Faculty

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Robert Alan Kloner, MD, PhD
Professor of Medicine (Clinical Scholar)
Medicine
IRD 620 Off Campus Los Angeles
+1 626 397 5811

Awards

American Society for Clinical Investigation: Elected Member, 1990

Institute for Scientific Information: Identified as one of the world's most highly cited authors, 2002

American Heart Association: Recipient of the Established Investigatorship Award, 1981-1986

American Society of Clinical Pathologists: Sheard-Sanford Award for Meritorius Original Student Research in Pathology During Medical School, 1976

NIH: Cardiovascular Study Section A, 1995-1998

American Heart Association: Inaugural Fellow of the Council on Basic Cardiovascular Sciences, 2001

Consumer's Research Council of America: Listed in Guide to America's Top Cardiologists, 2007

American College of Physicians: Research Prize, 1988

82nd Annual Scientific Assembly of the Southern Medical Association: Scientific Exhibit Achievement Award, 1988

Alpha Omega Alpha: Member, 1973

Merck: Award for Outstanding Achievement in the Study of Medicine, 1975

American Heart Association : Continuing Service Award, 1991

Good Samaritan Hospital : Physician Leadership Award, 2003

United States Israel Binational Science Foundation: The Henry N. Neufeld Memorial Award, 1996

Publications

Dai W, Cheung E, Alleman RJ, Perry JB, Allen ME, Brown DA, Kloner RA. Cardioprotective Effects of Mitochondria-Targeted Peptide SBT-20 in two Different Models of Rat Ischemia/Reperfusion. Cardiovasc Drugs Ther. 2016 Oct 17. View in: PubMed

Kloner RA, Hale SL, Dai W, Shi J. Cardioprotection: Where to from here? Cardiovasc Drugs Ther. 2016 Oct 6. View in: PubMed

Daaboul Y, Korjian S, Weaver WD, Kloner RA, Giugliano RP, Carr J, Neal BJ, Chi G, Cochet M, Goodell L, Michalak N, Rusowicz-Orazem L, Alkathery T, Allaham H, Routray S, Szlosek D, Jain P, Gibson CM. Relation of Left Ventricular Mass and Infarct Size in Anterior Wall ST-Segment Elevation Acute Myocardial Infarction (from the EMBRACE STEMI Clinical Trial). Am J Cardiol. 2016 Sep 1; 118(5):625-31. View in: PubMed

Rezkalla S, Stankowski R, Kloner RA. Cardiovascular Effects of Marijuana. J Cardiovasc Pharmacol Ther. 2016 Sep; 21(5):452-5. View in: PubMed

Kloner RA, Carson C, Dobs A, Kopecky S, Mohler ER. Reply: Testosterone and Cardiac Diastolic Function. J Am Coll Cardiol. 2016 Aug 2; 68(5):574-5. View in: PubMed

Kloner RA, Dai W, Hale SL, Shi J. Approaches to Improving Cardiac Structure and Function During and After an Acute Myocardial Infarction: Acute and Chronic Phases. J Cardiovasc Pharmacol Ther. 2016 Jul; 21(4):363-7. View in: PubMed

Kloner RA, Braunwald E. Intravenous Beta-Blockade for Limiting Myocardial Infarct Size: Rejuvenation of a Concept. J Am Coll Cardiol. 2016 May 10; 67(18):2105-7. View in: PubMed

Gibson CM, Giugliano RP, Kloner RA, Bode C, Tendera M, Jánosi A, Merkely B, Godlewski J, Halaby R, Korjian S, Daaboul Y, Chakrabarti AK, Spielman K, Neal BJ, Weaver WD. EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention. Eur Heart J. 2016 Apr 21; 37(16):1296-303. View in: PubMed

Kloner RA. Remote Ischemic Conditioning: Its Benefits and Limitations. J Cardiovasc Pharmacol Ther. 2016 Mar; 21(2):219-21. View in: PubMed

Kloner RA, Carson C, Dobs A, Kopecky S, Mohler ER. Testosterone and Cardiovascular Disease. J Am Coll Cardiol. 2016 Feb 9; 67(5):545-57. View in: PubMed

Stankowski RV, Kloner RA, Rezkalla SH. Letter to the editor response. Trends Cardiovasc Med. 2016 Feb; 26(2):203. View in: PubMed

Shi J, Dai W, Hale SL, Brown DA, Wang M, Han X, Kloner RA. Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. Life Sci. 2015 Nov 15; 141:170-8. View in: PubMed

Schwartz BG, Qualls C, Kloner RA, Laskey WK. Relation of Total and Cardiovascular Death Rates to Climate System, Temperature, Barometric Pressure, and Respiratory Infection. Am J Cardiol. 2015 Oct 15; 116(8):1290-7. View in: PubMed

Kloner RA, Dai W, Shi J, Hale S, Csete M. Rebuilding the infarcted heart with noncellular material. Regen Med. 2015 Sep; 10(6):683-5. View in: PubMed

Stankowski RV, Kloner RA, Rezkalla SH. Cardiovascular consequences of cocaine use. Trends Cardiovasc Med. 2015 Aug; 25(6):517-26. View in: PubMed

Mesbah Oskui P, Kloner RA, Burstein S, Zhiroff K, Kartub BR, Economides C, Brook J, Mayeda GS. The safety and efficacy of peripheral vascular procedures performed in the outpatient setting. J Invasive Cardiol. 2015 May; 27(5):243-9. View in: PubMed

Herring MJ, Dai W, Hale SL, Kloner RA. Rapid Induction of Hypothermia by the ThermoSuit System Profoundly Reduces Infarct Size and Anatomic Zone of No Reflow Following Ischemia-Reperfusion in Rabbit and Rat Hearts. J Cardiovasc Pharmacol Ther. 2015 Mar; 20(2):193-202. View in: PubMed

Kloner RA. Testosterone and Cardiovascular Health: Safety of Treatment of Hypogonadism. Sex Med Rev. 2015 Mar; 3(1):56-62. View in: PubMed

Kloner RA. New observations regarding post-ischemia/reperfusion myocardial swelling. J Am Coll Cardiol. 2015 Feb 3; 65(4):324-6. View in: PubMed

Kloner RA, Shi J, Dai W. New therapies for reducing post-myocardial left ventricular remodeling. Ann Transl Med. 2015 Feb; 3(2):20. View in: PubMed

Dai W, Herring MJ, Hale SL, Kloner RA. Rapid Surface Cooling by ThermoSuit System Dramatically Reduces Scar Size, Prevents Post-Infarction Adverse Left Ventricular Remodeling, and Improves Cardiac Function in Rats. J Am Heart Assoc. 2015; 4(7). View in: PubMed

Hale SL, Kloner RA. Dabigatran treatment: effects on infarct size and the no-reflow phenomenon in a model of acute myocardial ischemia/reperfusion. J Thromb Thrombolysis. 2015 Jan; 39(1):50-4. View in: PubMed

Dow JS, Bhandari A, Hale SL, Kloner RA. Does sex influence the incidence or severity of reperfusion-induced cardiac arrhythmias? Springerplus. 2015; 4:96. View in: PubMed

Dai W, Shi J, Gupta RC, Sabbah HN, Hale SL, Kloner RA. Bendavia, a mitochondria-targeting peptide, improves postinfarction cardiac function, prevents adverse left ventricular remodeling, and restores mitochondria-related gene expression in rats. J Cardiovasc Pharmacol. 2014 Dec; 64(6):543-53. View in: PubMed

Herring MJ, Hale SL, Dai W, Oskui PM, Kloner RA. Hypothermia in the setting of experimental acute myocardial infarction: a comprehensive review. Ther Hypothermia Temp Manag. 2014 Dec; 4(4):159-67. View in: PubMed

Sachdeva J, Dai W, Gerczuk PZ, Kloner RA. Combined remote perconditioning and postconditioning failed to attenuate infarct size and contractile dysfunction in a rat model of coronary artery occlusion. J Cardiovasc Pharmacol Ther. 2014 Nov; 19(6):567-73. View in: PubMed

