Faculty

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Thomas D Coates, MD
Professor of Pediatrics
Section Head of Hematology
Director of Sickle/Hemoglobinopathy Program
Pediatrics
CHL Mail Stop 54 Off Campus Los Angeles
+1 323 361 2352

Overview

I primarily work in two areas of basic and translational research: 1) the role of inflammation in the genesis of vascular disease in sickle cell disease; 2) the detection and management of transfusion related iron overload. Our research employs various engineering-intensive methodologies (MRI, laser Doppler flow, digital image analysis, signal processing) to explore the basic mechanisms of sickle cell disease and to measure the effect of various treatment modalities. We use direct measures of microvascular blood flow to monitor the process of vasoocclusion and relate it to simultaneous measures of autonomic nervous system function. These methodologies translate in measurements that can be used to follow patients clinically. In collaboration with members of the Cardiology, Pulmonology, and Radiology Departments at Children’s Hospital Los Angeles, the Departments of Biomedical Engineering and Physiology/Biophysics at the Keck School of Medicine, we devised methods to measure the sickling process in human sickle cell subjects and relate these measurements to clinical factors that modulate disease severity.

Publications

Bush AM, Borzage MT, Choi S, Václavu L, Tamrazi B, Nederveen AJ, Coates TD, Wood JC. Determinants of resting cerebral blood flow in sickle cell disease. Am J Hematol. 2016 Sep; 91(9):912-7. View in: PubMed

Wang L, Valderramos SG, Wu A, Ouyang S, Li C, Brasil P, Bonaldo M, Coates T, Nielsen-Saines K, Jiang T, Aliyari R, Cheng G. From Mosquitos to Humans: Genetic Evolution of Zika Virus. Cell Host Microbe. 2016 May 11; 19(5):561-5. View in: PubMed

Coates TD, Carson S, Wood JC, Berdoukas V. Management of iron overload in hemoglobinopathies: what is the appropriate target iron level? Ann N Y Acad Sci. 2016 Mar; 1368(1):95-106. View in: PubMed

Berdoukas V, Coates TD, Cabantchik ZI. Iron and oxidative stress in cardiomyopathy in thalassemia. Free Radic Biol Med. 2015 Nov; 88(Pt A):3-9. View in: PubMed

Reitman AJ, Coates TD, Freyer DR. Early Cardiac Iron Overload in a Child on Treatment of Acute Lymphoblastic Leukemia. Pediatrics. 2015 Sep; 136(3):e697-700. View in: PubMed

Detterich JA, Kato RM, Rabai M, Meiselman HJ, Coates TD, Wood JC. Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood. 2015 Aug 6; 126(6):703-10. View in: PubMed

Chalacheva P, Kato RM, Sangkatumvong S, Detterich J, Bush A, Wood JC, Meiselman H, Coates TD, Khoo MC. Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis. Physiol Rep. 2015 Jul 14; 3(7). View in: PubMed

Puliyel M, Mainous AG, Berdoukas V, Coates TD. Iron toxicity and its possible association with treatment of Cancer: lessons from hemoglobinopathies and rare, transfusion-dependent anemias. Free Radic Biol Med. 2015 Feb; 79:343-51. View in: PubMed

Huang KE, Mittelman SD, Coates TD, Geffner ME, Wood JC. A significant proportion of thalassemia major patients have adrenal insufficiency detectable on provocative testing. J Pediatr Hematol Oncol. 2015 Jan; 37(1):54-9. View in: PubMed

Young SD, Cumberland WG, Nianogo R, Menacho LA, Galea JT, Coates T. The HOPE social media intervention for global HIV prevention in Peru: a cluster randomised controlled trial. Lancet HIV. 2015 Jan; 2(1):e27-32. View in: PubMed

Paulukonis ST, Harris WT, Coates TD, Neumayr L, Treadwell M, Vichinsky E, Feuchtbaum LB. Population based surveillance in sickle cell disease: Methods, findings and implications from the California registry and surveillance system in hemoglobinopathies project (RuSH). Pediatr Blood Cancer. 2014 Dec; 61(12):2271-6. View in: PubMed

Mainous AG, Tanner RJ, Hulihan MM, Amaya M, Coates TD. The impact of chelation therapy on survival in transfusional iron overload: a meta-analysis of myelodysplastic syndrome. Br J Haematol. 2014 Dec; 167(5):720-3. View in: PubMed

