Faculty

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Terrence Christopher Town, PhD
Visiting Professor of Physiology & Biophysics
Zilkha Neurogenetic Institute
ZNI 321 1501 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 2492

Overview

The Town lab joined the Zilkha Neurogenetic Institute on May 1, 2013. My lab's focus is to develop a treatment for Alzheimer's disease by targeting the body's immune system. Most therapies targeting the disease are thwarted by the blood-brain barrier, a natural mechanism that protects brain cells from entry of peripheral substances, and by the fact that immune responses in the brain are typically muted. However, in laboratory mice programmed to develop Alzheimer's-like disease, my group has shown that certain immune cells can be coaxed into the brain from the circulation, where they attack the damaging sticky plaque buildup that is a defining feature of Alzheimer's disease.

My lab is continuing to pursue this line of research in hopes of developing a next-generation drug for Alzheimer's disease. This work, which has been funded by the National Institutes of Health, the Alzheimer's Association, and the American Federation for Aging Research, has been published in numerous high-impact peer-reviewed journals including Science, Nature, Nature Medicine, Nature Neuroscience, Immunity, Neuron, PNAS, Trends in Neurosciences, and The Journal of Neuroscience.

My lab revolutionized the field of Alzheimer's disease research by generating the first rat model of the disease that manifests all of the clinico-pathological hallmarks of the human syndrome. Specifically, we made transgenic rats that over-express two mutant human transgenes that are each independently causative of autosomal dominant Alzheimer's disease: "Swedish" mutant amyloid precursor protein and deltaE9 mutant presenilin-1. Unlike their transgenic mouse cousins that develop "senile" plaques but fail to manifest "tangles" and frank neuronal loss, these transgenic rats-for the first time-develop the full spectrum of Alzheimer pathologies. This makes them an invaluable tool for understanding Alzheimer's disease etiology and for pre-clinical testing of cutting-edge therapeutics.

Publications

Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ. Targeting innate immunity for neurodegenerative disorders of the central nervous system. J Neurochem. 2016 Sep; 138(5):653-93. View in: PubMed

Mott KR, Gate D, Matundan HH, Ghiasi YN, Town T, Ghiasi H. CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1. J Virol. 2016 May 15; 90(10):5059-67. View in: PubMed

Guillot-Sestier MV, Doty KR, Town T. Innate Immunity Fights Alzheimer's Disease. Trends Neurosci. 2015 Nov; 38(11):674-81. View in: PubMed

Tseng CW, Biancotti JC, Berg BL, Gate D, Kolar SL, Müller S, Rodriguez MD, Rezai-Zadeh K, Fan X, Beenhouwer DO, Town T, Liu GY. Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection. PLoS Pathog. 2015 Nov; 11(11):e1005292. View in: PubMed

Doty KR, Guillot-Sestier MV, Town T. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive? Brain Res. 2015 Aug 18; 1617:155-73. View in: PubMed

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015 Apr; 14(4):388-405. View in: PubMed

Stratigi K, Kapsetaki M, Aivaliotis M, Town T, Flavell RA, Spilianakis CG. Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):E1577-86. View in: PubMed

Guillot-Sestier MV, Doty KR, Gate D, Rodriguez J, Leung BP, Rezai-Zadeh K, Town T. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology. Neuron. 2015 Feb 4; 85(3):534-48. View in: PubMed

Gate D, Danielpour M, Bannykh S, Town T. Characterization of cancer stem cells and primary cilia in medulloblastoma. CNS Neurol Disord Drug Targets. 2015; 14(5):600-11. View in: PubMed

Daianu M, Jacobs RE, Weitz TM, Town TC, Thompson PM. Multi-Shell Hybrid Diffusion Imaging (HYDI) at 7 Tesla in TgF344-AD Transgenic Alzheimer Rats. PLoS One. 2015; 10(12):e0145205. View in: PubMed

Mori T, Koyama N, Segawa T, Maeda M, Maruyama N, Kinoshita N, Hou H, Tan J, Town T. Methylene Blue Modulates ß-Secretase, Reverses Cerebral Amyloidosis, and Improves Cognition in Transgenic Mice. J Biol Chem. 2014 Oct 31; 289(44):30303-17. View in: PubMed

Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-ß signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3458-66. View in: PubMed

Mott KR, Allen SJ, Zandian M, Konda B, Sharifi BG, Jones C, Wechsler SL, Town T, Ghiasi H. CD8a Dendritic Cells Drive Establishment of HSV-1 Latency. PLoS One. 2014; 9(4):e93444. View in: PubMed

Weitz TM, Gate D, Rezai-Zadeh K, Town T. MyD88 Is Dispensable for Cerebral Amyloidosis and Neuroinflammation in APP/PS1 Transgenic Mice. Am J Pathol. 2014; 184(11):2855-61. View in: PubMed

Guillot-Sestier MV, Town T. Innate immunity in Alzheimer's disease: a complex affair. CNS Neurol Disord Drug Targets. 2013 Aug; 12(5):593-607. View in: PubMed

Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aß, and frank neuronal loss. J Neurosci. 2013 Apr 10; 33(15):6245-56. View in: PubMed

Breunig JJ, Guillot-Sestier MV, Town T. Brain injury, neuroinflammation and Alzheimer's disease. Front Aging Neurosci. 2013; 5:26. View in: PubMed

Mori T, Koyama N, Guillot-Sestier MV, Tan J, Town T. Ferulic acid is a nutraceutical ß-secretase modulator that improves behavioral impairment and alzheimer-like pathology in transgenic mice. PLoS One. 2013; 8(2):e55774. View in: PubMed

Biancotti JC, Town T. Increasing hematopoietic stem cell yield to develop mice with human immune systems. Biomed Res Int. 2013; 2013:740892. View in: PubMed

Gate D, Danielpour M, Levy R, Breunig JJ, Town T. Basic biology and mechanisms of neural ciliogenesis and the B9 family. Mol Neurobiol. 2012 Jun; 45(3):564-70. View in: PubMed

Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012 Mar 23; 36(3):401-14. View in: PubMed

Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, Kakuda N, Horikoshi-Sakuraba Y, Tan J, Town T. Tannic acid is a natural ß-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem. 2012 Feb 24; 287(9):6912-27. View in: PubMed

Breunig JJ, Gate D, Levy R, Rodriguez J, Kim GB, Danielpour M, Svendsen CN, Town T. Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation. Neural Dev. 2012; 7:26. View in: PubMed

Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS One. 2012; 7(8):e44153. View in: PubMed

Weitz TM, Town T. Microglia in Alzheimer's Disease: It's All About Context. Int J Alzheimers Dis. 2012; 2012:314185. View in: PubMed

Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H. Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation. J Virol. 2011 Nov; 85(21):11448-56. View in: PubMed

Gray P, Dagvadorj J, Michelsen KS, Brikos C, Rentsendorj A, Town T, Crother TR, Arditi M. Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway. J Immunol. 2011 Oct 15; 187(8):4331-7. View in: PubMed

Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Control of TH17 cells occurs in the small intestine. Nature. 2011 Jul 28; 475(7357):514-8. View in: PubMed

Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol. 2011 May; 85(9):4184-97. View in: PubMed

Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, van Rooijen N, Chen S, Arditi M, Rouse BT, Flavell RA, Town T, Ghiasi H. Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2321-33. View in: PubMed

Zhu Y, Obregon D, Hou H, Giunta B, Ehrhart J, Fernandez F, Mori T, Nikolic W, Zhao Y, Morgan D, Town T, Tan J. Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology. J Cell Mol Med. 2011 Feb; 15(2):327-38. View in: PubMed

Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J. CD45 deficiency drives amyloid-ß peptide oligomers and neuronal loss in Alzheimer's disease mice. J Neurosci. 2011 Jan 26; 31(4):1355-65. View in: PubMed

Gate D, Rezai-Zadeh K, Jodry D, Rentsendorj A, Town T. Macrophages in Alzheimer's disease: the blood-borne identity. J Neural Transm. 2010 Aug; 117(8):961-70. View in: PubMed

