Faculty

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Senta K. Georgia, PhD
Assistant Professor of Pediatrics
Pediatrics
CHL Mail Stop 35 Off Campus Los Angeles
+1 323 361 6003

Overview

Georgia Lab Website

Georgia attended Stanford University, earning her BS in Biological Sciences, and dual departmental honors in Biological Sciences and Ethics in Society. She earned her PhD at UCLA in Molecular Biology. Her dissertation focused on the role of cell cycle molecules in the establishment, expansion and maintenance of beta cell mass. She was a postdoctoral fellow and assistant adjunct professor at the Hillblom Islet Research Center at UCLA.

Publications

Neuropeptide Y expression marks partially differentiated β cells in mice and humans. JCI Insight. 2017 Jun 15; 2(12). View in: PubMed

Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G678-90. View in: PubMed

Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology. 2013 Jul; 145(1):138-48. View in: PubMed

DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15; 27(4):372-7. View in: PubMed

Skp2 is required for incretin hormone-mediated ß-cell proliferation. Mol Endocrinol. 2011 Dec; 25(12):2134-43. View in: PubMed

Pancreatic ß cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29. View in: PubMed

Differential effects of prenatal and postnatal nutritional environment on ß-cell mass development and turnover in male and female rats. Endocrinology. 2010 Dec; 151(12):5647-56. View in: PubMed

Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20. View in: PubMed

Pregnancy hormones boost beta cells via serotonin. Nat Med. 2010 Jul; 16(7):756-7. View in: PubMed

Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96. View in: PubMed

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS One. 2009; 4(2):e4394. View in: PubMed

Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol. 2007 Dec; 19(6):634-45. View in: PubMed

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest. 2007 Oct; 117(10):2869-76. View in: PubMed

p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov; 55(11):2950-6. View in: PubMed

p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 1; 298(1):22-31. View in: PubMed

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest. 2004 Oct; 114(7):963-8. View in: PubMed

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