Faculty

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Rick Adam Friedman, MD, PhD
Professor of Otolaryngology Head and Neck Surgery
Division Director For Otology/Neurotology
Otolaryngology
CHP 204M 1540 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 5790

Overview

Dr. Friedman is a world renowned leader in the treatment of acoustic neuromas. He began his career as a fellow at House Clinic and later joined the group as an Associate where he had a busy practice for 15 years. He now serves as Division Director of Otology, Neurotology and Skull Base Surgery in the USC Caruso Department of Otolaryngology-Head and Neck Surgery at Keck Medicine of USC. Additional areas of expertise include, cochlear implants, glomus tumors, otosclerosis, meningiomas, chronic ear disorders and chronic otitis media. He is an NIH funded scientist and his laboratory studies the genetics of common forms of hearing loss. Dr. Friedman belongs to a majority of the societies in his area of specialization, including the American Academy of Otolaryngology-Head and Neck Surgery, the American Otological Society, the Acoustic Neuroma Association, the American Neurotology Society, the North American Skull Base Society, the Triological Society and the NIH/National Institute of Deafness and other Communication Disorders (NIDCD) where he serves as an Ad Hoc Reviewer.

Publications

Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. View in: PubMed

Schrauwen I, Hasin-Brumshtein Y, Corneveaux JJ, Ohmen J, White C, Allen AN, Lusis AJ, Van Camp G, Huentelman MJ, Friedman RA. A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear. Hear Res. 2016 Mar; 333:266-74. View in: PubMed

Myint A, White CH, Ohmen JD, Li X, Wang J, Lavinsky J, Salehi P, Crow AL, Ohyama T, Friedman RA. Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice. Hear Res. 2016 Feb; 332:113-20. View in: PubMed

Hoa M, Friedman RA, Fisher LM, Derebery MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope. 2015 Dec; 125 Suppl 12:S1-S12. View in: PubMed

Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. View in: PubMed

Aaron KA, Lavinsky J, Tuchman A, Go JL, Giannotta SL, Friedman RA. A case report of two different skull base pathologies causing hearing loss in the same ear: vestibular schwannoma and superior semicircular canal dehiscence. Am J Otolaryngol. 2015 May-Jun; 36(3):488-91. View in: PubMed

Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. Genome-wide association study identifies nox3 as a critical gene for susceptibility to noise-induced hearing loss. PLoS Genet. 2015 Apr; 11(4):e1005094. View in: PubMed

Fransen E, Bonneux S, Corneveaux JJ, Schrauwen I, Di Berardino F, White CH, Ohmen JD, Van de Heyning P, Ambrosetti U, Huentelman MJ, Van Camp G, Friedman RA. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. Eur J Hum Genet. 2015 Jan; 23(1):110-5. View in: PubMed

Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis AJ, Allayee H, Friedman RA. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015; 5(11):2329-39. View in: PubMed

Ohmen J, Kang EY, Li X, Joo JW, Hormozdiari F, Zheng QY, Davis RC, Lusis AJ, Eskin E, Friedman RA. Genome-Wide Association Study for Age-Related Hearing Loss (AHL) in the Mouse: A Meta-Analysis. J Assoc Res Otolaryngol. 2014 Jun; 15(3):335-52. View in: PubMed

Fayad JN, Ursick J, Brackmann DE, Friedman RA. Total ossiculoplasty: short- and long-term results using a titanium prosthesis with footplate shoe. Otol Neurotol. 2014 Jan; 35(1):108-13. View in: PubMed

Schwartz MS, Kari E, Strickland BM, Berliner K, Brackmann DE, House JW, Friedman RA. Evaluation of the increased use of partial resection of large vestibular schwanommas: facial nerve outcomes and recurrence/regrowth rates. Otol Neurotol. 2013 Oct; 34(8):1456-64. View in: PubMed

Ohmen JD, White CH, Li X, Wang J, Fisher LM, Zhang H, Derebery MJ, Friedman RA. Genetic evidence for an ethnic diversity in the susceptibility to Ménière's disease. Otol Neurotol. 2013 Sep; 34(7):1336-41. View in: PubMed

Rizk HG, Lorenz MB, Friedman R. Neuroglial heterotopia of the internal auditory canal. Otol Neurotol. 2013 Apr; 34(3):e22-3. View in: PubMed

Gázquez I, Moreno A, Requena T, Ohmen J, Santos-Perez S, Aran I, Soto-Varela A, Pérez-Garrigues H, López-Nevot A, Batuecas A, Friedman RA, López-Nevot MA, López-Escamez JA. Functional variants of MIF, INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with Ménière's disease. Eur Arch Otorhinolaryngol. 2013 Mar; 270(4):1521-9. View in: PubMed

