Faculty

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Rob Scot McConnell, MD
Professor of Preventive Medicine
Environmental Health
SSB 230D 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 1593

Overview

Dr. Rob McConnell is a physician and environmental epidemiologist, and Professor of Preventive Medicine. He directs the NIH/Environmental Protection Agency-supported Southern California Children’s Environmental Health Center. He has studied the effects of air pollution on children’s health, including the development of asthma and lung function deficits, and early markers for cardiovascular disease. Dr. McConnell has investigated susceptibility to the effects of environmental exposures conferred by psychosocial stress and social factors, exercise, genetics and co-exposures associated with housing conditions. He has interest, in addition, in the development of methods for estimating the burden of disease associated with near-roadway air pollution and for assessing exposure in environmental epidemiology. Currently funded research is focused on environmental determinants of autism and of obesity and its metabolic consequences in children; on respiratory hazards of e-cigarette use; and on the determinants of tobacco product use as a project director in the USC Tobacco Center for Regulatory Science. He co-directs the NIEHS T32 training program in environmental genomics and the Career Development Program of the NIEHS-supported Southern California Environmental Health Sciences Center. Prior to coming to USC, he directed a World Health Organization regional environmental health center for Latin America and the Caribbean. Dr. McConnell is a member of EPA’s Clean Air Scientific Advisory Committee (CASAC) Particulate Matter Panel. He is a fellow of the American Association for the Advancement of Science.

Selected peer-reviewed publications (from over 140):

1. Impact of air pollution on childhood respiratory disease and lung function and asthma.

a. McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002 Feb 2;359(9304):386-91. PubMed PMID: 11844508
b. Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, Lurmann F, Avol E, Kunzli N, Jerrett M, Peters J. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007 Feb 17;369(9561):571-7. PubMed PMID: 17307103.
c. McConnell R, Islam T, Shankardass K, Jerrett M, Lurmann F, Gilliland F, Gauderman J, Avol E, Künzli N, Yao L, Peters J, Berhane K. Childhood incident asthma and traffic-related air pollution at home and school. Environ Health Perspect. 2010 Jul;118(7):1021-6. PubMed PMID: 20371422; PubMed Central PMCID: PMC2920902.
d. *Urman R, McConnell R, Islam T, Avol EL, Lurmann FW, Vora H, Linn WS, Rappaport EB, Gilliland FD, Gauderman WJ. Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants. Thorax. 2014 Jun;69(6):540-7. PubMed PMID: 24253832; PubMed Central PMCID: PMC4191894.
e. Gauderman WJ, Urman R, Avol E, Berhane K, McConnell R, Rappaport E, Chang R, Lurmann F, Gilliland F. Association of improved air quality with lung development in children. N Engl J Med. 2015 Mar 5;372(10):905-13. PubMed PMID: 25738666; PubMed Central PMCID: PMC4430551.

2. Novel risk factors for respiratory disease and their interactions with air pollution that may provide clues to relevant biological pathways.

