Faculty

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Thomas G Keens, MD
Professor of Pediatrics
Pediatrics
CHL Mail Stop 83 Off Campus Los Angeles
+1 323 361 2101

Overview

An expert on respiratory and pulmonary disorders in children, including sudden infant death syndrome

Awards

Listed in The Best Doctors in America

Board of Directors, American Board of Pediatrics: Subspecialist representative member

Fellow of American Academy of Pediatrics and American College of Chest Physicians

Chair of California Sudden Infant Death Syndrome Advisory Council

Publications

Salinas DB, Azen C, Young S, Keens TG, Kharrazi M, Parad RB. Phenotypes of California CF Newborn Screen-Positive Children with CFTR 5T Allele by TG Repeat Length. Genet Test Mol Biomarkers. 2016 Sep; 20(9):496-503. View in: PubMed

Edwards JD, Houtrow AJ, Lucas AR, Miller RL, Keens TG, Panitch HB, Dudley RA. Children and Young Adults Who Received Tracheostomies or Were Initiated on Long-Term Ventilation in PICUs. Pediatr Crit Care Med. 2016 Aug; 17(8):e324-34. View in: PubMed

Ackerman MJ, Andrew TA, Baker AM, Devinsky O, Downs JC, Keens T, Kuntz J, Lin P, Lear-Kaul KC, Reichard R, Robinson DA. An Association of Hippocampal Malformations and Sudden Death? We Need More Data. Forensic Sci Med Pathol. 2016 Jun; 12(2):229-31. View in: PubMed

Stastny PF, Keens TG, Alkon A. Supporting SIDS Families: The Public Health Nurse SIDS Home Visit. Public Health Nurs. 2016 May; 33(3):242-8. View in: PubMed

Perez IA, Kun S, Keens TG. PATIENT EDUCATION | INFORMATION SERIES. Diaphragm Pacing by Phrenic Nerve Stimulation. Am J Respir Crit Care Med. 2016 Apr 15; 193(8):P13-4. View in: PubMed

Salinas DB, Sosnay PR, Azen C, Young S, Raraigh KS, Keens TG, Kharrazi M. Benign and Deleterious Cystic Fibrosis Transmembrane Conductance Regulator Mutations Identified by Sequencing in Positive Cystic Fibrosis Newborn Screen Children from California. PLoS One. 2016; 11(5):e0155624. View in: PubMed

Salinas DB, Sosnay PR, Azen C, Young S, Raraigh KS, Keens TG, Kharrazi M. Benign outcome among positive cystic fibrosis newborn screen children with non-CF-causing variants. J Cyst Fibros. 2015 Nov; 14(6):714-9. View in: PubMed

De A, Mascarenhas L, Kamath S, LaRiviere A, Goodarzian F, Keens TG, Venkatramani R. Pilot Feasibility Study of Comprehensive Pulmonary Evaluation Following Lung Radiation Therapy. J Pediatr Hematol Oncol. 2015 Oct; 37(7):e412-8. View in: PubMed

Kun SS, Beas VN, Keens TG, Ward SS, Gold JI. Examining pediatric emergency home ventilation practices in home health nurses: Opportunities for improved care. Pediatr Pulmonol. 2015 Jul; 50(7):691-7. View in: PubMed

De A, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Mascarenhas L, Keens TG, Venkatramani R. Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation. Pediatr Pulmonol. 2015 Jun; 50(6):596-603. View in: PubMed

Diep B, Wang A, Kun S, McComb JG, Shaul DB, Shin CE, Keens TG, Perez IA. Diaphragm Pacing without Tracheostomy in Congenital Central Hypoventilation Syndrome Patients. Respiration. 2015 Apr 25. View in: PubMed

Bhatia R, Lesser DJ, Oliveira FG, Tran WH, Keens TG, Khoo MC, Davidson Ward SL. Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children. J Clin Sleep Med. 2015; 11(9):1039-45. View in: PubMed

Chin CI, Kohn SL, Keens TG, Margetis MF, Kato RM. A physician survey reveals differences in management of idiopathic pulmonary hemosiderosis. Orphanet J Rare Dis. 2015; 10(1):98. View in: PubMed

