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Sophoclis Alexopoulos, MD
Associate Professor of Clinical Surgery
HCC 514 Health Sciences Campus Los Angeles
+1 323 442 5908


Sophoclis P. Alexopoulos was born in Athens, Greece and moved to the United States at a young age. He grew up in Northern California and graduated from the University of California at San Diego with a B.S. in Physics. Dr. Alexopoulos attended the College of Physicians and Surgeons of Columbia University in New York City for medical school. He then moved to Boston where he completed a general surgical residency at the Beth Israel Deaconess Medical Center, a major teaching hospital of Harvard Medical School. During residency he obtained extensive experience in complex pancreaticobiliary surgery. A strong interest in pediatric liver transplantation brought him back to Northern California where he completed a multi-organ abdominal transplant fellowship at Stanford University, one of the busiest pediatric transplant programs in the nation.

Dr. Alexopoulos is the surgical director of kidney transplantation at Keck Medical Center of the University of Southern California and associated program director for the pediatric liver transplantation at Children’s Hospital of Los Angeles. His non-transplant interests include the treatment of benign and malignant tumors of the liver, pancreas, and biliary tree including hepatocellular carcinoma, pancreatic cancer, and cholangiocarcinoma. His experience in split and live donor liver transplantation allow him to perform complex non-transplant liver surgery. Dr. Alexopoulos is funded in basic science research involving the detection and analysis of circulating tumor cells in liver cancer.


Alexopoulos SP, Nekrasov V, Cao S, Groshen S, Kaur N, Genyk YS, Matsuoka L. Effects of Recipient Size and Allograft Type on Pediatric Liver Transplantation for Biliary Atresia. Liver Transpl. 2016 Nov 10. View in: PubMed

Kasraianfard A, Watt KD, Lindberg L, Alexopoulos S, Rezaei N. HBIG Remains Significant in the Era of New Potent Nucleoside Analogues for Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation. Int Rev Immunol. 2016 Jul 3; 35(4):312-324. View in: PubMed

Yang CH, Zhou S, Alexopoulos S, Wang L, Baron HI, Genyk Y, Kerkar N. Orthotopic liver transplant for multifocal lymphangioendotheliomatosis with thrombocytopenia. Pediatr Transplant. 2016 Feb 25. View in: PubMed

Matsuoka L, Alicuben E, Woo K, Cao S, Groshen S, Qazi Y, Smogorzewski M, Selby R, Alexopoulos S. Kidney transplantation in the Hispanic population. Clin Transplant. 2016 Feb; 30(2):118-23. View in: PubMed

Rochefort H, Matsuoka L, Chouliaras K, Mwengela D, Buxbaum J, Alexopoulos SP. Multiple Preoperative Endoscopic Retrograde Cholangiopancreatography and Large Common Bile Duct Diameter Predict the Need for Complex Surgery. Am Surg. 2016 Feb; 82(2):122-7. View in: PubMed

Thomas E, Matsuoka L, Alexopoulos S, Selby R, Parekh D. Laparoscopic Hand-Assisted Parenchymal-Sparing Resections for Presumed Side-Branch Intraductal Papillary Mucinous Neoplasms. J Laparoendosc Adv Surg Tech A. 2015 Aug; 25(8):668-71. View in: PubMed

Ng TS, Rochefort H, Czaplicki C, Teixeira P, Zheng L, Matsuoka L, Van Dam J, Alexopoulos SP. Massive pancreatic pseudocyst with portal vein fistula: Case report and proposed treatment algorithm. Pancreatology. 2015 Jan-Feb; 15(1):88-93. View in: PubMed

Lee C, Kim A, Santos I, Cen Y, Alexopoulos S, Navarro S, Wallman M, Dhanireddy K, Grant E. Cardiophrenic lymph nodes in liver transplant candidates with hepatocellular carcinoma: imaging characteristics and post-transplant outcomes. Clin Transplant. 2014 Dec; 28(12):1402-9. View in: PubMed

Alhosh R, Genyk Y, Alexopoulos S, Thomas D, Zhou S, Yanni G, Kerkar N. Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child. Pediatr Transplant. 2014 Aug; 18(5):E157-60. View in: PubMed

Matsuoka L, Alexopoulos S, Petrovik L, Chan L, Genyk Y, Selby R. Trisectionectomy for cholangiocarcinoma: is it worth it? Am Surg. 2014 Jun; 80(6):544-8. View in: PubMed

Alexopoulos SP, Thomas E, Berry E, Whang G, Matsuoka L. The portal vein-variceal anastomosis: an important technique for establishing portal vein inflow. Clin Transplant. 2014 Jan; 28(1):52-7. View in: PubMed

Derek E, Matsuoka L, Alexopoulos S, Fedenko A, Genyk Y, Selby R. Combined surgical resection and radiofrequency ablation as treatment for metastatic ocular melanoma. Surg Today. 2013 Apr; 43(4):367-71. View in: PubMed

Alexopoulos S, Matsuoka L, Cho Y, Thomas E, Sheikh M, Stapfer M, Dhanireddy K, Sher L, Selby R, Genyk Y. Outcomes after liver transplantation in patients achieving a model for end-stage liver disease score of 40 or higher. Transplantation. 2013 Feb 15; 95(3):507-12. View in: PubMed

Alexopoulos SP, Merrill M, Kin C, Matsuoka L, Dorey F, Concepcion W, Esquivel C, Bonham A. The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia: Early failure adversely affects outcome. Pediatr Transplant. 2012 Jun; 16(4):373-8. View in: PubMed

Sher L, Jennings L, Rudich S, Alexopoulos SP, Netto G, Teperman L, Kinkhabwala M, Brown RS, Pomfret E, Klintmalm G. Results of live donor liver transplantation in patients with hepatitic C virus infection: the HCV 3 trial experience. Clin Transplant. 2012 May; 26(3):502-9. View in: PubMed

Alexopoulos SP. Editorial comment. Curr Opin Organ Transplant. 2011 Aug; 16(4):379. View in: PubMed

Alexopoulos S, Lightner A, Concepcion W, Rose M, Salcedo-Concepcion K, Salvatierra O. Pediatric kidney recipients with small capacity, defunctionalized urinary bladders receiving adult-sized kidney without prior bladder augmentation. Transplantation. 2011 Feb 27; 91(4):452-6. View in: PubMed

Loo J, Selby R, Genyk Y, Sher L, Alexopoulos S, Stapfer M. Removal of a large hepatic neuroendocrine tumor causing Budd-Chiari syndrome using a median sternotomy approach in conjunction with a midline laparotomy incision. Am Surg. 2011 Feb; 77(2):E27-9. View in: PubMed

Kennedy M, Alexopoulos SP. Hepatitis B virus infection and liver transplantation. Curr Opin Organ Transplant. 2010 Jun; 15(3):310-5. View in: PubMed

Alexopoulos SP, Henningsen JA, Jeffrey RB, Bonham CA, Ahmed A, Gonzalez SA. Management of biliary strictures following liver transplantation. Dig Dis Sci. 2009 Jan; 54(1):25-7. View in: PubMed

Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB. Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation. 2007 Jul 15; 84(1 Suppl):S12-6. View in: PubMed

Sánchez-Fueyo A, Domenig CM, Mariat C, Alexopoulos S, Zheng XX, Strom TB. Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation. Transpl Int. 2007 Jun; 20(6):534-41. View in: PubMed

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