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Senta K. Georgia, PhD
Assistant Professor of Pediatrics
CHL Mail Stop 35 Off Campus Los Angeles
+1 323 361 6003


Georgia Lab Website

Georgia attended Stanford University, earning her BS in Biological Sciences, and dual departmental honors in Biological Sciences and Ethics in Society. She earned her PhD at UCLA in Molecular Biology. Her dissertation focused on the role of cell cycle molecules in the establishment, expansion and maintenance of beta cell mass. She was a postdoctoral fellow and assistant adjunct professor at the Hillblom Islet Research Center at UCLA.


Martín MG, Lindberg I, Solorzano-Vargas RS, Wang J, Avitzur Y, Bandsma R, Sokollik C, Lawrence S, Pickett LA, Chen Z, Egritas O, Dalgic B, Albornoz V, de Ridder L, Hulst J, Gok F, Aydogan A, Al-Hussaini A, Gok DE, Yourshaw M, Wu SV, Cortina G, Stanford S, Georgia S. Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology. 2013 Jul; 145(1):138-48. View in: PubMed

Georgia S, Kanji M, Bhushan A. DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15; 27(4):372-7. View in: PubMed

Tschen SI, Georgia S, Dhawan S, Bhushan A. Skp2 is required for incretin hormone-mediated ß-cell proliferation. Mol Endocrinol. 2011 Dec; 25(12):2134-43. View in: PubMed

Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. Pancreatic ß cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29. View in: PubMed

Matveyenko AV, Singh I, Shin BC, Georgia S, Devaskar SU. Differential effects of prenatal and postnatal nutritional environment on ß-cell mass development and turnover in male and female rats. Endocrinology. 2010 Dec; 151(12):5647-56. View in: PubMed

Matveyenko AV, Georgia S, Bhushan A, Butler PC. Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20. View in: PubMed

Georgia S, Bhushan A. Pregnancy hormones boost beta cells via serotonin. Nat Med. 2010 Jul; 16(7):756-7. View in: PubMed

Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96. View in: PubMed

Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K. Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS One. 2009; 4(2):e4394. View in: PubMed

Dhawan S, Georgia S, Bhushan A. Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol. 2007 Dec; 19(6):634-45. View in: PubMed

Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest. 2007 Oct; 117(10):2869-76. View in: PubMed

Georgia S, Bhushan A. p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov; 55(11):2950-6. View in: PubMed

Georgia S, Soliz R, Li M, Zhang P, Bhushan A. p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 1; 298(1):22-31. View in: PubMed

Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest. 2004 Oct; 114(7):963-8. View in: PubMed

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