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Russell K. Brynes, MD
Professor of Clinical Pathology
GNH 3850 1200 North State Street Off Campus Los Angeles
+1 323 226 7068


A 2-Year, Longitudinal, Prospective Study of the Effects of Eltrombopag on Bone Marrow in Patients with Chronic Immune Thrombocytopenia. Acta Haematol. 2016 Dec 23; 137(2):66-72. View in: PubMed

Large soft-tissue masses in an adult patient with Gaucher disease. J Inherit Metab Dis. 2016 Nov; 39(6):887-888. View in: PubMed

Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations. Mod Pathol. 2016 Jun; 29(6):570-81. View in: PubMed

Bone marrow cellularity MRI calculation and correlation with bone marrow biopsy. Clin Imaging. 2016 May-Jun; 40(3):392-7. View in: PubMed

Preleukemic phase of chronic myelogenous leukemia: morphologic and immunohistochemical characterization of 7 cases. Ann Diagn Pathol. 2016 Apr; 21:53-8. View in: PubMed

Pegylated interferon for the treatment of early myelofibrosis: correlation of serial laboratory studies with response to therapy. Ann Hematol. 2016 Apr; 95(5):733-8. View in: PubMed

Recommendations for gross examination and sampling of surgical specimens of the spleen. Ann Diagn Pathol. 2015 Oct; 19(5):288-95. View in: PubMed

Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: Data from the EXTEND study. Am J Hematol. 2015 Jul; 90(7):598-601. View in: PubMed

Differentiating benign from malignant bone marrow B-cell lymphoid aggregates: a statistical analysis of distinguishing features. Arch Pathol Lab Med. 2015 Feb; 139(2):233-40. View in: PubMed

Autoimmune myelofibrosis: an update on morphologic features in 29 cases and review of the literature. Hum Pathol. 2014 Nov; 45(11):2183-91. View in: PubMed

Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. Hum Pathol. 2014 Apr; 45(4):768-84. View in: PubMed

Peripheral blood smears, bone marrow aspiration, trephine and clot biopsies: methods and protocols. Methods Mol Biol. 2014; 1180:257-69. View in: PubMed

Aplastic anemia secondary to azathioprine in systemic lupus erythematosus: report of a case with normal thiopurine S-methyltransferase enzyme activity and review of the literature. Lupus. 2013 Dec; 22(14):1526-8. View in: PubMed

Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. Leuk Res. 2013 Nov; 37(11):1572-5. View in: PubMed

Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases. Am J Surg Pathol. 2013 Aug; 37(8):1290-7. View in: PubMed

Benign lymphoid aggregates in the bone marrow: distribution patterns of B and T lymphocytes. Hum Pathol. 2013 Apr; 44(4):512-20. View in: PubMed

Histopathological findings in 29 lymph node biopsies with increased IgG4 plasma cells. Mod Pathol. 2012 Mar; 25(3):480-91. View in: PubMed

Spontaneous, transient regression of B lymphoblastic leukemia in an adult patient: A variant presentation of prodromal/pre-ALL. Leuk Res. 2012 Mar; 36(3):e57-9. View in: PubMed

B-cell lymphoma with hyaline vascular Castleman disease-like features: a clinicopathologic study. Am J Clin Pathol. 2011 Jun; 135(6):901-14. View in: PubMed

Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: report of 3 cases and review of the literature. Int J Clin Exp Pathol. 2011 Apr; 4(4):416-20. View in: PubMed

Adult leukemic synovitis is associated with leukemia of monocytic differentiation. J Clin Rheumatol. 2011 Apr; 17(3):130-4. View in: PubMed

Phlegmonous gastritis in a patient with myeloid sarcoma: a case report. Appl Immunohistochem Mol Morphol. 2009 Oct; 17(5):458-62. View in: PubMed

Systemic mastocytosis associated with t(8;21)(q22;q22) acute myeloid leukemia. J Hematop. 2009 Mar; 2(1):27-33. View in: PubMed

High lifetime incidence of adult acute lymphoblastic leukemia among Hispanics in California. Cancer Epidemiol Biomarkers Prev. 2009 Feb; 18(2):611-5. View in: PubMed

Indeterminate cell tumor: a rare dendritic neoplasm. Am J Surg Pathol. 2008 Dec; 32(12):1868-76. View in: PubMed

Ki67 expression in different epithelial types in columnar lined oesophagus indicates varying levels of expanded and aberrant proliferative patterns. Histopathology. 2005 Aug; 47(2):132-40. View in: PubMed

