Faculty

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Steve Kay, PhD
Professor
Zilkha Neurogenetic Institute
KAM 500 Health Sciences Campus Los Angeles
+1 323 442 1900

Publications

Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR, Kay SA, Downes M, Evans RM. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBa Degradation. Cell. 2016 Jun 16; 165(7):1644-57. View in: PubMed

Breton G, Kay SA, Pruneda-Paz JL. Identification of Arabidopsis Transcriptional Regulators by Yeast One-Hybrid Screens Using a Transcription Factor ORFeome. Methods Mol Biol. 2016; 1398:107-18. View in: PubMed

Huang H, Alvarez S, Bindbeutel R, Shen Z, Naldrett MJ, Evans BS, Briggs SP, Hicks LM, Kay SA, Nusinow DA. Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry. Mol Cell Proteomics. 2016 Jan; 15(1):201-17. View in: PubMed

Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA. The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. Elife. 2016; 5. View in: PubMed

Kay SA, Remigereau MS. Cultivated tomato clock runs slow. Nat Genet. 2015 Dec 29; 48(1):8-9. View in: PubMed

Kaiserli E, Páldi K, O'Donnell L, Batalov O, Pedmale UV, Nusinow DA, Kay SA, Chory J. Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci. Dev Cell. 2015 Nov 9; 35(3):311-21. View in: PubMed

Waadt R, Manalansan B, Rauniyar N, Munemasa S, Booker MA, Brandt B, Waadt C, Nusinow DA, Kay SA, Kunz HH, Schumacher K, DeLong A, Yates JR, Schroeder JI. Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses. Plant Physiol. 2015 Sep; 169(1):760-79. View in: PubMed

Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep; 10(9):1489-97. View in: PubMed

Nagel DH, Doherty CJ, Pruneda-Paz JL, Schmitz RJ, Ecker JR, Kay SA. Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis. Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):E4802-10. View in: PubMed

Zheng XY, Zhou M, Yoo H, Pruneda-Paz JL, Spivey NW, Kay SA, Dong X. Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9166-73. View in: PubMed

Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, Yoshimura T, Itami K. C?H activation generates period-shortening molecules that target cryptochrome in the Mammalian circadian clock. Angew Chem Int Ed Engl. 2015 Jun 8; 54(24):7193-7. View in: PubMed

Zhou Y, Liu X, Engstrom EM, Nimchuk ZL, Pruneda-Paz JL, Tarr PT, Yan A, Kay SA, Meyerowitz EM. Control of plant stem cell function by conserved interacting transcriptional regulators. Nature. 2015 Jan 15; 517(7534):377-80. View in: PubMed

Hirota T, Kay SA. Identification of small-molecule modulators of the circadian clock. Methods Enzymol. 2015; 551:267-82. View in: PubMed

Endo M, Shimizu H, Nohales MA, Araki T, Kay SA. Tissue-specific clocks in Arabidopsis show asymmetric coupling. Nature. 2014 Nov 20; 515(7527):419-22. View in: PubMed

Kolmos E, Chow BY, Pruneda-Paz JL, Kay SA. HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16172-7. View in: PubMed

Guan P, Wang R, Nacry P, Breton G, Kay SA, Pruneda-Paz JL, Davani A, Crawford NM. Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15267-72. View in: PubMed

Nagel DH, Pruneda-Paz JL, Kay SA. FBH1 affects warm temperature responses in the Arabidopsis circadian clock. Proc Natl Acad Sci U S A. 2014 Oct 7; 111(40):14595-600. View in: PubMed

Pruneda-Paz JL, Breton G, Nagel DH, Kang SE, Bonaldi K, Doherty CJ, Ravelo S, Galli M, Ecker JR, Kay SA. A genome-scale resource for the functional characterization of Arabidopsis transcription factors. Cell Rep. 2014 Jul 24; 8(2):622-32. View in: PubMed

Chow BY, Sanchez SE, Breton G, Pruneda-Paz JL, Krogan NT, Kay SA. Transcriptional regulation of LUX by CBF1 mediates cold input to the circadian clock in Arabidopsis. Curr Biol. 2014 Jul 7; 24(13):1518-24. View in: PubMed

St John PC, Hirota T, Kay SA, Doyle FJ. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. Proc Natl Acad Sci U S A. 2014 Feb 4; 111(5):2040-5. View in: PubMed

Matos DA, Cole BJ, Whitney IP, MacKinnon KJ, Kay SA, Hazen SP. Daily changes in temperature, not the circadian clock, regulate growth rate in Brachypodium distachyon. PLoS One. 2014; 9(6):e100072. View in: PubMed

