Faculty

Back to Index
Robinder G. Khemani, MD
Associate Professor of Clinical Pediatrics
Pediatrics
CHL Mail Stop 12 Off Campus Los Angeles
+1 323 361 2557

Overview

Dr. Khemani is a Pediatric Intensive Care Physician and Clinical Researcher at the Children's Hospital Los Angeles. His major area of research interest involves using observational data to answer important clinical questions in the realm of pediatric critical care. This includes but is not limited to the creation and validation of quality indicators and severity of illness scores to develop objective criteria for comparing pediatric intensive care unit (PICU) outcomes internationally. This work involves both disease specific markers for certain subgroups of PICU patients, or global ICU populations. These findings will help target specific areas for quality improvement, and help evaluate new interventions and treatment modalities.

He is also interested in pediatric mechanical ventilation, lung injury, and respiratory physiology, both translationally and at the bedside. He has specific interests in acute respiratory distress syndrome and upper airway obstruction: developing and validating minimally invasive pulmonary function techniques. Moreover, he uses his background in statistical modeling to examine the impact of different treatment regimens on cohorts of patients with specific respiratory disease such as upper airway obstruction, obstructive airways, hypoxemic respiratory failure, and acute lung injury.

Publications

Betters RZ, Khemani R, Ross P. 1014: ASTHMA PREDICTION MODEL. Crit Care Med. 2016 Dec; 44(12 Suppl 1):329. View in: PubMed

Sekayan T, Hotz J, Flink R, Iyer N, Newth C, Khemani R. 14: RISK FACTORS FOR PEDIATRIC EXTUBATION FAILURE: THE IMPORTANCE OF RESPIRATORY MUSCLE STRENGTH. Crit Care Med. 2016 Dec; 44(12 Suppl 1):90. View in: PubMed

Mueller D, Wee CP, Khemani R, Markovitz B. 631: IS FLUID OVERLOAD IN HEMATOPOIETIC STEM CELL TRANSPLANT PICU PATIENTS ASSOCIATED WITH OUTCOMES? Crit Care Med. 2016 Dec; 44(12 Suppl 1):234. View in: PubMed

Bhalla A, Yehya N, Newth C, Mack W, Khemani R. 942: THE ASSOCIATION OF INHALED NITRIC OXIDE WITH OUTCOMES IN CHILDREN WITH ARDS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):311. View in: PubMed

Khemani R, Smith L, Parvathaneni K, Sanchez-Pinto N, Newth C. 956: A MORTALITY PREDICTION MODEL FOR PEDIATRIC ACUTE RESPIRATORY DISTRESS SYNDROME. Crit Care Med. 2016 Dec; 44(12 Suppl 1):315. View in: PubMed

Leung D, Khemani R. 995: DIAGNOSES AND COMORBIDITIES ARE ASSOCIATED WITH MORTALITY IN PEDIATRIC HYPOXEMIC RESPIRATORY FAILURE. Crit Care Med. 2016 Dec; 44(12 Suppl 1):325. View in: PubMed

Willson DF, Hoot M, Khemani R, Carrol C, Kirby A, Schwarz A, Gedeit R, Nett ST, Erickson S, Flori H, Hays S, Hall M. Pediatric Ventilator-Associated Infections: The Ventilator-Associated INfection Study. Pediatr Crit Care Med. 2016 Nov 8. View in: PubMed

Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):907-916. View in: PubMed

Beltramo F, Menteer J, Razavi A, Khemani RG, Szmuszkovicz J, Newth CJ, Ross PA. Letter to Editor: Reliability of the Ultrasound Cardiac Output Monitor for Pediatric Patients. Pediatr Cardiol. 2016 Aug; 37(6):1189-90. View in: PubMed

Khemani RG, Hotz J, Morzov R, Flink RC, Kamerkar A, LaFortune M, Rafferty GF, Ross PA, Newth CJ. Pediatric extubation readiness tests should not use pressure support. Intensive Care Med. 2016 Aug; 42(8):1214-22. View in: PubMed

Markovitz BP, Kukuyeva I, Soto-Campos G, Khemani RG. PICU Volume and Outcome: A Severity-Adjusted Analysis. Pediatr Crit Care Med. 2016 Jun; 17(6):483-9. View in: PubMed

Sanchez-Pinto LN, Khemani RG. Development of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Electronic Health Record Data. Pediatr Crit Care Med. 2016 Jun; 17(6):508-15. View in: PubMed

Mandell I, Khemani RG. The authors reply. Pediatr Crit Care Med. 2016 Jun; 17(6):582. View in: PubMed

