Faculty

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Shikun He, MD
Associate Professor of Clinical Pathology
Pathology
NRT 1450 Biggy Street Off Campus Los Angeles
+1 323 442 6621

Overview

My research interests are focused on the roles of the retinal pigment epithelial (RPE) cell in the development of choroidal neovascularization(CNV) in age related macular degeneration and proliferative vitreoretinopathy (PVR). In particular I am interested in the roles of growth factors and cytokines produced by RPE and its regulation by epigenetic factors in pathogenesis of CNV and PVR by using molecular biology techniques and animal studies.

Publications

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SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. Cytokine. 2015 Dec; 76(2):549-52. View in: PubMed

Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Sci Rep. 2015 Nov 10; 5:16386. View in: PubMed

Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2015 Aug 1; 56(9):5579-89. View in: PubMed

Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5579-89. View in: PubMed

Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Sci Rep. 2015; 5:16386. View in: PubMed

Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One. 2015; 10(3):e0120587. View in: PubMed

IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014 Dec 4; 20(12):1372-5. View in: PubMed

IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014 Dec; 20(12):1372-5. View in: PubMed

Review: Epigenetic mechanisms in ocular disease. Mol Vis. 2013; 19:665-74. View in: PubMed

Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 1; 53(5):1111-22. View in: PubMed

Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol. 2012 Sep; 130(9):1127-34. View in: PubMed

Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 01; 53(5):1111-22. View in: PubMed

Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol. 2012 Sep 1; 130(9):1127-34. View in: PubMed

Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. View in: PubMed

Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul 07; 52(8):5068-78. View in: PubMed

Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5068-78. View in: PubMed

Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. FASEB J. 2011 Jul; 25(7):2221-33. View in: PubMed

alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. View in: PubMed

Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol. 2010; 2010:289360. View in: PubMed

Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. View in: PubMed

Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol. 2009 May; 247(5):651-9. View in: PubMed

Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):4078-88. View in: PubMed

Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2008 May; 246(5):677-83. View in: PubMed

In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007; 2(1):67-77. View in: PubMed

Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao. 2006 Dec; 22(4):265-74. View in: PubMed

Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. View in: PubMed

MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina. 2006 Apr; 26(4):454-61. View in: PubMed

Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. View in: PubMed

Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. View in: PubMed

Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. View in: PubMed

A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005 Jun 29; 5:16. View in: PubMed

Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005 Jun 16; 11:414-24. View in: PubMed

Carboxyamido-triazole modulates retinal pigment epithelial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells. Curr Eye Res. 2005 Feb; 30(2):103-13. View in: PubMed

Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005; 11:414-24. View in: PubMed

A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005; 5:16. View in: PubMed

Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 2004 Mar; 27(3):758-64. View in: PubMed

Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):323-9. View in: PubMed

A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol. 2003 Sep; 121(9):1283-8. View in: PubMed

Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2782-90. View in: PubMed

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