Faculty

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Steve Kay, PhD
Provost Professor of Neurology, Biomedical Engineering and Biological Sciences, Director of Convergent Bioscience
Zilkha Neurogenetic Institute
KAM 500 Health Sciences Campus Los Angeles
+1 323 442 1900

Publications

Plant Stress Tolerance Requires Auxin-Sensitive Aux/IAA Transcriptional Repressors. Curr Biol. 2017 Jan 18. View in: PubMed

Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes. PLoS One. 2017; 12(1):e0169923. View in: PubMed

Arabidopsis B-BOX32 interacts with CONSTANS-LIKE3 to regulate flowering. Proc Natl Acad Sci U S A. 2016 Dec 20. View in: PubMed

The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental Manager. Cold Spring Harb Perspect Biol. 2016 Dec 01; 8(12). View in: PubMed

Molecular mechanisms at the core of the plant circadian oscillator. Nat Struct Mol Biol. 2016 Dec; 23(12):1061-1069. View in: PubMed

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBa Degradation. Cell. 2016 Jun 16; 165(7):1644-57. View in: PubMed

Identification of Arabidopsis Transcriptional Regulators by Yeast One-Hybrid Screens Using a Transcription Factor ORFeome. Methods Mol Biol. 2016; 1398:107-18. View in: PubMed

Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry. Mol Cell Proteomics. 2016 Jan; 15(1):201-17. View in: PubMed

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. Elife. 2016; 5. View in: PubMed

Cultivated tomato clock runs slow. Nat Genet. 2015 Dec 29; 48(1):8-9. View in: PubMed

Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci. Dev Cell. 2015 Nov 9; 35(3):311-21. View in: PubMed

Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses. Plant Physiol. 2015 Sep; 169(1):760-79. View in: PubMed

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep; 10(9):1489-97. View in: PubMed

Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis. Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):E4802-10. View in: PubMed

Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9166-73. View in: PubMed

C?H activation generates period-shortening molecules that target cryptochrome in the Mammalian circadian clock. Angew Chem Int Ed Engl. 2015 Jun 8; 54(24):7193-7. View in: PubMed

Control of plant stem cell function by conserved interacting transcriptional regulators. Nature. 2015 Jan 15; 517(7534):377-80. View in: PubMed

Identification of small-molecule modulators of the circadian clock. Methods Enzymol. 2015; 551:267-82. View in: PubMed

Tissue-specific clocks in Arabidopsis show asymmetric coupling. Nature. 2014 Nov 20; 515(7527):419-22. View in: PubMed

HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16172-7. View in: PubMed

Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15267-72. View in: PubMed

FBH1 affects warm temperature responses in the Arabidopsis circadian clock. Proc Natl Acad Sci U S A. 2014 Oct 7; 111(40):14595-600. View in: PubMed

A genome-scale resource for the functional characterization of Arabidopsis transcription factors. Cell Rep. 2014 Jul 24; 8(2):622-32. View in: PubMed

Transcriptional regulation of LUX by CBF1 mediates cold input to the circadian clock in Arabidopsis. Curr Biol. 2014 Jul 7; 24(13):1518-24. View in: PubMed

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. Proc Natl Acad Sci U S A. 2014 Feb 4; 111(5):2040-5. View in: PubMed

Daily changes in temperature, not the circadian clock, regulate growth rate in Brachypodium distachyon. PLoS One. 2014; 9(6):e100072. View in: PubMed

Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Dev Biol. 2013 Aug 15; 380(2):259-73. View in: PubMed

Global approaches for telling time: omics and the Arabidopsis circadian clock. Semin Cell Dev Biol. 2013 May; 24(5):383-92. View in: PubMed

BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis. Plant Cell. 2013 Apr; 25(4):1228-42. View in: PubMed

Circadian surprise--it's not all about transcription. Science. 2012 Oct 19; 338(6105):338-40. View in: PubMed

CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17129-34. View in: PubMed

Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. View in: PubMed

Complexity in the wiring and regulation of plant circadian networks. Curr Biol. 2012 Aug 21; 22(16):R648-57. View in: PubMed

Linking photoreceptor excitation to changes in plant architecture. Genes Dev. 2012 Apr 15; 26(8):785-90. View in: PubMed

Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3167-72. View in: PubMed

Cell-autonomous hepatic circadian clock regulates polyamine synthesis. Cell Cycle. 2012 Feb 1; 11(3):422-3. View in: PubMed

ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock. Plant Signal Behav. 2012 Feb; 7(2):170-3. View in: PubMed