Beltramo F, Menteer J, Razavi A, Khemani RG, Szmuszkovicz J, Newth CJ, Ross PA. Reply to Letter to the Editor. Pediatr Cardiol. 2016 Mar; 37(3):619-20. View in: PubMed

Ross PA, Newth CJ, Leung D, Wetzel RC, Khemani RG. Obesity and Mortality Risk in Critically Ill Children. Pediatrics. 2016 Mar; 137(3):1-8. View in: PubMed

Bhalla AK, Khemani R. Recruitment Maneuvers to the Extreme. Respir Care. 2016 Feb; 61(2):260-1. View in: PubMed

Yehya N, Bhalla AK, Thomas NJ, Khemani RG. Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Feb; 17(2):101-9. View in: PubMed

Khemani RG, Hotz J, Morzov R, Flink R, Kamerkar A, Ross PA, Newth CJ. Evaluating Risk Factors for Pediatric Post-extubation Upper Airway Obstruction Using a Physiology-based Tool. Am J Respir Crit Care Med. 2016 Jan 15; 193(2):198-209. View in: PubMed

Bhalla A, Newth C, Khemani R. The authors reply. Crit Care Med. 2016 Jan; 44(1):e52-3. View in: PubMed

Beltramo F, Menteer J, Razavi A, Khemani RG, Szmuszkovicz J, Newth CJ, Ross PA. Validation of an Ultrasound Cardiac Output Monitor as a Bedside Tool for Pediatric Patients. Pediatr Cardiol. 2016 Jan; 37(1):177-83. View in: PubMed

Mandell IM, Aghamohammadi S, Deakers T, Khemani RG. Procalcitonin to Detect Suspected Bacterial Infections in the PICU. Pediatr Crit Care Med. 2016 Jan; 17(1):e4-e12. View in: PubMed

Frey LJ, Sward KA, Newth CJ, Khemani RG, Cryer ME, Thelen JL, Enriquez R, Shaoyu S, Pollack MM, Harrison RE, Meert KL, Berg RA, Wessel DL, Shanley TP, Dalton H, Carcillo J, Jenkins TL, Dean JM. Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc. 2015 Nov; 22(6):1271-6. View in: PubMed

Bhalla AK, Belani S, Leung D, Newth CJ, Khemani RG. Higher Dead Space Is Associated With Increased Mortality in Critically Ill Children. Crit Care Med. 2015 Nov; 43(11):2439-45. View in: PubMed

Erickson S, Smith LS, Khemani RG, Willson DF, Jouvet P, Thomas NJ. The authors reply. Pediatr Crit Care Med. 2015 Nov; 16(9):899-900. View in: PubMed

Kim P, Salazar A, Ross PA, Newth CJ, Khemani RG. Comparison of Tidal Volumes at the Endotracheal Tube and at the Ventilator. Pediatr Crit Care Med. 2015 Nov; 16(9):e324-31. View in: PubMed

Bhalla AK, Rubin S, Newth CJ, Ross P, Morzov R, Soto-Campos G, Khemani R. Monitoring Dead Space in Mechanically Ventilated Children: Volumetric Capnography Versus Time-Based Capnography. Respir Care. 2015 Nov; 60(11):1548-55. View in: PubMed

Sanchez-Pinto LN, Goldstein SL, Schneider JB, Khemani RG. Association Between Progression and Improvement of Acute Kidney Injury and Mortality in Critically Ill Children. Pediatr Crit Care Med. 2015 Oct; 16(8):703-10. View in: PubMed

Smith LS, Khemani RG, Erickson S, Willson DF, Jouvet P, Thomas NJ. The authors reply. Pediatr Crit Care Med. 2015 Sep; 16(7):689-91. View in: PubMed

Khemani RG, Smith LS, Zimmerman JJ, Erickson S. Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the pediatric acute lung injury consensus conference. Pediatr Crit Care Med. 2015 Jun; 16(5 Suppl 1):S23-40. View in: PubMed

Salazar AM, Newth CC, Khemani RG, Jürg H, Ross PA. Pulmonary function testing in infants with tetralogy of Fallot and absent pulmonary valve syndrome. Ann Pediatr Cardiol. 2015 May-Aug; 8(2):108-12. View in: PubMed

Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015; 19(1):435. View in: PubMed

Khemani RG, Flink R, Hotz J, Ross PA, Ghuman A, Newth CJ. Respiratory inductance plethysmography calibration for pediatric upper airway obstruction: an animal model. Pediatr Res. 2015 Jan; 77(1-1):75-83. View in: PubMed

