Faculty

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Takahiro Ohyama, PhD
Assistant Professor of Research Otolaryngology Head and Neck Surgery
Otolaryngology
CHP 204M 1540 Alcazar Street Health Sciences Campus Los Angeles
+1 323 442 4413

Overview

Hearing loss is one of the most common birth defects. Approximately one in five hundred newborns suffer from significant hearing impairment. In addition, once mechanosensory hair cells in the inner ear are damaged and lost by any of a variety of reasons such as aging and loud noises, they never regenerate. Thus, majority of sensorineural hearing loss, such as age-related hearing loss and noise-induced hearing loss is permanent and significantly affect the quality of one?s life. Recently, stem cell research has shed light on the possibility of regeneration of hair cells in humans. Our research goal is to understand the molecular mechanisms of inner ear development and to explore the possibility of regenerating sensory cells to treat hearing and balance disorders.

Publications

Salehi P, Myint A, Kim YJ, Ge MX, Lavinsky J, Ho MK, Crow AL, Cruz C, Monges-Hernadez M, Wang J, Hartiala J, Zhang LI, Allayee H, Lusis AJ, Ohyama T, Friedman RA. Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. J Assoc Res Otolaryngol. 2016 Oct; 17(5):417-31. View in: PubMed

Shibata S, Miwa T, Wu HH, Levitt P, Ohyama T. Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing. J Neurosci. 2016 Aug 3; 36(31):8200-9. View in: PubMed

Shirokova V, Biggs LC, Jussila M, Ohyama T, Groves AK, Mikkola ML. Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation. Stem Cells. 2016 Jul; 34(7):1896-908. View in: PubMed

Myint A, White CH, Ohmen JD, Li X, Wang J, Lavinsky J, Salehi P, Crow AL, Ohyama T, Friedman RA. Large-scale phenotyping of noise-induced hearing loss in 100 strains of mice. Hear Res. 2016 Feb; 332:113-20. View in: PubMed

Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK. The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016 Jan 1; 409(1):139-51. View in: PubMed

Jussila M, Aalto AJ, Sanz Navarro M, Shirokova V, Balic A, Kallonen A, Ohyama T, Groves AK, Mikkola ML, Thesleff I. Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. Development. 2015 Nov 15; 142(22):3954-63. View in: PubMed

Urness LD, Wang X, Shibata S, Ohyama T, Mansour SL. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015 Apr 1; 400(1):59-71. View in: PubMed

Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK. Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1; 390(1):1-13. View in: PubMed

Basch ML, Ohyama T, Segil N, Groves AK. Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. J Neurosci. 2011 Jun 1; 31(22):8046-58. View in: PubMed

Reginensi A, Clarkson M, Neirijnck Y, Lu B, Ohyama T, Groves AK, Sock E, Wegner M, Costantini F, Chaboissier MC, Schedl A. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet. 2011 Mar 15; 20(6):1143-53. View in: PubMed

Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK. BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10; 30(45):15044-51. View in: PubMed

Ohyama T. Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice. Brain Res. 2009 Jun 24; 1277:84-9. View in: PubMed

Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N. Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti. Dev Cell. 2009 Jan; 16(1):58-69. View in: PubMed

Jayasena CS, Ohyama T, Segil N, Groves AK. Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development. 2008 Jul; 135(13):2251-61. View in: PubMed

Ohyama T, Groves AK, Martin K. The first steps towards hearing: mechanisms of otic placode induction. Int J Dev Biol. 2007; 51(6-7):463-72. View in: PubMed

Arnold JS, Braunstein EM, Ohyama T, Groves AK, Adams JC, Brown MC, Morrow BE. Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet. 2006 May 15; 15(10):1629-39. View in: PubMed

Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK. Wnt signals mediate a fate decision between otic placode and epidermis. Development. 2006 Mar; 133(5):865-75. View in: PubMed

Narita T, Sasaoka S, Udagawa K, Ohyama T, Wada N, Nishimatsu S, Takada S, Nohno T. Wnt10a is involved in AER formation during chick limb development. Dev Dyn. 2005 Jun; 233(2):282-7. View in: PubMed

Ohyama T, Groves AK. Expression of mouse Foxi class genes in early craniofacial development. Dev Dyn. 2004 Nov; 231(3):640-6. View in: PubMed

Ohyama T, Groves AK. Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis. 2004 Apr; 38(4):195-9. View in: PubMed

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