Faculty

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Raymond Stevens, PhD
Provost Professor of Biological Sciences and Chemistry / Director, The Bridge@Usc
Broad CIRM Center
TRF 114B University Park Campus Los Angeles
+1 213 740 1992

Publications

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Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody. Proc Natl Acad Sci U S A. 2017 Aug 01; 114(31):8223-8228. View in: PubMed

Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature. 2017 Jul 27; 547(7664):468-471. View in: PubMed

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell. 2017 Jul 27; 170(3):457-469. e13. View in: PubMed

How Ligands Illuminate GPCR Molecular Pharmacology. Cell. 2017 Jul 27; 170(3):414-427. View in: PubMed

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Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 2017 Jun 20; 46(6):1005-1017. e5. View in: PubMed

Structural Basis for Apelin Control of the Human Apelin Receptor. Structure. 2017 Jun 06; 25(6):858-866. e4. View in: PubMed

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun. 2017 May 17; 8:15383. View in: PubMed

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor. J Med Chem. 2017 Apr 13; 60(7):3070-3081. View in: PubMed

Structural basis for selectivity and diversity in angiotensin II receptors. Nature. 2017 Apr 05. View in: PubMed

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 06 08; 546(7657):312-315. View in: PubMed

Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017 06 08; 546(7657):259-264. View in: PubMed

ß2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop. Structure. 2016 Dec 06; 24(12):2190-2197. View in: PubMed

Crystal Structure of the Human Cannabinoid Receptor CB1. Cell. 2016 Oct 20; 167(3):750-762. e14. View in: PubMed

Native phasing of x-ray free-electron laser data for a G protein-coupled receptor. Sci Adv. 2016 Sep; 2(9):e1600292. View in: PubMed

The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 Aug 22; 55(35):10331-5. View in: PubMed

Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R). J Biol Chem. 2016 Jun 17; 291(25):12991-3004. View in: PubMed

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Sci Data. 2016 Apr 12; 3:160021. View in: PubMed

An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels. Nat Commun. 2016 Jan 12; 7:8770. View in: PubMed

In vitro expression and analysis of the 826 human G protein-coupled receptors. Protein Cell. 2016 05; 7(5):325-37. View in: PubMed

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 12 15; 540(7633):458-461. View in: PubMed

In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs. Angew Chem Int Ed Engl. 2015 Dec 07; 54(50):15246-9. View in: PubMed

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J Biol Chem. 2015 Dec 04; 290(49):29127-39. View in: PubMed

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor. Structure. 2015 Dec 01; 23(12):2291-9. View in: PubMed

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor ß2AR. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14254-9. View in: PubMed

Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4733-9. View in: PubMed

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):11852-7. View in: PubMed

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information. J Comput Aided Mol Des. 2015 Aug; 29(8):737-56. View in: PubMed

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol Pharmacol. 2015 Aug; 88(2):220-30. View in: PubMed

Conformational states of the full-length glucagon receptor. Nat Commun. 2015 Jul 31; 6:7859. View in: PubMed

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature. 2015 Jul 30; 523(7562):561-7. View in: PubMed

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 2015 Jun 18; 161(7):1633-43. View in: PubMed

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chem Biol. 2015 Jun 18; 22(6):764-75. View in: PubMed

Exploring the potential impact of an expanded genetic code on protein function. Proc Natl Acad Sci U S A. 2015 Jun 2; 112(22):6961-6. View in: PubMed

Exploring the potential impact of an expanded genetic code on protein function. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):6961-6. View in: PubMed

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell. 2015 May 07; 161(4):833-44. View in: PubMed

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell. 2015 May 7; 161(4):833-44. View in: PubMed

Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 Apr 16; 520(7547):317-21. View in: PubMed

Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science. 2015 Mar 06; 347(6226):1117-22. View in: PubMed

Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science. 2015 Mar 6; 347(6226):1117-22. View in: PubMed

Structural basis for bifunctional peptide recognition at human d-opioid receptor. Nat Struct Mol Biol. 2015 Mar; 22(3):265-8. View in: PubMed

The importance of ligands for G protein-coupled receptor stability. Trends Biochem Sci. 2015 Feb; 40(2):79-87. View in: PubMed

Sodium ion binding pocket mutations and adenosine A2A receptor function. Mol Pharmacol. 2015 Feb; 87(2):305-13. View in: PubMed

Generic GPCR residue numbers - aligning topology maps while minding the gaps. Trends Pharmacol Sci. 2015 Jan; 36(1):22-31. View in: PubMed