Friedman RA, Hoa M, Brackmann DE. Surgical management of endolymphatic sac tumors. J Neurol Surg B Skull Base. 2013 Feb; 74(1):12-9. View in: PubMed

Goddard JC, Go JL, Friedman RA. Imaging case of the month: Fibrous dysplasia causing superior canal dehiscence. Otol Neurotol. 2013 Jan; 34(1):e1-2. View in: PubMed

Fisher LM, Derebery MJ, Friedman RA. Oral steroid treatment for hearing improvement in Ménière's disease and endolymphatic hydrops. Otol Neurotol. 2012 Dec; 33(9):1685-91. View in: PubMed

Newman DL, Fisher LM, Ohmen J, Parody R, Fong CT, Frisina ST, Mapes F, Eddins DA, Robert Frisina D, Frisina RD, Friedman RA. GRM7 variants associated with age-related hearing loss based on auditory perception. Hear Res. 2012 Dec; 294(1-2):125-32. View in: PubMed

Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, Leboeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. View in: PubMed

Kari E, Friedman RA. Hearing preservation: microsurgery. Curr Opin Otolaryngol Head Neck Surg. 2012 Oct; 20(5):358-66. View in: PubMed

Friedman RA, Goddard JC, Wilkinson EP, Schwartz MS, Slattery WH, Fayad JN, Brackmann DE. Hearing preservation with the middle cranial fossa approach for neurofibromatosis type 2. Otol Neurotol. 2011 Dec; 32(9):1530-7. View in: PubMed

Friedman RA, Berliner KI, Bassim M, Ursick J, Slattery WH, Schwartz MS, Brackmann DE. A paradigm shift in salvage surgery for radiated vestibular schwannoma. Otol Neurotol. 2011 Oct; 32(8):1322-8. View in: PubMed

Wilkinson EP, Hoa M, Slattery WH, Fayad JN, Friedman RA, Schwartz MS, Brackmann DE. Evolution in the management of facial nerve schwannoma. Laryngoscope. 2011 Oct; 121(10):2065-74. View in: PubMed

Slattery WH, Hoa M, Bonne N, Friedman RA, Schwartz MS, Fisher LM, Brackmann DE. Middle fossa decompression for hearing preservation: a review of institutional results and indications. Otol Neurotol. 2011 Aug; 32(6):1017-24. View in: PubMed

Goddard JC, Schwartz MS, Friedman RA. Fundal fluid as a predictor of hearing preservation in the middle cranial fossa approach for vestibular schwannoma. Otol Neurotol. 2010 Sep; 31(7):1128-34. View in: PubMed

Bassim MK, Berliner KI, Fisher LM, Brackmann DE, Friedman RA. Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature. Otol Neurotol. 2010 Jun; 31(4):567-73. View in: PubMed

White CH, Ohmen JD, Sheth S, Zebboudj AF, McHugh RK, Hoffman LF, Lusis AJ, Davis RC, Friedman RA. Genome-wide screening for genetic loci associated with noise-induced hearing loss. Mamm Genome. 2009 Apr; 20(4):207-13. View in: PubMed

Hilgert N, Monahan K, Kurima K, Li C, Friedman RA, Griffith AJ, Van Camp G. Amino acid 572 in TMC1: hot spot or critical functional residue for dominant mutations causing hearing impairment. J Hum Genet. 2009 Mar; 54(3):188-90. View in: PubMed

Friedman RA, Van Laer L, Huentelman MJ, Sheth SS, Van Eyken E, Corneveaux JJ, Tembe WD, Halperin RF, Thorburn AQ, Thys S, Bonneux S, Fransen E, Huyghe J, Pyykkö I, Cremers CW, Kremer H, Dhooge I, Stephens D, Orzan E, Pfister M, Bille M, Parving A, Sorri M, Van de Heyning PH, Makmura L, Ohmen JD, Linthicum FH, Fayad JN, Pearson JV, Craig DW, Stephan DA, Van Camp G. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009 Feb 15; 18(4):785-96. View in: PubMed

Niu H, Li X, Makmura L, Friedman RA. Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness. Mamm Genome. 2008 Sep; 19(9):634-9. View in: PubMed

Wilkinson EP, Friedman RA. Acute suppurative otitis media. Ear Nose Throat J. 2008 May; 87(5):250. View in: PubMed