Young SD, Holloway I, Jaganath D, Rice E, Westmoreland D, Coates T. Project HOPE: Online Social Network Changes in an HIV Prevention Randomized Controlled Trial for African American and Latino Men Who Have Sex With Men. Am J Public Health. 2014 Sep; 104(9):1707-12. View in: PubMed

Green ST, Martin MB, Haines D, Carson S, Coates T, Oliveros O, Gerstenberger E, Trachtenberg F, Kwiatkowski JL. Variance of pain prevalence and associated severity during the transfusion cycle of adult thalassaemia patients. Br J Haematol. 2014 Sep; 166(5):797-800. View in: PubMed

Coates TD. Physiology and pathophysiology of iron in hemoglobin-associated diseases. Free Radic Biol Med. 2014 Jul; 72:23-40. View in: PubMed

Meloni A, Puliyel M, Pepe A, Berdoukas V, Coates TD, Wood JC. Cardiac iron overload in sickle-cell disease. Am J Hematol. 2014 Jul; 89(7):678-83. View in: PubMed

Williams DA, Bennett C, Bertuch A, Bessler M, Coates T, Corey S, Dror Y, Huang J, Lipton J, Olson TS, Reiss UM, Rogers ZR, Sieff C, Vlachos A, Walkovich K, Wang W, Shimamura A. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May; 61(5):869-74. View in: PubMed

Vichinsky E, Neumayr L, Trimble S, Giardina PJ, Cohen AR, Coates T, Boudreaux J, Neufeld EJ, Kenney K, Grant A, Thompson AA. Transfusion complications in thalassemia patients: a report from the Centers for Disease Control and Prevention (CME). Transfusion. 2014 Apr; 54(4):972-81. View in: PubMed

Koblin BA, Mansergh G, Chesney M, Coates T. Moving the Bar to the Right Place: Positioning Interventions in HIV Prevention. AIDS Behav. 2014 Apr; 18(4):634-7. View in: PubMed

Puliyel M, Sposto R, Berdoukas VA, Hofstra TC, Nord A, Carson S, Wood J, Coates TD. Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload. Am J Hematol. 2014 Apr; 89(4):391-4. View in: PubMed

Coates TD. Bad liver and a broken heart. Blood. 2014 Mar 6; 123(10):1434-6. View in: PubMed

Mainous AG, Tanner RJ, Coates TD, Baker R. Prediabetes, elevated iron and all-cause mortality: a cohort study. BMJ Open. 2014; 4(12):e006491. View in: PubMed

Daniels J, Komárek A, Makusha T, Van Heerden A, Gray G, Chingono A, Mbwambo JK, Coates T, Richter L. Effects of a Community Intervention on HIV Prevention Behaviors among Men Who Experienced Childhood Sexual or Physical Abuse in Four African Settings: Findings from NIMH Project Accept (HPTN 043). PLoS One. 2014; 9(6):e99643. View in: PubMed

Berdoukas V, Nord A, Carson S, Puliyel M, Hofstra T, Wood J, Coates TD. Tissue iron evaluation in chronically transfused children shows significant levels of iron loading at a very young age. Am J Hematol. 2013 Nov; 88(11):E283-5. View in: PubMed

van Rooyen H, McGrath N, Chirowodza A, Joseph P, Fiamma A, Gray G, Richter L, Coates T. Mobile VCT: reaching men and young people in urban and rural South African pilot studies (NIMH Project Accept, HPTN 043). AIDS Behav. 2013 Nov; 17(9):2946-53. View in: PubMed

Young SD, Cumberland WG, Lee SJ, Jaganath D, Szekeres G, Coates T. Social networking technologies as an emerging tool for HIV prevention: a cluster randomized trial. Ann Intern Med. 2013 Sep 3; 159(5):318-24. View in: PubMed

Wanyenze RK, Kamya MR, Fatch R, Mayanja-Kizza H, Baveewo S, Szekeres G, Bangsberg DR, Coates T, Hahn JA. Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial. Lancet Glob Health. 2013 Sep; 1(3):e137-45. View in: PubMed

Young SD, Szekeres G, Coates T. Sexual risk and HIV prevention behaviours among African-American and Latino MSM social networking users. Int J STD AIDS. 2013 Aug; 24(8):643-9. View in: PubMed

Switzer WM, Shankar A, Trimble SR, Thompson AA, Giardina PJ, Cohen AR, Coates TD, Vichinsky E, Neufeld EJ, Boudreaux JM, Heneine W. Human T cell lymphotropic virus type 1 infection among U. S. thalassemia patients. AIDS Res Hum Retroviruses. 2013 Jul; 29(7):1006-9. View in: PubMed