Hale SL, Kloner RA. Ranolazine treatment for myocardial infarction? Effects on the development of necrosis, left ventricular function and arrhythmias in experimental models. Cardiovasc Drugs Ther. 2014 Oct; 28(5):469-75. View in: PubMed

Dow J, Simkhovich BZ, Hale SL, Kay G, Kloner RA. Is hypothermia or the salvage kinase pathway involved? Cardiovasc Drugs Ther. 2014 Aug; 28(4):295-301. View in: PubMed

Gandaglia G, Briganti A, Jackson G, Kloner RA, Montorsi F, Montorsi P, Vlachopoulos C. A systematic review of the association between erectile dysfunction and cardiovascular disease. Eur Urol. 2014 May; 65(5):968-78. View in: PubMed

Miner M, Nehra A, Jackson G, Bhasin S, Billups K, Burnett AL, Buvat J, Carson C, Cunningham G, Ganz P, Goldstein I, Guay A, Hackett G, Kloner RA, Kostis JB, LaFlamme KE, Montorsi P, Ramsey M, Rosen R, Sadovsky R, Seftel A, Shabsigh R, Vlachopoulos C, Wu F. All men with vasculogenic erectile dysfunction require a cardiovascular workup. Am J Med. 2014 Mar; 127(3):174-82. View in: PubMed

Brown DA, Hale SL, Baines CP, Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA. Reduction of early reperfusion injury with the mitochondria-targeting Peptide bendavia. J Cardiovasc Pharmacol Ther. 2014 Jan; 19(1):121-32. View in: PubMed

Oskui PM, Mayeda GS, Burstein S, Gheissari A, French WJ, Thomas J, Kloner RA. Improved myocardial perfusion after transmyocardial laser revascularization in a patient with microvascular coronary artery disease. SAGE Open Med Case Rep. 2014; 2:2050313X14526873. View in: PubMed

Sachdeva J, Dai W, Kloner RA. Functional and Histological Assessment of an Experimental Model of Takotsubo's Cardiomyopathy. J Am Heart Assoc. 2014; 3(3). View in: PubMed

Rezkalla S, Kloner RA. Recreational Marijuana Use: Is it Safe for Your Patient? J Am Heart Assoc. 2014; 3(2):e000904. View in: PubMed

Thomas G, Kloner RA, Rezkalla S. Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know. Am J Cardiol. 2014 Jan 1; 113(1):187-90. View in: PubMed

Schwartz BG, McDonald SA, Kloner RA. Super Bowl outcome's association with cardiovascular death. Clin Res Cardiol. 2013 Nov; 102(11):807-11. View in: PubMed

Simkhovich BZ, Przyklenk K, Kloner RA. Role of protein kinase C in ischemic "conditioning": from first evidence to current perspectives. J Cardiovasc Pharmacol Ther. 2013 Nov; 18(6):525-32. View in: PubMed

Kloner RA, Hines ME, Geunes-Boyer S. Efficacy and safety of ranolazine in patients with chronic stable angina. Postgrad Med. 2013 Nov; 125(6):53-61. View in: PubMed

Kloner RA. Current state of clinical translation of cardioprotective agents for acute myocardial infarction. Circ Res. 2013 Aug 2; 113(4):451-63. View in: PubMed

Herring MJ, Oskui PM, Hale SL, Kloner RA. Testosterone and the cardiovascular system: a comprehensive review of the basic science literature. J Am Heart Assoc. 2013 Aug; 2(4):e000271. View in: PubMed

Sabbagh S, Henry Salzman MM, Kloner RA, Simkhovich BZ, Rezkalla SH. Remote ischemic preconditioning for coronary artery bypass graft operations. Ann Thorac Surg. 2013 Aug; 96(2):727-36. View in: PubMed

Kloner RA. Can myocardial infarct size be reduced by mechanically unloading the left ventricle? Circulation. 2013 Jul 23; 128(4):318-21. View in: PubMed

Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, Buvat J, Carson CC, Cunningham GR, Goldstein I, Guay AT, Hackett G, Kloner RA, Kostis J, Montorsi P, Ramsey M, Rosen RC, Sadovsky R, Seftel AD, Vlachopoulos C, Wu FC. Diagnosis and treatment of erectile dysfunction for reduction of cardiovascular risk. J Urol. 2013 Jun; 189(6):2031-8. View in: PubMed

Kloner RA, Henderson L. Sexual function in patients with chronic angina pectoris. Am J Cardiol. 2013 Jun 1; 111(11):1671-6. View in: PubMed

Kloner RA. A brief review of useful tips for publishing your scientific manuscript. J Cardiovasc Pharmacol Ther. 2013 May; 18(3):197-8. View in: PubMed

Dai W, Gerczuk P, Zhang Y, Smith L, Kopyov O, Kay GL, Jyrala AJ, Kloner RA. Intramyocardial injection of heart tissue-derived extracellular matrix improves postinfarction cardiac function in rats. J Cardiovasc Pharmacol Ther. 2013 May; 18(3):270-9. View in: PubMed

Chakrabarti AK, Feeney K, Abueg C, Brown DA, Czyz E, Tendera M, Janosi A, Giugliano RP, Kloner RA, Weaver WD, Bode C, Godlewski J, Merkely B, Gibson CM. Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction. Am Heart J. 2013 Apr; 165(4):509-514. e7. View in: PubMed

Schwartz BG, Jackson G, Stecher VJ, Campoli-Richards DM, Kloner RA. Phosphodiesterase type 5 inhibitors improve endothelial function and may benefit cardiovascular conditions. Am J Med. 2013 Mar; 126(3):192-9. View in: PubMed

Hale SL, Herring MJ, Kloner RA. Delayed treatment with hypothermia protects against the no-reflow phenomenon despite failure to reduce infarct size. J Am Heart Assoc. 2013 Feb; 2(1):e004234. View in: PubMed

Dai W, Kay GL, Jyrala AJ, Kloner RA. Experience from experimental cell transplantation therapy of myocardial infarction: what have we learned? Cell Transplant. 2013; 22(3):563-8. View in: PubMed

Hale SL, Vanderipe DR, Kloner RA. Continuous heliox breathing and the extent of anatomic zone of noreflow and necrosis following ischemia/reperfusion in the rabbit heart. Open Cardiovasc Med J. 2013; 8:1-5. View in: PubMed

Oskui PM, French WJ, Herring MJ, Mayeda GS, Burstein S, Kloner RA. Testosterone and the cardiovascular system: a comprehensive review of the clinical literature. J Am Heart Assoc. 2013; 2(6):e000272. View in: PubMed

Sasaki T, Hwang H, Nguyen C, Kloner RA, Kahn M. The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium. PLoS One. 2013; 8(9):e75010. View in: PubMed

Dow J, Bhandari A, Simkhovich BZ, Hale SL, Kloner RA. The effect of acute versus delayed remote ischemic preconditioning on reperfusion induced ventricular arrhythmias. J Cardiovasc Electrophysiol. 2012 Dec; 23(12):1374-83. View in: PubMed

Dow J, Painovich J, Hale SL, Tjen-A-Looi S, Longhurst JC, Kloner RA. Absence of actions of commonly used Chinese herbal medicines and electroacupuncture on myocardial infarct size. J Cardiovasc Pharmacol Ther. 2012 Dec; 17(4):403-11. View in: PubMed

Gerczuk PZ, Breckenridge DG, Liles JT, Budas GR, Shryock JC, Belardinelli L, Kloner RA, Dai W. An Apoptosis Signal-regulating Kinase 1 Inhibitor Reduces Cardiomyocyte Apoptosis and Infarct Size in a Rat Ischemia-reperfusion Model. J Cardiovasc Pharmacol. 2012 Sep; 60(3):276-82. View in: PubMed

Al-Ameri H, Clavijo L, Matthews RV, Kloner RA, Shavelle DM. Devices to treat peripheral chronic total occlusions. J Interv Cardiol. 2012 Aug; 25(4):395-403. View in: PubMed

