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Sanda Win, MBBS, PhD
Assistant Professor of Research Medicine
HMR 612 Health Sciences Campus Los Angeles
+1 323 442 3175


Dr. Win's major areas of research interest are signal transduction in drug-induced hepatotoxicity, regulation of mitochondrial bioenergetic signaling in hepatotoxicity, non-alcoholic steatohepatitis and alcoholic hepatitis, oxidative stress, and identification of therapeutic target to prevent drug-induced hepatotoxicity. Her current research includes cellular mechanisms of hepatotoxicity.

Dr. Win earned her medical degree from University of Yangon Institute of Medicine. She then went on to perform her Medicine and Surgery Internship and Residency at University of Yangon General Hospital, followed by her PhD in Immunology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.


Sagawa Scholarship Award


Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 Mar 22. View in: PubMed

Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 Feb 11; 106:111-117. View in: PubMed

Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2016 Oct 11. View in: PubMed

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 Jun; 63(6):1987-2003. View in: PubMed

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. View in: PubMed

Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. View in: PubMed

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. View in: PubMed

In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. View in: PubMed

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014; 5:e989. View in: PubMed

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. View in: PubMed

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 7; 286(40):35071-8. View in: PubMed

Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. View in: PubMed

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. View in: PubMed

Cryptic CTL epitope on a murine sarcoma Meth A generated by exon extension as a novel mechanism. J Immunol. 2003 May 1; 170(9):4862-8. View in: PubMed

Immune responses against allogeneic and syngeneic tumors in aged C57BL/6 mice. Microbiol Immunol. 2002; 46(7):513-9. View in: PubMed

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