Town T. Alzheimer's Disease Beyond Abeta. Expert Rev Neurother. 2010 May; 10(5):671-5. View in: PubMed

Town T. Inflammation, immunity, and Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010 Apr; 9(2):129-31. View in: PubMed

Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia. 2010 Feb; 58(3):300-14. View in: PubMed

Mori T, Asano T, Town T. Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease. Cardiovasc Psychiatry Neurol. 2010; 2010. View in: PubMed

Rezai-Zadeh K, Gate D, Town T. CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? J Neuroimmune Pharmacol. 2009 Dec; 4(4):462-75. View in: PubMed

Rezai-Zadeh K, Gate D, Szekely CA, Town T. Can peripheral leukocytes be used as Alzheimer's disease biomarkers? Expert Rev Neurother. 2009 Nov; 9(11):1623-33. View in: PubMed

Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog. 2009 Oct; 5(10):e1000610. View in: PubMed

O'Connor W, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol. 2009 Jun; 10(6):603-9. View in: PubMed

Town T. Alternative Abeta immunotherapy approaches for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Apr; 8(2):114-27. View in: PubMed

Rezai-Zadeh K, Douglas Shytle R, Bai Y, Tian J, Hou H, Mori T, Zeng J, Obregon D, Town T, Tan J. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. J Cell Mol Med. 2009 Mar; 13(3):574-88. View in: PubMed

Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity. 2009 Feb 20; 30(2):242-53. View in: PubMed

Amsen D, de Visser KE, Town T. Approaches to determine expression of inflammatory cytokines. Methods Mol Biol. 2009; 511:107-42. View in: PubMed

Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H. A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virol J. 2009; 6:56. View in: PubMed

Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):13127-32. View in: PubMed

Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10865-70. View in: PubMed

Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. J Immunol. 2008 Aug 1; 181(3):2084-91. View in: PubMed

Mori T, Tan J, Arendash GW, Koyama N, Nojima Y, Town T. Overexpression of human S100B exacerbates brain damage and periinfarct gliosis after permanent focal ischemia. Stroke. 2008 Jul; 39(7):2114-21. View in: PubMed

Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med. 2008 Jun; 14(6):681-7. View in: PubMed

Nikolic WV, Hou H, Town T, Zhu Y, Giunta B, Sanberg CD, Zeng J, Luo D, Ehrhart J, Mori T, Sanberg PR, Tan J. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev. 2008 Jun; 17(3):423-39. View in: PubMed

Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proc Natl Acad Sci U S A. 2008 Apr 1; 105(13):5063-8. View in: PubMed

Dai J, Wang P, Bai F, Town T, Fikrig E. Icam-1 participates in the entry of west nile virus into the central nervous system. J Virol. 2008 Apr; 82(8):4164-8. View in: PubMed

Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA. The stumpy gene is required for mammalian ciliogenesis. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2853-8. View in: PubMed

Giunta B, Fernandez F, Nikolic WV, Obregon D, Rrapo E, Town T, Tan J. Inflammaging as a prodrome to Alzheimer's disease. J Neuroinflammation. 2008; 5:51. View in: PubMed

Arjona A, Ledizet M, Anthony K, Bonafé N, Modis Y, Town T, Fikrig E. West Nile virus envelope protein inhibits dsRNA-induced innate immune responses. J Immunol. 2007 Dec 15; 179(12):8403-9. View in: PubMed

Griffith JW, O'Connor C, Bernard K, Town T, Goldstein DR, Bucala R. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis. 2007 Nov 15; 196(10):1553-64. View in: PubMed

Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, Mehal WZ. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology. 2007 Nov; 46(5):1509-18. View in: PubMed

Deane JA, Pisitkun P, Barrett RS, Feigenbaum L, Town T, Ward JM, Flavell RA, Bolland S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity. 2007 Nov; 27(5):801-10. View in: PubMed

Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest. 2007 Oct; 117(10):3059-66. View in: PubMed

Nikolic WV, Bai Y, Obregon D, Hou H, Mori T, Zeng J, Ehrhart J, Shytle RD, Giunta B, Morgan D, Town T, Tan J. Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2507-12. View in: PubMed

