Faculty

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Russell E. Jacobs
Professor of Research Physiology and Biophysics
Zilkha Neurogenetic Institute
1501 SAN PABLO Health Sciences Campus Los Angeles

Publications

Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep; 14(9):e2000197. View in: PubMed

Delora A, Gonzales A, Medina CS, Mitchell A, Mohed AF, Jacobs RE, Bearer EL. A simple rapid process for semi-automated brain extraction from magnetic resonance images of the whole mouse head. J Neurosci Methods. 2016 Jan 15; 257:185-93. View in: PubMed

Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2015 Jun 16. View in: PubMed

Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. View in: PubMed

Sta Maria NS, Barnes SR, Weist MR, Colcher D, Raubitschek AA, Jacobs RE. Low Dose Focused Ultrasound Induces Enhanced Tumor Accumulation of Natural Killer Cells. PLoS One. 2015; 10(11):e0142767. View in: PubMed

Daianu M, Jacobs RE, Weitz TM, Town TC, Thompson PM. Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats. PLoS One. 2015; 10(12):e0145205. View in: PubMed

Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015; 15(1):19. View in: PubMed

Malkova NV, Gallagher JJ, Yu CZ, Jacobs RE, Patterson PH. Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):E2492-500. View in: PubMed

Tu C, Ng TS, Jacobs RE, Louie AY. Multimodality PET/MRI agents targeted to activated macrophages. J Biol Inorg Chem. 2014 Feb; 19(2):247-58. View in: PubMed

Sta Maria NS, Barnes SR, Jacobs RE. In vivo monitoring of natural killer cell trafficking during tumor immunotherapy. Magn Reson Insights. 2014; 7:15-21. View in: PubMed

Ng TS, Wert D, Sohi H, Procissi D, Colcher D, Raubitschek AA, Jacobs RE. Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101. Clin Cancer Res. 2013 May 1; 19(9):2518-27. View in: PubMed

Gallagher JJ, Zhang X, Hall FS, Uhl GR, Bearer EL, Jacobs RE. Altered reward circuitry in the norepinephrine transporter knockout mouse. PLoS One. 2013; 8(3):e57597. View in: PubMed

Ng TS, Bading JR, Park R, Sohi H, Procissi D, Colcher D, Conti PS, Cherry SR, Raubitschek AA, Jacobs RE. Quantitative, Simultaneous PET/MRI for Intratumoral Imaging with an MRI-Compatible PET Scanner. J Nucl Med. 2012 Jul; 53(7):1102-9. View in: PubMed

MacKenzie-Graham AJ, Rinek GA, Avedisian A, Morales LB, Umeda E, Boulat B, Jacobs RE, Toga AW, Voskuhl RR. Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis. J Neurosci Res. 2012 Jul; 90(7):1310-23. View in: PubMed

Gallagher JJ, Zhang X, Ziomek GJ, Jacobs RE, Bearer EL. Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI. Neuroimage. 2012 Apr 15; 60(3):1856-66. View in: PubMed

Perles-Barbacaru TA, Procissi D, Demyanenko AV, Jacobs RE. Quantitative pharmacologic MRI in mice. NMR Biomed. 2012 Apr; 25(4):498-505. View in: PubMed

Tu C, Ng TS, Sohi HK, Palko HA, House A, Jacobs RE, Louie AY. Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques. Biomaterials. 2011 Oct; 32(29):7209-16. View in: PubMed

Perles-Barbacaru TA, Procissi D, Demyanenko AV, Hall FS, Uhl GR, Jacobs RE. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. Neuroimage. 2011 Mar 15; 55(2):622-8. View in: PubMed

Ruffins SW, Jacobs RE. MRI in developmental biology and the construction of developmental atlases. Cold Spring Harb Protoc. 2011 Mar; 2011(3):top100. View in: PubMed