Nicholson KJ, Nosanov LB, Bowen KA, Kun SS, Perez IA, Keens TG, Shin CE. Thoracoscopic placement of phrenic nerve pacers for diaphragm pacing in congenital central hypoventilation syndrome. J Pediatr Surg. 2015 Jan; 50(1):78-81. View in: PubMed

De A, Guryev I, LaRiviere A, Kato R, Wee CP, Mascarenhas L, Keens TG, Venkatramani R. Pulmonary function abnormalities in childhood cancer survivors treated with bleomycin. Pediatr Blood Cancer. 2014 Sep; 61(9):1679-84. View in: PubMed

Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. View in: PubMed

Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 1; 86(5):942-8. View in: PubMed

Sohn EY, Kato R, Noetzli LJ, Gera A, Coates T, Harmatz P, Keens TG, Wood JC. Exercise performance in thalassemia major: correlation with cardiac iron burden. Am J Hematol. 2013 Mar; 88(3):193-7. View in: PubMed

Perez IA, Keens TG. Peripheral chemoreceptors in congenital central hypoventilation syndrome. Respir Physiol Neurobiol. 2013 Jan 1; 185(1):186-93. View in: PubMed

Jassal MS, Yu AM, Bhatia R, Keens TG, Davidson Ward SL. Effect of residential proximity to major roadways on cystic fibrosis exacerbations. Int J Environ Health Res. 2013; 23(2):119-31. View in: PubMed

Yuan HC, Sohn EY, Abouezzeddine T, Mahrer NE, Barber BA, Keens TG, Davidson Ward SL, Gold JI. Neurocognitive functioning in children with obstructive sleep apnea syndrome: a pilot study of positive airway pressure therapy. J Pediatr Nurs. 2012 Dec; 27(6):607-13. View in: PubMed

Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SD, Khoo MC, Davidson Ward SL. Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males. Pediatr Res. 2012 Sep; 72(3):293-8. View in: PubMed

Kun SS, Edwards JD, Davidson Ward SL, Keens TG. Hospital readmissions for newly discharged pediatric home mechanical ventilation patients. Pediatr Pulmonol. 2012 Apr; 47(4):409-14. View in: PubMed

Edwards JD, Kun SS, Graham RJ, Keens TG. End-of-life discussions and advance care planning for children on long-term assisted ventilation with life-limiting conditions. J Palliat Care. 2012; 28(1):21-7. View in: PubMed

Sohn EY, Noetzli LJ, Gera A, Kato R, Coates TD, Harmatz P, Keens TG, Wood JC. Pulmonary function in thalassaemia major and its correlation with body iron stores. Br J Haematol. 2011 Oct; 155(1):102-5. View in: PubMed

Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. View in: PubMed

Edwards JD, Rivanis C, Kun SS, Caughey AB, Keens TG. Costs of hospitalized ventilator-dependent children: differences between a ventilator ward and intensive care unit. Pediatr Pulmonol. 2011 Apr; 46(4):356-61. View in: PubMed

Edwards JD, Kun SS, Keens TG. Outcomes and causes of death in children on home mechanical ventilation via tracheostomy: an institutional and literature review. J Pediatr. 2010 Dec; 157(6):955-959. e2. View in: PubMed

Edwards JD, Kun SS, Keens TG, Khemani RG, Moromisato DY. Children with corrected or palliated congenital heart disease on home mechanical ventilation. Pediatr Pulmonol. 2010 Jul; 45(7):645-9. View in: PubMed

Weese-Mayer DE, Berry-Kravis EM, Ceccherini I, Keens TG, Loghmanee DA, Trang H. An official ATS clinical policy statement: Congenital central hypoventilation syndrome: genetic basis, diagnosis, and management. Am J Respir Crit Care Med. 2010 Mar 15; 181(6):626-44. View in: PubMed

Kun SS, Davidson-Ward SL, Hulse LM, Keens TG. How much do primary care givers know about tracheostomy and home ventilator emergency care? Pediatr Pulmonol. 2010 Mar; 45(3):270-4. View in: PubMed

Keens TG. Postdoctoral fellowship training in pediatric pulmonology in the United States of America. Paediatr Respir Rev. 2010 Mar; 11(1):66-7. View in: PubMed