Khemani RG, Rubin S, Belani S, Leung D, Erickson S, Smith LS, Zimmerman JJ, Newth CJ. Pulse oximetry vs. PaO2 metrics in mechanically ventilated children: Berlin definition of ARDS and mortality risk. Intensive Care Med. 2015 Jan; 41(1):94-102. View in: PubMed

Khemani RG, Celikkaya EB, Shelton CR, Kale D, Ross PA, Wetzel RC, Newth CJ. Algorithms to estimate PaCO2 and pH using noninvasive parameters for children with hypoxemic respiratory failure. Respir Care. 2014 Aug; 59(8):1248-57. View in: PubMed

Shibata S, Khemani RG, Markovitz B. Patient Origin Is Associated With Duration of Endotracheal Intubation and PICU Length of Stay for Children With Status Asthmaticus. J Intensive Care Med. 2014 May-Jun; 29(3):154-9. View in: PubMed

Bennett TD, Spaeder MC, Matos RI, Watson RS, Typpo KV, Khemani RG, Crow S, Benneyworth BD, Thiagarajan RR, Dean JM, Markovitz BP. Existing data analysis in pediatric critical care research. Front Pediatr. 2014; 2:79. View in: PubMed

Rubin S, Ghuman A, Deakers T, Khemani R, Ross P, Newth CJ. Effort of breathing in children receiving high-flow nasal cannula. Pediatr Crit Care Med. 2014 Jan; 15(1):1-6. View in: PubMed

Ross PA, Khemani RG, Rubin SS, Bhalla AK, Newth CJ. Elevated positive end-expiratory pressure decreases cardiac index in a rhesus monkey model. Front Pediatr. 2014; 2:134. View in: PubMed

Ross PA, Newth CJ, Khemani RG. Accuracy of pulse oximetry in children. Pediatrics. 2014 Jan; 133(1):22-9. View in: PubMed

Ingaramo OA, Ngo T, Khemani RG, Newth CJ. Impact of positive end-expiratory pressure on cardiac index measured by ultrasound cardiac output monitor*. Pediatr Crit Care Med. 2014 Jan; 15(1):15-20. View in: PubMed

Khemani RG, Wilson DF, Esteban A, Ferguson ND. Evaluating the Berlin Definition in pediatric ARDS. Intensive Care Med. 2013 Dec; 39(12):2213-6. View in: PubMed

Yasaka Y, Khemani RG, Markovitz BP. Is shock index associated with outcome in children with sepsis/septic shock? *. Pediatr Crit Care Med. 2013 Oct; 14(8):e372-9. View in: PubMed

Ghuman AK, Newth CJ, Khemani RG. Impact of gender on sepsis mortality and severity of illness for prepubertal and postpubertal children. J Pediatr. 2013 Sep; 163(3):835-40. e1. View in: PubMed

Khemani RG, Schneider JB, Morzov R, Markovitz B, Newth CJ. Pediatric upper airway obstruction: interobserver variability is the road to perdition. J Crit Care. 2013 Aug; 28(4):490-7. View in: PubMed

Khemani RG. Dead space to tidal volume ratio (VD/VT) to explain extubation failure in children: the limitations of current evidence. J Pediatr (Rio J). 2012 May; 88(3):191-4. View in: PubMed

Radhakrishna SM, Reiff AO, Marzan KA, Azen C, Khemani RG, Rubin S, Menteer J, Brown DE, Shaham B. Pediatric rheumatic disease in the intensive care unit: Lessons learned from 15 years of experience in a tertiary care pediatric hospital. Pediatr Crit Care Med. 2012 May; 13(3):e181-6. View in: PubMed

Khemani RG, Thomas NJ, Venkatachalam V, Scimeme JP, Berutti T, Schneider JB, Ross PA, Willson DF, Hall MW, Newth CJ. Comparison of SpO(2) to PaO(2) based markers of lung disease severity for children with acute lung injury. Crit Care Med. 2012 Apr; 40(4):1309-16. View in: PubMed

Ingaramo OA, Khemani RG, Markovitz BP, Epstein D. Effect of race on the timing of the Glenn and Fontan procedures for single-ventricle congenital heart disease*. Pediatr Crit Care Med. 2012 Mar; 13(2):174-7. View in: PubMed

Ghuman AK, Newth CJ, Khemani RG. The association between the end tidal alveolar dead space fraction and mortality in pediatric acute hypoxemic respiratory failure*. Pediatr Crit Care Med. 2012 Jan; 13(1):11-5. View in: PubMed