Nehra A, Jackson G, Miner M, Billups KL, Burnett AL, Buvat J, Carson CC, Cunningham GR, Ganz P, Goldstein I, Guay AT, Hackett G, Kloner RA, Kostis J, Montorsi P, Ramsey M, Rosen R, Sadovsky R, Seftel AD, Shabsigh R, Vlachopoulos C, Wu FC. The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease. Mayo Clin Proc. 2012 Aug; 87(8):766-78. View in: PubMed

Schwartz BG, Kloner RA, Thomas JL, Bui Q, Mayeda GS, Burstein S, Hale SL, Economides C, French WJ. Therapeutic hypothermia for acute myocardial infarction and cardiac arrest. Am J Cardiol. 2012 Aug 1; 110(3):461-6. View in: PubMed

Miner M, Seftel AD, Nehra A, Ganz P, Kloner RA, Montorsi P, Vlachopoulos C, Ramsey M, Sigman M, Tilkemeier P, Jackson G. Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes. Am Heart J. 2012 Jul; 164(1):21-8. View in: PubMed

Kloner RA, Hale SL, Dai W, Gorman RC, Shuto T, Koomalsingh KJ, Gorman JH, Sloan RC, Frasier CR, Watson CA, Bostian PA, Kypson AP, Brown DA. Reduction of ischemia/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective Peptide. J Am Heart Assoc. 2012 Jun; 1(3):e001644. View in: PubMed

Schwartz BG, Kloner RA, Burstein S, Economides C, Mayeda GS. Treating peripheral arterial disease percutaneously with atherectomy. J Invasive Cardiol. 2012 Jun; 24(6):263-9. View in: PubMed

Schwartz BG, Pezzullo JC, McDonald SA, Poole WK, Kloner RA. How the 2008 stock market crash and seasons affect total and cardiac deaths in los angeles county. Am J Cardiol. 2012 May 15; 109(10):1445-8. View in: PubMed

Schwartz BG, Kloner RA. Coronary no reflow. J Mol Cell Cardiol. 2012 Apr; 52(4):873-82. View in: PubMed

Dai W, Kloner RA. Is inhibition of phosphodiesterase type 5 by sildenafil a promising therapy for volume-overload heart failure? Circulation. 2012 Mar 20; 125(11):1341-3. View in: PubMed

Gerczuk PZ, Kloner RA. An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials. J Am Coll Cardiol. 2012 Mar 13; 59(11):969-78. View in: PubMed

Levine GN, Steinke EE, Bakaeen FG, Bozkurt B, Cheitlin MD, Conti JB, Foster E, Jaarsma T, Kloner RA, Lange RA, Lindau ST, Maron BJ, Moser DK, Ohman EM, Seftel AD, Stewart WJ. Sexual activity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation. 2012 Feb 28; 125(8):1058-72. View in: PubMed

Schwartz BG, Levine LA, Comstock G, Stecher VJ, Kloner RA. Cardiac uses of phosphodiesterase-5 inhibitors. J Am Coll Cardiol. 2012 Jan 3; 59(1):9-15. View in: PubMed

Kearns-Jonker M, Dai W, Gunthart M, Fuentes T, Yeh HY, Gerczuk P, Pera M, Mummery C, Kloner RA. Genetically Engineered Mesenchymal Stem Cells Influence Gene Expression in Donor Cardiomyocytes and the Recipient Heart. J Stem Cell Res Ther. 2012; S1. View in: PubMed

Schwartz BG, Ludeman DJ, Mayeda GS, Kloner RA, Economides C, Burstein S. High-risk percutaneous coronary intervention with the TandemHeart and Impella devices: a single-center experience. J Invasive Cardiol. 2011 Oct; 23(10):417-24. View in: PubMed

Kloner RA, Comstock G, Levine LA, Tiger S, Stecher VJ. Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors. Expert Opin Pharmacother. 2011 Oct; 12(15):2297-313. View in: PubMed

Schwartz Longacre L, Kloner RA, Arai AE, Baines CP, Bolli R, Braunwald E, Downey J, Gibbons RJ, Gottlieb RA, Heusch G, Jennings RB, Lefer DJ, Mentzer RM, Murphy E, Ovize M, Ping P, Przyklenk K, Sack MN, Vander Heide RS, Vinten-Johansen J, Yellon DM. New horizons in cardioprotection: recommendations from the 2010 National Heart, Lung, and Blood Institute Workshop. Circulation. 2011 Sep 6; 124(10):1172-9. View in: PubMed

Kloner RA, Schwartz Longacre L. Introduction to proceedings of the NHLBI workshop: New Horizons in cardioprotection--a focused issue of journal of cardiovascular pharmacology and therapeutics. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec; 16(3-4):222. View in: PubMed

Kloner RA. No-reflow phenomenon: maintaining vascular integrity. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec; 16(3-4):244-50. View in: PubMed

Kloner RA, Schwartz Longacre L. State of the science of cardioprotection: Challenges and opportunities-- proceedings of the 2010 NHLBI workshop on cardioprotection. J Cardiovasc Pharmacol Ther. 2011 Sep-Dec; 16(3-4):223-32. View in: PubMed

Kloner RA, Dow JS, Bhandari A. The antianginal agent ranolazine is a potent antiarrhythmic agent that reduces ventricular arrhythmias: through a mechanism favoring inhibition of late sodium channel. Cardiovasc Ther. 2011 Aug; 29(4):e36-41. View in: PubMed

Gerczuk PZ, Kloner RA. Protecting the heart from ischemia: an update on ischemic and pharmacologic conditioning. Hosp Pract (Minneap). 2011 Aug; 39(3):35-43. View in: PubMed

Dai W, Kloner RA. Cardioprotection of insulin-like growth factor-1 during reperfusion therapy: what is the underlying mechanism or mechanisms? Circ Cardiovasc Interv. 2011 Aug; 4(4):311-3. View in: PubMed

Hale SL, Allison AC, Kloner RA. Diannexin reduces no-reflow after reperfusion in rabbits with large ischemic myocardial risk zones. Cardiovasc Ther. 2011 Aug; 29(4):e42-52. View in: PubMed

Kloner RA, Dow JS, Bhandari A. First direct comparison of the late sodium current blocker ranolazine to established antiarrhythmic agents in an ischemia/reperfusion model. J Cardiovasc Pharmacol Ther. 2011 Jun; 16(2):192-6. View in: PubMed

Hale SL, Kloner RA. Mild hypothermia as a cardioprotective approach for acute myocardial infarction: laboratory to clinical application. J Cardiovasc Pharmacol Ther. 2011 Jun; 16(2):131-9. View in: PubMed

Schwartz BG, Kloner RA. Cardiology patient page: cardiovascular implications of erectile dysfunction. Circulation. 2011 May 31; 123(21):e609-11. View in: PubMed

Hwang H, Kloner RA. The combined administration of multiple soluble factors in the repair of chronically infarcted rat myocardium. J Cardiovasc Pharmacol. 2011 Mar; 57(3):282-6. View in: PubMed

Dai W, Kloner RA. Potential role of renin-angiotensin system blockade for preventing myocardial ischemia/reperfusion injury and remodeling after myocardial infarction. Postgrad Med. 2011 Mar; 123(2):49-55. View in: PubMed

Kloner RA, McDonald SA, Leeka J, Poole WK. Role of age, sex, and race on cardiac and total mortality associated with Super Bowl wins and losses. Clin Cardiol. 2011 Feb; 34(2):102-7. View in: PubMed

Schwartz BG, Kloner RA. Clinical cardiology: physician update: erectile dysfunction and cardiovascular disease. Circulation. 2011 Jan 4; 123(1):98-101. View in: PubMed

Gajarsa JJ, Kloner RA. Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities. Heart Fail Rev. 2011 Jan; 16(1):13-21. View in: PubMed

Schwartz BG, Rezkalla S, Kloner RA. Cardiovascular effects of cocaine. Circulation. 2010 Dec 14; 122(24):2558-69. View in: PubMed

Hwang H, Hale SL, Leeka J, Kloner RA. Effects of zoledronate in the repair of chronically infarcted rat myocardium. J Cardiovasc Pharmacol. 2010 Dec; 56(6):604-9. View in: PubMed