Lesser DJ, Fleming MM, Maher CA, Kim SB, Woo MS, Keens TG. Does the 6-min walk test correlate with the exercise stress test in children? Pediatr Pulmonol. 2010 Feb; 45(2):135-40. View in: PubMed

Kun WW, Kun SS, Keens TG. Do sequential chest radiographs prompt changes in therapy for home mechanical ventilation children admitted for pneumonia? Care Manag J. 2010; 11(4):217-9. View in: PubMed

Chaicharn J, Lin Z, Chen ML, Ward SL, Keens T, Khoo MC. Model-based assessment of cardiovascular autonomic control in children with obstructive sleep apnea. Sleep. 2009 Jul; 32(7):927-38. View in: PubMed

Lesser DJ, Ward SL, Kun SS, Keens TG. Congenital hypoventilation syndromes. Semin Respir Crit Care Med. 2009 Jun; 30(3):339-47. View in: PubMed

Chang RK, Keens TG, Rodriguez S, Chen AY. Sudden infant death syndrome: changing epidemiologic patterns in California 1989-2004. J Pediatr. 2008 Oct; 153(4):498-502. View in: PubMed

Tablizo MA, Jacinto P, Parsley D, Chen ML, Ramanathan R, Keens TG. Supine sleeping position does not cause clinical aspiration in neonates in hospital newborn nurseries. Arch Pediatr Adolesc Med. 2007 May; 161(5):507-10. View in: PubMed

Claudius I, Keens T. Do all infants with apparent life-threatening events need to be admitted? Pediatrics. 2007 Apr; 119(4):679-83. View in: PubMed

Chen ML, Turkel SB, Jacobson JR, Keens TG. Alcohol use in congenital central hypoventilation syndrome. Pediatr Pulmonol. 2006 Mar; 41(3):283-5. View in: PubMed

Yuan N, Skaggs DL, Dorey F, Keens TG. Preoperative predictors of prolonged postoperative mechanical ventilation in children following scoliosis repair. Pediatr Pulmonol. 2005 Nov; 40(5):414-9. View in: PubMed

Chen ML, Tablizo MA, Kun S, Keens TG. Diaphragm pacers as a treatment for congenital central hypoventilation syndrome. Expert Rev Med Devices. 2005 Sep; 2(5):577-85. View in: PubMed

Kumar R, Macey PM, Woo MA, Alger JR, Keens TG, Harper RM. Neuroanatomic deficits in congenital central hypoventilation syndrome. J Comp Neurol. 2005 Jul 11; 487(4):361-71. View in: PubMed

Chen ML, Witmans MB, Tablizo MA, Jubran RF, Turkel SB, Tavaré CJ, Keens TG. Disordered respiratory control in children with partial cerebellar resections. Pediatr Pulmonol. 2005 Jul; 40(1):88-91. View in: PubMed

Woo MA, Macey PM, Macey KE, Keens TG, Woo MS, Harper RK, Harper RM. FMRI responses to hyperoxia in congenital central hypoventilation syndrome. Pediatr Res. 2005 Apr; 57(4):510-8. View in: PubMed

Macey PM, Macey KE, Woo MA, Keens TG, Harper RM. Aberrant neural responses to cold pressor challenges in congenital central hypoventilation syndrome. Pediatr Res. 2005 Apr; 57(4):500-9. View in: PubMed

Lin Z, K Khoo M, Chen M, Keens T, Davidson Ward SL. Noninvasive assessment of cardiovascular autonomic control in pediatric obstructive sleep apnea syndrome. Conf Proc IEEE Eng Med Biol Soc. 2005; 1:776-9. View in: PubMed

Lynn Chen M, Davidson Ward SL, Keens T, Lin Z, K Khoo M. Cardio-respiratory Uncoupling in Congenital Central Hypoventilation Syndrome. Conf Proc IEEE Eng Med Biol Soc. 2005; 4:4412-5. View in: PubMed

Lin Z, K Khoo M, Chen M, Keens T, Davidson Ward SL. Noninvasive assessment of cardiovascular autonomic control in pediatric obstructive sleep apnea syndrome. Conf Proc IEEE Eng Med Biol Soc. 2005; 4:4416-9. View in: PubMed