Clark J, Salvatierra J, Segura E, Salazar X, Konda K, Perez-Brumer A, Hall E, Klausner J, Caceres C, Coates T. Moderno love: sexual role-based identities and HIV/STI prevention among men who have sex with men in Lima, Peru. AIDS Behav. 2013 May; 17(4):1313-28. View in: PubMed

Detterich JA, Sangkatumvong S, Kato R, Dongelyan A, Bush A, Khoo M, Meiselman HJ, Coates TD, Wood JC. Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion. 2013 May; 53(5):1059-68. View in: PubMed

Jordan L, Swerdlow P, Coates TD. Systematic review of transition from adolescent to adult care in patients with sickle cell disease. J Pediatr Hematol Oncol. 2013 Apr; 35(3):165-9. View in: PubMed

Meloni A, Detterich J, Berdoukas V, Pepe A, Lombardi M, Coates TD, Wood JC. Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron. Am J Hematol. 2013 Mar; 88(3):213-8. View in: PubMed

Sohn EY, Kato R, Noetzli LJ, Gera A, Coates T, Harmatz P, Keens TG, Wood JC. Exercise performance in thalassemia major: correlation with cardiac iron burden. Am J Hematol. 2013 Mar; 88(3):193-7. View in: PubMed

Haines D, Martin M, Carson S, Oliveros O, Green S, Coates T, Eile J, Schilling L, Dinu B, Mendoza T, Gerstenberger E, Trachtenberg F, Vichinsky E. Pain in thalassaemia: the effects of age on pain frequency and severity. Br J Haematol. 2013 Mar; 160(5):680-7. View in: PubMed

Connes P, Coates TD. Autonomic nervous system dysfunction: implication in sickle cell disease. C R Biol. 2013 Mar; 336(3):142-7. View in: PubMed

Detterich J, Alexy T, Rabai M, Wenby R, Dongelyan A, Coates T, Wood J, Meiselman H. Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion. 2013 Feb; 53(2):297-305. View in: PubMed

Walter PB, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, Coates T, Giardina PJ, Grady RW, Vichinsky E, Olivieri N, Trachtenberg F, Alberti D, Fung E, Ames B, Higa A, Harmatz P. Increased leucocyte apoptosis in transfused ß-thalassaemia patients. Br J Haematol. 2013 Feb; 160(3):399-403. View in: PubMed

James MM, Laeyendecker O, Sun J, Hoover DR, Mullis CE, Cousins MM, Coates T, Moore RD, Kelen GD, Fowler MG, Kumwenda JJ, Mofenson LM, Kumwenda NI, Taha TE, Eshleman SH. Antibody maturation and viral diversification in HIV-infected women. PLoS One. 2013; 8(2):e57350. View in: PubMed

Laeyendecker O, Kulich M, Donnell D, Komárek A, Omelka M, Mullis CE, Szekeres G, Piwowar-Manning E, Fiamma A, Gray RH, Lutalo T, Morrison CS, Salata RA, Chipato T, Celum C, Kahle EM, Taha TE, Kumwenda NI, Karim QA, Naranbhai V, Lingappa JR, Sweat MD, Coates T, Eshleman SH. Development of Methods for Cross-Sectional HIV Incidence Estimation in a Large, Community Randomized Trial. PLoS One. 2013; 8(11):e78818. View in: PubMed

Laeyendecker O, Piwowar-Manning E, Fiamma A, Kulich M, Donnell D, Bassuk D, Mullis CE, Chin C, Swanson P, Hackett J, Clarke W, Marzinke M, Szekeres G, Gray G, Richter L, Alexandre MW, Chariyalertsak S, Chingono A, Celentano DD, Morin SF, Sweat M, Coates T, Eshleman SH. Estimation of HIV incidence in a large, community-based, randomized clinical trial: NIMH project accept (HIV Prevention Trials Network 043). PLoS One. 2013; 8(7):e68349. View in: PubMed

Young SD, Szekeres G, Coates T. The relationship between online social networking and sexual risk behaviors among men who have sex with men (MSM). PLoS One. 2013; 8(5):e62271. View in: PubMed

Sullivan PS, Carballo-Diéguez A, Coates T, Goodreau SM, McGowan I, Sanders EJ, Smith A, Goswami P, Sanchez J. Successes and challenges of HIV prevention in men who have sex with men. Lancet. 2012 Jul 28; 380(9839):388-99. View in: PubMed