Schwartz BG, Burstein S, Economides C, Kloner RA, Shavelle DM, Mayeda GS. Review of vascular closure devices. J Invasive Cardiol. 2010 Dec; 22(12):599-607. View in: PubMed

Leeka J, Schwartz BG, Kloner RA. Sporting events affect spectators' cardiovascular mortality: it is not just a game. Am J Med. 2010 Nov; 123(11):972-7. View in: PubMed

Rezkalla SH, Dharmashankar KC, Abdalrahman IB, Kloner RA. No-reflow phenomenon following percutaneous coronary intervention for acute myocardial infarction: incidence, outcome, and effect of pharmacologic therapy. J Interv Cardiol. 2010 Oct; 23(5):429-36. View in: PubMed

Reffelmann T, Kloner RA. Blood supply of the graft after cellular cardiomyoplasty. Regen Med. 2010 Sep; 5(5):777-86. View in: PubMed

Kearns-Jonker M, Dai W, Kloner RA. Stem cells for the treatment of heart failure. Curr Opin Mol Ther. 2010 Aug; 12(4):432-41. View in: PubMed

Landgraf J, Wishner SH, Kloner RA. Comparison of automated oscillometric versus auscultatory blood pressure measurement. Am J Cardiol. 2010 Aug 1; 106(3):386-8. View in: PubMed

Rezkalla SH, Kloner RA. Influenza-related viral myocarditis. WMJ. 2010 Aug; 109(4):209-13. View in: PubMed

Schwartz BG, Mayeda GS, Burstein S, Economides C, Kloner RA. When and why do heart attacks occur? Cardiovascular triggers and their potential role. Hosp Pract (Minneap). 2010 Aug; 38(5):144-52. View in: PubMed

Schwartz BG, Kloner RA. Drug interactions with phosphodiesterase-5 inhibitors used for the treatment of erectile dysfunction or pulmonary hypertension. Circulation. 2010 Jul 6; 122(1):88-95. View in: PubMed

Hwang H, Kloner RA. Improving regenerating potential of the heart after myocardial infarction: factor-based approach. Life Sci. 2010 Mar 27; 86(13-14):461-72. View in: PubMed

Hale SL, Kloner RA. Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbit. J Cardiovasc Pharmacol Ther. 2010 Mar; 15(1):60-7. View in: PubMed

Reffelmann T, Kloner RA. Ranolazine: an anti-anginal drug with further therapeutic potential. Expert Rev Cardiovasc Ther. 2010 Mar; 8(3):319-29. View in: PubMed

Dai W, Kloner RA. Experimental cell transplantation therapy in rat myocardial infarction model including nude rat preparation. Methods Mol Biol. 2010; 660:99-109. View in: PubMed

Dai W, Hale SL, Kay GL, Jyrala AJ, Kloner RA. Cardioprotective effects of angiotensin II type 1 receptor blockade with olmesartan on reperfusion injury in a rat myocardial ischemia-reperfusion model. Cardiovasc Ther. 2010; 28(1):30-7. View in: PubMed

Dhalla AK, Wang WQ, Dow J, Shryock JC, Belardinelli L, Bhandari A, Kloner RA. Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1923-9. View in: PubMed

Simkhovich BZ, Kleinman MT, Kloner RA. Particulate air pollution and coronary heart disease. Curr Opin Cardiol. 2009 Nov; 24(6):604-9. View in: PubMed

Hwang H, Arcidi JM, Hale SL, Simkhovich BZ, Belardinelli L, Dhalla AK, Shryock JC, Kloner RA. Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. Circulation. 2009 Sep 15; 120(11 Suppl):S16-21. View in: PubMed

Little GH, Saw A, Bai Y, Dow J, Marjoram P, Simkhovich B, Leeka J, Kedes L, Kloner RA, Poizat C. Critical role of nuclear calcium/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy. J Biol Chem. 2009 Sep 11; 284(37):24857-68. View in: PubMed

Reffelmann T, Kloner RA. Intracoronary blood- or bone marrow-derived cell transplantation in patients with ischemic heart disease. Regen Med. 2009 Sep; 4(5):709-19. View in: PubMed

Al-Ameri H, Shin V, Mayeda GS, Burstein S, Matthews RV, Kloner RA, Shavelle DM. Peripheral chronic total occlusions treated with subintimal angioplasty and a true lumen re-entry device. J Invasive Cardiol. 2009 Sep; 21(9):468-72. View in: PubMed

Kloner RA. A salute to our founding editor-in-chief Bramah N. Singh, MD, DPhil, DSc, FRCP. J Cardiovasc Pharmacol Ther. 2009 Sep; 14(3):154-6. View in: PubMed

Reffelmann T, Kloner RA. Phosphodiesterase 5 inhibitors: are they cardioprotective? Cardiovasc Res. 2009 Jul 15; 83(2):204-12. View in: PubMed

Kloner RA, McDonald S, Leeka J, Poole WK. Comparison of total and cardiovascular death rates in the same city during a losing versus winning super bowl championship. Am J Cardiol. 2009 Jun 15; 103(12):1647-50. View in: PubMed

Dow J, Bhandari A, Kloner RA. The mechanism by which ischemic postconditioning reduces reperfusion arrhythmias in rats remains elusive. J Cardiovasc Pharmacol Ther. 2009 Jun; 14(2):99-103. View in: PubMed

Ai L, Yu H, Dai W, Hale SL, Kloner RA, Hsiai TK. Real-time intravascular shear stress in the rabbit abdominal aorta. IEEE Trans Biomed Eng. 2009 Jun; 56(6):1755-64. View in: PubMed

Hwang H, Arcidi JM, Hale SL, Simkhovich BZ, Belardinelli L, Dhalla AK, Shryock JC, Kloner RA. Ranolazine as an adjunct to cardioplegia: a potential new therapeutic application. J Cardiovasc Pharmacol Ther. 2009 Jun; 14(2):125-33. View in: PubMed

Dai W, Hale SL, Kay GL, Jyrala AJ, Kloner RA. Delivering stem cells to the heart in a collagen matrix reduces relocation of cells to other organs as assessed by nanoparticle technology. Regen Med. 2009 May; 4(3):387-95. View in: PubMed

Dai W, Simkhovich BZ, Kloner RA. Ischemic preconditioning maintains cardioprotection in aging normotensive and spontaneously hypertensive rats. Exp Gerontol. 2009 May; 44(5):344-9. View in: PubMed

Al-Ameri H, Thomas ML, Yoon A, Mayeda GS, Burstein S, Kloner RA, Shavelle DM. Complication rate of diagnostic carotid angiography performed by interventional cardiologists. Catheter Cardiovasc Interv. 2009 Apr 1; 73(5):661-5. View in: PubMed

Kloner RA. Clinical application of remote ischemic preconditioning. Circulation. 2009 Feb 17; 119(6):776-8. View in: PubMed

Reffelmann T, Könemann S, Kloner RA. Promise of blood- and bone marrow-derived stem cell transplantation for functional cardiac repair: putting it in perspective with existing therapy. J Am Coll Cardiol. 2009 Jan 27; 53(4):305-8. View in: PubMed

Dai W, Hale SL, Nayak R, Kloner RA. ATL 313, A Selective A(2A) Adenosine Receptor Agonist, Reduces Myocardial Infarct Size in a Rat Ischemia/Reperfusion Model. Open Cardiovasc Med J. 2009; 3:166-72. View in: PubMed

Rezkalla SH, Kloner RA. Coronary no-reflow phenomenon: from the experimental laboratory to the cardiac catheterization laboratory. Catheter Cardiovasc Interv. 2008 Dec 1; 72(7):950-7. View in: PubMed

Kloner RA, Neutel J, Roth EM, Weiss R, Weinberger MH, Thakker KM, Schwartz B, Shi H, Gregg AM. Blood pressure control with amlodipine add-on therapy in patients with hypertension and diabetes: results of the Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial. Ann Pharmacother. 2008 Nov; 42(11):1552-62. View in: PubMed

Hale SL, Dai W, Dow JS, Kloner RA. Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessment. Life Sci. 2008 Sep 26; 83(13-14):511-5. View in: PubMed