Weger M, Weger BD, Diotel N, Rastegar S, Hirota T, Kay SA, Strähle U, Dickmeis T. Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Dev Biol. 2013 Aug 15; 380(2):259-73. View in: PubMed

Chow BY, Kay SA. Global approaches for telling time: omics and the Arabidopsis circadian clock. Semin Cell Dev Biol. 2013 May; 24(5):383-92. View in: PubMed

Niwa M, Daimon Y, Kurotani K, Higo A, Pruneda-Paz JL, Breton G, Mitsuda N, Kay SA, Ohme-Takagi M, Endo M, Araki T. BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis. Plant Cell. 2013 Apr; 25(4):1228-42. View in: PubMed

Doherty CJ, Kay SA. Circadian surprise--it's not all about transcription. Science. 2012 Oct 19; 338(6105):338-40. View in: PubMed

Lai AG, Doherty CJ, Mueller-Roeber B, Kay SA, Schippers JH, Dijkwel PP. CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17129-34. View in: PubMed

Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay SA. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. View in: PubMed

Nagel DH, Kay SA. Complexity in the wiring and regulation of plant circadian networks. Curr Biol. 2012 Aug 21; 22(16):R648-57. View in: PubMed

Li L, Ljung K, Breton G, Schmitz RJ, Pruneda-Paz J, Cowing-Zitron C, Cole BJ, Ivans LJ, Pedmale UV, Jung HS, Ecker JR, Kay SA, Chory J. Linking photoreceptor excitation to changes in plant architecture. Genes Dev. 2012 Apr 15; 26(8):785-90. View in: PubMed

Gendron JM, Pruneda-Paz JL, Doherty CJ, Gross AM, Kang SE, Kay SA. Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3167-72. View in: PubMed

Sawa M, Kay SA. [Circadian clocks and photoperiodism]. Fukuoka Igaku Zasshi. 2012 Feb; 103(2):29-34. View in: PubMed

Chow BY, Helfer A, Nusinow DA, Kay SA. ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock. Plant Signal Behav. 2012 Feb; 7(2):170-3. View in: PubMed

Atwood A, Kay SA. Cell-autonomous hepatic circadian clock regulates polyamine synthesis. Cell Cycle. 2012 Feb 1; 11(3):422-3. View in: PubMed

Taton A, Lis E, Adin DM, Dong G, Cookson S, Kay SA, Golden SS, Golden JW. Gene transfer in Leptolyngbya sp. strain BL0902, a cyanobacterium suitable for production of biomass and bioproducts. PLoS One. 2012; 7(1):e30901. View in: PubMed

Gaudinier A, Zhang L, Reece-Hoyes JS, Taylor-Teeples M, Pu L, Liu Z, Breton G, Pruneda-Paz JL, Kim D, Kay SA, Walhout AJ, Ware D, Brady SM. Enhanced Y1H assays for Arabidopsis. Nat Methods. 2011 Dec; 8(12):1053-5. View in: PubMed

Atwood A, DeConde R, Wang SS, Mockler TC, Sabir JS, Ideker T, Kay SA. Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis. Proc Natl Acad Sci U S A. 2011 Nov 8; 108(45):18560-5. View in: PubMed

Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay SA. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4; 50(45):10608-11. View in: PubMed

Nusinow DA, Helfer A, Hamilton EE, King JJ, Imaizumi T, Schultz TF, Farré EM, Kay SA. The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth. Nature. 2011 Jul 21; 475(7356):398-402. View in: PubMed

Sawa M, Kay SA. GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11698-703. View in: PubMed

Cole B, Kay SA, Chory J. Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis. Plant J. 2011 Mar; 65(6):991-1000. View in: PubMed

Helfer A, Nusinow DA, Chow BY, Gehrke AR, Bulyk ML, Kay SA. LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock. Curr Biol. 2011 Jan 25; 21(2):126-33. View in: PubMed

Filichkin SA, Breton G, Priest HD, Dharmawardhana P, Jaiswal P, Fox SE, Michael TP, Chory J, Kay SA, Mockler TC. Global profiling of rice and poplar transcriptomes highlights key conserved circadian-controlled pathways and cis-regulatory modules. PLoS One. 2011; 6(6):e16907. View in: PubMed

Zhang EE, Kay SA. Clocks not winding down: unravelling circadian networks. Nat Rev Mol Cell Biol. 2010 Nov; 11(11):764-76. View in: PubMed

Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. View in: PubMed

Pruneda-Paz JL, Kay SA. An expanding universe of circadian networks in higher plants. Trends Plant Sci. 2010 May; 15(5):259-65. View in: PubMed