Kwiatkowski JL, Kim HY, Thompson AA, Quinn CT, Mueller BU, Odame I, Giardina PJ, Vichinsky EP, Boudreaux JM, Cohen AR, Porter JB, Coates T, Olivieri NF, Neufeld EJ. Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort. Blood. 2012 Mar 22; 119(12):2746-53. View in: PubMed

Noetzli LJ, Mittelman SD, Watanabe RM, Coates TD, Wood JC. Pancreatic iron and glucose dysregulation in thalassemia major. Am J Hematol. 2012 Feb; 87(2):155-60. View in: PubMed

Detterich J, Noetzli L, Dorey F, Bar-Cohen Y, Harmatz P, Coates T, Wood J. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012 Feb; 87(2):139-44. View in: PubMed

Noetzli LJ, Panigrahy A, Mittelman SD, Hyderi A, Dongelyan A, Coates TD, Wood JC. Pituitary iron and volume predict hypogonadism in transfusional iron overload. Am J Hematol. 2012 Feb; 87(2):167-71. View in: PubMed

Baveewo S, Kamya MR, Mayanja-Kizza H, Fatch R, Bangsberg DR, Coates T, Hahn JA, Wanyenze RK. Potential for false positive HIV test results with the serial rapid HIV testing algorithm. BMC Res Notes. 2012; 5:154. View in: PubMed

Wolfson JA, Schrager SM, Khanna R, Coates TD, Kipke MD. Sickle cell disease in California: Sociodemographic predictors of emergency department utilization. Pediatr Blood Cancer. 2012 Jan; 58(1):66-73. View in: PubMed

Berdoukas V, Farmaki K, Carson S, Wood J, Coates T. Treating thalassemia major-related iron overload: the role of deferiprone. J Blood Med. 2012; 3:119-29. View in: PubMed

Coates TD. Is it time to SWiTCH to composite primary endpoints? Pediatr Blood Cancer. 2011 Dec 1; 57(6):906-7. View in: PubMed

Sohn EY, Noetzli LJ, Gera A, Kato R, Coates TD, Harmatz P, Keens TG, Wood JC. Pulmonary function in thalassaemia major and its correlation with body iron stores. Br J Haematol. 2011 Oct; 155(1):102-5. View in: PubMed

Sohn EY, Noetzli LJ, Gera A, Kato R, Coates TD, Harmatz P, Keens TG, Wood JC. Pulmonary function in thalassaemia major and its correlation with body iron stores. Br J Haematol. 2011 Oct; 155(1):102-5. View in: PubMed

Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. View in: PubMed

Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. View in: PubMed

Vichinsky E, Bernaudin F, Forni GL, Gardner R, Hassell K, Heeney MM, Inusa B, Kutlar A, Lane P, Mathias L, Porter J, Tebbi C, Wilson F, Griffel L, Deng W, Giannone V, Coates T. Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease. Br J Haematol. 2011 Aug; 154(3):387-97. View in: PubMed

Sweat M, Morin S, Celentano D, Mulawa M, Singh B, Mbwambo J, Kawichai S, Chingono A, Khumalo-Sakutukwa G, Gray G, Richter L, Kulich M, Sadowski A, Coates T. Community-based intervention to increase HIV testing and case detection in people aged 16-32 years in Tanzania, Zimbabwe, and Thailand (NIMH Project Accept, HPTN 043): a randomised study. Lancet Infect Dis. 2011 Jul; 11(7):525-32. View in: PubMed

Young SD, Konda K, Caceres C, Galea J, Sung-Jae L, Salazar X, Coates T. Effect of a community popular opinion leader HIV/STI intervention on stigma in urban, coastal Peru. AIDS Behav. 2011 Jul; 15(5):930-7. View in: PubMed

Wood JC, Glynos T, Thompson A, Giardina P, Harmatz P, Kang BP, Paley C, Coates TD. Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial. Haematologica. 2011 Jul; 96(7):1055-8. View in: PubMed

Wood JC, Mo A, Gera A, Koh M, Coates T, Gilsanz V. Quantitative computed tomography assessment of transfusional iron overload. Br J Haematol. 2011 Jun; 153(6):780-5. View in: PubMed

Trachtenberg F, Vichinsky E, Haines D, Pakbaz Z, Mednick L, Sobota A, Kwiatkowski J, Thompson AA, Porter J, Coates T, Giardina PJ, Olivieri N, Yamashita R, Neufeld EJ. Iron chelation adherence to deferoxamine and deferasirox in thalassemia. Am J Hematol. 2011 May; 86(5):433-6. View in: PubMed

