Faculty

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Sebastien G. Bouret, PhD
Associate Professor of Pediatrics
Pediatrics
CHL Mail Stop 135 Off Campus Los Angeles
+1 323 361 8743

Overview

The long-range goal of the Bouret's lab is to study the hormonal and molecular signals that direct development of brain feeding circuits. Research in the Bouret’s lab has directly led to several breakthroughs in the understanding of the complex hormonal signals and neurodevelopmental substrates responsible for appetite regulation. Most notably, we found that metabolic hormones (such as leptin and ghrelin) influence the development and architecture of hypothalamic circuits involved in energy balance regulation. More recently, our lab has discovered a role for autophagy (a cellular process that degrades cytoplasmic materials, including organelles and misfolded proteins) in hypothalamic development and metabolic regulation.

Our current research projects aim at examining the cellular (e.g., ER stress and autophagy) and molecular (e.g., miRNAs, axon guidance cues) events involved in hypothalamic development and lifelong metabolic regulation. Our current research goal is also to study the molecular signals that link nmaternal obesity and the abnormal development of hypothalamic feeding circuits.

Publications

Croizier S, Prevot V, Bouret SG. Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life. Cell Rep. 2016 Apr 5; 15(1):36-44. View in: PubMed

Zigman JM, Bouret SG, Andrews ZB. Obesity Impairs the Action of the Neuroendocrine Ghrelin System. Trends Endocrinol Metab. 2016 Jan; 27(1):54-63. View in: PubMed

Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, Bouret SG. Neonatal ghrelin programs development of hypothalamic feeding circuits. J Clin Invest. 2015 Feb 2; 125(2):846-58. View in: PubMed

Bouret S, Levin BE, Ozanne SE. Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev. 2015 Jan; 95(1):47-82. View in: PubMed

Kayser BD, Goran MI, Bouret SG. Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. PLoS One. 2015; 10(3):e0121954. View in: PubMed

Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, Bouret SG. Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Mol Metab. 2015 Jan; 4(1):15-24. View in: PubMed

Bellefontaine N, Chachlaki K, Parkash J, Vanacker C, Colledge W, d'Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V. Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. J Clin Invest. 2014 Jun 2; 124(6):2550-9. View in: PubMed

Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prévot V. Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain. Cell Metab. 2014 Feb 4; 19(2):293-301. View in: PubMed

Langlet F, Mullier A, Bouret SG, Prevot V, Dehouck B. Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain. J Comp Neurol. 2013 Oct 15; 521(15):3389-405. View in: PubMed

Goran MI, Dumke K, Bouret SG, Kayser B, Walker RW, Blumberg B. The obesogenic effect of high fructose exposure during early development. Nat Rev Endocrinol. 2013 Aug; 9(8):494-500. View in: PubMed

Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013 Apr 2; 17(4):607-17. View in: PubMed

Bouret SG. Organizational actions of metabolic hormones. Front Neuroendocrinol. 2013 Jan; 34(1):18-26. View in: PubMed

Coupe B, Bouret SG. Development of the hypothalamic melanocortin system. Front Endocrinol (Lausanne). 2013; 4:38. View in: PubMed

Bouret SG. RIPping off GABA release in hypothalamic circuits causes obesity. Cell Metab. 2012 Nov 7; 16(5):557-8. View in: PubMed

Laloux C, Mairesse J, Van Camp G, Giovine A, Branchi I, Bouret S, Morley-Fletcher S, Bergonzelli G, Malagodi M, Gradini R, Nicoletti F, Darnaudéry M, Maccari S. Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress. Psychoneuroendocrinology. 2012 Oct; 37(10):1646-58. View in: PubMed

Caron E, Ciofi P, Prevot V, Bouret SG. Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci. 2012 Aug 15; 32(33):11486-94. View in: PubMed

Ishii Y, Bouret SG. Embryonic birthdate of hypothalamic leptin-activated neurons in mice. Endocrinology. 2012 Aug; 153(8):3657-67. View in: PubMed

Coupé B, Bouret SG. Weighing on autophagy: A novel mechanism for the CNS regulation of energy balance. Cell Cycle. 2012 Apr 15; 11(8):1477-8. View in: PubMed

Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation. Cell Metab. 2012 Feb 8; 15(2):247-55. View in: PubMed

Bouret SG, Bates SH, Chen S, Myers MG, Simerly RB. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci. 2012 Jan 25; 32(4):1244-52. View in: PubMed

Steculorum SM, Bouret SG. Developmental effects of ghrelin. Peptides. 2011 Nov; 32(11):2362-6. View in: PubMed

Steculorum SM, Bouret SG. Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Endocrinology. 2011 Nov; 152(11):4171-9. View in: PubMed

Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice. J Mol Neurosci. 2011 Mar; 43(3):478-84. View in: PubMed

Bouret SG. Neurodevelopmental actions of leptin. Brain Res. 2010 Sep 2; 1350:2-9. View in: PubMed

Patterson CM, Bouret SG, Park S, Irani BG, Dunn-Meynell AA, Levin BE. Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese. Endocrinology. 2010 Sep; 151(9):4270-9. View in: PubMed

Mullier A, Bouret SG, Prevot V, Dehouck B. Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. J Comp Neurol. 2010 Apr 1; 518(7):943-62. View in: PubMed

Bouret SG. Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development. J Nutr. 2010 Mar; 140(3):653-7. View in: PubMed

Caron E, Sachot C, Prevot V, Bouret SG. Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J Comp Neurol. 2010 Feb 15; 518(4):459-76. View in: PubMed

Bouret SG. Development of hypothalamic neural networks controlling appetite. Forum Nutr. 2010; 63:84-93. View in: PubMed

Bouret SG. Leptin, nutrition, and the programming of hypothalamic feeding circuits. Nestle Nutr Workshop Ser Pediatr Program. 2010; 65:25-35; discussion 35-9. View in: PubMed

Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE. Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R537-48. View in: PubMed

Bouret SG. Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr. 2009 Mar; 48 Suppl 1:S31-8. View in: PubMed

Bouret SG. Crossing the border: developmental regulation of leptin transport to the brain. Endocrinology. 2008 Mar; 149(3):875-6. View in: PubMed

Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB. Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. Cell Metab. 2008 Feb; 7(2):179-85. View in: PubMed

Bouret SG, Simerly RB. Development of leptin-sensitive circuits. J Neuroendocrinol. 2007 Aug; 19(8):575-82. View in: PubMed

Prevot V, Dehouck B, Poulain P, Beauvillain JC, Buée-Scherrer V, Bouret S. Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction. Psychoneuroendocrinology. 2007 Aug; 32 Suppl 1:S46-51. View in: PubMed

Bouret SG, Simerly RB. Developmental programming of hypothalamic feeding circuits. Clin Genet. 2006 Oct; 70(4):295-301. View in: PubMed

Gohlke BC, Huber A, Bartmann P, Fimmers R, Hecher K, Bouret SG, Roth CL. Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins. J Pediatr Endocrinol Metab. 2006 Jan; 19(1):3-9. View in: PubMed

Bouret SG, Simerly RB. Minireview: Leptin and development of hypothalamic feeding circuits. Endocrinology. 2004 Jun; 145(6):2621-6. View in: PubMed

Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004 Apr 2; 304(5667):108-10. View in: PubMed

Bouret S, De Seranno S, Beauvillain JC, Prevot V. Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus. Endocrinology. 2004 Apr; 145(4):1794-801. View in: PubMed

Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci. 2004 Mar 17; 24(11):2797-805. View in: PubMed

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