Conformational states of the full-length glucagon receptor. Nat Commun. 2015; 6:7859. View in: PubMed

Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes. ACS Chem Biol. 2014 Dec 19; 9(12):2833-42. View in: PubMed

Constitutive phospholipid scramblase activity of a G protein-coupled receptor. Nat Commun. 2014 Oct 08; 5:5115. View in: PubMed

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure. 2014 Aug 05; 22(8):1120-1139. View in: PubMed

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure. 2014 Aug 05; 22(8):1120-39. View in: PubMed

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure. 2014 Aug 5; 22(8):1120-39. View in: PubMed

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun. 2014 Jul 10; 5:4355. View in: PubMed

Agonist-bound structure of the human P2Y12 receptor. Nature. 2014 May 1; 509(7498):119-22. View in: PubMed

Allosteric sodium in class A GPCR signaling. Trends Biochem Sci. 2014 May; 39(5):233-44. View in: PubMed

Agonist-bound structure of the human P2Y12 receptor. Nature. 2014 May 01; 509(7498):119-22. View in: PubMed

Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature. 2014 May 01; 509(7498):115-8. View in: PubMed

Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature. 2014 May 1; 509(7498):115-8. View in: PubMed

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science. 2014 Apr 4; 344(6179):58-64. View in: PubMed

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science. 2014 Apr 04; 344(6179):58-64. View in: PubMed

Molecular control of d-opioid receptor signalling. Nature. 2014 Feb 13; 506(7487):191-6. View in: PubMed

The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J Mol Biol. 2014 Jan 9; 426(1):150-68. View in: PubMed

The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J Mol Biol. 2014 Jan 09; 426(1):150-68. View in: PubMed

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat Commun. 2014; 5:3309. View in: PubMed

Insights into the structure of class B GPCRs. Trends Pharmacol Sci. 2014 Jan; 35(1):12-22. View in: PubMed

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs. Nat Commun. 2014; 5:4355. View in: PubMed

Serial femtosecond crystallography of G protein-coupled receptors. Science. 2013 Dec 20; 342(6165):1521-4. View in: PubMed

Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell. 2013 Dec 5; 155(6):1258-69. View in: PubMed

Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell. 2013 Dec 05; 155(6):1258-69. View in: PubMed

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure. 2013 Dec 3; 21(12):2175-85. View in: PubMed

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure. 2013 Dec 03; 21(12):2175-85. View in: PubMed

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors. Mol Pharmacol. 2013 Dec; 84(6):794-807. View in: PubMed

Chemotype-selective modes of action of ?-opioid receptor agonists. J Biol Chem. 2013 Nov 29; 288(48):34470-83. View in: PubMed

ß2-adrenergic receptor activation by agonists studied with ¹?F NMR spectroscopy. Angew Chem Int Ed Engl. 2013 Oct 04; 52(41):10762-5. View in: PubMed

ß2-adrenergic receptor activation by agonists studied with ¹?F NMR spectroscopy. Angew Chem Int Ed Engl. 2013 Oct 4; 52(41):10762-5. View in: PubMed

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science. 2013 Sep 20; 341(6152):1387-90. View in: PubMed

Asia growth in membrane protein structure. Curr Opin Struct Biol. 2013 Aug; 23(4):481-2. View in: PubMed

Engineered nanostructured ß-sheet peptides protect membrane proteins. Nat Methods. 2013 Aug; 10(8):759-61. View in: PubMed

Structure of the human glucagon class B G-protein-coupled receptor. Nature. 2013 Jul 25; 499(7459):444-9. View in: PubMed

Structure of the human smoothened receptor bound to an antitumour agent. Nature. 2013 May 16; 497(7449):338-43. View in: PubMed

Structural features for functional selectivity at serotonin receptors. Science. 2013 May 03; 340(6132):615-9. View in: PubMed

Structural basis for molecular recognition at serotonin receptors. Science. 2013 May 03; 340(6132):610-4. View in: PubMed

Structural features for functional selectivity at serotonin receptors. Science. 2013 May 3; 340(6132):615-9. View in: PubMed

Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. J Am Chem Soc. 2013 Apr 24; 135(16):6289-99. View in: PubMed

Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):E1203-11. View in: PubMed

Coordinating the impact of structural genomics on the human a-helical transmembrane proteome. Nat Struct Mol Biol. 2013 Feb; 20(2):135-8. View in: PubMed

Opportunities for functional selectivity in GPCR antibodies. Biochem Pharmacol. 2013 Jan 15; 85(2):147-52. View in: PubMed