Wanyenze RK, Hahn JA, Liechty CA, Ragland K, Ronald A, Mayanja-Kizza H, Coates T, Kamya MR, Bangsberg DR. Linkage to HIV care and survival following inpatient HIV counseling and testing. AIDS Behav. 2011 May; 15(4):751-60. View in: PubMed

Mindry D, Maman S, Chirowodza A, Muravha T, van Rooyen H, Coates T. Looking to the future: South African men and women negotiating HIV risk and relationship intimacy. Cult Health Sex. 2011 May; 13(5):589-602. View in: PubMed

Parekh C, Hofstra T, Church JA, Coates TD. Hemophagocytic lymphohistiocytosis in children with chronic granulomatous disease. Pediatr Blood Cancer. 2011 Mar; 56(3):460-2. View in: PubMed

Wolfson JA, Schrager SM, Coates TD, Kipke MD. Sickle-cell disease in California: a population-based description of emergency department utilization. Pediatr Blood Cancer. 2011 Mar; 56(3):413-9. View in: PubMed

Berdoukas V, Farmaki K, Wood JC, Coates T. Iron chelation in thalassemia: time to reconsider our comfort zones. Expert Rev Hematol. 2011 Feb; 4(1):17-26. View in: PubMed

Noetzli LJ, Carson S, Coates TD, Wood JC. Revisiting the relationship between vitamin D deficiency, cardiac iron and cardiac function in thalassemia major. Eur J Haematol. 2011 Feb; 86(2):176-7. View in: PubMed

Coates TD. So what if blood is thicker than water? Blood. 2011 Jan 20; 117(3):745-6. View in: PubMed

Cousins MM, Laeyendecker O, Beauchamp G, Brookmeyer R, Towler WI, Hudelson SE, Khaki L, Koblin B, Chesney M, Moore RD, Kelen GD, Coates T, Celum C, Buchbinder SP, Seage GR, Quinn TC, Donnell D, Eshleman SH. Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infection. PLoS One. 2011; 6(11):e27211. View in: PubMed

Wanyenze RK, Kamya MR, Fatch R, Mayanja-Kizza H, Baveewo S, Sawires S, Bangsberg DR, Coates T, Hahn JA. Missed opportunities for HIV testing and late-stage diagnosis among HIV-infected patients in Uganda. PLoS One. 2011; 6(7):e21794. View in: PubMed

Noetzli LJ, Coates TD, Wood JC. Pancreatic iron loading in chronically transfused sickle cell disease is lower than in thalassaemia major. Br J Haematol. 2011 Jan; 152(2):229-33. View in: PubMed

Piwowar-Manning E, Fiamma A, Laeyendecker O, Kulich M, Donnell D, Szekeres G, Robins-Morris L, Mullis CE, Vallari A, Hackett J, Mastro TD, Gray G, Richter L, Alexandre MW, Chariyalertsak S, Chingono A, Sweat M, Coates T, Eshleman SH. HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043). BMC Infect Dis. 2011; 11:251. View in: PubMed

Young SD, Hlavka Z, Modiba P, Gray G, Van Rooyen H, Richter L, Szekeres G, Coates T. HIV-related stigma, social norms, and HIV testing in Soweto and Vulindlela, South Africa: National Institutes of Mental Health Project Accept (HPTN 043). J Acquir Immune Defic Syndr. 2010 Dec 15; 55(5):620-4. View in: PubMed

Berdoukas V, Carson S, Nord A, Dongelyan A, Gavin S, Hofstra TC, Wood JC, Coates T. Combining two orally active iron chelators for thalassemia. Ann Hematol. 2010 Nov; 89(11):1177-8. View in: PubMed

Wood JC, Glynos T, Thompson A, Giardina P, Harmatz P, Kang BP, Paley C, Coates TD. Follow-up report on the 2-year cardiac data from a deferasirox monotherapy trial. Am J Hematol. 2010 Oct; 85(10):818-9. View in: PubMed

Donnell D, Mimiaga MJ, Mayer K, Chesney M, Koblin B, Coates T. Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial. AIDS Behav. 2010 Oct; 14(5):1182-9. View in: PubMed

Wood JC, Noetzl L, Hyderi A, Joukar M, Coates T, Mittelman S. Predicting pituitary iron and endocrine dysfunction. Ann N Y Acad Sci. 2010 Aug; 1202:123-8. View in: PubMed

