Faculty

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Shigang Xiong, MD, PhD
Assistant Professor of Research Medicine
Medicine
NOR 5429 Health Sciences Campus Los Angeles
+1 323 865 0577

Overview

Dr. Xiong's research interests include neuroimmune interaction in the pathogenesis of inflammatory diseases, intracellular iron signaling for IKK and NF-kB activation in Kupffer cells, hepatic stem cells and liver reconstruction, and prostate cancer transdifferentiation and endocrinology.

Dr. Xiong earned his medical degree from Bengbu Medical College. He stayed on to perform his internship and residency in pathology. Dr. Xiong then completed his Master's in Pathology from Anhui Medical University, followed by his PhD in Oncology from Peking Union Medical College. He also completed two pathology fellowships.

Awards

53rd Annual Meeting of the American Association for the Study of Liver Diseases: Outstanding Research Award, 2002

Cooley's Anemia Foundation: Research Fellowship, 2001-2002

Cooley's Anemia Foundation: Research Fellowship, 2000-2001

Irish National Foundation for Children Research: Senior Research Fellowship, 1996-1998

Publications

Effects of luteinizing hormone receptor signaling in prostate cancer cells. Prostate. 2015 Feb; 75(2):141-50. View in: PubMed

Efficacy of oxaliplatin plus pemetrexed in chemotherapy pretreated metastatic castration-resistant prostate cancer. Clin Genitourin Cancer. 2013 Dec; 11(4):416-22. View in: PubMed

Ethnic differences in neuroendocrine expression in prostate cancer tissue. Anticancer Res. 2011 Nov; 31(11):3897-901. View in: PubMed

Effect of luteinizing hormone on the steroidogenic pathway in prostate cancer. Prostate. 2011 Jun 1; 71(8):892-8. View in: PubMed

A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res. 2011 Apr 15; 71(8):2848-57. View in: PubMed

The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes. Prostate. 2010 Nov 1; 70(15):1692-700. View in: PubMed

Expression of receptors for luteinizing hormone-releasing hormone (LH-RH) in prostate cancers following therapy with LH-RH agonists. Clin Cancer Res. 2010 Sep 15; 16(18):4675-80. View in: PubMed

Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells. Prostate. 2009 Jan 1; 69(1):12-23. View in: PubMed

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. View in: PubMed

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008 Jan 15; 68(2):498-505. View in: PubMed

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. View in: PubMed

Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. J Biol Chem. 2007 Feb 23; 282(8):5582-8. View in: PubMed

Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J Biol Chem. 2005 Dec 9; 280(49):40650-9. View in: PubMed

Steatohepatitis induced by intragastric overfeeding in mice. Hepatology. 2005 Oct; 42(4):905-14. View in: PubMed

Yang MD, Deng QG, Chen S, Xiong S, Koop D, Tsukamoto H. Hepatoprotective mechanisms of Yan-gan-wan. Hepatol Res. 2005 Aug; 32(4):202-12. View in: PubMed

Yang MD, Deng QG, Chen S, Xiong S, Koop D, Tsukamoto H. Hepatoprotective mechanisms of Yan-gan-wan. Hepatol Res. 2005 Aug; 32(4):202-12. View in: PubMed

She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005 Feb 11; 280(6):4959-67. View in: PubMed

She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005 Feb 11; 280(6):4959-67. View in: PubMed

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. View in: PubMed

Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G722-9. View in: PubMed

Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem. 2004 Mar 19; 279(12):11392-401. View in: PubMed

Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem. 2004 Feb 6; 279(6):4820-8. View in: PubMed

Signaling role of iron in NF-kappa B activation in hepatic macrophages. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S36. View in: PubMed

Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol. 2003 Jun; 30(2):107-13. View in: PubMed

Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. View in: PubMed

Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. View in: PubMed

Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. View in: PubMed

IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. View in: PubMed

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