ß2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements. Angew Chem Int Ed Engl. 2013 Jan 02; 52(1):331-5. View in: PubMed

ß2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements. Angew Chem Int Ed Engl. 2013 Jan 2; 52(1):331-5. View in: PubMed

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov. 2013 01; 12(1):25-34. View in: PubMed

Structure-function of the G protein-coupled receptor superfamily. Annu Rev Pharmacol Toxicol. 2013; 53:531-56. View in: PubMed

Sphingosine-1-phosphate and its receptors: structure, signaling, and influence. Annu Rev Biochem. 2013; 82:637-62. View in: PubMed

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov. 2013 Jan; 12(1):25-34. View in: PubMed

Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A). PLoS Pathog. 2013; 9(5):e1003369. View in: PubMed

A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods Mol Biol. 2013; 1013:93-127. View in: PubMed

Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes. J Biol Chem. 2012 Dec 14; 287(51):43063-70. View in: PubMed

Synthesis and properties of dodecyl trehaloside detergents for membrane protein studies. Langmuir. 2012 Jul 31; 28(30):11173-81. View in: PubMed

Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity. ACS Chem Biol. 2012 Jul 20; 7(7):1184-9. View in: PubMed

Structural basis for allosteric regulation of GPCRs by sodium ions. Science. 2012 Jul 13; 337(6091):232-6. View in: PubMed

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure. 2012 Jun 6; 20(6):967-76. View in: PubMed

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure. 2012 Jun 06; 20(6):967-76. View in: PubMed

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 2012 May 17; 485(7398):395-9. View in: PubMed

Structure of the human ?-opioid receptor in complex with JDTic. Nature. 2012 May 17; 485(7398):327-32. View in: PubMed

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature. 2012 May 16; 485(7398):395-9. View in: PubMed

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. J Med Chem. 2012 May 10; 55(9):4297-308. View in: PubMed

Structure of the human ?-opioid receptor in complex with JDTic. Nature. 2012 Mar 21; 485(7398):327-32. View in: PubMed

Biased signaling pathways in ß2-adrenergic receptor characterized by 19F-NMR. Science. 2012 Mar 02; 335(6072):1106-10. View in: PubMed

Biased signaling pathways in ß2-adrenergic receptor characterized by 19F-NMR. Science. 2012 Mar 2; 335(6072):1106-10. View in: PubMed

Crystal structure of a lipid G protein-coupled receptor. Science. 2012 Feb 17; 335(6070):851-5. View in: PubMed

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor. J Med Chem. 2012 Jan 12; 55(1):538-52. View in: PubMed

Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci. 2012 Jan; 33(1):17-27. View in: PubMed

Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response? JIMD Rep. Chaperone-like therapy with tetrahydrobiopterin in clinical trials for phenylketonuria: is genotype a predictor of response? JIMD Rep. 2012; 5:59-70. View in: PubMed

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem. 2011 Dec 8; 54(23):8195-206. View in: PubMed

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem. 2011 Dec 08; 54(23):8195-206. View in: PubMed

GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods. 2011 Dec; 55(4):310-7. View in: PubMed

A roadmap to membrane protein structures. Methods. 2011 Dec; 55(4):271-2. View in: PubMed

Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria. Mol Genet Metab. 2011 Nov; 104(3):249-54. View in: PubMed

Ligand-dependent perturbation of the conformational ensemble for the GPCR ß2 adrenergic receptor revealed by HDX. Structure. 2011 Oct 12; 19(10):1424-32. View in: PubMed

Trapping small caffeine in a large GPCR pocket. Structure. 2011 Sep 7; 19(9):1204-7. View in: PubMed

Trapping small caffeine in a large GPCR pocket. Structure. 2011 Sep 07; 19(9):1204-7. View in: PubMed

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure. 2011 Aug 10; 19(8):1108-26. View in: PubMed

Structure of the human histamine H1 receptor complex with doxepin. Nature. 2011 Jul 7; 475(7354):65-70. View in: PubMed

Structure of the human histamine H1 receptor complex with doxepin. Nature. 2011 Jun 22; 475(7354):65-70. View in: PubMed

The crystal structure of the a-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure. 2011 Jun 08; 19(6):767-78. View in: PubMed

The crystal structure of the a-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure. 2011 Jun 8; 19(6):767-78. View in: PubMed

Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222. Appl Environ Microbiol. 2011 Jun; 77(12):4217-22. View in: PubMed

Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility. Biochemistry. 2011 May 17; 50(19):4019-28. View in: PubMed

Reversible competitive a-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. J Med Chem. 2011 Apr 28; 54(8):2805-22. View in: PubMed

Structure of an agonist-bound human A2A adenosine receptor. Science. 2011 Apr 15; 332(6027):322-7. View in: PubMed

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. Cryst Growth Des. 2011 Apr 06; 11(4):1193-1201. View in: PubMed

Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent a-ketoheterocycle inhibitor of fatty acid amide hydrolase. J Am Chem Soc. 2011 Mar 23; 133(11):4092-100. View in: PubMed

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science. 2010 Nov 19; 330(6007):1091-5. View in: PubMed

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010 Nov 19; 330(6007):1066-71. View in: PubMed

RAMP-ing up class-B GPCR ECD structural coverage. Structure. 2010 Sep 08; 18(9):1067-8. View in: PubMed

RAMP-ing up class-B GPCR ECD structural coverage. Structure. 2010 Sep 8; 18(9):1067-8. View in: PubMed

Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. J Am Chem Soc. 2010 Aug 25; 132(33):11443-5. View in: PubMed

FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A. Proteins. 2010 Aug 1; 78(10):2189-201. View in: PubMed

Growth and excitement in membrane protein structural biology. Curr Opin Struct Biol. 2010 Aug; 20(4):399-400. View in: PubMed

FoldGPCR: structure prediction protocol for the transmembrane domain of G protein-coupled receptors from class A. Proteins. 2010 Aug 01; 78(10):2189-201. View in: PubMed

Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. J Mol Biol. 2010 Jul 23; 400(4):743-54. View in: PubMed

Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26. Langmuir. 2010 Jun 01; 26(11):8690-6. View in: PubMed

Design, synthesis, and properties of branch-chained maltoside detergents for stabilization and crystallization of integral membrane proteins: human connexin 26. Langmuir. 2010 Jun 1; 26(11):8690-6. View in: PubMed

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. J Biol Chem. 2010 Apr 23; 285(17):13032-44. View in: PubMed

LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment. Biophys J. 2010 Apr 21; 98(8):1539-48. View in: PubMed

Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding. J Mol Biol. 2010 Apr 16; 397(5):1287-97. View in: PubMed

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. J Mol Biol. 2010 Apr 09; 397(4):1106-18. View in: PubMed

A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. J Mol Biol. 2010 Apr 9; 397(4):1106-18. View in: PubMed

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25; 53(4):1799-809. View in: PubMed

Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Anal Chem. 2010 Feb 1; 82(3):1100-8. View in: PubMed

Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Anal Chem. 2010 Feb 01; 82(3):1100-8. View in: PubMed

X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J Med Chem. 2010 Jan 14; 53(1):230-40. View in: PubMed

Converting an injectable protein therapeutic into an oral form: phenylalanine ammonia lyase for phenylketonuria. Mol Genet Metab. 2010 Jan; 99(1):4-9. View in: PubMed

Rescue of misfolded proteins and stabilization by small molecules. Methods Mol Biol. 2010; 648:313-24. View in: PubMed

Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets. Methods Mol Biol. 2010; 654:141-68. View in: PubMed

Structural aspects of therapeutic enzymes to treat metabolic disorders. Hum Mutat. 2009 Dec; 30(12):1591-610. View in: PubMed

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface. 2009 Oct 06; 6 Suppl 5:S587-97. View in: PubMed

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface. 2009 Oct 6; 6 Suppl 5:S587-97. View in: PubMed

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. J Am Chem Soc. 2009 Aug 05; 131(30):10497-506. View in: PubMed

Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. J Am Chem Soc. 2009 Aug 5; 131(30):10497-506. View in: PubMed

Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2. 0 A resolution. Nat Struct Mol Biol. 2009 Jul; 16(7):795. View in: PubMed

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. Nat Rev Drug Discov. 2009 Jun; 8(6):455-63. View in: PubMed

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24; 16(4):411-20. View in: PubMed

Discovery of new GPCR biology: one receptor structure at a time. Structure. 2009 Jan 14; 17(1):8-14. View in: PubMed

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. Nat Rev Drug Discov. 2009 06; 8(6):455-63. View in: PubMed

Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20894-9. View in: PubMed

Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. Biochemistry. 2008 Dec 23; 47(51):13514-23. View in: PubMed

The 2. 6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science. 2008 Nov 21; 322(5905):1211-7. View in: PubMed