Wood JC, Kang BP, Thompson A, Giardina P, Harmatz P, Glynos T, Paley C, Coates TD. The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood. 2010 Jul 29; 116(4):537-43. View in: PubMed

Trachtenberg F, Foote D, Martin M, Carson S, Coates T, Beams O, Vega O, Merelles-Pulcini M, Giardina PJ, Kleinert DA, Kwiatkowski J, Thompson AA, Neufeld EJ, Schilling L, Thayalasuthan V, Pakbaz Z, Yamashita R. Pain as an emergent issue in thalassemia. Am J Hematol. 2010 May; 85(5):367-70. View in: PubMed

Casella JF, King AA, Barton B, White DA, Noetzel MJ, Ichord RN, Terrill C, Hirtz D, McKinstry RC, Strouse JJ, Howard TH, Coates TD, Minniti CP, Campbell AD, Vendt BA, Lehmann H, Debaun MR. Design of the silent cerebral infarct transfusion (SIT) trial. Pediatr Hematol Oncol. 2010 Mar; 27(2):69-89. View in: PubMed

Sangkatumvong S, Coates TD, Wood JC, Meiselman HJ, Kato R, Detterich JA, Bush A, Khoo MC. Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1626-9. View in: PubMed

Adamkiewicz TV, Abboud MR, Paley C, Olivieri N, Kirby-Allen M, Vichinsky E, Casella JF, Alvarez OA, Barredo JC, Lee MT, Iyer RV, Kutlar A, McKie KM, McKie V, Odo N, Gee B, Kwiatkowski JL, Woods GM, Coates T, Wang W, Adams RJ. Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury. Blood. 2009 Nov 19; 114(21):4632-8. View in: PubMed

Noetzli LJ, Papudesi J, Coates TD, Wood JC. Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood. 2009 Nov 5; 114(19):4021-6. View in: PubMed

Singer ST, Kim HY, Olivieri NF, Kwiatkowski JL, Coates TD, Carson S, Neufeld E, Cunningham MJ, Giardina PJ, Mueller BU, Quinn CT, Fung E, Vichinsky E. Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications. Am J Hematol. 2009 Nov; 84(11):759-61. View in: PubMed

Eshleman SH, Khaki L, Laeyendecker O, Piwowar-Manning E, Johnson-Lewis L, Husnik M, Koblin B, Coates T, Chesney M, Vallari A, Devare SG, Hackett J. Detection of individuals with acute HIV-1 infection using the ARCHITECT HIV Ag/Ab Combo assay. J Acquir Immune Defic Syndr. 2009 Sep 1; 52(1):121-4. View in: PubMed

Ghugre NR, Gonzalez-Gomez I, Butensky E, Noetzli L, Fischer R, Williams R, Harmatz P, Coates TD, Wood JC. Patterns of hepatic iron distribution in patients with chronically transfused thalassemia and sickle cell disease. Am J Hematol. 2009 Aug; 84(8):480-3. View in: PubMed

Hudelson SE, Marlowe N, Huang W, Bruce R, Church JD, Husnik M, Donnell D, Coates T, Jackson JB, Chesney M, Koblin B, Eshleman SH. Analysis of HIV type 1 gp41 and enfuvirtide susceptibility among men in the United States who were HIV infected prior to availability of HIV entry inhibitors. AIDS Res Hum Retroviruses. 2009 Jul; 25(7):701-5. View in: PubMed

Claster S, Wood JC, Noetzli L, Carson SM, Hofstra TC, Khanna R, Coates TD. Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. Am J Hematol. 2009 Jun; 84(6):344-8. View in: PubMed

Kauf TL, Coates TD, Huazhi L, Mody-Patel N, Hartzema AG. The cost of health care for children and adults with sickle cell disease. Am J Hematol. 2009 Jun; 84(6):323-7. View in: PubMed

Inamo J, Connes P, Barthélémy JC, Dan V, Coates T, Loko G. Pulmonary hypertension does not affect the autonomic nervous system dysfunction of sickle cell disease. Am J Hematol. 2009 May; 84(5):311-2. View in: PubMed

Brewer CJ, Coates TD, Wood JC. Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major. J Magn Reson Imaging. 2009 Feb; 29(2):357-64. View in: PubMed

Wong LH, Rooyen HV, Modiba P, Richter L, Gray G, McIntyre JA, Schetter CD, Coates T. Test and tell: correlates and consequences of testing and disclosure of HIV status in South Africa (HPTN 043 Project Accept). J Acquir Immune Defic Syndr. 2009 Feb 1; 50(2):215-22. View in: PubMed