Wilkinson EP, Liu GC, Friedman RA. Correction of progressive hearing loss in superior canal dehiscence syndrome. Laryngoscope. 2008 Jan; 118(1):10-3. View in: PubMed

Kutz JW, Friedman RA. Congenital middle ear cholesteatoma. Ear Nose Throat J. 2007 Nov; 86(11):654. View in: PubMed

Friedman RA, Cullen RD, Ulis J, Brackmann DE. Management of cerebrospinal fluid leaks after acoustic tumor removal. Neurosurgery. 2007 Sep; 61(3 Suppl):35-9; discussion 39-40. View in: PubMed

Kutz JW, Verma S, Tan HT, Lo WW, Slattery WH, Friedman RA. Surgical management of skull base chondroblastoma. Laryngoscope. 2007 May; 117(5):848-53. View in: PubMed

Slattery WH, Fisher LM, Hitselberger W, Friedman RA, Brackmann DE. Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg. 2007 Apr; 106(4 Suppl):255-60. View in: PubMed

Starkweather A, Friedman RA. Effect of ciprodex on graft healing in tympanoplasty. Adv Ther. 2007 Mar-Apr; 24(2):427-35. View in: PubMed

Doherty JK, Friedman RA. Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg. 2006 Oct; 14(5):305-13. View in: PubMed

Niu H, Makmura L, Shen T, Sheth SS, Blair K, Friedman RA. Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice. Genomics. 2006 Sep; 88(3):302-8. View in: PubMed

McHugh RK, Friedman RA. Genetics of hearing loss: Allelism and modifier genes produce a phenotypic continuum. Anat Rec A Discov Mol Cell Evol Biol. 2006 Apr; 288(4):370-81. View in: PubMed

Friedman RA, Brackmann DE, Hitselberger WE, Schwartz MS, Iqbal Z, Berliner KI. Surgical salvage after failed irradiation for vestibular schwannoma. Laryngoscope. 2005 Oct; 115(10):1827-32. View in: PubMed

Slattery WH, Fisher LM, Iqbal Z, Friedman RA, Liu N. Intratympanic steroid injection for treatment of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg. 2005 Aug; 133(2):251-9. View in: PubMed

Friedman RA, Makmura L, Biesiada E, Wang X, Keithley EM. Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May; 122(5):625-34. View in: PubMed

Cunningham CD, Friedman RA, Brackmann DE, Hitselberger WE, Lin HW. Neurotologic skull base surgery in pediatric patients. Otol Neurotol. 2005 Mar; 26(2):231-6. View in: PubMed

Zhang Y, Knosp BM, Maconochie M, Friedman RA, Smith RJ. A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10. J Assoc Res Otolaryngol. 2004 Sep; 5(3):295-304. View in: PubMed

Shen T, Friedman RA, Brackmann DE, Slattery WH, Hitselberger WE, Schwartz MS, Fisher L. The evolution of surgical approaches for posterior fossa meningiomas. Otol Neurotol. 2004 May; 25(3):394-7. View in: PubMed

Matz G, Rybak L, Roland PS, Hannley M, Friedman R, Manolidis S, Stewart MG, Weber P, Owens F. Ototoxicity of ototopical antibiotic drops in humans. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S79-82. View in: PubMed

Roland PS, Stewart MG, Hannley M, Friedman R, Manolidis S, Matz G, Rybak L, Weber P, Owens F. Consensus panel on role of potentially ototoxic antibiotics for topical middle ear use: Introduction, methodology, and recommendations. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S51-6. View in: PubMed

Roland PS, Rybak L, Hannley M, Matz G, Stewart MG, Manolidis S, Friedman R, Weber P, Owens F. Animal ototoxicity of topical antibiotics and the relevance to clinical treatment of human subjects. Otolaryngol Head Neck Surg. 2004 Mar; 130(3 Suppl):S57-78. View in: PubMed

Li X, Fischel-Ghodsian N, Schwartz F, Yan Q, Friedman RA, Guan MX. Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness. Nucleic Acids Res. 2004; 32(3):867-77. View in: PubMed

Friedman RA, Kesser B, Brackmann DE, Fisher LM, Slattery WH, Hitselberger WE. Long-term hearing preservation after middle fossa removal of vestibular schwannoma. Otolaryngol Head Neck Surg. 2003 Dec; 129(6):660-5. View in: PubMed

Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman RA, Yu HT, Moriwaki K, Shiroishi T, Hamilton BA. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. View in: PubMed

Li XC, Friedman RA. Nonsyndromic hereditary hearing loss. Otolaryngol Clin North Am. 2002 Apr; 35(2):275-85. View in: PubMed

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