Body cavity-based presentation of natural killer cell lymphoma. Leuk Lymphoma. 2005 Feb; 46(2):293-6. View in: PubMed

beta-Catenin expression in thyroid follicular lesions: potential role in nuclear envelope changes in papillary carcinomas. Endocr Pathol. 2004; 15(4):329-37. View in: PubMed

Systemic mastocytosis with associated clonal hematological non-mast-cell lineage disease: analysis of clinicopathologic features and activating c-kit mutations. Am J Hematol. 2003 May; 73(1):12-7. View in: PubMed

Primary autoimmune myelofibrosis: definition of a distinct clinicopathologic syndrome. Am J Hematol. 2003 Jan; 72(1):8-12. View in: PubMed

Immunohistochemical expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma. Appl Immunohistochem Mol Morphol. 2002 Dec; 10(4):322-6. View in: PubMed

Immunohistochemical expression of cyclin D1, E2F-1, and Ki-67 in benign and malignant thyroid lesions. J Pathol. 2002 Oct; 198(2):157-62. View in: PubMed

Reduced risk of synovial sarcoma in females: X-chromosome inactivation? Br J Cancer. Reduced risk of synovial sarcoma in females: X-chromosome inactivation? Br J Cancer. 2002 Jul 1; 87(1):28-30. View in: PubMed

Clinical, immunologic, and pathologic correlates of bone marrow involvement in 291 patients with acquired immunodeficiency syndrome-related lymphoma. Blood. 2001 Oct 15; 98(8):2358-63. View in: PubMed

Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease. Mod Pathol. 2001 Oct; 14(10):1036-42. View in: PubMed

Hyperplasia of mantle/marginal zone B cells with clear cytoplasm in peripheral lymph nodes. A clinicopathologic study of 35 cases. Am J Clin Pathol. 2001 Oct; 116(4):550-9. View in: PubMed

DNA topoisomerase IIalpha in multiple myeloma: a marker of cell proliferation and not drug resistance. Mod Pathol. 2001 Sep; 14(9):886-91. View in: PubMed

Pathology of autoimmune myelofibrosis. A report of three cases and a review of the literature. Am J Clin Pathol. 2001 Aug; 116(2):211-6. View in: PubMed

Cyclin D1 and E2F-1 immunoreactivity in bone marrow biopsy specimens of multiple myeloma: relationship to proliferative activity, cytogenetic abnormalities and DNA ploidy. Br J Haematol. 2001 Mar; 112(3):776-82. View in: PubMed

Cyclin D1 expression in dysplastic nevi: an immunohistochemical study. Arch Pathol Lab Med. 2001 Feb; 125(2):208-10. View in: PubMed

Mast cell disease associated with acute myeloid leukemia: detection of a new c-kit mutation Asp816His. Am J Hematol. 2000 Dec; 65(4):307-9. View in: PubMed

Intravascular large B-cell lymphoma. A report of five cases initially diagnosed by bone marrow biopsy. Am J Clin Pathol. 1999 Aug; 112(2):248-55. View in: PubMed

Cyclin D1 overexpression in Spitz nevi: an immunohistochemical study. Am J Dermatopathol. 1999 Apr; 21(2):115-20. View in: PubMed

Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study. Mod Pathol. 1999 Apr; 12(4):412-6. View in: PubMed

Acute lymphoblastic leukemia. Survey of immunophenotype, French-American-British classification, frequency of myeloid antigen expression, and karyotypic abnormalities in 210 pediatric and adult cases. Am J Clin Pathol. 1999 Apr; 111(4):467-76. View in: PubMed

Untreated chronic lymphocytic leukemia concurrent with or followed by acute myelogenous leukemia or myelodysplastic syndrome. A report of five cases and review of the literature. Am J Clin Pathol. 1999 Mar; 111(3):373-8. View in: PubMed

Differential expression of cyclin D1 in breast papillary carcinomas and benign papillomas: an immunohistochemical study. Arch Pathol Lab Med. 1999 Feb; 123(2):152-6. View in: PubMed

Using fluorescence-based human androgen receptor gene assay to analyze the clonality of microdissected dendritic cell tumors. Am J Clin Pathol. 1999 Jan; 111(1):105-10. View in: PubMed

The immunophenotype of blast transformation of chronic myelogenous leukemia: a high frequency of mixed lineage phenotype in "lymphoid" blasts and A comparison of morphologic, immunophenotypic, and molecular findings. Mod Pathol. 1998 Dec; 11(12):1211-21. View in: PubMed

Cyclin D1 expression in renal carcinomas and oncocytomas: an immunohistochemical study. Mod Pathol. 1998 Nov; 11(11):1075-81. View in: PubMed

Intravascular large B-cell lymphoma: the CD5 antigen is expressed by a subset of cases. Mod Pathol. 1998 Oct; 11(10):983-8. View in: PubMed