Noetzli LJ, Carson SM, Nord AS, Coates TD, Wood JC. Longitudinal analysis of heart and liver iron in thalassemia major. Blood. 2008 Oct 1; 112(7):2973-8. View in: PubMed

Schein A, Enriquez C, Coates TD, Wood JC. Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis. J Magn Reson Imaging. 2008 Sep; 28(3):698-704. View in: PubMed

Fung EB, Harmatz PR, Milet M, Coates TD, Thompson AA, Ranalli M, Mignaca R, Scher C, Giardina P, Robertson S, Neumayr L, Vichinsky EP. Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia. Bone. 2008 Jul; 43(1):162-8. View in: PubMed

Walter PB, Macklin EA, Porter J, Evans P, Kwiatkowski JL, Neufeld EJ, Coates T, Giardina PJ, Vichinsky E, Olivieri N, Alberti D, Holland J, Harmatz P. Inflammation and oxidant-stress in beta-thalassemia patients treated with iron chelators deferasirox (ICL670) or deferoxamine: an ancillary study of the Novartis CICL670A0107 trial. Haematologica. 2008 Jun; 93(6):817-25. View in: PubMed

Wood JC, Claster S, Carson S, Menteer JD, Hofstra T, Khanna R, Coates T. Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major. Br J Haematol. 2008 Jun; 141(6):891-4. View in: PubMed

Wood JC, Origa R, Agus A, Matta G, Coates TD, Galanello R. Onset of cardiac iron loading in pediatric patients with thalassemia major. Haematologica. 2008 Jun; 93(6):917-20. View in: PubMed

Delea TE, Hagiwara M, Thomas SK, Baladi JF, Phatak PD, Coates TD. Outcomes, utilization, and costs among thalassemia and sickle cell disease patients receiving deferoxamine therapy in the United States. Am J Hematol. 2008 Apr; 83(4):263-70. View in: PubMed

Li W, Coates T, Wood JC. Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major. Haematologica. 2008 Feb; 93(2):311-2. View in: PubMed

Sangkatumvong S, Khoo MC, Coates TD. Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1996-9. View in: PubMed

Vichinsky E, Pakbaz Z, Onyekwere O, Porter J, Swerdlow P, Coates T, Lane P, Files B, Mueller BU, Coïc L, Forni GL, Fischer R, Marks P, Rofail D, Abetz L, Baladi JF. Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial. Acta Haematol. 2008; 119(3):133-41. View in: PubMed

Delea TE, Edelsberg J, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD. Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion. 2007 Oct; 47(10):1919-29. View in: PubMed

Eshleman SH, Husnik M, Hudelson S, Donnell D, Huang Y, Huang W, Hart S, Jackson B, Coates T, Chesney M, Koblin B. Antiretroviral drug resistance, HIV-1 tropism, and HIV-1 subtype among men who have sex with men with recent HIV-1 infection. AIDS. 2007 May 31; 21(9):1165-74. View in: PubMed

Cappellini MD, Bejaoui M, Agaoglu L, Porter J, Coates T, Jeng M, Lai ME, Mangiagli A, Strauss G, Girot R, Watman N, Ferster A, Loggetto S, Abish S, Cario H, Zoumbos N, Vichinsky E, Opitz H, Ressayre-Djaffer C, Abetz L, Rofail D, Baladi JF. Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia. Clin Ther. 2007 May; 29(5):909-17. View in: PubMed

Maiorana A, Kegeles S, Fernandez P, Salazar X, Cáceres C, Sandoval C, Rosasco AM, Coates T. Implementation and evaluation of an HIV/STD intervention in Peru. Eval Program Plann. 2007 Feb; 30(1):82-93. View in: PubMed

Vichinsky E, Onyekwere O, Porter J, Swerdlow P, Eckman J, Lane P, Files B, Hassell K, Kelly P, Wilson F, Bernaudin F, Forni GL, Okpala I, Ressayre-Djaffer C, Alberti D, Holland J, Marks P, Fung E, Fischer R, Mueller BU, Coates T. A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease. Br J Haematol. 2007 Feb; 136(3):501-8. View in: PubMed

Delea TE, Sofrygin O, Thomas SK, Baladi JF, Phatak PD, Coates TD. Cost effectiveness of once-daily oral chelation therapy with deferasirox versus infusional deferoxamine in transfusion-dependent thalassaemia patients: US healthcare system perspective. Pharmacoeconomics. 2007; 25(4):329-42. View in: PubMed