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5847-50. View in: PubMed

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature. 2008 Nov 06; 456(7218):121-4. View in: PubMed

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature. 2008 Nov 6; 456(7218):121-4. View in: PubMed

Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):12820-4. View in: PubMed

Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12820-4. View in: PubMed

Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. PLoS Pathog. 2008 Aug 15; 4(8):e1000129. View in: PubMed

Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase. J Mol Biol. 2008 Jul 18; 380(4):623-35. View in: PubMed

Microscale NMR screening of new detergents for membrane protein structural biology. J Am Chem Soc. 2008 Jun 11; 130(23):7357-63. View in: PubMed

Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. J Virol. 2008 Jun; 82(11):5279-94. View in: PubMed

A specific cholesterol binding site is established by the 2. 8 A structure of the human beta2-adrenergic receptor. Structure. 2008 Jun; 16(6):897-905. View in: PubMed

Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments. J Membr Biol. 2008 May; 223(1):13-26. View in: PubMed

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3. 41), a critical residue in GPCR structure. J Mol Biol. 2008 Mar 07; 376(5):1305-19. View in: PubMed

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3. 41), a critical residue in GPCR structure. J Mol Biol. 2008 Mar 7; 376(5):1305-19. View in: PubMed

Microscale fluorescent thermal stability assay for membrane proteins. Structure. 2008 Mar; 16(3):351-9. View in: PubMed

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog. J Mol Biol. 2008 Feb 22; 376(3):758-70. View in: PubMed

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallogr D Biol Crystallogr. 2008 Feb; 64(Pt 2):189-97. View in: PubMed

Protein production and purification. Nat Methods. 2008 Feb; 5(2):135-46. View in: PubMed

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2. 05 A resolution. Proteins. 2008 Feb 1; 70(2):603-8. View in: PubMed

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2. 05 A resolution. Proteins. 2008 Feb 01; 70(2):603-8. View in: PubMed

Protein crystallization in restricted geometry: advancing old ideas for modern times in structural proteomics. Methods Mol Biol. 2008; 426:363-76. View in: PubMed

LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization. Cryst Growth Des. 2008; 8(12):4307-4315. View in: PubMed

Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. PLoS Pathog. 2008; 4(8):e1000129. View in: PubMed

Molecular genetics of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Hum Mutat. 2008 Jan; 29(1):167-75. View in: PubMed

Generation of protein structures for the 21(st) century. Structure. 2007 Dec; 15(12):1517-9. View in: PubMed

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science. 2007 Nov 23; 318(5854):1266-73. View in: PubMed

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science. 2007 Nov 23; 318(5854):1258-65. View in: PubMed

Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. J Virol. 2007 Nov; 81(21):12049-60. View in: PubMed

Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expr Purif. 2007 Nov; 56(1):85-92. View in: PubMed

Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria. Mol Genet Metab. 2007 Aug; 91(4):325-34. View in: PubMed

Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. J Virol. 2007 Jun; 81(12):6700-8. View in: PubMed

Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein. J Virol. 2007 Apr; 81(8):3913-21. View in: PubMed

Designing facial amphiphiles for the stabilization of integral membrane proteins. Angew Chem Int Ed Engl. 2007; 46(37):7023-5. View in: PubMed

Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin. Nat Biotechnol. 2007 Jan; 25(1):107-16. View in: PubMed

Mutations in the regulatory domain of phenylalanine hydroxylase and response to tetrahydrobiopterin. Genet Test. 2007; 11(2):174-8. View in: PubMed

Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature. 2006 Dec 21; 444(7122):1096-100. View in: PubMed

Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8156-60. View in: PubMed

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2. 0 A resolution. Proteins. 2006 Nov 15; 65(3):527-37. View in: PubMed

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2. 6 A resolution reveals a new fold with a novel active site. Proteins. 2006 Nov 15; 65(3):771-6. View in: PubMed

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1. 75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Proteins. 2006 Nov 15; 65(3):777-82. View in: PubMed

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1. 90 A resolution. Proteins. 2006 Oct 01; 65(1):249-54. View in: PubMed

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1. 90 A resolution. Proteins. 2006 Oct 1; 65(1):249-54. View in: PubMed

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2. 70 A resolution reveals a new fold. Proteins. 2006 Oct 01; 65(1):243-8. View in: PubMed

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2. 70 A resolution reveals a new fold. Proteins. 2006 Oct 1; 65(1):243-8. View in: PubMed

A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol. 2006 Sep 29; 362(4):733-42. View in: PubMed