Bai F, Town T, Pradhan D, Cox J. Antiviral peptides targeting the west nile virus envelope protein. J Virol. 2007 Feb; 81(4):2047-55. View in: PubMed

Szekely CA, Town T, Zandi PP. NSAIDs for the chemoprevention of Alzheimer's disease. Subcell Biochem. 2007; 42:229-48. View in: PubMed

Wang R, Town T, Gokarn V, Flavell RA, Chandawarkar RY. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. J Surg Res. 2006 Nov; 136(1):58-69. View in: PubMed

Mori T, Town T, Tan J, Yada N, Horikoshi Y, Yamamoto J, Shimoda T, Kamanaka Y, Tateishi N, Asano T. Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J Pharmacol Exp Ther. 2006 Aug; 318(2):571-8. View in: PubMed

Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein. J Biol Chem. 2006 Jun 16; 281(24):16419-27. View in: PubMed

Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA. Microglia recognize double-stranded RNA via TLR3. J Immunol. 2006 Mar 15; 176(6):3804-12. View in: PubMed

Town T, Nikolic V, Tan J. The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation. 2005 Oct 31; 2:24. View in: PubMed

Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci. 2005 Sep 21; 25(38):8807-14. View in: PubMed

Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. J Neurosci. 2005 Jun 8; 25(23):5533-43. View in: PubMed

Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature. 2005 Jun 2; 435(7042):637-45. View in: PubMed

Mori T, Town T, Tan J, Tateishi N, Asano T. Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice. J Cereb Blood Flow Metab. 2005 Jun; 25(6):748-62. View in: PubMed

Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. Eur J Immunol. 2005 Mar; 35(3):901-10. View in: PubMed

Town T, Tan J, Flavell RA, Mullan M. T-cells in Alzheimer's disease. Neuromolecular Med. 2005; 7(3):255-64. View in: PubMed

Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med. 2004 Dec; 10(12):1366-73. View in: PubMed

Todd Roach J, Volmar CH, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M. Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain Res. 2004 Jul 23; 1015(1-2):161-8. View in: PubMed

Mori T, Town T, Kobayashi M, Tan J, Fujita SC, Asano T. Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice. J Cereb Blood Flow Metab. 2004 Jun; 24(6):646-56. View in: PubMed

Townsend KP, Vendrame M, Ehrhart J, Faza B, Zeng J, Town T, Tan J. CD45 isoform RB as a molecular target to oppose lipopolysaccharide-induced microglial activation in mice. Neurosci Lett. 2004 May 13; 362(1):26-30. View in: PubMed

Mott RT, Ait-Ghezala G, Town T, Mori T, Vendrame M, Zeng J, Ehrhart J, Mullan M, Tan J. Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia. 2004 May; 46(4):369-79. View in: PubMed

Mori T, Kobayashi M, Town T, Fujita SC, Asano T. Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice. J Neuropathol Exp Neurol. 2003 Mar; 62(3):280-91. View in: PubMed

Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci. 2002 Dec; 5(12):1288-93. View in: PubMed

Town T, Vendrame M, Patel A, Poetter D, DelleDonne A, Mori T, Smeed R, Crawford F, Klein T, Tan J, Mullan M. Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's beta-amyloid(1-42). J Neuroimmunol. 2002 Nov; 132(1-2):49-59. View in: PubMed

Tan J, Town T, Abdullah L, Wu Y, Placzek A, Small B, Kroeger J, Crawford F, Richards D, Mullan M. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease. J Neuroimmunol. 2002 Nov; 132(1-2):164-72. View in: PubMed

Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M. p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. J Neurosci Res. 2002 Aug 1; 69(3):362-72. View in: PubMed

Tan J, Town T, Mullan M. CD40-CD40L interaction in Alzheimer's disease. Curr Opin Pharmacol. 2002 Aug; 2(4):445-51. View in: PubMed

Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. CD40 is expressed and functional on neuronal cells. EMBO J. 2002 Feb 15; 21(4):643-52. View in: PubMed

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