Faculty

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Shahab Asgharzadeh, MD
Associate Professor of Pediatrics and Pathology
Pediatrics
CHL Mail Stop 54 Off Campus Los Angeles
+1 323 361 8643

Publications

Cancer-Associated Fibroblasts Share Characteristics and Pro-tumorigenic Activity with Mesenchymal Stromal Cells. Cancer Res. 2017 Jul 07. View in: PubMed

TGFßR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of Anti-GD2 Antibody Dinutuximab (ch14. 18) with Natural Killer Cells. Clin Cancer Res. 2016 Oct 10. View in: PubMed

More than the genes, the tumor microenvironment in neuroblastoma. Cancer Lett. 2016 Sep 28; 380(1):304-14. View in: PubMed

MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma. Cancer Lett. 2016 Feb 28; 371(2):214-24. View in: PubMed

BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One. 2016; 11(6):e0156907. View in: PubMed

Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy. Neuro Oncol. 2016 Jan; 18(1):126-31. View in: PubMed

A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer Cell. 2015 Nov 9; 28(5):599-609. View in: PubMed

CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. Cancer Res. 2015 Aug 1; 75(15):3155-66. View in: PubMed

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nat Genet. 2015 Aug; 47(8):864-71. View in: PubMed

Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). View in: PubMed

Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study. Br J Cancer. 2015 Jun 30; 113(1):57-63. View in: PubMed

Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration. Exp Cell Res. 2015 May 15; 334(1):78-89. View in: PubMed

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers. Clin Cancer Res. 2015 Apr 15; 21(8):1904-15. View in: PubMed

Tumor-Associated Macrophages in SHH Subgroup of Medulloblastomas. Clin Cancer Res. 2015 Mar 15; 21(6):1457-65. View in: PubMed

Pediatric brain tumor cell lines. J Cell Biochem. 2015 Feb; 116(2):218-24. View in: PubMed

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome Biol. 2015; 16:133. View in: PubMed

Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia. Front Oncol. 2015; 5:191. View in: PubMed

MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. Cancer Res. 2014 Nov 1; 74(21):5999-6009. View in: PubMed

PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas. Clin Cancer Res. 2014 Feb 15; 20(4):827-36. View in: PubMed

Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling. PLoS One. 2014; 9(10):e108818. View in: PubMed

Trends in childhood brain tumor incidence, 1973-2009. J Neurooncol. 2013 Nov; 115(2):153-60. View in: PubMed

Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells. Clin Immunol. 2013 Oct; 149(1):55-64. View in: PubMed

Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFß1. Cancer Immunol Immunother. 2013 Oct; 62(10):1637-48. View in: PubMed

Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells. J Immunother. 2013 Jun; 36(5):319-29. View in: PubMed

The genetic landscape of high-risk neuroblastoma. Nat Genet. 2013 Mar; 45(3):279-84. View in: PubMed

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene. 2012 Nov 15; 31(46):4859-67. View in: PubMed

Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. J Clin Oncol. 2012 Oct 1; 30(28):3525-32. View in: PubMed

IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity. J Clin Invest. 2012 Jun 1; 122(6):2221-33. View in: PubMed

Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer Res. 2012 Apr 15; 72(8):2068-78. View in: PubMed

Novel pathways to erythropoiesis induced by dimerization of intracellular C-mpl in human hematopoietic progenitors. Stem Cells. 2012 Apr; 30(4):697-708. View in: PubMed

Neuroblastoma: issues in transplantation. Biol Blood Marrow Transplant. 2012 Jan; 18(1 Suppl):S92-S100. View in: PubMed

Copy number variation signature to predict human ancestry. BMC Bioinformatics. 2012; 13:336. View in: PubMed

TARGETgene: A Tool for Identification of Potential Therapeutic Targets in Cancer. PLoS One. 2012; 7(8):e43305. View in: PubMed

Bioinformatics for copy number variation data. Methods Mol Biol. 2011; 719:235-49. View in: PubMed

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell. 2010 Jul 23; 142(2):218-29. View in: PubMed

Prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol. 2010 Jul 20; 28(21):3506-15. View in: PubMed

Prediction of human functional genetic networks from heterogeneous data using RVM-based ensemble learning. Bioinformatics. 2010 Mar 15; 26(6):807-13. View in: PubMed

Evaluation of endothelial and inducible nitric oxide synthase genes expression in the heart of broiler chickens with experimental pulmonary hypertension. Br Poult Sci. 2009 Nov; 50(6):725-32. View in: PubMed

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet. 2009 Jun; 41(6):718-23. View in: PubMed

Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. J Clin Invest. 2009 Jun; 119(6):1524-36. View in: PubMed

Joint estimation of copy number variation and reference intensities on multiple DNA arrays using GADA. Bioinformatics. 2009 May 15; 25(10):1223-30. View in: PubMed

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 7; 15(4):328-40. View in: PubMed

An integrated cross-platform prognosis study on neuroblastoma patients. Genomics. 2008 Oct; 92(4):195-203. View in: PubMed

Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors. Pediatr Blood Cancer. 2008 Aug; 51(2):235-40. View in: PubMed

Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med. 2008 Jun 12; 358(24):2585-93. View in: PubMed

Sparse representation and Bayesian detection of genome copy number alterations from microarray data. Bioinformatics. 2008 Feb 1; 24(3):309-18. View in: PubMed

Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience. Pediatr Blood Cancer. 2008 Feb; 50(2):312-8. View in: PubMed

Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. Pediatr Blood Cancer. 2007 Jul; 49(1):34-40. View in: PubMed

Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. J Natl Cancer Inst. 2006 Sep 6; 98(17):1193-203. View in: PubMed

Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. J Exp Med. 2004 May 3; 199(9):1213-21. View in: PubMed

Dinucleotide repeat polymorphism at the human erythroid alpha spectrin (SPTA1) locus. Hum Mol Genet. 1992 Jun; 1(3):218. View in: PubMed

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