Hale SL, Kloner RA. The antianginal agent, ranolazine, reduces myocardial infarct size but does not alter anatomic no-reflow or regional myocardial blood flow in ischemia/reperfusion in the rabbit. J Cardiovasc Pharmacol Ther. 2008 Sep; 13(3):226-32. View in: PubMed

Hwang H, Kloner RA, Kleinman MT, Simkhovich BZ. Direct and acute cardiotoxic effects of ultrafine air pollutants in spontaneously hypertensive rats and Wistar--Kyoto rats. J Cardiovasc Pharmacol Ther. 2008 Sep; 13(3):189-98. View in: PubMed

Simkhovich BZ, Kleinman MT, Kloner RA. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms. J Am Coll Cardiol. 2008 Aug 26; 52(9):719-26. View in: PubMed

Kloner RA, Hwang H. New insights into the open artery hypothesis. Circ Res. 2008 Jul 3; 103(1):1-3. View in: PubMed

Hale SL, Shryock JC, Belardinelli L, Sweeney M, Kloner RA. Late sodium current inhibition as a new cardioprotective approach. J Mol Cell Cardiol. 2008 Jun; 44(6):954-67. View in: PubMed

Dow J, Bhandari A, Kloner RA. Ischemic postconditioning's benefit on reperfusion ventricular arrhythmias is maintained in the senescent heart. J Cardiovasc Pharmacol Ther. 2008 Jun; 13(2):141-8. View in: PubMed

Kloner RA. Erectile dysfunction: the new harbinger for major adverse cardiac events in the diabetic patient. J Am Coll Cardiol. 2008 May 27; 51(21):2051-2. View in: PubMed

Kloner RA, Nesto RW. Glucose-insulin-potassium for acute myocardial infarction: continuing controversy over cardioprotection. Circulation. 2008 May 13; 117(19):2523-33. View in: PubMed

Hale SL, Mehra A, Leeka J, Kloner RA. Postconditioning fails to improve no reflow or alter infarct size in an open-chest rabbit model of myocardial ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H421-5. View in: PubMed

Reffelmann T, Kieback A, Kloner RA. The cardiovascular safety of tadalafil. Expert Opin Drug Saf. 2008 Jan; 7(1):43-52. View in: PubMed

Rezkalla SH, Kloner RA. Preconditioning in humans. Heart Fail Rev. 2007 Dec; 12(3-4):201-6. View in: PubMed

Simkhovich BZ, Marjoram P, Kleinman MT, Kloner RA. Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. Basic Res Cardiol. 2007 Nov; 102(6):467-75. View in: PubMed

Kloner RA. Case studies: applying JNC-7 treatment guidelines. JAAPA. 2007 Nov; Suppl Hypertension:14-8. View in: PubMed

Dai W, Field LJ, Rubart M, Reuter S, Hale SL, Zweigerdt R, Graichen RE, Kay GL, Jyrala AJ, Colman A, Davidson BP, Pera M, Kloner RA. Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts. J Mol Cell Cardiol. 2007 Oct; 43(4):504-16. View in: PubMed

Rezkalla SH, Kloner RA. Cocaine-induced acute myocardial infarction. Clin Med Res. 2007 Oct; 5(3):172-6. View in: PubMed

Kloner RA, Rezkalla SH. To drink or not to drink? That is the question. Circulation. 2007 Sep 11; 116(11):1306-17. View in: PubMed

Artaza JN, Reisz-Porszasz S, Dow JS, Kloner RA, Tsao J, Bhasin S, Gonzalez-Cadavid NF. Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. J Endocrinol. 2007 Jul; 194(1):63-76. View in: PubMed

Kloner RA, Cannom DS. Uncertainty on the use of aldosterone antagonists for primary therapy for sudden cardiac death in the setting of implanted devices. Circulation. 2007 Jun 12; 115(23):2983-9; discussion 2989. View in: PubMed

Dow J, Kloner RA. Postconditioning does not reduce myocardial infarct size in an in vivo regional ischemia rodent model. J Cardiovasc Pharmacol Ther. 2007 Jun; 12(2):153-63. View in: PubMed

Reffelmann T, Kloner RA. Vardenafil: a selective inhibitor of phosphodiesterase-5 for the treatment of erectile dysfunction. Expert Opin Pharmacother. 2007 May; 8(7):965-74. View in: PubMed

Dai W, Kloner RA. Myocardial regeneration by human amniotic fluid stem cells: challenges to be overcome. J Mol Cell Cardiol. 2007 Apr; 42(4):730-2. View in: PubMed

Dai W, Hale SL, Kloner RA. Development of a spontaneously beating vein by cardiomyocyte transplantation in the wall of the inferior vena cava in a rat: a pilot study. J Vasc Surg. 2007 Apr; 45(4):817-20. View in: PubMed

Omato J, Muller JE, Froelicher ES, Kloner RA. ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats. Task Force II: indirect and secondary cardiovascular effects of biological terrorism agents and diseases. Circulation. 2007 Mar 27; 115(12):1672-80. View in: PubMed

Mensah GA, Grant AO, Pepine CJ, Baddour LM, Cooper LT, Dunbar SB, Froelicher ES, Greenlund KJ, Kaplan EL, Kloner RA, Labarthe DR, Luepker RV, Madjid M, Muller JE, O'Connor S, Ornato JP, Robertson RM, Roy MJ, Shah PK, Taubert KA, Wilson WR, Zheng ZJ, Harrington RA, Abrams J, Anderson JL, Bates ER, Eisenberg MJ, Grines CL, Hlatky MA, Lichtenberg RC, Lindner JR, Pohost GM, Schofield RS, Shubrooks SJ, Stein JH, Tracy CM, Vogel RA, Wesley DJ. ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases. Circulation. 2007 Mar 27; 115(12):1656-95. View in: PubMed

Ornato JP, Muller JE, Froelicher ES, Kloner RA. ACCF/AHA/CDC Conference report on emerging infectious diseases and biological terrorism threats. Task Force II: indirect and secondary cardiovascular effects of biological terrorism agents and diseases. J Am Coll Cardiol. 2007 Mar 27; 49(12):1389-97. View in: PubMed

Mensah GA, Grant AO, Pepine CJ, Baddour LM, Cooper LT, Dunbar SB, Froelicher ES, Greenlund KJ, Kaplan EL, Kloner RA, Labarthe DR, Luepker RV, Madjid M, Muller JE, O'Connor S, Ornato JP, Robertson RM, Roy MJ, Shah PK, Taubert KA, Wilson WR, Zheng ZJ, Harrington RA, Abrams J, Anderson JL, Bates ER, Eisenberg MJ, Grines CL, Hlatky MA, Lichtenberg RC, Lindner JR, Pohost GM, Schofield RS, Shubrooks SJ, Stein JH, Tracy CM, Vogel RA, Wesley DJ. ACCF/AHA/CDC conference report on emerging infectious diseases and biological terrorism threats: the clinical and public health implications for the prevention and control of cardiovascular diseases. J Am Coll Cardiol. 2007 Mar 27; 49(12):1373-412. View in: PubMed

Wold LE, Dai W, Dow JS, Kloner RA. Stem cell therapy in the heart and vasculature. Methods Mol Med. 2007; 139:355-65. View in: PubMed

Dai W, Hale SL, Kloner RA. Role of a paracrine action of mesenchymal stem cells in the improvement of left ventricular function after coronary artery occlusion in rats. Regen Med. 2007 Jan; 2(1):63-8. View in: PubMed

Hale SL, Kloner RA. Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. J Cardiovasc Pharmacol Ther. 2006 Dec; 11(4):249-55. View in: PubMed

Rosen RC, Catania JA, Ehrhardt AA, Burnett AL, Lue TF, McKenna K, Heiman JR, Schwarcz S, Ostrow DG, Hirshfield S, Purcell DW, Fisher WA, Stall R, Halkitis PN, Latini DM, Elford J, Laumann EO, Sonenstein FL, Greenblatt DJ, Kloner RA, Lee J, Malebranche D, Janssen E, Diaz R, Klausner JD, Caplan AL, Jackson G, Shabsigh R, Khalsa JH, Stoff DM, Goldmeier D, Lamba H, Richardson D, Sadeghi-Nejad H. The Bolger conference on PDE-5 inhibition and HIV risk: implications for health policy and prevention. J Sex Med. 2006 Nov; 3(6):960-75; discussion 973-5. View in: PubMed