Zhang X, Bearer EL, Perles-Barbacaru AT, Jacobs RE. Increased anatomical detail by in vitro MR microscopy with a modified Golgi impregnation method. Magn Reson Med. 2010 May; 63(5):1391-7. View in: PubMed

Ng TS, Procissi D, Wu Y, Jacobs RE. A robust coregistration method for in vivo studies using a first generation simultaneous PET/MR scanner. Med Phys. 2010 May; 37(5):1995-2003. View in: PubMed

Zhang X, Bearer EL, Boulat B, Hall FS, Uhl GR, Jacobs RE. Altered neurocircuitry in the dopamine transporter knockout mouse brain. PLoS One. 2010; 5(7):e11506. View in: PubMed

MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR. Purkinje cell loss in experimental autoimmune encephalomyelitis. Neuroimage. 2009 Dec; 48(4):637-51. View in: PubMed

Bearer EL, Zhang X, Janvelyan D, Boulat B, Jacobs RE. Reward circuitry is perturbed in the absence of the serotonin transporter. Neuroimage. 2009 Jul 15; 46(4):1091-104. View in: PubMed

Lazovic J, Jensen MC, Ferkassian E, Aguilar B, Raubitschek A, Jacobs RE. Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme. Clin Cancer Res. 2008 Jun 15; 14(12):3832-9. View in: PubMed

Catana C, Procissi D, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Jacobs RE, Cherry SR. Simultaneous in vivo positron emission tomography and magnetic resonance imaging. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3705-10. View in: PubMed

Zinnanti WJ, Lazovic J, Housman C, LaNoue K, O'Callaghan JP, Simpson I, Woontner M, Goodman SI, Connor JR, Jacobs RE, Cheng KC. Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. J Clin Invest. 2007 Nov; 117(11):3258-70. View in: PubMed

Bearer EL, Zhang X, Jacobs RE. Live imaging of neuronal connections by magnetic resonance: Robust transport in the hippocampal-septal memory circuit in a mouse model of Down syndrome. Neuroimage. 2007 Aug 1; 37(1):230-42. View in: PubMed

Papan C, Boulat B, Velan SS, Fraser SE, Jacobs RE. Formation of the dorsal marginal zone in Xenopus laevis analyzed by time-lapse microscopic magnetic resonance imaging. Dev Biol. 2007 May 1; 305(1):161-71. View in: PubMed

Martin M, Reyes SD, Hiltner TD, Givogri MI, Tyszka JM, Fisher R, Campagnoni AT, Fraser SE, Jacobs RE, Readhead C. T(2)-weighted microMRI and evoked potential of the visual system measurements during the development of hypomyelinated transgenic mice. Neurochem Res. 2007 Feb; 32(2):159-65. View in: PubMed

Papan C, Boulat B, Velan SS, Fraser SE, Jacobs RE. Two-dimensional and three-dimensional time-lapse microscopic magnetic resonance imaging of Xenopus gastrulation movements using intrinsic tissue-specific contrast. Dev Dyn. 2007 Feb; 236(2):494-501. View in: PubMed

Bearer EL, Falzone TL, Zhang X, Biris O, Rasin A, Jacobs RE. Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI). Neuroimage. 2007; 37 Suppl 1:S37-46. View in: PubMed

Ruffins SW, Martin M, Keough L, Truong S, Fraser SE, Jacobs RE, Lansford R. Digital three-dimensional atlas of quail development using high-resolution MRI. ScientificWorldJournal. 2007; 7:592-604. View in: PubMed

Obenaus A, Jacobs RE. Magnetic resonance imaging of functional anatomy: use for small animal epilepsy models. Epilepsia. 2007; 48 Suppl 4:11-7. View in: PubMed

Mackenzie-Graham AJ, Lee EF, Dinov ID, Yuan H, Jacobs RE, Toga AW. Multimodal, multidimensional models of mouse brain. Epilepsia. 2007; 48 Suppl 4:75-81. View in: PubMed