Surface immunoglobulin light chain-positive acute lymphoblastic leukemia of FAB L1 or L2 type: a report of 6 cases in adults. Am J Clin Pathol. 1998 Aug; 110(2):143-9. View in: PubMed

Expression of the cell-cycle-related proteins E2F-1, p53, mdm-2, p21waf-1, and Ki-67 in multiple myeloma: correlation with cyclin-D1 immunoreactivity. Mod Pathol. 1998 Jul; 11(7):642-7. View in: PubMed

Immunohistochemical detection of E2F-1 in non-Hodgkin's lymphomas: a survey of 124 cases. Mod Pathol. 1998 May; 11(5):457-63. View in: PubMed

The immunophenotype of adult acute myeloid leukemia: high frequency of lymphoid antigen expression and comparison of immunophenotype, French-American-British classification, and karyotypic abnormalities. Am J Clin Pathol. 1998 Feb; 109(2):211-20. View in: PubMed

Expression of p53, MDM2, p21waf1, bcl-2, and retinoblastoma gene proteins in myelodysplastic syndrome after autologous bone marrow transplantation for lymphoma. Mod Pathol. 1997 Nov; 10(11):1120-7. View in: PubMed

Myelodysplastic syndrome occurring after autologous bone marrow transplantation for lymphoma. Morphologic features. Am J Clin Pathol. 1997 Oct; 108(4):369-77. View in: PubMed

Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections. Mod Pathol. 1997 Sep; 10(9):927-32. View in: PubMed

Cyclin D1 immunohistochemical staining is useful in distinguishing mantle cell lymphoma from other low-grade B-cell neoplasms in bone marrow. Am J Clin Pathol. 1997 Sep; 108(3):302-7. View in: PubMed

Acute myeloid leukemia with t(6;9) (p23;q34): association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype. Am J Clin Pathol. 1997 Apr; 107(4):430-7. View in: PubMed

Numerical cytogenetic abnormalities of chromosomes 3, 7, and 12 in marginal zone B-cell lymphomas. Mod Pathol. 1996 Oct; 9(10):995-1000. View in: PubMed

Certification and training in molecular pathology. Hum Pathol. 1996 Apr; 27(4):430-1. View in: PubMed

Myelodysplasia and acute myeloid leukemia occurring after autologous bone marrow transplantation for lymphoma. Leuk Lymphoma. 1996 Feb; 20(5-6):365-72. View in: PubMed

Dendritic cell tumors associated with low-grade B-cell malignancies. Report of three cases. Am J Clin Pathol. 1995 Dec; 104(6):696-701. View in: PubMed

Trisomy 12 in Richter's transformation of chronic lymphocytic leukemia. Am J Clin Pathol. 1995 Aug; 104(2):199-203. View in: PubMed

Detection of trisomy 8 by fluorescence in situ hybridization on bone marrow smears from patients with subtle myelodysplastic changes. Arch Pathol Lab Med. 1994 Dec; 118(12):1196-200. View in: PubMed

Clonal karyotypic hematopoietic cell abnormalities occurring after autologous bone marrow transplantation for Hodgkin's disease and non-Hodgkin's lymphoma. Blood. 1994 Aug 1; 84(3):957-63. View in: PubMed

Detection of the Philadelphia chromosome in paraffin-embedded tissue by fluorescence in situ hybridization. Mod Pathol. 1994 Jun; 7(5):565-9. View in: PubMed

Osteitis fibrosa cystica simulating metastatic tumor. An almost-forgotten relationship. Am J Clin Pathol. 1993 Dec; 100(6):697-700. View in: PubMed

Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol. 1993 Oct; 17(10):1011-9. View in: PubMed

Graft versus leukemia effect after transplantation with interleukin-2-activated bone marrow. Correlation with eradication of residual disease. Transplantation. 1993 Jul; 56(1):31-7. View in: PubMed

Terminal acute myelogenous leukemia in a patient with congenital agranulocytosis. Am J Hematol. 1993 Jun; 43(2):133-8. View in: PubMed

Chronic lymphoproliferative disorders involving blood and bone marrow. Am J Clin Pathol. 1993 Apr; 99(4):494-503. View in: PubMed

Epidemiological and biological study of acquired immunodeficiency syndrome-related lymphoma in the County of Los Angeles: preliminary results. Cancer Res. 1992 Oct 1; 52(19 Suppl):5482s-5484s. View in: PubMed

Monocytoid B-cell lymphomas: an assessment of diagnostic criteria and a perspective on histogenesis. Hum Pathol. 1992 Sep; 23(9):1061-71. View in: PubMed