Hamutcu R, Nield TA, Garg M, Keens TG, Platzker AC. Long-term pulmonary sequelae in children who were treated with extracorporeal membrane oxygenation for neonatal respiratory failure. Pediatrics. 2004 Nov; 114(5):1292-6. View in: PubMed

Chen ML, Keens TG. Congenital central hypoventilation syndrome: not just another rare disorder. Paediatr Respir Rev. 2004 Sep; 5(3):182-9. View in: PubMed

Yuan N, Skaggs DL, Davidson Ward SL, Platzker AC, Keens TG. Preoperative polysomnograms and infant pulmonary function tests do not predict prolonged postoperative mechanical ventilation in children following scoliosis repair. Pediatr Pulmonol. 2004 Sep; 38(3):256-60. View in: PubMed

Krous HF, Beckwith JB, Byard RW, Rognum TO, Bajanowski T, Corey T, Cutz E, Hanzlick R, Keens TG, Mitchell EA. Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach. Pediatrics. 2004 Jul; 114(1):234-8. View in: PubMed

Macey PM, Valderama C, Kim AH, Woo MA, Gozal D, Keens TG, Harper RK, Harper RM. Temporal trends of cardiac and respiratory responses to ventilatory challenges in congenital central hypoventilation syndrome. Pediatr Res. 2004 Jun; 55(6):953-9. View in: PubMed

Stastny PF, Ichinose TY, Thayer SD, Olson RJ, Keens TG. Infant sleep positioning by nursery staff and mothers in newborn hospital nurseries. Nurs Res. 2004 Mar-Apr; 53(2):122-9. View in: PubMed

Witmans MB, Keens TG, Davidson Ward SL, Marcus CL. Obstructive hypopneas in children and adolescents: normal values. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1540. View in: PubMed

Ner Z, Ross LA, Horn MV, Keens TG, MacLaughlin EF, Starnes VA, Woo MS. Bordetella bronchiseptica infection in pediatric lung transplant recipients. Pediatr Transplant. 2003 Oct; 7(5):413-7. View in: PubMed

Sritippayawan S, Keens TG, Horn MV, Starnes VA, Woo MS. What are the best pulmonary function test parameters for early detection of post-lung transplant bronchiolitis obliterans syndrome in children? Pediatr Transplant. 2003 Jun; 7(3):200-3. View in: PubMed

Sritippayawan S, Kun SS, Keens TG, Davidson Ward SL. Initiation of home mechanical ventilation in children with neuromuscular diseases. J Pediatr. 2003 May; 142(5):481-5. View in: PubMed

Sritippayawan S, Keens TG, Horn MV, MacLaughlin EF, Barr ML, Starnes VA, Woo MS. Does lung growth occur when mature lobes are transplanted into children? Pediatr Transplant. 2002 Dec; 6(6):500-4. View in: PubMed

Sritippayawan S, Hamutcu R, Kun SS, Ner Z, Ponce M, Keens TG. Mother-daughter transmission of congenital central hypoventilation syndrome. Am J Respir Crit Care Med. 2002 Aug 1; 166(3):367-9. View in: PubMed

Shaul DB, Danielson PD, McComb JG, Keens TG. Thoracoscopic placement of phrenic nerve electrodes for diaphragmatic pacing in children. J Pediatr Surg. 2002 Jul; 37(7):974-8; discussion 974-8. View in: PubMed

Nakamura CT, Ng GY, Paton JY, Keens TG, Witmer JC, Bautista-Bolduc D, Woo MS. Correlation between digital clubbing and pulmonary function in cystic fibrosis. Pediatr Pulmonol. 2002 May; 33(5):332-8. View in: PubMed

Keens TG, Oki GS, Gilsanz V, Roe TF, Goodman W, Tsang RC, Specker BL, Saenger EL. Does radiation research in healthy children pose greater than minimal risk? IRB. 1994 Sep-Oct; 16(5):5-10. View in: PubMed

Yuan N, Fraire JA, Margetis MM, Skaggs DL, Tolo VT, Keens TG. The effect of scoliosis surgery on lung function in the immediate postoperative period. Spine (Phila Pa 1976). 2005 Oct 1; 30(19):2182-5. View in: PubMed

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