Baudry A, Ito S, Song YH, Strait AA, Kiba T, Lu S, Henriques R, Pruneda-Paz JL, Chua NH, Tobin EM, Kay SA, Imaizumi T. F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression. Plant Cell. 2010 Mar; 22(3):606-22. View in: PubMed

Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase. PLoS Biol. 2010; 8(12):e1000559. View in: PubMed

Ko CH, Yamada YR, Welsh DK, Buhr ED, Liu AC, Zhang EE, Ralph MR, Kay SA, Forger DB, Takahashi JS. Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol. 2010; 8(10):e1000513. View in: PubMed

Doherty CJ, Kay SA. Circadian control of global gene expression patterns. Annu Rev Genet. 2010; 44:419-44. View in: PubMed

Welsh DK, Takahashi JS, Kay SA. Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol. 2010; 72:551-77. View in: PubMed

Zhang EE, Liu AC, Hirota T, Miraglia LJ, Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW, Janes J, Su AI, Hogenesch JB, Kay SA. A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell. 2009 Oct 2; 139(1):199-210. View in: PubMed

Hirota T, Kay SA. High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chem Biol. 2009 Sep 25; 16(9):921-7. View in: PubMed

Mirsky HP, Liu AC, Welsh DK, Kay SA, Doyle FJ. A model of the cell-autonomous mammalian circadian clock. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11107-12. View in: PubMed

Hung HC, Kay SA, Weber F. HSP90, a capacitor of behavioral variation. J Biol Rhythms. 2009 Jun; 24(3):183-92. View in: PubMed

Pan Y, Michael TP, Hudson ME, Kay SA, Chory J, Schuler MA. Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways. Plant Physiol. 2009 Jun; 150(2):858-78. View in: PubMed

Pruneda-Paz JL, Breton G, Para A, Kay SA. A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock. Science. 2009 Mar 13; 323(5920):1481-5. View in: PubMed

Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2097-103. View in: PubMed

Hazen SP, Naef F, Quisel T, Gendron JM, Chen H, Ecker JR, Borevitz JO, Kay SA. Exploring the transcriptional landscape of plant circadian rhythms using genome tiling arrays. Genome Biol. 2009; 10(2):R17. View in: PubMed

Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20746-51. View in: PubMed

Hamilton EE, Kay SA. SnapShot: circadian clock proteins. Cell. 2008 Oct 17; 135(2):368-368. e1. View in: PubMed

Michael TP, Breton G, Hazen SP, Priest H, Mockler TC, Kay SA, Chory J. A morning-specific phytohormone gene expression program underlying rhythmic plant growth. PLoS Biol. 2008 Sep 16; 6(9):e225. View in: PubMed

Sawa M, Kay SA. [Molecular mechanism by which plant determines flowering timing with circadian clock]. Tanpakushitsu Kakusan Koso. 2008 May; 53(6):739-46. View in: PubMed

Sawa M, Kay SA, Imaizumi T. Photoperiodic flowering occurs under internal and external coincidence. Plant Signal Behav. 2008 Apr; 3(4):269-71. View in: PubMed

Michael TP, Mockler TC, Breton G, McEntee C, Byer A, Trout JD, Hazen SP, Shen R, Priest HD, Sullivan CM, Givan SA, Yanovsky M, Hong F, Kay SA, Chory J. Network discovery pipeline elucidates conserved time-of-day-specific cis-regulatory modules. PLoS Genet. 2008 Feb; 4(2):e14. View in: PubMed

Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA. Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008 Feb; 4(2):e1000023. View in: PubMed

Covington MF, Maloof JN, Straume M, Kay SA, Harmer SL. Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development. Genome Biol. 2008; 9(8):R130. View in: PubMed

Imaizumi T, Kay SA, Schroeder JI. Circadian rhythms. Daily watch on metabolism. Science. 2007 Dec 14; 318(5857):1730-1. View in: PubMed

Para A, Farré EM, Imaizumi T, Pruneda-Paz JL, Harmon FG, Kay SA. PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock. Plant Cell. 2007 Nov; 19(11):3462-73. View in: PubMed

Farré EM, Kay SA. PRR7 protein levels are regulated by light and the circadian clock in Arabidopsis. Plant J. 2007 Nov; 52(3):548-60. View in: PubMed

Hung HC, Maurer C, Kay SA, Weber F. Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP. J Biol Chem. 2007 Oct 26; 282(43):31349-57. View in: PubMed

Sawa M, Nusinow DA, Kay SA, Imaizumi T. FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science. 2007 Oct 12; 318(5848):261-5. View in: PubMed

Liu AC, Lewis WG, Kay SA. Mammalian circadian signaling networks and therapeutic targets. Nat Chem Biol. 2007 Oct; 3(10):630-9. View in: PubMed