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1. 58 A resolution. Proteins. 2006 Sep 1; 64(4):1083-90. View in: PubMed

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1. 58 A resolution. Proteins. 2006 Sep 01; 64(4):1083-90. View in: PubMed

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2. 06 angstrom resolution. Proteins. 2006 Aug 15; 64(3):808-13. View in: PubMed

Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol. 2006 Aug; 80(16):7894-901. View in: PubMed

Crystal structure of TM1367 from Thermotoga maritima at 1. 90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 1; 63(4):1112-8. View in: PubMed

Crystal structure of TM1367 from Thermotoga maritima at 1. 90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins. 2006 Jun 01; 63(4):1112-8. View in: PubMed

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2. 15 A resolution. Proteins. 2006 Jun 01; 63(4):1106-11. View in: PubMed

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2. 15 A resolution. Proteins. 2006 Jun 1; 63(4):1106-11. View in: PubMed

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5717-22. View in: PubMed

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2. 60 A resolution. Proteins. 2006 Apr 1; 63(1):256-60. View in: PubMed

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2. 60 A resolution. Proteins. 2006 Apr 01; 63(1):256-60. View in: PubMed

Structure of botulinum neurotoxin type D light chain at 1. 65 A resolution: repercussions for VAMP-2 substrate specificity. Biochemistry. 2006 Mar 14; 45(10):3255-62. View in: PubMed

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2. 25 A resolution reveals a new fold. Proteins. 2006 Jan 1; 62(1):292-6. View in: PubMed

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2. 25 A resolution reveals a new fold. Proteins. 2006 Jan 01; 62(1):292-6. View in: PubMed

Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 01; 61(Pt 12):1035-8. View in: PubMed

Response of patients with phenylketonuria in the US to tetrahydrobiopterin. Mol Genet Metab. 2005 Dec; 86 Suppl 1:S17-21. View in: PubMed

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1. 90 A resolution reveals a new fold. Proteins. 2005 Dec 01; 61(4):1132-6. View in: PubMed

In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr. 2005 Dec; 38(6):900-905. View in: PubMed

Crystallization Optimum Solubility Screening: using crystallization results to identify the optimal buffer for protein crystal formation. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1; 61(Pt 12):1035-8. View in: PubMed

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR. J Struct Funct Genomics. 2005 Dec; 6(4):259-67. View in: PubMed

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1. 90 A resolution reveals a new fold. Proteins. 2005 Dec 1; 61(4):1132-6. View in: PubMed

Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2. 20 A resolution. Proteins. 2005 Nov 15; 61(3):669-73. View in: PubMed

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1. 95 A resolution reveals a new fold. Proteins. 2005 Nov 1; 61(2):444-8. View in: PubMed

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1. 95 A resolution reveals a new fold. Proteins. 2005 Nov 01; 61(2):444-8. View in: PubMed

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2. 05 A resolution reveals a new fold. Proteins. 2005 Nov 1; 61(2):449-53. View in: PubMed

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2. 05 A resolution reveals a new fold. Proteins. 2005 Nov 01; 61(2):449-53. View in: PubMed

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure. 2005 Nov; 13(11):1665-75. View in: PubMed

Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. J Virol. 2005 Oct; 79(20):12905-13. View in: PubMed

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1. 83 A resolution. Proteins. 2005 Sep 1; 60(4):797-802. View in: PubMed

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1. 83 A resolution. Proteins. 2005 Sep 01; 60(4):797-802. View in: PubMed

The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure. 2005 Sep; 13(9):1385-96. View in: PubMed

Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria. Mol Genet Metab. 2005 Sep-Oct; 86(1-2):134-40. View in: PubMed

Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition. Biochemistry. 2005 Jul 19; 44(28):9574-80. View in: PubMed

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2. 0 A resolution reveals a new fold. Proteins. 2005 Jun 01; 59(4):869-74. View in: PubMed

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1. 90 A resolution reveals a new fold. Proteins. 2005 Jun 1; 59(4):864-8. View in: PubMed

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2. 0 A resolution reveals a new fold. Proteins. 2005 Jun 1; 59(4):869-74. View in: PubMed

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1. 90 A resolution reveals a new fold. Proteins. 2005 Jun 01; 59(4):864-8. View in: PubMed

Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria. Mol Ther. 2005 Jun; 11(6):986-9. View in: PubMed

The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex. J Mol Biol. 2005 Mar 4; 346(4):1083-93. View in: PubMed