a. McConnell R, Berhane K, Molitor J, Gilliland F, Künzli N, Thorne PS, Thomas D, Gauderman WJ, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environ Health Perspect. 2006 Dec;114(12):1910-5. PubMed PMID: 17185284; PubMed Central PMCID: PMC1764158.
b. *Shankardass K, McConnell R, Jerrett M, Milam J, Richardson J, Berhane K. Parental stress increases the effect of traffic-related air pollution on childhood asthma incidence. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12406-11. PubMed PMID: 19620729; PubMed Central PMCID: PMC2718368.
c. *Islam T, McConnell R, Gauderman WJ, Berhane K, Avol E, Peters JM,Gilliland FD. Glutathione-S-Transferase (GST) P1, exercise, ozone and asthma incidence in school children. Thorax. 2009 Mar; 64(3):197-202. PubMed PMID: 18988661; PubMed Central PMCID: PMC2738935.
d. *Islam T, Urman R, Gauderman WJ, Milam J, Lurmann F, Shankardass K, Avol E, Gilliland F, McConnell R. Parental Stress Increases the Detrimental Effect of Traffic Exposure on Children's Lung Function. Am J Respir Crit Care Med. 2011 Oct 1;184(7):822-7. PubMed PMID: 21700914; PMCID: PMC3208647.
3. Neurological effects of diverse environmental exposures in studies of children and workers.
a. Rosenstock L, Keifer M, Daniell WE, McConnell R, Claypoole K. Chronic central nervous system effects of acute organophosphate pesticide intoxication. The Pesticide Health Effects Study Group. Lancet. 1991 Jul 27;338(8761):223-7. PubMed PMID: 1676786.
b. *Volk HE, Hertz-Picciotto I, Delwiche L, Lurmann F, McConnell R. Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect. 2011 Jun;119(6):873-7. PubMed PMID: 21156395; PubMed Central PMCID: PMC3114825.
c. *Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry. 2013 Jan;70(1):71-7. PubMed PMID: 23404082; PubMed Central PMCID: PMC4019010.
d. *Volk HE, Kerin T, Lurmann F, Hertz-Picciotto I, McConnell R, Campbell DB. Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene. Epidemiology. 2014 Jan;25(1):44-7. PubMed PMID: 24240654; PubMed Central PMCID: PMC4019012.

4. Associations of air pollution in children with obesogenic and cardiometabolic outcomes.

a. Breton CV, Wang X, Mack WJ, Berhane K, Lopez M, Islam TS, Feng M, Lurmann F, McConnell R, Hodis HN, Künzli N, Avol E. Childhood air pollutant exposure and carotid artery intima-media thickness in young adults. Circulation. 2012 Sep 25;126(13):1614-20. PubMed PMID: 22896588; PubMed Central PMCID: PMC3474843.
b. Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, Gilliland F, Lurmann F, Islam T, Berhane K. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environ Health. 2014 Jun 9;13:49. PubMed PMID: 24913018; PubMed Central PMCID: PMC4106205.
c. McConnell R, Shen E, Gilliland FD, Jerrett M, Wolch J, Chang CC, Lurmann F, Berhane K. A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children's Health Study. Environ Health Perspect. 2015 Apr;123(4):360-6. PubMed PMID: 25389275; PubMed Central PMCID: PMC4384197.
d. *Ghosh R, Gauderman W, Minor H, Youn H, Lurman F, Cromar K, Chatzi L, Belcher B, Ren Fielding C, McConnell R. Air pollution, weight loss and metabolic benefits of bariatric surgery: A potential model for study of metabolic effects of environmental exposures. International Journal of Pediatric Obesity in press.

5. Emerging risks of e-cigarettes, cigarettes, and other alternative tobacco products

a. *Barrington-Trimis, JL, Samet, JM, McConnell, R. Flavorings in Electronic Cigarettes: An Unrecognized Respiratory Health Hazard? JAMA. 2014 Dec 17;312(23):2493-4.doi:10.1001/jama.2014.14830.
b. *Barrington-Trimis JL, Urman R, Berhane K, Unger JB, Cruz TB, Pentz MA, Samet JM, Leventhal AM, McConnell R. E-Cigarettes and Future Cigarette Use. Pediatrics. 2016;138(1). PubMed PMID: 27296866; PMCID: PMC4925085.
c. *Barrington-Trimis JL, Urman R, Leventhal AM, Gauderman WJ, Cruz TB, Gilreath TD, Howland S, Unger JB, Berhane K, Samet JM, McConnell R. E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use. Pediatrics. 2016; 138(2). PubMed PMID: 27401102; PMCID: PNC4960723.
d. McConnell R, Barrington-Trimis JL, Wang K, Urman R, Hong H, Unger J, Samet J, Leventhal A, Berhane K. Electronic-cigarette Use and Respiratory Symptoms in Adolescents. Am J Respir Crit Care Med. 2017;195(8):1043-1049. PubMed PMID: 27806211.