Breton G, Kay SA. Plant biology: time for growth. Nature. 2007 Jul 19; 448(7151):265-6. View in: PubMed

Borevitz JO, Hazen SP, Michael TP, Morris GP, Baxter IR, Hu TT, Chen H, Werner JD, Nordborg M, Salt DE, Kay SA, Chory J, Weigel D, Jones JD, Ecker JR. Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12057-62. View in: PubMed

Imaizumi T, Schroeder JI, Kay SA. In SYNC: the ins and outs of circadian oscillations in calcium. Sci STKE. 2007 Jun 30; 2007(390):pe32. View in: PubMed

Liu AC, Welsh DK, Ko CH, Tran HG, Zhang EE, Priest AA, Buhr ED, Singer O, Meeker K, Verma IM, Doyle FJ, Takahashi JS, Kay SA. Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell. 2007 May 4; 129(3):605-16. View in: PubMed

Fernández MP, Chu J, Villella A, Atkinson N, Kay SA, Ceriani MF. Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5650-5. View in: PubMed

Imaizumi T, Kay SA. Photoperiodic control of flowering: not only by coincidence. Trends Plant Sci. 2006 Nov; 11(11):550-8. View in: PubMed

Faigón-Soverna A, Harmon FG, Storani L, Karayekov E, Staneloni RJ, Gassmann W, Más P, Casal JJ, Kay SA, Yanovsky MJ. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell. 2006 Nov; 18(11):2919-28. View in: PubMed

Allen T, Koustenis A, Theodorou G, Somers DE, Kay SA, Whitelam GC, Devlin PF. Arabidopsis FHY3 specifically gates phytochrome signaling to the circadian clock. Plant Cell. 2006 Oct; 18(10):2506-16. View in: PubMed

Weber F, Hung HC, Maurer C, Kay SA. Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. J Neurochem. 2006 Jul; 98(1):248-57. View in: PubMed

Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay SA, Ueda HR, Hogenesch JB. Feedback repression is required for mammalian circadian clock function. Nat Genet. 2006 Mar; 38(3):312-9. View in: PubMed

Breton G, Kay SA. Circadian rhythms lit up in Chlamydomonas. Genome Biol. 2006; 7(4):215. View in: PubMed

Zeilinger MN, Farré EM, Taylor SR, Kay SA, Doyle FJ. A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9. Mol Syst Biol. 2006; 2:58. View in: PubMed

Hazen SP, Schultz TF, Pruneda-Paz JL, Borevitz JO, Ecker JR, Kay SA. LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10387-92. View in: PubMed

Imaizumi T, Schultz TF, Harmon FG, Ho LA, Kay SA. FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science. 2005 Jul 8; 309(5732):293-7. View in: PubMed

Harmer SL, Kay SA. Positive and negative factors confer phase-specific circadian regulation of transcription in Arabidopsis. Plant Cell. 2005 Jul; 17(7):1926-40. View in: PubMed

Hazen SP, Borevitz JO, Harmon FG, Pruneda-Paz JL, Schultz TF, Yanovsky MJ, Liljegren SJ, Ecker JR, Kay SA. Rapid array mapping of circadian clock and developmental mutations in Arabidopsis. Plant Physiol. 2005 Jun; 138(2):990-7. View in: PubMed

Welsh DK, Kay SA. Bioluminescence imaging in living organisms. Curr Opin Biotechnol. 2005 Feb; 16(1):73-8. View in: PubMed

Farré EM, Harmer SL, Harmon FG, Yanovsky MJ, Kay SA. Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock. Curr Biol. 2005 Jan 11; 15(1):47-54. View in: PubMed

Welsh DK, Imaizumi T, Kay SA. Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells. Methods Enzymol. 2005; 393:269-88. View in: PubMed

Welsh DK, Yoo SH, Liu AC, Takahashi JS, Kay SA. Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr Biol. 2004 Dec 29; 14(24):2289-95. View in: PubMed

Flechner SM, Kurian SM, Head SR, Sharp SM, Whisenant TC, Zhang J, Chismar JD, Horvath S, Mondala T, Gilmartin T, Cook DJ, Kay SA, Walker JR, Salomon DR. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant. 2004 Sep; 4(9):1475-89. View in: PubMed

Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA, Hogenesch JB. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004 Aug 19; 43(4):527-37. View in: PubMed

Ueda HR, Hayashi S, Matsuyama S, Yomo T, Hashimoto S, Kay SA, Hogenesch JB, Iino M. Universality and flexibility in gene expression from bacteria to human. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3765-9. View in: PubMed