[Circadian clocks and photoperiodism]. Fukuoka Igaku Zasshi. 2012 Feb; 103(2):29-34. View in: PubMed

Gene transfer in Leptolyngbya sp. strain BL0902, a cyanobacterium suitable for production of biomass and bioproducts. PLoS One. 2012; 7(1):e30901. View in: PubMed

Enhanced Y1H assays for Arabidopsis. Nat Methods. 2011 Dec; 8(12):1053-5. View in: PubMed

Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis. Proc Natl Acad Sci U S A. 2011 Nov 8; 108(45):18560-5. View in: PubMed

A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4; 50(45):10608-11. View in: PubMed

The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth. Nature. 2011 Jul 21; 475(7356):398-402. View in: PubMed

GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11698-703. View in: PubMed

Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis. Plant J. 2011 Mar; 65(6):991-1000. View in: PubMed

LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock. Curr Biol. 2011 Jan 25; 21(2):126-33. View in: PubMed

Global profiling of rice and poplar transcriptomes highlights key conserved circadian-controlled pathways and cis-regulatory modules. PLoS One. 2011; 6(6):e16907. View in: PubMed

Clocks not winding down: unravelling circadian networks. Nat Rev Mol Cell Biol. 2010 Nov; 11(11):764-76. View in: PubMed

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. View in: PubMed

An expanding universe of circadian networks in higher plants. Trends Plant Sci. 2010 May; 15(5):259-65. View in: PubMed

F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression. Plant Cell. 2010 Mar; 22(3):606-22. View in: PubMed

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase. PLoS Biol. 2010; 8(12):e1000559. View in: PubMed

Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol. 2010; 8(10):e1000513. View in: PubMed

Circadian control of global gene expression patterns. Annu Rev Genet. 2010; 44:419-44. View in: PubMed

Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol. 2010; 72:551-77. View in: PubMed

A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell. 2009 Oct 2; 139(1):199-210. View in: PubMed

High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chem Biol. 2009 Sep 25; 16(9):921-7. View in: PubMed

A model of the cell-autonomous mammalian circadian clock. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11107-12. View in: PubMed

Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways. Plant Physiol. 2009 Jun; 150(2):858-78. View in: PubMed

HSP90, a capacitor of behavioral variation. J Biol Rhythms. 2009 Jun; 24(3):183-92. View in: PubMed

A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock. Science. 2009 Mar 13; 323(5920):1481-5. View in: PubMed

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2097-103. View in: PubMed

Exploring the transcriptional landscape of plant circadian rhythms using genome tiling arrays. Genome Biol. 2009; 10(2):R17. View in: PubMed

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20746-51. View in: PubMed

SnapShot: circadian clock proteins. Cell. 2008 Oct 17; 135(2):368-368. e1. View in: PubMed

A morning-specific phytohormone gene expression program underlying rhythmic plant growth. PLoS Biol. 2008 Sep 16; 6(9):e225. View in: PubMed

[Molecular mechanism by which plant determines flowering timing with circadian clock]. Tanpakushitsu Kakusan Koso. 2008 May; 53(6):739-46. View in: PubMed

Photoperiodic flowering occurs under internal and external coincidence. Plant Signal Behav. 2008 Apr; 3(4):269-71. View in: PubMed

Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008 Feb; 4(2):e1000023. View in: PubMed

Network discovery pipeline elucidates conserved time-of-day-specific cis-regulatory modules. PLoS Genet. 2008 Feb; 4(2):e14. View in: PubMed

Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development. Genome Biol. 2008; 9(8):R130. View in: PubMed

Circadian rhythms. Daily watch on metabolism. Science. 2007 Dec 14; 318(5857):1730-1. View in: PubMed

PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock. Plant Cell. 2007 Nov; 19(11):3462-73. View in: PubMed

PRR7 protein levels are regulated by light and the circadian clock in Arabidopsis. Plant J. 2007 Nov; 52(3):548-60. View in: PubMed

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP. J Biol Chem. 2007 Oct 26; 282(43):31349-57. View in: PubMed

FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science. 2007 Oct 12; 318(5848):261-5. View in: PubMed

Mammalian circadian signaling networks and therapeutic targets. Nat Chem Biol. 2007 Oct; 3(10):630-9. View in: PubMed

Plant biology: time for growth. Nature. 2007 Jul 19; 448(7151):265-6. View in: PubMed

Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12057-62. View in: PubMed

In SYNC: the ins and outs of circadian oscillations in calcium. Sci STKE. 2007 Jun 30; 2007(390):pe32. View in: PubMed

Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell. 2007 May 4; 129(3):605-16. View in: PubMed

Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5650-5. View in: PubMed

Photoperiodic control of flowering: not only by coincidence. Trends Plant Sci. 2006 Nov; 11(11):550-8. View in: PubMed

A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell. 2006 Nov; 18(11):2919-28. View in: PubMed

Arabidopsis FHY3 specifically gates phytochrome signaling to the circadian clock. Plant Cell. 2006 Oct; 18(10):2506-16. View in: PubMed

Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. J Neurochem. 2006 Jul; 98(1):248-57. View in: PubMed

Feedback repression is required for mammalian circadian clock function. Nat Genet. 2006 Mar; 38(3):312-9. View in: PubMed

A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9. Mol Syst Biol. 2006; 2:58. View in: PubMed

Circadian rhythms lit up in Chlamydomonas. Genome Biol. 2006; 7(4):215. View in: PubMed

LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10387-92. View in: PubMed

FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science. 2005 Jul 8; 309(5732):293-7. View in: PubMed

Positive and negative factors confer phase-specific circadian regulation of transcription in Arabidopsis. Plant Cell. 2005 Jul; 17(7):1926-40. View in: PubMed

Rapid array mapping of circadian clock and developmental mutations in Arabidopsis. Plant Physiol. 2005 Jun; 138(2):990-7. View in: PubMed

Bioluminescence imaging in living organisms. Curr Opin Biotechnol. 2005 Feb; 16(1):73-8. View in: PubMed

Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock. Curr Biol. 2005 Jan 11; 15(1):47-54. View in: PubMed

Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells. Methods Enzymol. 2005; 393:269-88. View in: PubMed

Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr Biol. 2004 Dec 29; 14(24):2289-95. View in: PubMed

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant. 2004 Sep; 4(9):1475-89. View in: PubMed

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004 Aug 19; 43(4):527-37. View in: PubMed

Universality and flexibility in gene expression from bacteria to human. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3765-9. View in: PubMed

A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS Lett. 2003 Dec 4; 555(2):341-5. View in: PubMed

Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Nature. 2003 Dec 4; 426(6966):567-70. View in: PubMed

The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling. Curr Biol. 2003 Dec 2; 13(23):2091-6. View in: PubMed

HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression. Plant Physiol. 2003 Dec; 133(4):1565-77. View in: PubMed

A genomic analysis of the shade avoidance response in Arabidopsis. Plant Physiol. 2003 Dec; 133(4):1617-29. View in: PubMed

FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis. Nature. 2003 Nov 20; 426(6964):302-6. View in: PubMed

Gene arrays are not just for measuring gene expression. Trends Plant Sci. 2003 Sep; 8(9):413-6. View in: PubMed

Melanopsin is required for non-image-forming photic responses in blind mice. Science. 2003 Jul 25; 301(5632):525-7. View in: PubMed

Circadian clocks in daily and seasonal control of development. Science. 2003 Jul 18; 301(5631):326-8. View in: PubMed

Living by the calendar: how plants know when to flower. Nat Rev Mol Cell Biol. 2003 Apr; 4(4):265-75. View in: PubMed

DNA arrays: applications and implications for circadian biology. J Biol Rhythms. 2003 Apr; 18(2):96-105. View in: PubMed

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3380-5. View in: PubMed

Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis. Plant Cell. 2003 Jan; 15(1):223-36. View in: PubMed

Circadian light input in plants, flies and mammals. Novartis Found Symp. 2003; 253:73-82; discussion 82-8, 102-9, 281-4. View in: PubMed

Circadian transcriptional output in the SCN and liver of the mouse. Novartis Found Symp. 2003; 253:171-80; discussion 52-5, 102-9, 180-3 passim. View in: PubMed

Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science. 2002 Dec 13; 298(5601):2213-6. View in: PubMed

Divergent perspectives on GM food. Nat Biotechnol. 2002 Dec; 20(12):1195-6; author reply 1197. View in: PubMed

Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci. 2002 Nov 1; 22(21):9305-19. View in: PubMed

Molecular basis of seasonal time measurement in Arabidopsis. Nature. 2002 Sep 19; 419(6904):308-12. View in: PubMed

tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator. Dev Cell. 2002 Jul; 3(1):51-61. View in: PubMed

Circadian rhythms from flies to human. Nature. 2002 May 16; 417(6886):329-35. View in: PubMed

Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002 May 3; 109(3):307-20. View in: PubMed

Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Curr Biol. 2002 Apr 30; 12(9):757-61. View in: PubMed

A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock. Mol Cell Neurosci. 2002 Apr; 19(4):501-14. View in: PubMed

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