6. Novel methods for assessing burden and cost of disease associated with near-roadway air pollution and applications to engagement of Southern California stakeholders

a. Künzli N, Perez L, Lurmann F, Hricko A, Penfold B, McConnell R. An attributable risk model for exposures assumed to cause both chronic disease and its exacerbations. Epidemiology. 2008;19(2):179-85. PubMed PMID: 18300703
b. *Brandt S, Perez L, Künzli N, Lurmann F, McConnell R. Costs of childhood asthma due to traffic-related pollution in two California communities. European Respiratory Journal. 2012 Aug;40(2):363-70. PubMed PMID: 22267764; PMCID: PMC4396740.
c. *Perez L, Lurman F, Wilson J, Pastor M, Brandt S, Kunzli N, McConnell R. Near-Roadway Pollution and Childhood Asthma: Implications for Developing “Win-Win” Compact Urban Development and Clean Vehicle Strategies. Environ Health Perspect. 2012; 120(11):1619-26. PubMed PMID: 23008270; PMCID: PMC3556611.
d. Brandt, S, Perez, L, Kunzil, N, Lurman, F, Wilson, J, Pastor, McConnell, R. Cost of near-roadway and regional air pollution–attributable childhood asthma in Los Angeles County.Journal of Allergy and Clinical Immunology. 2014,134:5;1028-1035. PubMed PMID: 25439228; PMCID: PMC4257136.
e. *Ghosh R, Lurmann F, Perez L, Penfold B, Brandt S, Wilson J, Milet M, Künzli N, McConnell R. Near-Roadway Air Pollution and Coronary Heart Disease: Burden of Disease and Potential Impact of a Greenhouse Gas Reduction Strategy in Southern California. Environ Health Perspect. 2016 Aug;124(2):193-200. PubMed PMID: 26149207; PMCID: PMC4749075.

*Student or junior faculty mentored by McConnell

A complete list of peer reviewed publications is available at:

http://www.ncbi.nlm.nih.gov/sites/myncbi/rob.mcconnell.1/bibliography/40704438/public/?sort=date&direction= descending

Publications

Type of E-Cigarette Device Used among Adolescents and Young Adults: Findings from a pooled analysis of 8 studies of 2,166 vapers. Nicotine Tob Res. 2017 Mar 22. View in: PubMed

Emerging exposures of developmental toxicants. Curr Opin Pediatr. 2017 Jan 05. View in: PubMed

Electronic-cigarette Use and Respiratory Symptoms in Adolescents. Am J Respir Crit Care Med. 2016 Nov 2. View in: PubMed

E-cigarettes, Cigarettes, and the Prevalence of Adolescent Tobacco Use. Pediatrics. 2016 Aug; 138(2). View in: PubMed

Environmental Determinants of Aggression in Adolescents: Role of Urban Neighborhood Greenspace. J Am Acad Child Adolesc Psychiatry. 2016 Jul; 55(7):591-601. View in: PubMed

The E-cigarette Social Environment, E-cigarette Use, and Susceptibility to Cigarette Smoking. J Adolesc Health. 2016 Jul; 59(1):75-80. View in: PubMed

E-Cigarettes and Future Cigarette Use. Pediatrics. 2016 Jul; 138(1). View in: PubMed

Association of Changes in Air Quality With Bronchitic Symptoms in Children in California, 1993-2012. JAMA. 2016 Apr 12; 315(14):1491-501. View in: PubMed

Patterns of Alternative Tobacco Product Use: Emergence of Hookah and E-cigarettes as Preferred Products Amongst Youth. J Adolesc Health. 2016 Feb; 58(2):181-5. View in: PubMed

Near-Roadway Air Pollution and Coronary Heart Disease: Burden of Disease and Potential Impact of a Greenhouse Gas Reduction Strategy in Southern California. Environ Health Perspect. 2016 Feb; 124(2):193-200. View in: PubMed

Momentary Assessment of Psychosocial Stressors, Context, and Asthma Symptoms in Hispanic Adolescents. Behav Modif. 2016 Jan; 40(1-2):257-80. View in: PubMed

Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults. PLoS One. 2016; 11(3):e0150825. View in: PubMed

Psychosocial Factors Associated With Adolescent Electronic Cigarette and Cigarette Use. Pediatrics. 2015 Aug; 136(2):308-17. View in: PubMed

