Dr. Win's major areas of research interest are signal transduction in drug-induced hepatotoxicity, regulation of mitochondrial bioenergetic signaling in hepatotoxicity, non-alcoholic steatohepatitis and alcoholic hepatitis, oxidative stress, and identification of therapeutic target to prevent drug-induced hepatotoxicity. Her current research includes cellular mechanisms of hepatotoxicity.
Dr. Win earned her medical degree from University of Yangon Institute of Medicine. She then went on to perform her Medicine and Surgery Internship and Residency at University of Yangon General Hospital, followed by her PhD in Immunology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.
Sagawa Scholarship Award
Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 Jun; 63(6):1987-2003. View in: PubMed
Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. View in: PubMed
Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. View in: PubMed
Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. View in: PubMed
Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. View in: PubMed
Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 7; 286(40):35071-8. View in: PubMed
Than TA, Lou H, Ji C, Win S, Kaplowitz N. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. View in: PubMed
Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. View in: PubMed
Uenaka A, Hirano Y, Hata H, Win S, Aji T, Tanaka M, Ono T, Skipper JC, Shimizu K, Nakayama E. Cryptic CTL epitope on a murine sarcoma Meth A generated by exon extension as a novel mechanism. J Immunol. 2003 May 1; 170(9):4862-8. View in: PubMed
Win S, Uenaka A, Nakayama E. Immune responses against allogeneic and syngeneic tumors in aged C57BL/6 mice. Microbiol Immunol. 2002; 46(7):513-9. View in: PubMed