Kloner RA, Forman MB, Gibbons RJ, Ross AM, Alexander RW, Stone GW. Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial. Eur Heart J. 2006 Oct; 27(20):2400-5. View in: PubMed

Reffelmann T, Kloner RA. The no-reflow phenomenon: A basic mechanism of myocardial ischemia and reperfusion. Basic Res Cardiol. 2006 Sep; 101(5):359-72. View in: PubMed

Kloner RA. Moving preconditioning from bench to bedside. J Am Coll Cardiol. 2006 Jul 4; 48(1):215-6. View in: PubMed

Hale SL, Leeka JA, Kloner RA. Improved left ventricular function and reduced necrosis after myocardial ischemia/reperfusion in rabbits treated with ranolazine, an inhibitor of the late sodium channel. J Pharmacol Exp Ther. 2006 Jul; 318(1):418-23. View in: PubMed

Kloner RA, Jackson G, Hutter AM, Mittleman MA, Chan M, Warner MR, Costigan TM, Vail GM. Cardiovascular safety update of Tadalafil: retrospective analysis of data from placebo-controlled and open-label clinical trials of Tadalafil with as needed, three times-per-week or once-a-day dosing. Am J Cardiol. 2006 Jun 15; 97(12):1778-84. View in: PubMed

Rezkalla SH, Kloner RA. Ischemic preconditioning for the clinician. WMJ. 2006 Jun; 105(4):22-6. View in: PubMed

Kloner RA, Rezkalla SH. Preconditioning, postconditioning and their application to clinical cardiology. Cardiovasc Res. 2006 May 1; 70(2):297-307. View in: PubMed

Dai W, Kloner RA. Myocardial regeneration by embryonic stem cell transplantation: present and future trends. Expert Rev Cardiovasc Ther. 2006 May; 4(3):375-83. View in: PubMed

Sesti C, Simkhovich BZ, Kalvinsh I, Kloner RA. Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics. J Cardiovasc Pharmacol. 2006 Mar; 47(3):493-9. View in: PubMed

Kloner RA, Dow J, Bhandari A. Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion. J Cardiovasc Pharmacol Ther. 2006 Mar; 11(1):55-63. View in: PubMed

Kloner RA. Attempts to recruit stem cells for repair of acute myocardial infarction: a dose of reality. JAMA. 2006 Mar 1; 295(9):1058-60. View in: PubMed

Nordlie MA, Wold LE, Simkhovich BZ, Sesti C, Kloner RA. Molecular aspects of ischemic heart disease: ischemia/reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy. J Cardiovasc Pharmacol Ther. 2006 Mar; 11(1):17-30. View in: PubMed

Dai W, Hale SL, Kloner RA. Cardiac cells implanted within the outer aortic wall of rats generate measurable contractile force. Regen Med. 2006 Jan; 1(1):119-24. View in: PubMed

Jackson G, Rosen RC, Kloner RA, Kostis JB. The second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine. J Sex Med. 2006 Jan; 3(1):28-36; discussion 36. View in: PubMed

Kloner RA. Natural and unnatural triggers of myocardial infarction. Prog Cardiovasc Dis. 2006 Jan-Feb; 48(4):285-300. View in: PubMed

Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovasc Toxicol. 2006; 6(1):69-78. View in: PubMed

Reffelmann T, Kloner RA. Sexual function in hypertensive patients receiving treatment. Vasc Health Risk Manag. 2006; 2(4):447-55. View in: PubMed

Reffelmann T, Kloner RA. Cardiovascular effects of phosphodiesterase 5 inhibitors. Curr Pharm Des. 2006; 12(27):3485-94. View in: PubMed

Kostis JB, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett AL, Carson C, Cheitlin M, Debusk R, Fonseca V, Ganz P, Goldstein I, Guay A, Hatzichristou D, Hollander JE, Hutter A, Katz S, Kloner RA, Mittleman M, Montorsi F, Montorsi P, Nehra A, Sadovsky R, Shabsigh R. Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol. 2005 Dec 26; 96(12B):85M-93M. View in: PubMed

Kloner RA. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am J Cardiol. 2005 Dec 26; 96(12B):42M-46M. View in: PubMed

Dai W, Hale SL, Kloner RA. Stem cell transplantation for the treatment of myocardial infarction. Transpl Immunol. 2005 Dec; 15(2):91-7. View in: PubMed

Patterson D, Kloner R, Effron M, Emmick J, Bedding A, Warner M, Mitchell M, Braat S, MacDonald T. The effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease. Br J Clin Pharmacol. 2005 Nov; 60(5):459-68. View in: PubMed

Sesti C, Hale SL, Lutzko C, Kloner RA. Granulocyte colony-stimulating factor and stem cell factor improve contractile reserve of the infarcted left ventricle independent of restoring muscle mass. J Am Coll Cardiol. 2005 Nov 1; 46(9):1662-9. View in: PubMed

Kloner RA. Erectile dysfunction and cardiovascular risk factors. Urol Clin North Am. 2005 Nov; 32(4):397-402, v. View in: PubMed

Nordlie MA, Wold LE, Kloner RA. Genetic contributors toward increased risk for ischemic heart disease. J Mol Cell Cardiol. 2005 Oct; 39(4):667-79. View in: PubMed

Kloner RA, Montorsi P, DeBusk RF. Commentaries on Jackson et al. "Successful withdrawal of oral long-acting nitrates to facilitate phosphodiesterase type 5 inhibitor use in stable coronary disease patients with erectile dysfunction". J Sex Med. 2005 Sep; 2(5):740-2; author reply 742. View in: PubMed

Dai W, Wold LE, Dow JS, Kloner RA. Thickening of the infarcted wall by collagen injection improves left ventricular function in rats: a novel approach to preserve cardiac function after myocardial infarction. J Am Coll Cardiol. 2005 Aug 16; 46(4):714-9. View in: PubMed

Beasley CM, Mitchell MI, Dmitrienko AA, Emmick JT, Shen W, Costigan TM, Bedding AW, Turik MA, Bakhtyari A, Warner MR, Ruskin JN, Cantilena LR, Kloner RA. The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval. J Am Coll Cardiol. 2005 Aug 16; 46(4):678-87. View in: PubMed

Dow J, Simkhovich BZ, Kedes L, Kloner RA. Washout of transplanted cells from the heart: a potential new hurdle for cell transplantation therapy. Cardiovasc Res. 2005 Aug 1; 67(2):301-7. View in: PubMed

Hale SL, Sesti C, Kloner RA. Administration of erythropoietin fails to improve long-term healing or cardiac function after myocardial infarction in the rat. J Cardiovasc Pharmacol. 2005 Aug; 46(2):211-5. View in: PubMed

Kostis JB, Jackson G, Rosen R, Barrett-Connor E, Billups K, Burnett AL, Carson C, Cheitlin M, Debusk R, Fonseca V, Ganz P, Goldstein I, Guay A, Hatzichristou D, Hollander JE, Hutter A, Katz S, Kloner RA, Mittleman M, Montorsi F, Montorsi P, Nehra A, Sadovsky R, Shabsigh R. Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol. 2005 Jul 15; 96(2):313-21. View in: PubMed

Dai W, Hale SL, Martin BJ, Kuang JQ, Dow JS, Wold LE, Kloner RA. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation. 2005 Jul 12; 112(2):214-23. View in: PubMed

Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol. 2005 Jun 7; 45(11):1775-80. View in: PubMed

Hale SL, Kloner RA. Acetaminophen and myocardial stunning after transient ischemia in rabbit hearts. J Cardiovasc Pharmacol Ther. 2005 Jun; 10(2):121-9. View in: PubMed

