NaF inhibition of the initial binding of aminoacyl-sRNA to reticulocyte ribosomes. Proc Natl Acad Sci U S A. 1966 Aug; 56(2):701-8. View in: PubMed

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