Faculty

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Robinder G. Khemani, MD
Associate Professor of Clinical Pediatrics
Pediatrics
CHL Mail Stop 12 Off Campus Los Angeles
+1 323 361 2557

Overview

Dr. Khemani is a Pediatric Intensive Care Physician and Clinical Researcher at the Children's Hospital Los Angeles. His major area of research interest involves using observational data to answer important clinical questions in the realm of pediatric critical care. This includes but is not limited to the creation and validation of quality indicators and severity of illness scores to develop objective criteria for comparing pediatric intensive care unit (PICU) outcomes internationally. This work involves both disease specific markers for certain subgroups of PICU patients, or global ICU populations. These findings will help target specific areas for quality improvement, and help evaluate new interventions and treatment modalities.

He is also interested in pediatric mechanical ventilation, lung injury, and respiratory physiology, both translationally and at the bedside. He has specific interests in acute respiratory distress syndrome and upper airway obstruction: developing and validating minimally invasive pulmonary function techniques. Moreover, he uses his background in statistical modeling to examine the impact of different treatment regimens on cohorts of patients with specific respiratory disease such as upper airway obstruction, obstructive airways, hypoxemic respiratory failure, and acute lung injury.

Publications

Volume and Pressure Delivery During Pediatric High-Frequency Oscillatory Ventilation. Pediatr Crit Care Med. 2017 Feb 16. View in: PubMed

Change in Oxygen Consumption Following Inhalation of Albuterol in Comparison with Levalbuterol in Healthy Adult Volunteers. Lung. 2017 Feb 16. View in: PubMed

The authors reply. Pediatr Crit Care Med. 2017 Feb; 18(2):204-205. View in: PubMed

Bayes to the Rescue: Continuous Positive Airway Pressure Has Less Mortality Than High-Flow Oxygen. Pediatr Crit Care Med. 2017 Feb; 18(2):e92-e99. View in: PubMed

Evaluating the Performance of the Pediatric Acute Lung Injury Consensus Conference Definition of Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2017 Jan; 18(1):17-25. View in: PubMed

Cardiac output and systemic vascular resistance: Clinical assessment compared with a noninvasive objective measurement in children with shock. J Crit Care. 2016 Dec 28; 39:6-10. View in: PubMed

Pediatric Ventilator-Associated Infections: The Ventilator-Associated INfection Study. Pediatr Crit Care Med. 2016 Nov 8. View in: PubMed

CPAP alone best estimates post-extubation effort during spontaneous breathing trials in children. Intensive Care Med. 2016 Oct 14. View in: PubMed

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):907-916. View in: PubMed

Letter to Editor: Reliability of the Ultrasound Cardiac Output Monitor for Pediatric Patients. Pediatr Cardiol. 2016 Aug; 37(6):1189-90. View in: PubMed

Pediatric extubation readiness tests should not use pressure support. Intensive Care Med. 2016 Aug; 42(8):1214-22. View in: PubMed

Development of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Electronic Health Record Data. Pediatr Crit Care Med. 2016 Jun; 17(6):508-15. View in: PubMed

PICU Volume and Outcome: A Severity-Adjusted Analysis. Pediatr Crit Care Med. 2016 Jun; 17(6):483-9. View in: PubMed

The authors reply. Pediatr Crit Care Med. 2016 Jun; 17(6):582. View in: PubMed

Reply to Letter to the Editor. Pediatr Cardiol. 2016 Mar; 37(3):619-20. View in: PubMed

Obesity and Mortality Risk in Critically Ill Children. Pediatrics. 2016 Mar; 137(3):1-8. View in: PubMed

Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Feb; 17(2):101-9. View in: PubMed

Recruitment Maneuvers to the Extreme. Respir Care. 2016 Feb; 61(2):260-1. View in: PubMed

Evaluating Risk Factors for Pediatric Post-extubation Upper Airway Obstruction Using a Physiology-based Tool. Am J Respir Crit Care Med. 2016 Jan 15; 193(2):198-209. View in: PubMed

Validation of an Ultrasound Cardiac Output Monitor as a Bedside Tool for Pediatric Patients. Pediatr Cardiol. 2016 Jan; 37(1):177-83. View in: PubMed