A Longitudinal Cohort Study of Body Mass Index and Childhood Exposure to Secondhand Tobacco Smoke and Air Pollution: The Southern California Children's Health Study. Environ Health Perspect. 2015 Apr; 123(4):360-6. View in: PubMed

Design of a smartphone application to monitor stress, asthma symptoms, and asthma inhaler use. Ann Allergy Asthma Immunol. 2015 Apr; 114(4):341-342. e2. View in: PubMed

Association of improved air quality with lung development in children. N Engl J Med. 2015 Mar 5; 372(10):905-13. View in: PubMed

Flavorings in electronic cigarettes: an unrecognized respiratory health hazard? JAMA. Flavorings in electronic cigarettes: an unrecognized respiratory health hazard? JAMA. 2014 Dec 17; 312(23):2493-4. View in: PubMed

Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants. Thorax. 2014 Jun; 69(6):540-7. View in: PubMed

Evaluating children's location using a personal GPS logging instrument: limitations and lessons learned. J Expo Sci Environ Epidemiol. 2014 May; 24(3):244-52. View in: PubMed

Hair Cortisol, Perceived Stress and Dispositional Optimism: A Pilot Study among Adolescents. J Trauma Stress Disord Treat. 2014 Mar 18; 3(3):1000126. View in: PubMed

Autism Spectrum Disorder: Interaction of Air Pollution with the MET Receptor Tyrosine Kinase Gene. Epidemiology. 2014 Jan; 25(1):44-7. View in: PubMed

Inflammatory cytokine response to ambient particles varies due to field collection procedures. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):497-502. View in: PubMed

Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. PLoS One. 2013; 8(5):e64128. View in: PubMed

Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry. 2013 Jan; 70(1):71-7. View in: PubMed

Accuracy of a new time-resolved step counter in children. Pediatr Exerc Sci. 2012 Nov; 24(4):622-33. View in: PubMed

Childhood air pollutant exposure and carotid artery intima-media thickness in young adults. Circulation. 2012 Sep 25; 126(13):1614-20. View in: PubMed

Organized physical activity in young school children and subsequent 4-year change in body mass index. Arch Pediatr Adolesc Med. 2012 Aug 1; 166(8):713-8. View in: PubMed

Predictors of intra-community variation in air quality. J Expo Sci Environ Epidemiol. 2012 Mar; 22(2):135-47. View in: PubMed

Parental stress increases the detrimental effect of traffic exposure on children's lung function. Am J Respir Crit Care Med. 2011 Oct 1; 184(7):822-7. View in: PubMed

Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect. 2011 Jun; 119(6):873-7. View in: PubMed

Ethnic differences in the effect of asthma on pulmonary function in children. Am J Respir Crit Care Med. 2011 Mar 1; 183(5):596-603. View in: PubMed

Asthma and school commuting time. J Occup Environ Med. 2010 Aug; 52(8):827-8. View in: PubMed

Childhood incident asthma and traffic-related air pollution at home and school. Environ Health Perspect. 2010 Jul; 118(7):1021-6. View in: PubMed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax. 2010 Feb; 65(2):139-45. View in: PubMed

Long-term outcome of subcutaneously preserved autologous cranioplasty. Neurosurgery. 2009 Sep; 65(3):505-10; discussion 510. View in: PubMed

Significant clinical and radiological resolution of a spinal cord syrinx following the release of a tethered cord in a patient with an anatomically normal conus medullaris. Case report. J Neurosurg Pediatr. 2008 May; 1(5):396-8. View in: PubMed

Parental stress and childhood wheeze in a prospective cohort study. J Asthma. 2008 May; 45(4):319-23. View in: PubMed

Use of an electrostatic dust cloth for self-administered home allergen collection. Twin Res Hum Genet. 2008 Apr; 11(2):150-5. View in: PubMed

Ozone, oxidant defense genes, and risk of asthma during adolescence. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):388-95. View in: PubMed

Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. Am J Respir Crit Care Med. 2007 Dec 15; 176(12):1192-9. View in: PubMed