Human immunodeficiency virus-related lymphoma. Prognostic factors predictive of survival. Cancer. 1991 Dec 1; 68(11):2466-72. View in: PubMed

Bone marrow examination for the diagnosis of mycobacterial and fungal infections in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1991 Nov; 115(11):1125-32. View in: PubMed

Auer rod-like inclusions in circulating lymphoma cells. Am J Clin Pathol. 1991 Jul; 96(1):111-5. View in: PubMed

Hodgkin's disease occurring in monocytoid B-cell clusters. Am J Clin Pathol. 1991 Jun; 95(6):802-8. View in: PubMed

Induction of graft versus leukemia effect in bone marrow transplantation: dosage and time schedule dependency of interleukin 2 therapy. Cancer Res. 1991 Apr 15; 51(8):2015-20. View in: PubMed

Kaposi's sarcoma in the bone marrow of a patient with AIDS. Am J Clin Pathol. 1991 Apr; 95(4):561-4. View in: PubMed

Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma. Blood. 1991 Apr 1; 77(7):1527-33. View in: PubMed

Anti-BLA. 36 monoclonal antibody shows reactivity with Hodgkin's cells and B lymphocytes in frozen and paraffin-embedded tissues. Hematol Oncol. 1991 Mar-Apr; 9(2):103-14. View in: PubMed

Bone marrow transplantation with interleukin-2-activated bone marrow followed by interleukin-2 therapy for acute myeloid leukemia in mice. Blood. 1990 Dec 1; 76(11):2187-90. View in: PubMed

Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J Surg Pathol. 1990 Jun; 14(6):514-23. View in: PubMed

Transient stress lymphocytosis during crisis of sickle cell anemia and emergency trauma and medical conditions. An immunophenotyping study. Arch Pathol Lab Med. 1990 Jun; 114(6):570-6. View in: PubMed

Detection of specific t(14;18) chromosomal translocations in fixed tissues. Hum Pathol. 1990 Feb; 21(2):199-203. View in: PubMed

Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1). Ann Intern Med. 1989 Dec 1; 111(11):871-5. View in: PubMed

Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction. Am J Pathol. 1989 Oct; 135(4):697-702. View in: PubMed

Acute myeloid leukemia, FAB M-1 microgranular variant: a multiparameter study. Hematol Pathol. 1989; 3(1):11-22. View in: PubMed

Reactive immunoblastic proliferations. Semin Diagn Pathol. 1988 Nov; 5(4):317-28. View in: PubMed

Third-World Hodgkin's disease at Los Angeles County-University of Southern California Medical Center. J Clin Oncol. 1988 Aug; 6(8):1285-92. View in: PubMed

Peripheral T-cell lymphoma in a patient with acquired immune deficiency syndrome. Cancer. 1988 Mar 1; 61(5):947-51. View in: PubMed

Primary non-Hodgkin's lymphoma of the heart in two patients with the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1987 Mar; 111(3):254-6. View in: PubMed

Immunoglobulin and T cell receptor gene rearrangements in human lymphoma and leukemia. Blood. 1987 Jan; 69(1):79-86. View in: PubMed

The phenotypic diversity of peripheral T-cell lymphomas: the Southeastern Cancer Study Group experience. Hum Pathol. 1986 Jun; 17(6):567-74. View in: PubMed

Percutaneous needle biopsy in the diagnosis and classification of lymphoma. Cancer. 1986 Mar 1; 57(5):1074-8. View in: PubMed

Lymphocyte subsets in lymph nodes of homosexual men with generalized unexplained lymphadenopathy. Correlation with morphology and blood changes. Arch Pathol Lab Med. 1985 Feb; 109(2):133-7. View in: PubMed

Value of lymph node biopsy in unexplained lymphadenopathy in homosexual men. JAMA. 1983 Sep 9; 250(10):1313-7. View in: PubMed

Plasmacytoma arising in giant lymph node hyperplasia. Am J Clin Pathol. 1982 Oct; 78(4):541-4. View in: PubMed

Prolymphocytic leukemia of helper cell phenotype: report of a case and review of the scientific literature. Am J Clin Pathol. 1982 May; 77(5):643-7. View in: PubMed

Cycochemical profiles in acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1979; 1(3):263-75. View in: PubMed

Bone marrow aspiration and trephine biopsy. An approach to a thorough study. Am J Clin Pathol. 1978 Nov; 70(5):753-9. View in: PubMed

Acute monocytic leukemia. Cytologic, histologic, cytochemical, ultrastructural, and cytogenetic observations. Am J Clin Pathol. 1976 Apr; 65(4):471-82. View in: PubMed

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