Procalcitonin to Detect Suspected Bacterial Infections in the PICU. Pediatr Crit Care Med. 2016 Jan; 17(1):e4-e12. View in: PubMed

The authors reply. Crit Care Med. 2016 Jan; 44(1):e52-3. View in: PubMed

Interpretable Deep Models for ICU Outcome Prediction. AMIA Annu Symp Proc. 2016; 2016:371-380. View in: PubMed

Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc. 2015 Nov; 22(6):1271-6. View in: PubMed

Monitoring Dead Space in Mechanically Ventilated Children: Volumetric Capnography Versus Time-Based Capnography. Respir Care. 2015 Nov; 60(11):1548-55. View in: PubMed

Comparison of Tidal Volumes at the Endotracheal Tube and at the Ventilator. Pediatr Crit Care Med. 2015 Nov; 16(9):e324-31. View in: PubMed

The authors reply. Pediatr Crit Care Med. 2015 Nov; 16(9):899-900. View in: PubMed

Higher Dead Space Is Associated With Increased Mortality in Critically Ill Children. Crit Care Med. 2015 Nov; 43(11):2439-45. View in: PubMed

Association Between Progression and Improvement of Acute Kidney Injury and Mortality in Critically Ill Children. Pediatr Crit Care Med. 2015 Oct; 16(8):703-10. View in: PubMed

The authors reply. Pediatr Crit Care Med. 2015 Sep; 16(7):689-91. View in: PubMed

Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the pediatric acute lung injury consensus conference. Pediatr Crit Care Med. 2015 Jun; 16(5 Suppl 1):S23-40. View in: PubMed

Are we ready to accept the berlin definition of acute respiratory distress syndrome for use in children? Crit Care Med. Are we ready to accept the berlin definition of acute respiratory distress syndrome for use in children? Crit Care Med. 2015 May; 43(5):1132-4. View in: PubMed

Pulmonary function testing in infants with tetralogy of Fallot and absent pulmonary valve syndrome. Ann Pediatr Cardiol. 2015 May-Aug; 8(2):108-12. View in: PubMed

Respiratory inductance plethysmography calibration for pediatric upper airway obstruction: an animal model. Pediatr Res. 2015 Jan; 77(1-1):75-83. View in: PubMed

Pulse oximetry vs. PaO2 metrics in mechanically ventilated children: Berlin definition of ARDS and mortality risk. Intensive Care Med. 2015 Jan; 41(1):94-102. View in: PubMed

Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015; 19(1):435. View in: PubMed

Algorithms to estimate PaCO2 and pH using noninvasive parameters for children with hypoxemic respiratory failure. Respir Care. 2014 Aug; 59(8):1248-57. View in: PubMed

Patient Origin Is Associated With Duration of Endotracheal Intubation and PICU Length of Stay for Children With Status Asthmaticus. J Intensive Care Med. 2014 May-Jun; 29(3):154-9. View in: PubMed

Effort of breathing in children receiving high-flow nasal cannula. Pediatr Crit Care Med. 2014 Jan; 15(1):1-6. View in: PubMed

Impact of positive end-expiratory pressure on cardiac index measured by ultrasound cardiac output monitor*. Pediatr Crit Care Med. 2014 Jan; 15(1):15-20. View in: PubMed

Existing data analysis in pediatric critical care research. Front Pediatr. 2014; 2:79. View in: PubMed

Accuracy of pulse oximetry in children. Pediatrics. 2014 Jan; 133(1):22-9. View in: PubMed

Elevated positive end-expiratory pressure decreases cardiac index in a rhesus monkey model. Front Pediatr. 2014; 2:134. View in: PubMed

Evaluating the Berlin Definition in pediatric ARDS. Intensive Care Med. 2013 Dec; 39(12):2213-6. View in: PubMed

Is shock index associated with outcome in children with sepsis/septic shock?*. Is shock index associated with outcome in children with sepsis/septic shock? *. Pediatr Crit Care Med. 2013 Oct; 14(8):e372-9. View in: PubMed

Impact of gender on sepsis mortality and severity of illness for prepubertal and postpubertal children. J Pediatr. 2013 Sep; 163(3):835-40. e1. View in: PubMed