Weber F, Kay SA. A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS Lett. 2003 Dec 4; 555(2):341-5. View in: PubMed

Más P, Kim WY, Somers DE, Kay SA. Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Nature. 2003 Dec 4; 426(6966):567-70. View in: PubMed

Harmon FG, Kay SA. The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling. Curr Biol. 2003 Dec 2; 13(23):2091-6. View in: PubMed

Devlin PF, Yanovsky MJ, Kay SA. A genomic analysis of the shade avoidance response in Arabidopsis. Plant Physiol. 2003 Dec; 133(4):1617-29. View in: PubMed

Maxwell BB, Andersson CR, Poole DS, Kay SA, Chory J. HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression. Plant Physiol. 2003 Dec; 133(4):1565-77. View in: PubMed

Imaizumi T, Tran HG, Swartz TE, Briggs WR, Kay SA. FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis. Nature. 2003 Nov 20; 426(6964):302-6. View in: PubMed

Hazen SP, Kay SA. Gene arrays are not just for measuring gene expression. Trends Plant Sci. 2003 Sep; 8(9):413-6. View in: PubMed

Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, Pletcher MT, Sato TK, Wiltshire T, Andahazy M, Kay SA, Van Gelder RN, Hogenesch JB. Melanopsin is required for non-image-forming photic responses in blind mice. Science. 2003 Jul 25; 301(5632):525-7. View in: PubMed

Schultz TF, Kay SA. Circadian clocks in daily and seasonal control of development. Science. 2003 Jul 18; 301(5631):326-8. View in: PubMed

Yanovsky MJ, Kay SA. Living by the calendar: how plants know when to flower. Nat Rev Mol Cell Biol. 2003 Apr; 4(4):265-75. View in: PubMed

Sato TK, Panda S, Kay SA, Hogenesch JB. DNA arrays: applications and implications for circadian biology. J Biol Rhythms. 2003 Apr; 18(2):96-105. View in: PubMed

Wiltshire T, Pletcher MT, Batalov S, Barnes SW, Tarantino LM, Cooke MP, Wu H, Smylie K, Santrosyan A, Copeland NG, Jenkins NA, Kalush F, Mural RJ, Glynne RJ, Kay SA, Adams MD, Fletcher CF. Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3380-5. View in: PubMed

Hogenesch JB, Panda S, Kay S, Takahashi JS. Circadian transcriptional output in the SCN and liver of the mouse. Novartis Found Symp. 2003; 253:171-80; discussion 52-5, 102-9, 180-3 passim. View in: PubMed

Más P, Alabadí D, Yanovsky MJ, Oyama T, Kay SA. Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis. Plant Cell. 2003 Jan; 15(1):223-36. View in: PubMed

Panda S, Hogenesch JB, Kay SA. Circadian light input in plants, flies and mammals. Novartis Found Symp. 2003; 253:73-82; discussion 82-8, 102-9, 281-4. View in: PubMed

Panda S, Sato TK, Castrucci AM, Rollag MD, DeGrip WJ, Hogenesch JB, Provencio I, Kay SA. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science. 2002 Dec 13; 298(5601):2213-6. View in: PubMed

Beachy R, Bennetzen JL, Chassy BM, Chrispeels M, Chory J, Ecker JR, Noel JP, Kay SA, Dean C, Lamb C, Jones J, Santerre CR, Schroeder JI, Umen J, Yanofsky M, Wessler S, Zhao Y, Parrott W. Divergent perspectives on GM food. Nat Biotechnol. 2002 Dec; 20(12):1195-6; author reply 1197. View in: PubMed

Ceriani MF, Hogenesch JB, Yanovsky M, Panda S, Straume M, Kay SA. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci. 2002 Nov 1; 22(21):9305-19. View in: PubMed

Yanovsky MJ, Kay SA. Molecular basis of seasonal time measurement in Arabidopsis. Nature. 2002 Sep 19; 419(6904):308-12. View in: PubMed

Panda S, Poirier GG, Kay SA. tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator. Dev Cell. 2002 Jul; 3(1):51-61. View in: PubMed

Panda S, Hogenesch JB, Kay SA. Circadian rhythms from flies to human. Nature. 2002 May 16; 417(6886):329-35. View in: PubMed

Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002 May 3; 109(3):307-20. View in: PubMed

Alabadí D, Yanovsky MJ, Más P, Harmer SL, Kay SA. Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Curr Biol. 2002 Apr 30; 12(9):757-61. View in: PubMed

Scully AL, Zelhof AC, Kay SA. A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock. Mol Cell Neurosci. 2002 Apr; 19(4):501-14. View in: PubMed

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