The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex. J Mol Biol. 2005 Mar 04; 346(4):1083-93. View in: PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 1; 58(4):971-5. View in: PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2. 80 A resolution reveals a new fold. Proteins. 2005 Mar 1; 58(4):976-81. View in: PubMed

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1. 70 A resolution reveals a noncovalently linked PLP cofactor. Proteins. 2005 Mar 01; 58(4):971-5. View in: PubMed

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2. 80 A resolution reveals a new fold. Proteins. 2005 Mar 01; 58(4):976-81. View in: PubMed

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1. 85 A resolution. Proteins. 2005 Feb 15; 58(3):755-8. View in: PubMed

NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):1901-5. View in: PubMed

NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline. Proc Natl Acad Sci U S A. 2005 Feb 8; 102(6):1901-5. View in: PubMed

Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins. J Struct Funct Genomics. 2005; 6(2-3):209-17. View in: PubMed

Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics. J Mol Biol. 2004 Dec 3; 344(4):977-91. View in: PubMed

Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics. J Mol Biol. 2004 Dec 03; 344(4):977-91. View in: PubMed

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16903-8. View in: PubMed

Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. Hum Mutat. 2004 Nov; 24(5):388-99. View in: PubMed

Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens. Methods. 2004 Nov; 34(3):373-89. View in: PubMed

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1. 87 A resolution. Proteins. 2004 Oct 01; 57(1):213-7. View in: PubMed

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1. 87 A resolution. Proteins. 2004 Oct 1; 57(1):213-7. View in: PubMed

Scalable high-throughput micro-expression device for recombinant proteins. Biotechniques. 2004 Sep; 37(3):364, 366, 368 passim. View in: PubMed

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2. 4 A resolution. Proteins. 2004 Aug 15; 56(3):619-24. View in: PubMed

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2. 00-A resolution reveals a new fold. Proteins. 2004 Aug 15; 56(3):607-10. View in: PubMed

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2. 10 A resolution. Proteins. 2004 Aug 15; 56(3):629-33. View in: PubMed

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1. 65 A resolution. Proteins. 2004 Aug 15; 56(3):611-4. View in: PubMed

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1. 83 A resolution. Proteins. 2004 Aug 15; 56(3):615-8. View in: PubMed

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1. 95 A resolution. Proteins. 2004 Aug 01; 56(2):392-5. View in: PubMed

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1. 95 A resolution. Proteins. 2004 Aug 1; 56(2):392-5. View in: PubMed

Trends in enzyme therapy for phenylketonuria. Mol Ther. 2004 Aug; 10(2):220-4. View in: PubMed

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1. 9 A resolution. Proteins. 2004 Aug 01; 56(2):396-400. View in: PubMed

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1. 9 A resolution. Proteins. 2004 Aug 1; 56(2):396-400. View in: PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1. 8 A resolution. Proteins. 2004 Aug 01; 56(2):387-91. View in: PubMed

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1. 90 A resolution. Proteins. 2004 Aug 01; 56(2):404-8. View in: PubMed

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1. 8 A resolution. Proteins. 2004 Aug 1; 56(2):387-91. View in: PubMed

A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform. Chembiochem. 2004 Jul 05; 5(7):921-7. View in: PubMed

A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a Desorption/Ionization on Silicon (DIOS) platform. Chembiochem. 2004 Jul 5; 5(7):921-7. View in: PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1. 60 A resolution. Proteins. 2004 Jul 01; 56(1):167-70. View in: PubMed

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1. 90 A resolution. Proteins. 2004 Jul 01; 56(1):171-5. View in: PubMed

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1. 90 A resolution. Proteins. 2004 Jul 1; 56(1):171-5. View in: PubMed

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1. 60 A resolution. Proteins. 2004 Jul 1; 56(1):167-70. View in: PubMed

Structural commonalities among integral membrane enzymes. FEBS Lett. 2004 Jun 4; 567(2-3):159-65. View in: PubMed

Structural commonalities among integral membrane enzymes. FEBS Lett. 2004 Jun 04; 567(2-3):159-65. View in: PubMed

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2. 3 A resolution. Proteins. 2004 Jun 1; 55(4):1078-81. View in: PubMed

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2. 3 A resolution. Proteins. 2004 Jun 01; 55(4):1078-81. View in: PubMed

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2. 50 A resolution. Proteins. 2004 May 15; 55(3):768-71. View in: PubMed

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1. 90 A resolution. Proteins. 2004 May 15; 55(3):759-63. View in: PubMed

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1. 77-A resolution. Proteins. 2004 May 1; 55(2):474-8. View in: PubMed