Pediatric upper airway obstruction: interobserver variability is the road to perdition. J Crit Care. 2013 Aug; 28(4):490-7. View in: PubMed

Pediatric rheumatic disease in the intensive care unit: Lessons learned from 15 years of experience in a tertiary care pediatric hospital. Pediatr Crit Care Med. 2012 May; 13(3):e181-6. View in: PubMed

Dead space to tidal volume ratio (VD/VT) to explain extubation failure in children: the limitations of current evidence. J Pediatr (Rio J). 2012 May; 88(3):191-4. View in: PubMed

Comparison of SpO(2) to PaO(2) based markers of lung disease severity for children with acute lung injury. Crit Care Med. 2012 Apr; 40(4):1309-16. View in: PubMed

Effect of race on the timing of the Glenn and Fontan procedures for single-ventricle congenital heart disease*. Pediatr Crit Care Med. 2012 Mar; 13(2):174-7. View in: PubMed

The association between the end tidal alveolar dead space fraction and mortality in pediatric acute hypoxemic respiratory failure*. Pediatr Crit Care Med. 2012 Jan; 13(1):11-5. View in: PubMed

Variability in usual care mechanical ventilation for pediatric acute lung injury: the potential benefit of a lung protective computer protocol. Intensive Care Med. 2011 Nov; 37(11):1840-8. View in: PubMed

Race/Ethnicity is not associated with mortality in the PICU. Pediatrics. 2011 Mar; 127(3):e588-97. View in: PubMed

The design of future pediatric mechanical ventilation trials for acute lung injury. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1465-74. View in: PubMed

Steroids for post extubation stridor: pediatric evidence is still inconclusive. Intensive Care Med. 2010 Jul; 36(7):1276-7. View in: PubMed

Children with corrected or palliated congenital heart disease on home mechanical ventilation. Pediatr Pulmonol. 2010 Jul; 45(7):645-9. View in: PubMed

Pressure-rate product and phase angle as measures of acute inspiratory upper airway obstruction in rhesus monkeys. Pediatr Pulmonol. 2010 Jul; 45(7):639-44. View in: PubMed

Reducing the incidence of necrotizing enterocolitis in neonates with hypoplastic left heart syndrome with the introduction of an enteral feed protocol. Pediatr Crit Care Med. 2010 May; 11(3):373-7. View in: PubMed

Post extubation stridor the call for objectivity. Indian Pediatr. 2010 Apr; 47(4):307-8. View in: PubMed

Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit. Crit Care Med. 2010 Mar; 38(3):933-9. View in: PubMed

Outcome analysis of neonates with congenital diaphragmatic hernia treated with venovenous vs venoarterial extracorporeal membrane oxygenation. J Pediatr Surg. 2009 Sep; 44(9):1691-701. View in: PubMed

Characteristics of children intubated and mechanically ventilated in 16 PICUs. Chest. 2009 Sep; 136(3):765-71. View in: PubMed

Effect of tidal volume in children with acute hypoxemic respiratory failure. Intensive Care Med. 2009 Aug; 35(8):1428-37. View in: PubMed

Can the Kawashima procedure be performed in younger patients? Ann Thorac Surg. Can the Kawashima procedure be performed in younger patients? Ann Thorac Surg. 2009 Aug; 88(2):581-6; discussion 586-7. View in: PubMed

Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery. Ann Thorac Surg. 2009 Jul; 88(1):246-51; discussion 251-2. View in: PubMed

Comparison of the pulse oximetric saturation/fraction of inspired oxygen ratio and the PaO2/fraction of inspired oxygen ratio in children. Chest. 2009 Mar; 135(3):662-8. View in: PubMed

Disseminated intravascular coagulation score is associated with mortality for children with shock. Intensive Care Med. 2009 Feb; 35(2):327-33. View in: PubMed

Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2009; (3):CD001000. View in: PubMed

Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2008; (2):CD001000. View in: PubMed

Continuous infusion of bupivacaine reduces postoperative morphine use in adolescent idiopathic scoliosis after posterior spine fusion. Spine (Phila Pa 1976). 2011 Aug 15; 36(18):1478-83. View in: PubMed

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