Faculty

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Saverio Bellusci, PhD
Research Associate Professor of Surgery (Part Time)
Pediatrics
CHL Mail Stop 35 Off Campus Los Angeles
+1 323 669 5467

Overview

In 2010, Dr. Bellusci moved to the Justus Liebig University in Giessen, Germany as a full Professor. He holds currently the chair of lung extracellular matrix in the Excellent Cluster Cardio Pulmonary System. Prof. Bellusci’s research is mostly focusing on the role of FGF in lung development and disease. He will serve as the chair of the next Gordon Conference on FGF in 2014, which will take place in Ventura, California.

Publications

Ex vivo analysis of the contribution of FGF10+ cells to airway smooth muscle cell formation during early lung development. Dev Dyn. 2017 Apr 07. View in: PubMed

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. Cell Stem Cell. 2017 Apr 06; 20(4):571. View in: PubMed

Alveologenesis: key cellular players and fibroblast growth factor 10 signaling. Mol Cell Pediatr. 2016 Dec; 3(1):17. View in: PubMed

Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development. Mol Cell Pediatr. 2016 Dec; 3(1):23. View in: PubMed

MicroRNA-142 is a multifaceted regulator in organogenesis, homeostasis, and disease. Dev Dyn. 2016 Nov 24. View in: PubMed

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis. Cell Stem Cell. 2016 Nov 14. View in: PubMed

Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate. EMBO Mol Med. 2016 Nov 7. View in: PubMed

Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases. Dev Dyn. 2016 Oct 26. View in: PubMed

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. J Pathol. 2016 Oct 22. View in: PubMed

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. PLoS Pathog. 2016 Jun; 12(6):e1005544. View in: PubMed

Role of fibroblast growth factors in organ regeneration and repair. Semin Cell Dev Biol. 2016 May; 53:76-84. View in: PubMed

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L519-31. View in: PubMed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016; 14(1):19. View in: PubMed

Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications. Stem Cells Int. 2016; 2016:3157365. View in: PubMed

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 1; 142(23):4139-50. View in: PubMed

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis. Thorax. 2015 Nov; 70(11):1022-32. View in: PubMed

Characterization of the platelet-derived growth factor receptor-a-positive cell lineage during murine late lung development. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1; 309(9):L942-58. View in: PubMed

Non-canonical WNT signalling in the lung. J Biochem. 2015 Nov; 158(5):355-65. View in: PubMed

High mobility group protein-mediated transcription requires DNA damage marker ?-H2AX. High mobility group protein-mediated transcription requires DNA damage marker? -H2AX. Cell Res. 2015 Jul; 25(7):837-50. View in: PubMed

Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1014-24. View in: PubMed

Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G678-90. View in: PubMed

A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia. Front Med (Lausanne). 2015; 2:27. View in: PubMed

Generation and Validation of miR-142 Knock Out Mice. PLoS One. 2015; 10(9):e0136913. View in: PubMed

CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis. Biomed Res Int. 2015; 2015:189638. View in: PubMed

Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. BMC Biol. 2015; 13:42. View in: PubMed

Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis. Respir Res. 2015; 16:83. View in: PubMed

Validation of Tuba1a as Appropriate Internal Control for Normalization of Gene Expression Analysis during Mouse Lung Development. Int J Mol Sci. 2015; 16(3):4492-511. View in: PubMed

Pharmacological application of growth factors: basic and clinical. Biomed Res Int. 2015; 2015:141794. View in: PubMed

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry. Cardiovasc Res. 2014 Dec 1; 104(3):432-42. View in: PubMed

Regulation of Induced Pluripotent Stem (iPS) Cell Induction by Wnt/ß-Catenin Signaling. J Biol Chem. 2014 Mar 28; 289(13):9221-32. View in: PubMed

miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development. Development. 2014 Mar; 141(6):1272-81. View in: PubMed

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development. 2014 Jan; 141(2):296-306. View in: PubMed

Hmga2 is required for canonical WNT signaling during lung development. BMC Biol. 2014; 12(1):21. View in: PubMed

Walking along the Fibroblast Growth Factor 10 Route: A Key Pathway to Understand the Control and Regulation of Epithelial and Mesenchymal Cell-Lineage Formation during Lung Development and Repair after Injury. Scientifica (Cairo). 2014; 2014:538379. View in: PubMed

Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling. J Proteome Res. 2013 Dec 6; 12(12):5598-608. View in: PubMed

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs. Mol Cell. 2013 Sep 26; 51(6):707-22. View in: PubMed

Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus. J Neurosci. 2013 Apr 3; 33(14):6170-80. View in: PubMed

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax. 2013 Apr; 68(4):380-4. View in: PubMed

FGF10 Signaling Enhances Epicardial Cell Expansion during Neonatal Mouse Heart Repair. J Cardiovasc Dis Diagn. 2013 Mar; 1(1). View in: PubMed

Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular ß-catenin organization and signaling in AER during mouse limb development. PLoS One. 2013; 8(10):e76248. View in: PubMed

The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo. PLoS One. 2013; 8(4):e59966. View in: PubMed

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1; 122(11):3862-72. View in: PubMed

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15; 369(2):340-8. View in: PubMed

Embryonic epithelial Pten deletion through Nkx2. 1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-22. View in: PubMed

Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model. Pediatr Pulmonol. 2012 Feb; 47(2):162-71. View in: PubMed

Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS One. 2012; 7(11):e49127. View in: PubMed

Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Development. PLoS One. 2012; 7(6):e38452. View in: PubMed

Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest. 2011 Nov 1; 121(11):4409-19. View in: PubMed

Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15; 353(2):242-58. View in: PubMed

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development. 2011 Apr; 138(7):1395-407. View in: PubMed

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1; 350(1):112-26. View in: PubMed

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011; 6(8):e23139. View in: PubMed

Ectodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by Gli3. PLoS One. 2011; 6(10):e26242. View in: PubMed

FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development. 2011 Jan; 138(2):273-82. View in: PubMed

Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. View in: PubMed

Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet. 2010 Sep 1; 19(17):3457-67. View in: PubMed

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia. Am J Respir Crit Care Med. 2010 Jul 15; 182(2):207-19. View in: PubMed

Signaling via Alk5 controls the ontogeny of lung Clara cells. Development. 2010 Mar; 137(5):825-33. View in: PubMed

Lung organogenesis. Curr Top Dev Biol. 2010; 90:73-158. View in: PubMed

Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. View in: PubMed

Wnt5a knock-out mouse as a new model of anorectal malformation. J Surg Res. 2009 Oct; 156(2):278-82. View in: PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res. 2009 Oct; 66(4):386-90. View in: PubMed

miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 2009 Sep 15; 333(2):238-50. View in: PubMed

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):424-36. View in: PubMed

Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009 Feb; 238(2):294-301. View in: PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. View in: PubMed

Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc. 2008 Aug 15; 5(6):703-6. View in: PubMed

Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2. 1 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. View in: PubMed

Lung stem cells in the balance. Nat Genet. 2008 Jul; 40(7):822-4. View in: PubMed

Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Mol Cell Neurosci. 2008 Apr; 37(4):857-68. View in: PubMed

Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway. Mech Dev. 2008 Mar-Apr; 125(3-4):314-24. View in: PubMed

SMAD3 prevents binding of NKX2. 1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains. Nucleic Acids Res. 2008 Jan; 36(1):179-88. View in: PubMed

Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. View in: PubMed

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. View in: PubMed

Lung development and adult lung diseases. Chest. 2007 Aug; 132(2):651-6. View in: PubMed

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. View in: PubMed

Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol. 2006 Nov 15; 299(2):373-85. View in: PubMed

Lung development and susceptibility to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. View in: PubMed

Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol. 2006 Nov 1; 299(1):52-62. View in: PubMed

Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development. 2006 Jun; 133(12):2325-35. View in: PubMed

Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology. 2006 Apr; 130(4):1233-44. View in: PubMed

The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. J Pediatr Surg. 2006 Jan; 41(1):132-6; discussion 132-6. View in: PubMed

Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev Biol. 2005 Nov 1; 287(1):86-97. View in: PubMed

A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Dev Biol. 2005 Jun 15; 282(2):422-31. View in: PubMed

Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development. 2005 May; 132(9):2157-66. View in: PubMed

Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. View in: PubMed

Protein interaction mapping: a Drosophila case study. Genome Res. 2005 Mar; 15(3):376-84. View in: PubMed

Fibroblast growth factor-10 serves a regulatory role in duodenal development. J Pediatr Surg. 2005 Feb; 40(2):313-6. View in: PubMed

Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. View in: PubMed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol. 2005 Jan 15; 277(2):316-31. View in: PubMed

FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005; 5:11. View in: PubMed

Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. View in: PubMed

Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. J Pediatr Surg. 2004 Jun; 39(6):872-4. View in: PubMed

Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. J Pediatr Surg. 2004 Mar; 39(3):360-5; discussion 360-5. View in: PubMed

Identification of the mammary line in mouse by Wnt10b expression. Dev Dyn. 2004 Feb; 229(2):349-56. View in: PubMed

The molecular genetics of lung morphogenesis and injury repair. Paediatr Respir Rev. 2004; 5 Suppl A:S283-7. View in: PubMed

Functional analysis of the human Sprouty2 gene promoter. Gene. 2003 Dec 11; 322:175-85. View in: PubMed

Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res. 2003; 4:5. View in: PubMed

Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation. Differentiation. 2003 Jan; 71(1):1-17. View in: PubMed

Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development. 2002 Jan; 129(1):53-60. View in: PubMed

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