Relationship between air pollution, lung function and asthma in adolescents. Thorax. 2007 Nov; 62(11):957-63. View in: PubMed

The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children. Soc Sci Med. 2007 Oct; 65(8):1792-806. View in: PubMed

Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007 Feb 17; 369(9561):571-7. View in: PubMed

Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environ Health Perspect. 2006 Dec; 114(12):1910-5. View in: PubMed

Health effects of the 2003 Southern California wildfires on children. Am J Respir Crit Care Med. 2006 Dec 1; 174(11):1221-8. View in: PubMed

Regular smoking and asthma incidence in adolescents. Am J Respir Crit Care Med. 2006 Nov 15; 174(10):1094-100. View in: PubMed

Cathepsin S expression: An independent prognostic factor in glioblastoma tumours--A pilot study. Int J Cancer. 2006 Aug 15; 119(4):854-60. View in: PubMed

Bayesian modeling of air pollution health effects with missing exposure data. Am J Epidemiol. 2006 Jul 1; 164(1):69-76. View in: PubMed

Predicting residential ozone deficits from nearby traffic. Sci Total Environ. 2006 Jun 15; 363(1-3):166-74. View in: PubMed

Mode of delivery is associated with asthma and allergy occurrences in children. Ann Epidemiol. 2006 May; 16(5):341-6. View in: PubMed

Traffic, susceptibility, and childhood asthma. Environ Health Perspect. 2006 May; 114(5):766-72. View in: PubMed

Competing definitions of contextual environments. Int J Health Geogr. 2006; 5:55. View in: PubMed

TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8. View in: PubMed

Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology. 2005 Nov; 16(6):737-43. View in: PubMed

Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environ Health Perspect. 2005 Oct; 113(10):1447-54. View in: PubMed

Surface sampling for endotoxin assessment using electrostatic wiping cloths. Ann Occup Hyg. 2005 Jul; 49(5):401-6. View in: PubMed

Educational intervention to control cockroach allergen exposure in the homes of hispanic children in Los Angeles: results of the La Casa study. Clin Exp Allergy. 2005 Apr; 35(4):426-33. View in: PubMed

Effects of ambient air pollutants on asthma medication use and wheezing among fourth-grade school children from 12 Southern California communities enrolled in The Children's Health Study. Arch Environ Health. 2004 Oct; 59(10):505-14. View in: PubMed

The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med. 2004 Sep 9; 351(11):1057-67. View in: PubMed

Knowledge of skin test results among parents of asthmatic children. J Asthma. 2004 Apr; 41(2):199-204. View in: PubMed

Cockroach counts and house dust allergen concentrations after professional cockroach control and cleaning. Ann Allergy Asthma Immunol. 2003 Dec; 91(6):546-52. View in: PubMed

Prospective study of air pollution and bronchitic symptoms in children with asthma. Am J Respir Crit Care Med. 2003 Oct 1; 168(7):790-7. View in: PubMed

Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. Am J Epidemiol. 2003 Sep 15; 158(6):576-84. View in: PubMed

Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol. 2003 Sep 1; 158(5):406-15. View in: PubMed

Breathless in Los Angeles: the exhausting search for clean air. Am J Public Health. 2003 Sep; 93(9):1494-9. View in: PubMed

Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63. View in: PubMed

Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. Am J Respir Crit Care Med. 2002 Aug 1; 166(3):346-51. View in: PubMed

Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002 Jul 1; 166(1):76-84. View in: PubMed

Indoor risk factors for asthma in a prospective study of adolescents. Epidemiology. 2002 May; 13(3):288-95. View in: PubMed

Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002 Feb 2; 359(9304):386-91. View in: PubMed

Spatial Variation in Particulate Matter Components over a Large Urban Area. Atmos Environ (1994). 2014 Feb 1; 83:211-219. View in: PubMed

Determinants of the Spatial Distributions of Elemental Carbon and Particulate Matter in Eight Southern Californian Communities. Atmos Environ (1994). 2014 Apr 1; 86:84-92. View in: PubMed

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