Reffelmann T, Kloner RA. Pharmacotherapy of erectile dysfunction: focus on cardiovascular safety. Expert Opin Drug Saf. 2005 May; 4(3):531-40. View in: PubMed

Estes NA, Kloner R, Olshansky B, Virmani R. Task Force 9: drugs and performance-enhancing substances. J Am Coll Cardiol. 2005 Apr 19; 45(8):1368-9. View in: PubMed

Kloner RA, Simkhovich BZ. Benefit of an exercise program before myocardial infarction. J Am Coll Cardiol. 2005 Mar 15; 45(6):939-40. View in: PubMed

Poole WK, Chi JS, Walton JD, Kandefer S, Kloner RA. Increased cardiovascular mortality associated with the turn of the millennium in Los Angeles County, California. J Epidemiol Community Health. 2005 Mar; 59(3):205-6. View in: PubMed

Kloner RA. The "Merry Christmas Coronary" and "Happy New Year Heart Attack" phenomenon. Circulation. 2004 Dec 21; 110(25):3744-5. View in: PubMed

Rezkalla SH, Kloner RA. Ischemic preconditioning and preinfarction angina in the clinical arena. Nat Clin Pract Cardiovasc Med. 2004 Dec; 1(2):96-102. View in: PubMed

Kloner RA. Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction. Circulation. 2004 Nov 9; 110(19):3149-55. View in: PubMed

Kloner RA, Jackson G, Emmick JT, Mitchell MI, Bedding A, Warner MR, Pereira A. Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men. J Urol. 2004 Nov; 172(5 Pt 1):1935-40. View in: PubMed

Wold LE, Dai W, Sesti C, Hale SL, Dow JS, Martin BJ, Kloner RA. Stem cell therapy for the heart. Congest Heart Fail. 2004 Nov-Dec; 10(6):293-301. View in: PubMed

Jackson G, Kloner RA, Costigan TM, Warner MR, Emmick JT. Update on clinical trials of tadalafil demonstrates no increased risk of cardiovascular adverse events. J Sex Med. 2004 Sep; 1(2):161-7. View in: PubMed

Reffelmann T, Reffemann T, Kloner RA. Microvascular alterations after temporary coronary artery occlusion: the no-reflow phenomenon. J Cardiovasc Pharmacol Ther. 2004 Sep; 9(3):163-72. View in: PubMed

Kedes L, Kloner R, Kong K, Poizat C, Simkhovich B, Iso T, Hamamori Y. New cellular and molecular approaches for the treatment of cardiac disease. Semin Nephrol. 2004 Sep; 24(5):437-40. View in: PubMed

Padma-Nathan H, Christ G, Adaikan G, Becher E, Brock G, Carrier S, Carson C, Corbin J, Francis S, DeBusk R, Eardley I, Hedlund H, Hutter A, Jackson G, Kloner R, Lin CS, Lin S, McVary K, McCullough A, Nehra A, Porst H, Schulman C, Seftel A, Sharlip I, Stief C, Teloken C. Pharmacotherapy for erectile dysfunction. J Sex Med. 2004 Sep; 1(2):128-40. View in: PubMed

Kloner RA, Rezkalla SH. Cardiac protection during acute myocardial infarction: where do we stand in 2004? J Am Coll Cardiol. 2004 Jul 21; 44(2):276-86. View in: PubMed

Dai W, Hale SL, Kloner RA. Implantation of immature neonatal cardiac cells into the wall of the aorta in rats: a novel model for studying morphological and functional development of heart cells in an extracardiac environment. Circulation. 2004 Jul 20; 110(3):324-9. View in: PubMed

Sesti C, Kloner RA. Gene therapy in congestive heart failure. Circulation. 2004 Jul 20; 110(3):242-3. View in: PubMed

Simkhovich BZ, Hale SL, Kloner RA. Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue. J Cardiovasc Pharmacol Ther. 2004 Jun; 9(2):83-90. View in: PubMed

Kloner RA. Novel phosphodiesterase type 5 inhibitors: assessing hemodynamic effects and safety parameters. Clin Cardiol. 2004 Apr; 27(4 Suppl 1):I20-5. View in: PubMed

Reffelmann T, Kloner RA. Effects of adenosine and verapamil on anatomic no-reflow in a rabbit model of coronary artery occlusion and reperfusion. J Cardiovasc Pharmacol. 2004 Apr; 43(4):580-8. View in: PubMed

Hale SL, Kloner RA. Acetaminophen and experimental acute myocardial infarction. Cardiovasc Drugs Ther. 2004 Mar; 18(2):121-5. View in: PubMed

Dai W, Kloner RA. Relationship between cyclooxygenase-2 inhibition and thrombogenesis. J Cardiovasc Pharmacol Ther. 2004 Mar; 9(1):51-9. View in: PubMed

Kloner RA. Assessment of cardiovascular risk in patients with erectile dysfunction: focus on the diabetic patient. Endocrine. 2004 Mar-Apr; 23(2-3):125-9. View in: PubMed

Kloner RA, Dai W. Glycoprotein IIb/IIIa inhibitors and no-reflow. J Am Coll Cardiol. 2004 Jan 21; 43(2):284-6. View in: PubMed

Kloner RA. Erectile dysfunction in the cardiac patient. Compr Ther. 2004; 30(1):50-4. View in: PubMed

Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA. Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Arch Biochem Biophys. 2003 Dec 15; 420(2):268-78. View in: PubMed

Reffelmann T, Hale SL, Dow JS, Kloner RA. No-reflow phenomenon persists long-term after ischemia/reperfusion in the rat and predicts infarct expansion. Circulation. 2003 Dec 9; 108(23):2911-7. View in: PubMed

Dai W, Kloner RA. Effects of acetaminophen on myocardial infarct size in rats. J Cardiovasc Pharmacol Ther. 2003 Dec; 8(4):277-84. View in: PubMed

Kloner RA. Erectile dysfunction in the cardiac patient. Curr Urol Rep. 2003 Dec; 4(6):466-71. View in: PubMed

Przyklenk K, Li G, Simkhovich BZ, Kloner RA. Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits. J Appl Physiol. 2003 Dec; 95(6):2563-9. View in: PubMed

Kloner RA, Hutter AM, Emmick JT, Mitchell MI, Denne J, Jackson G. Time course of the interaction between tadalafil and nitrates. J Am Coll Cardiol. 2003 Nov 19; 42(10):1855-60. View in: PubMed

Kloner RA, Mitchell M, Emmick JT. Cardiovascular effects of tadalafil. Am J Cardiol. 2003 Nov 6; 92(9A):37M-46M. View in: PubMed

Kloner RA, Brindis RG, Cheitlin MD, Kuritzky L, Miller TA, Padma-Nathan H, Rosen RC. Roundtable discussion: tadalafil study group. Am J Cardiol. 2003 Nov 6; 92(9A):58M-65M. View in: PubMed

Brindis RG, Kloner RA. Sildenafil in patients with cardiovascular disease. Am J Cardiol. 2003 Nov 6; 92(9A):26M-36M. View in: PubMed

Kloner RA. Introduction: Erectile dysfunction and cardiovascular risk factors. Am J Cardiol. 2003 Nov 6; 92(9A):1-2. View in: PubMed

Kloner RA, Mitchell M, Emmick JT. Cardiovascular effects of tadalafil in patients on common antihypertensive therapies. Am J Cardiol. 2003 Nov 6; 92(9A):47M-57M. View in: PubMed

Kloner RA. New therapy update. Inspra (eplerenone tablets). Congest Heart Fail. 2003 Nov-Dec; 9(6):341-2. View in: PubMed

Chi JS, Poole WK, Kandefer SC, Kloner RA. Cardiovascular mortality in New York City after September 11, 2001. Am J Cardiol. 2003 Oct 1; 92(7):857-61. View in: PubMed

Reffelmann T, Kloner RA. Transthoracic echocardiography in rats. Evalution of commonly used indices of left ventricular dimensions, contractile performance, and hypertrophy in a genetic model of hypertrophic heart failure (SHHF-Mcc-facp-Rats) in comparison with Wistar rats during aging. Basic Res Cardiol. 2003 Sep; 98(5):275-84. View in: PubMed