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1. 77-A resolution. Proteins. 2004 May 01; 55(2):474-8. View in: PubMed

Automated sample mounting and alignment system for biological crystallography at a synchrotron source. Structure. 2004 Apr; 12(4):537-45. View in: PubMed

Long live structural biology. Nat Struct Mol Biol. 2004 Apr; 11(4):293-5. View in: PubMed

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2. 5 A resolution. Proteins. 2004 Mar 1; 54(4):810-3. View in: PubMed

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1. 7 A resolution. Proteins. 2004 Mar 01; 54(4):801-5. View in: PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1. 75 A resolution. Proteins. 2004 Mar 1; 54(4):806-9. View in: PubMed

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1. 75 A resolution. Proteins. 2004 Mar 01; 54(4):806-9. View in: PubMed

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1. 7 A resolution. Proteins. 2004 Mar 1; 54(4):801-5. View in: PubMed

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2. 5 A resolution. Proteins. 2004 Mar 01; 54(4):810-3. View in: PubMed

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):751-6. View in: PubMed

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1. 3 A resolution. Proteins. 2004 Jan 1; 54(1):174-7. View in: PubMed

Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase. Mol Ther. 2004 Jan; 9(1):124-9. View in: PubMed

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1. 3 A resolution. Proteins. 2004 Jan 01; 54(1):174-7. View in: PubMed

Biopterin responsive phenylalanine hydroxylase deficiency. Genet Med. 2004 Jan-Feb; 6(1):27-32. View in: PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2. 0 A resolution. Proteins. 2004 Jan 1; 54(1):157-61. View in: PubMed

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2. 0 A resolution. Proteins. 2004 Jan 01; 54(1):157-61. View in: PubMed

Structural studies on phenylalanine hydroxylase and implications toward understanding and treating phenylketonuria. Pediatrics. 2003 Dec; 112(6 Pt 2):1557-65. View in: PubMed

Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2. 85 A resolution. Proteins. 2003 Oct 01; 53(1):142-5. View in: PubMed

Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2. 85 A resolution. Proteins. 2003 Oct 1; 53(1):142-5. View in: PubMed

Structural plasticity and the evolution of antibody affinity and specificity. J Mol Biol. 2003 Jul 18; 330(4):651-6. View in: PubMed

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Crystallogr D Biol Crystallogr. 2003 Jun; 59(Pt 6):1028-37. View in: PubMed

PAHdb 2003: what a locus-specific knowledgebase can do. Hum Mutat. 2003 Apr; 21(4):333-44. View in: PubMed

A fully integrated protein crystallization platform for small-molecule drug discovery. J Struct Biol. 2003 Apr; 142(1):207-17. View in: PubMed

Structural evidence for substrate strain in antibody catalysis. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):856-61. View in: PubMed

Structural evidence for substrate strain in antibody catalysis. Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):856-61. View in: PubMed

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1. 5 A resolution. Proteins. 2003 Feb 1; 50(2):371-4. View in: PubMed

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1. 5 A resolution. Proteins. 2003 Feb 01; 50(2):371-4. View in: PubMed

Robotics for automated crystal formation and analysis. Methods Enzymol. 2003; 368:45-76. View in: PubMed

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science. 2002 Nov 29; 298(5599):1793-6. View in: PubMed

Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry. 2002 Oct 22; 41(42):12569-74. View in: PubMed

Three-dimensiofal structure of human tryptophaf hydroxylase and its implicatiofs for the biosyfthesis of the neurotransmitters serotonin and melatonin. Biocheeistry. 2002 Oct 22; 41(42):12561-74. View in: PubMed

The genesis of high-throughput structure-based drug discovery using protein crystallography. Curr Opin Chem Biol. 2002 Oct; 6(5):704-10. View in: PubMed

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2. 25 A resolution. Proteins. 2002 Oct 01; 49(1):142-5. View in: PubMed

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2. 25 A resolution. Proteins. 2002 Oct 1; 49(1):142-5. View in: PubMed

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3; 99(18):11664-9. View in: PubMed

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11664-9. View in: PubMed

Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates. J Mol Biol. 2002 Jul 12; 320(3):645-61. View in: PubMed

Morphological manipulation of bolaamphiphilic polydiacetylene assemblies by controlled lipid doping. Chem Phys Lipids. 2002 Feb; 114(2):203-14. View in: PubMed

Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms. Chem Rev. 1999 Aug 11; 99(8):2137-2160. View in: PubMed

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