Martin M, Hiltner TD, Wood JC, Fraser SE, Jacobs RE, Readhead C. Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice. J Neurosci Res. 2006 Dec; 84(8):1716-26. View in: PubMed

Papan C, Boulat B, Velan SS, Fraser SE, Jacobs RE. Time-lapse tracing of mitotic cell divisions in the early Xenopus embryo using microscopic MRI. Dev Dyn. 2006 Nov; 235(11):3059-62. View in: PubMed

MacKenzie-Graham A, Tinsley MR, Shah KP, Aguilar C, Strickland LV, Boline J, Martin M, Morales L, Shattuck DW, Jacobs RE, Voskuhl RR, Toga AW. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006 Sep; 32(3):1016-23. View in: PubMed

Tyszka JM, Readhead C, Bearer EL, Pautler RG, Jacobs RE. Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant. Neuroimage. 2006 Feb 15; 29(4):1058-65. View in: PubMed

Lee EF, Jacobs RE, Dinov I, Leow A, Toga AW. Standard atlas space for C57BL/6J neonatal mouse brain. Anat Embryol (Berl). 2005 Nov; 210(4):245-63. View in: PubMed

Jacobs EC, Pribyl TM, Feng JM, Kampf K, Spreur V, Campagnoni C, Colwell CS, Reyes SD, Martin M, Handley V, Hiltner TD, Readhead C, Jacobs RE, Messing A, Fisher RS, Campagnoni AT. Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene. J Neurosci. 2005 Jul 27; 25(30):7004-13. View in: PubMed

Tyszka JM, Fraser SE, Jacobs RE. Magnetic resonance microscopy: recent advances and applications. Curr Opin Biotechnol. 2005 Feb; 16(1):93-9. View in: PubMed

MacKenzie-Graham A, Lee EF, Dinov ID, Bota M, Shattuck DW, Ruffins S, Yuan H, Konstantinidis F, Pitiot A, Ding Y, Hu G, Jacobs RE, Toga AW. A multimodal, multidimensional atlas of the C57BL/6J mouse brain. J Anat. 2004 Feb; 204(2):93-102. View in: PubMed

Jacobs RE, Papan C, Ruffins S, Tyszka JM, Fraser SE. MRI: volumetric imaging for vital imaging and atlas construction. Nat Rev Mol Cell Biol. 2003 Sep; Suppl:SS10-6. View in: PubMed

Pautler RG, Mongeau R, Jacobs RE. In vivo trans-synaptic tract tracing from the murine striatum and amygdala utilizing manganese enhanced MRI (MEMRI). Magn Reson Med. 2003 Jul; 50(1):33-9. View in: PubMed

Redwine JM, Kosofsky B, Jacobs RE, Games D, Reilly JF, Morrison JH, Young WG, Bloom FE. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):1381-6. View in: PubMed

Gardner D, Toga AW, Ascoli GA, Beatty JT, Brinkley JF, Dale AM, Fox PT, Gardner EP, George JS, Goddard N, Harris KM, Herskovits EH, Hines ML, Jacobs GA, Jacobs RE, Jones EG, Kennedy DN, Kimberg DY, Mazziotta JC, Miller PL, Mori S, Mountain DC, Reiss AL, Rosen GD, Rottenberg DA, Shepherd GM, Smalheiser NR, Smith KP, Strachan T, Van Essen DC, Williams RW, Wong ST. Towards effective and rewarding data sharing. Neuroinformatics. 2003; 1(3):289-95. View in: PubMed

Ruffins SW, Jacobs RE, Fraser SE. Towards a Tralfamadorian view of the embryo: multidimensional imaging of development. Curr Opin Neurobiol. 2002 Oct; 12(5):580-6. View in: PubMed

Dhenain M, Privat N, Duyckaerts C, Jacobs RE. Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed. 2002 May; 15(3):197-203. View in: PubMed

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