Rezkalla SH, Sharma P, Kloner RA. Coronary no-flow and ventricular tachycardia associated with habitual marijuana use. Ann Emerg Med. 2003 Sep; 42(3):365-9. View in: PubMed

Hale SL, Dae MW, Kloner RA. Hypothermia during reperfusion limits 'no-reflow' injury in a rabbit model of acute myocardial infarction. Cardiovasc Res. 2003 Sep 1; 59(3):715-22. View in: PubMed

Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, Miller L, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation. 2003 Aug 19; 108(7):863-8. View in: PubMed

Kloner RA, Mullin SH, Shook T, Matthews R, Mayeda G, Burstein S, Peled H, Pollick C, Choudhary R, Rosen R, Padma-Nathan H. Erectile dysfunction in the cardiac patient: how common and should we treat? J Urol. 2003 Aug; 170(2 Pt 2):S46-50; discussion S50. View in: PubMed

Reffelmann T, Kloner RA. Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation. Cardiovasc Res. 2003 Aug 1; 59(2):441-9. View in: PubMed

Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA. Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Cardiovasc Res. 2003 Aug 1; 59(2):450-9. View in: PubMed

Nehra A, Steers WD, Althof SE, Andersson KE, Burnett AL, Costabile RA, Goldstein I, Kloner RA, Lue TF, Morales A, Rosen RC, Shabsigh R, Siroky MB, King L. Third International Conference on the Management of Erectile Dysfunction: Linking Pathophysiology and Therapeutic Response. J Urol. 2003 Aug; 170(2 Pt 2):S3-5. View in: PubMed

Reffelmann T, Kloner RA. Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease. Circulation. 2003 Jul 15; 108(2):239-44. View in: PubMed

Reffelmann T, Leor J, Müller-Ehmsen J, Kedes L, Kloner RA. Cardiomyocyte transplantation into the failing heart-new therapeutic approach for heart failure? Heart Fail Rev. 2003 Jul; 8(3):201-11. View in: PubMed

Leor J, Battler A, Kloner RA, Etzion S. Reprogramming cells for transplantation. Heart Fail Rev. 2003 Jul; 8(3):285-92. View in: PubMed

Chi JS, Speakman MT, Poole WK, Kandefer SC, Kloner RA. Hospital admissions for cardiac events in New York City after September 11, 2001. Am J Cardiol. 2003 Jul 1; 92(1):61-3. View in: PubMed

Simkhovich BZ, Kloner RA, Poizat C, Marjoram P, Kedes LH. Gene expression profiling--a new approach in the study of myocardial ischemia. Cardiovasc Pathol. 2003 Jul-Aug; 12(4):180-5. View in: PubMed

Reffelmann T, Dow JS, Dai W, Hale SL, Simkhovich BZ, Kloner RA. Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases regional blood flow of infarcted myocardium. J Mol Cell Cardiol. 2003 Jun; 35(6):607-13. View in: PubMed

Yao M, Dieterle T, Hale SL, Dow JS, Kedes LH, Peterson KL, Kloner RA. Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function. J Mol Cell Cardiol. 2003 Jun; 35(6):661-70. View in: PubMed

Reffelmann T, Kloner RA. Cellular cardiomyoplasty--cardiomyocytes, skeletal myoblasts, or stem cells for regenerating myocardium and treatment of heart failure? Cardiovasc Res. 2003 May 1; 58(2):358-68. View in: PubMed

Whittaker P, Müller-Ehmsen J, Dow JS, Kedes LH, Kloner RA. Development of abnormal tissue architecture in transplanted neonatal rat myocytes. Ann Thorac Surg. 2003 May; 75(5):1450-6. View in: PubMed

Reffelmann T, Kloner RA. Is microvascular protection by cariporide and ischemic preconditioning causally linked to myocardial salvage? Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1134-41. View in: PubMed

Kloner RA, Rezkalla SH. Cocaine and the heart. N Engl J Med. 2003 Feb 6; 348(6):487-8. View in: PubMed

Phillips RA, Kloner RA, Grimm RH, Weinberger M. The effects of amlodipine compared to losartan in patients with mild to moderately severe hypertension. J Clin Hypertens (Greenwich). 2003 Jan-Feb; 5(1):17-23. View in: PubMed

Etzion S, Barbash IM, Feinberg MS, Zarin P, Miller L, Guetta E, Holbova R, Kloner RA, Kedes LH, Leor J. Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair. Circulation. 2002 Sep 24; 106(12 Suppl 1):I125-30. View in: PubMed

Kloner RA, Speakman M. Erectile dysfunction and atherosclerosis. Curr Atheroscler Rep. 2002 Sep; 4(5):397-401. View in: PubMed

Reffelmann T, Kloner RA. Microvascular reperfusion injury: rapid expansion of anatomic no reflow during reperfusion in the rabbit. Am J Physiol Heart Circ Physiol. 2002 Sep; 283(3):H1099-107. View in: PubMed

Padma-nathan H, Eardley I, Kloner RA, Laties AM, Montorsi F. A 4-year update on the safety of sildenafil citrate (Viagra). Urology. 2002 Sep; 60(2 Suppl 2):67-90. View in: PubMed

Kloner RA, Speakman MT, Przyklenk K. Ischemic preconditioning: a plea for rationally targeted clinical trials. Cardiovasc Res. 2002 Aug 15; 55(3):526-33. View in: PubMed

Albaugh J, Amargo I, Capelson R, Flaherty E, Forest C, Goldstein I, Jensen PK, Jones K, Kloner R, Lewis J, Mullin S, Payton T, Rines B, Rosen R, Sadovsky R, Snow K, Vetrosky D. Health care clinicians in sexual health medicine: focus on erectile dysfunction. Urol Nurs. 2002 Aug; 22(4):217-31; quiz 232. View in: PubMed

Müller-Ehmsen J, Kedes LH, Schwinger RH, Kloner RA. Cellular cardiomyoplasty--a novel approach to treat heart disease. Congest Heart Fail. 2002 Jul-Aug; 8(4):220-7. View in: PubMed

Kloner RA, Poole K, Shook T, Przyklenk K, Perritt K, Cannon CP. Comparison of acute myocardial infarct size in patients > or =65 years versus < 65 years in the prethrombolytic period versus the thrombolytic period. Am J Cardiol. 2002 Jun 1; 89(11):1291-3. View in: PubMed

Li G, Whittaker P, Yao M, Kloner RA, Przyklenk K. The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts. Cardiovasc Pathol. 2002 May-Jun; 11(3):158-65. View in: PubMed

Hale SL, Kloner RA. Elevated body temperature during myocardial ischemia/reperfusion exacerbates necrosis and worsens no-reflow. Coron Artery Dis. 2002 May; 13(3):177-81. View in: PubMed

Müller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW, Kloner RA. Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation. 2002 Apr 9; 105(14):1720-6. View in: PubMed

Simkhovich BZ, Abdishoo S, Poizat C, Hale SL, Kedes LH, Kloner RA. Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study. Heart Dis. 2002 Mar-Apr; 4(2):63-9. View in: PubMed

Kloner RA, Textor SC, Tavel ME. Renovascular hypertension: problems in evaluation and management. Chest. 2002 Mar; 121(3):964-8. View in: PubMed

Rezkalla SH, Kloner RA. No-reflow phenomenon. Circulation. 2002 Feb 5; 105(5):656-62. View in: PubMed

Reffelmann T, Kloner RA. The "no-reflow" phenomenon: basic science and clinical correlates. Heart. 2002 Feb; 87(2):162-8. View in: PubMed

Müller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, Laird PW, Kedes L. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol. 2002 Feb; 34(2):107-16. View in: PubMed

Reffelmann T, Hale SL, Li G, Kloner RA. Relationship between no reflow and infarct size as influenced by the duration of ischemia and reperfusion. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H766-72. View in: PubMed

Rezkalla SH, Mesa J, Sharma P, Kloner RA. Myocardial infarction temporally related to ephedra--a possible role for the coronary microcirculation. WMJ. 2002; 101(7):64-6. View in: PubMed

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