Faculty

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Sebastien G. Bouret, PhD
Associate Professor of Pediatrics
Pediatrics
CHL Mail Stop 135 Off Campus Los Angeles
+1 323 361 8743

Publications

Croizier S, Prevot V, Bouret SG. Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life. Cell Rep. 2016 Apr 5; 15(1):36-44. View in: PubMed

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2; 12(1):1-222. View in: PubMed

Zigman JM, Bouret SG, Andrews ZB. Obesity Impairs the Action of the Neuroendocrine Ghrelin System. Trends Endocrinol Metab. 2016 Jan; 27(1):54-63. View in: PubMed

Masi S, Bouret S. Odor signals in wild western lowland gorillas: an involuntary and extra-group communication hypothesis. Physiol Behav. 2015 Jun 1; 145:123-6. View in: PubMed

Varazzani C, San-Galli A, Gilardeau S, Bouret S. Noradrenaline and dopamine neurons in the reward/effort trade-off: a direct electrophysiological comparison in behaving monkeys. J Neurosci. 2015 May 20; 35(20):7866-77. View in: PubMed

Bouret S, Richmond BJ. Sensitivity of locus ceruleus neurons to reward value for goal-directed actions. J Neurosci. 2015 Mar 4; 35(9):4005-14. View in: PubMed

Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, Bouret SG. Neonatal ghrelin programs development of hypothalamic feeding circuits. J Clin Invest. 2015 Feb 2; 125(2):846-58. View in: PubMed

San-Galli A, Bouret S. Assessing value representation in animals. J Physiol Paris. 2015 Feb-Jun; 109(1-3):64-9. View in: PubMed

Laubach M, Bouret S, Sallet J. Special issue: Neural basis of adaptive control. J Physiol Paris. 2015 Feb-Jun; 109(1-3):1-2. View in: PubMed

Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, Bouret SG. Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Mol Metab. 2015 Jan; 4(1):15-24. View in: PubMed

Bouret S, Levin BE, Ozanne SE. Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev. 2015 Jan; 95(1):47-82. View in: PubMed

Kayser BD, Goran MI, Bouret SG. Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. PLoS One. 2015; 10(3):e0121954. View in: PubMed

Bellefontaine N, Chachlaki K, Parkash J, Vanacker C, Colledge W, d'Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V. Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. J Clin Invest. 2014 Jun 2; 124(6):2550-9. View in: PubMed

Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prévot V. Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain. Cell Metab. 2014 Feb 4; 19(2):293-301. View in: PubMed

Langlet F, Mullier A, Bouret SG, Prevot V, Dehouck B. Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain. J Comp Neurol. 2013 Oct 15; 521(15):3389-405. View in: PubMed

Goran MI, Dumke K, Bouret SG, Kayser B, Walker RW, Blumberg B. The obesogenic effect of high fructose exposure during early development. Nat Rev Endocrinol. 2013 Aug; 9(8):494-500. View in: PubMed

Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013 Apr 2; 17(4):607-17. View in: PubMed

Clark AM, Bouret S, Young AM, Murray EA, Richmond BJ. Interaction between orbital prefrontal and rhinal cortex is required for normal estimates of expected value. J Neurosci. 2013 Jan 30; 33(5):1833-45. View in: PubMed

Coupe B, Bouret SG. Development of the hypothalamic melanocortin system. Front Endocrinol (Lausanne). 2013; 4:38. View in: PubMed

Bouret SG. Organizational actions of metabolic hormones. Front Neuroendocrinol. 2013 Jan; 34(1):18-26. View in: PubMed

Bouret SG. RIPping off GABA release in hypothalamic circuits causes obesity. Cell Metab. 2012 Nov 7; 16(5):557-8. View in: PubMed

Sara SJ, Bouret S. Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal. Neuron. 2012 Oct 4; 76(1):130-41. View in: PubMed

Laloux C, Mairesse J, Van Camp G, Giovine A, Branchi I, Bouret S, Morley-Fletcher S, Bergonzelli G, Malagodi M, Gradini R, Nicoletti F, Darnaudéry M, Maccari S. Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress. Psychoneuroendocrinology. 2012 Oct; 37(10):1646-58. View in: PubMed

Caron E, Ciofi P, Prevot V, Bouret SG. Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci. 2012 Aug 15; 32(33):11486-94. View in: PubMed

Ishii Y, Bouret SG. Embryonic birthdate of hypothalamic leptin-activated neurons in mice. Endocrinology. 2012 Aug; 153(8):3657-67. View in: PubMed

Clark AM, Bouret S, Young AM, Richmond BJ. Intersection of reward and memory in monkey rhinal cortex. J Neurosci. 2012 May 16; 32(20):6869-77. View in: PubMed

Coupé B, Bouret SG. Weighing on autophagy: A novel mechanism for the CNS regulation of energy balance. Cell Cycle. 2012 Apr 15; 11(8):1477-8. View in: PubMed

Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation. Cell Metab. 2012 Feb 8; 15(2):247-55. View in: PubMed

Bouret SG, Bates SH, Chen S, Myers MG, Simerly RB. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci. 2012 Jan 25; 32(4):1244-52. View in: PubMed

Bouret S, Ravel S, Richmond BJ. Complementary neural correlates of motivation in dopaminergic and noradrenergic neurons of monkeys. Front Behav Neurosci. 2012; 6:40. View in: PubMed

Steculorum SM, Bouret SG. Developmental effects of ghrelin. Peptides. 2011 Nov; 32(11):2362-6. View in: PubMed

Steculorum SM, Bouret SG. Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Endocrinology. 2011 Nov; 152(11):4171-9. View in: PubMed

Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice. J Mol Neurosci. 2011 Mar; 43(3):478-84. View in: PubMed

Bouret SG. Neurodevelopmental actions of leptin. Brain Res. 2010 Sep 2; 1350:2-9. View in: PubMed

Patterson CM, Bouret SG, Park S, Irani BG, Dunn-Meynell AA, Levin BE. Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese. Endocrinology. 2010 Sep; 151(9):4270-9. View in: PubMed

Bouret S, Richmond BJ. Ventromedial and orbital prefrontal neurons differentially encode internally and externally driven motivational values in monkeys. J Neurosci. 2010 Jun 23; 30(25):8591-601. View in: PubMed

Mullier A, Bouret SG, Prevot V, Dehouck B. Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. J Comp Neurol. 2010 Apr 1; 518(7):943-62. View in: PubMed

Bouret SG. Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development. J Nutr. 2010 Mar; 140(3):653-7. View in: PubMed

Caron E, Sachot C, Prevot V, Bouret SG. Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J Comp Neurol. 2010 Feb 15; 518(4):459-76. View in: PubMed

Bouret SG. Leptin, nutrition, and the programming of hypothalamic feeding circuits. Nestle Nutr Workshop Ser Pediatr Program. 2010; 65:25-35; discussion 35-9. View in: PubMed

Bouret SG. Development of hypothalamic neural networks controlling appetite. Forum Nutr. 2010; 63:84-93. View in: PubMed

Bouret SG. Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr. 2009 Mar; 48 Suppl 1:S31-8. View in: PubMed

Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE. Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R537-48. View in: PubMed

Bouret S, Richmond BJ. Relation of locus coeruleus neurons in monkeys to Pavlovian and operant behaviors. J Neurophysiol. 2009 Feb; 101(2):898-911. View in: PubMed

Bouret SG. Crossing the border: developmental regulation of leptin transport to the brain. Endocrinology. 2008 Mar; 149(3):875-6. View in: PubMed

Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB. Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. Cell Metab. 2008 Feb; 7(2):179-85. View in: PubMed

Prevot V, Dehouck B, Poulain P, Beauvillain JC, Buée-Scherrer V, Bouret S. Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction. Psychoneuroendocrinology. 2007 Aug; 32 Suppl 1:S46-51. View in: PubMed

Bouret SG, Simerly RB. Development of leptin-sensitive circuits. J Neuroendocrinol. 2007 Aug; 19(8):575-82. View in: PubMed

Bouret SG, Simerly RB. Developmental programming of hypothalamic feeding circuits. Clin Genet. 2006 Oct; 70(4):295-301. View in: PubMed

Gohlke BC, Huber A, Bartmann P, Fimmers R, Hecher K, Bouret SG, Roth CL. Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins. J Pediatr Endocrinol Metab. 2006 Jan; 19(1):3-9. View in: PubMed

Bouret S, Sara SJ. Network reset: a simplified overarching theory of locus coeruleus noradrenaline function. Trends Neurosci. 2005 Nov; 28(11):574-82. View in: PubMed

Bouret S, Sara SJ. Reward expectation, orientation of attention and locus coeruleus-medial frontal cortex interplay during learning. Eur J Neurosci. 2004 Aug; 20(3):791-802. View in: PubMed

Bouret SG, Simerly RB. Minireview: Leptin and development of hypothalamic feeding circuits. Endocrinology. 2004 Jun; 145(6):2621-6. View in: PubMed

Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004 Apr 2; 304(5667):108-10. View in: PubMed

Bouret S, De Seranno S, Beauvillain JC, Prevot V. Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus. Endocrinology. 2004 Apr; 145(4):1794-801. View in: PubMed

Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci. 2004 Mar 17; 24(11):2797-805. View in: PubMed

Bouret S, Duvel A, Onat S, Sara SJ. Phasic activation of locus ceruleus neurons by the central nucleus of the amygdala. J Neurosci. 2003 Apr 15; 23(8):3491-7. View in: PubMed

Bouret S, Sara SJ. Locus coeruleus activation modulates firing rate and temporal organization of odour-induced single-cell responses in rat piriform cortex. Eur J Neurosci. 2002 Dec; 16(12):2371-82. View in: PubMed

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