Khemani RG, Sward K, Morris A, Dean JM, Newth CJ. Variability in usual care mechanical ventilation for pediatric acute lung injury: the potential benefit of a lung protective computer protocol. Intensive Care Med. 2011 Nov; 37(11):1840-8. View in: PubMed

Epstein D, Wong CF, Khemani RG, Moromisato DY, Waters K, Kipke MD, Markovitz BP. Race/Ethnicity is not associated with mortality in the PICU. Pediatrics. 2011 Mar; 127(3):e588-97. View in: PubMed

Khemani RG, Newth CJ. The design of future pediatric mechanical ventilation trials for acute lung injury. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1465-74. View in: PubMed

Khemani RG, Randolph A, Markovitz B. Steroids for post extubation stridor: pediatric evidence is still inconclusive. Intensive Care Med. 2010 Jul; 36(7):1276-7. View in: PubMed

Edwards JD, Kun SS, Keens TG, Khemani RG, Moromisato DY. Children with corrected or palliated congenital heart disease on home mechanical ventilation. Pediatr Pulmonol. 2010 Jul; 45(7):645-9. View in: PubMed

Ross PA, Hammer J, Khemani R, Klein M, Newth CJ. Pressure-rate product and phase angle as measures of acute inspiratory upper airway obstruction in rhesus monkeys. Pediatr Pulmonol. 2010 Jul; 45(7):639-44. View in: PubMed

del Castillo SL, McCulley ME, Khemani RG, Jeffries HE, Thomas DW, Peregrine J, Wells WJ, Starnes VA, Moromisato DY. Reducing the incidence of necrotizing enterocolitis in neonates with hypoplastic left heart syndrome with the introduction of an enteral feed protocol. Pediatr Crit Care Med. 2010 May; 11(3):373-7. View in: PubMed

Khemani RG. Post extubation stridor the call for objectivity. Indian Pediatr. 2010 Apr; 47(4):307-8. View in: PubMed

Schneider J, Khemani R, Grushkin C, Bart R. Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit. Crit Care Med. 2010 Mar; 38(3):933-9. View in: PubMed

Khemani RG, Markovitz BP, Curley MA. Characteristics of children intubated and mechanically ventilated in 16 PICUs. Chest. 2009 Sep; 136(3):765-71. View in: PubMed

Guner YS, Khemani RG, Qureshi FG, Wee CP, Austin MT, Dorey F, Rycus PT, Ford HR, Friedlich P, Stein JE. Outcome analysis of neonates with congenital diaphragmatic hernia treated with venovenous vs venoarterial extracorporeal membrane oxygenation. J Pediatr Surg. 2009 Sep; 44(9):1691-701. View in: PubMed

Nath DS, Carden AJ, Nussbaum DP, Shin AJ, Khemani RG, Starnes VA, Wells WJ. Can the Kawashima procedure be performed in younger patients? Ann Thorac Surg. 2009 Aug; 88(2):581-6; discussion 586-7. View in: PubMed

Khemani RG, Conti D, Alonzo TA, Bart RD, Newth CJ. Effect of tidal volume in children with acute hypoxemic respiratory failure. Intensive Care Med. 2009 Aug; 35(8):1428-37. View in: PubMed

Nath DS, Savla J, Khemani RG, Nussbaum DP, Greene CL, Wells WJ. Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery. Ann Thorac Surg. 2009 Jul; 88(1):246-51; discussion 251-2. View in: PubMed

Khemani RG, Patel NR, Bart RD, Newth CJ. Comparison of the pulse oximetric saturation/fraction of inspired oxygen ratio and the PaO2/fraction of inspired oxygen ratio in children. Chest. 2009 Mar; 135(3):662-8. View in: PubMed

Khemani RG, Bart RD, Alonzo TA, Hatzakis G, Hallam D, Newth CJ. Disseminated intravascular coagulation score is associated with mortality for children with shock. Intensive Care Med. 2009 Feb; 35(2):327-33. View in: PubMed

Khemani RG, Randolph A, Markovitz B. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2009; (3):CD001000. View in: PubMed

Markovitz BP, Randolph AG, Khemani RG. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2008; (2):CD001000. View in: PubMed

Ross PA, Smith BM, Tolo VT, Khemani RG. Continuous infusion of bupivacaine reduces postoperative morphine use in adolescent idiopathic scoliosis after posterior spine fusion. Spine (Phila Pa 1976). 2011 Aug 15; 36(18):1478-83. View in: PubMed

Powered bySC CTSI