Morris SR, Klausner JD, Buchbinder SP, Wheeler SL, Koblin B, Coates T, Chesney M, Colfax GN. Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. Clin Infect Dis. 2006 Nov 15; 43(10):1284-9. View in: PubMed

Sayles JN, Pettifor A, Wong MD, MacPhail C, Lee SJ, Hendriksen E, Rees HV, Coates T. Factors associated with self-efficacy for condom use and sexual negotiation among South african youth. J Acquir Immune Defic Syndr. 2006 Oct 1; 43(2):226-33. View in: PubMed

Ghugre NR, Enriquez CM, Gonzalez I, Nelson MD, Coates TD, Wood JC. MRI detects myocardial iron in the human heart. Magn Reson Med. 2006 Sep; 56(3):681-6. View in: PubMed

McNamara G, Gupta A, Reynaert J, Coates TD, Boswell C. Spectral imaging microscopy web sites and data. Cytometry A. 2006 Aug 1; 69(8):863-71. View in: PubMed

Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, Aydinok Y, Kattamis A, Kilinc Y, Porter J, Capra M, Galanello R, Fattoum S, Drelichman G, Magnano C, Verissimo M, Athanassiou-Metaxa M, Giardina P, Kourakli-Symeonidis A, Janka-Schaub G, Coates T, Vermylen C, Olivieri N, Thuret I, Opitz H, Ressayre-Djaffer C, Marks P, Alberti D. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood. 2006 May 1; 107(9):3455-62. View in: PubMed

Ghugre NR, Enriquez CM, Coates TD, Nelson MD, Wood JC. Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging. 2006 Jan; 23(1):9-16. View in: PubMed

Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Kuypers FA, Michael Grindel J. Secretory phospholipase A2 levels in patients with sickle cell disease and acute chest syndrome. Hemoglobin. 2006; 30(2):165-70. View in: PubMed

Wu S, Gonzalez-Gomez I, Coates T, Yano S. Cobalamin C disease presenting with hemophagocytic lymphohistiocytosis. Pediatr Hematol Oncol. 2005 Dec; 22(8):717-21. View in: PubMed

Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP. Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome. Br J Haematol. 2005 Nov; 131(3):378-88. View in: PubMed

Ghugre NR, Coates TD, Nelson MD, Wood JC. Mechanisms of tissue-iron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med. 2005 Nov; 54(5):1185-93. View in: PubMed

Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD, Coates TD. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005 Aug 15; 106(4):1460-5. View in: PubMed

Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD, Pollack H, Moats R. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation. 2005 Jul 26; 112(4):535-43. View in: PubMed

Wood JC, Enriquez C, Ghugre N, Otto-Duessel M, Aguilar M, Nelson MD, Moats R, Coates TD. Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci. 2005; 1054:386-95. View in: PubMed

Singer ST, Kuypers FA, Olivieri NF, Weatherall DJ, Mignacca R, Coates TD, Davies S, Sweeters N, Vichinsky EP. Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment. Ann N Y Acad Sci. 2005; 1054:250-6. View in: PubMed

Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Grindel JM. Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome. Hemoglobin. 2004 May; 28(2):85-102. View in: PubMed

Wood JC, Tyszka JM, Carson S, Nelson MD, Coates TD. Myocardial iron loading in transfusion-dependent thalassemia and sickle cell disease. Blood. 2004 Mar 1; 103(5):1934-6. View in: PubMed

Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra VK, Malik P. Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood. 2003 Aug 15; 102(4):1506-14. View in: PubMed

Coates TD, Larson-Prior LJ, Wolpert S, Prior F. Classification of simple stimuli based on detected nerve activity. IEEE Eng Med Biol Mag. 2003 Jan-Feb; 22(1):64-76. View in: PubMed

Kyono W, Coates TD. A practical approach to neutrophil disorders. Pediatr Clin North Am. 2002 Oct; 49(5):929-71, viii. View in: PubMed

Sheikh J, Goldberg BJ, Kaplan MS, Staveren AM, Coates TD. A case of neutropenia with transient absence of neutrophil chemotaxis. Ann Allergy Asthma Immunol. 2002 May; 88(5):445-50. View in: PubMed

Borzage MT, Bush AM, Choi S, Nederveen AJ, Václavu L, Coates TD, Wood JC. Predictors of cerebral blood flow in patients with and without anemia. J Appl Physiol (1985). 2016 Apr 15; 120(8):976-81. View in: PubMed

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