Dr. Tiffany Chow was a Senior Clinician-Scientist at the Rotman Research Institute and staff Behavioural Neurologist at the University of Toronto until she moved to Hawai’i to join Big Island Comprehensive Neurological Services in 2014. After 14 months in a small private general neurology practice, she returned to academics, to serve as the Medical Director within the Medical Safety Core of the USC Alzheimer’s Therapeutic Research Institute. She was promoted to Professor of Clinical Neurology in this return to the University of Southern California. For the majority of her career, Dr. Chow has served patients with early-onset dementias and their families. Her research has spanned observational studies of behavioral disturbance in dementia, structural and functional neuroimaging, clinical trials, and knowledge translation. Her publications include reporting from both quantitative and qualitative approaches to the field.
Dr. Chow’s commitment to caregiver issues in dementia has motivated her active participation on the Boards of Directors for the Alzheimer’s Association and the Alzheimer’s Society, as well as her position as a charter Medical Advisory Council member of the international Association for Frontotemporal Degeneration. She has brought an intergenerational approach to her outreach to caregivers: the website for children who are caregivers to middle-aged parents with dementia, www.lifeandminds.ca/whendementiaisinthehouse, has been translated into French and Chinese, thereby receiving hits from all over the globe continuously since its launch in 2011. There is also an educational activity book for children too young to access the internet, Frank and Tess, Detectives! which was translated into Welsh.
Building on her work with the Asian and Pacific Islander community in Los Angeles that began during her Fellowship training, she now finally has a mandate to operate nationally through the ATRI’s Recruitment and Diversity Task Force. This and intergenerational programming to improve quality of life for those living with dementia would be her major advocacy angles for the Board of Directors. In the past, she has served as a Councilor and Education Chair for the AAN’s Geriatric Neurology section; she has also been a member of the Behavioral Neurology section and earned UCNS certification for Behavioral Neurology in 2013.
USC Legacy: Dr. Chow’s dad graduated from the dental school in 1964.
Dr. Chow’s first job at USC was as an executive assistant in the Purchasing Department.
Linds AB, Kirstein AB, Freedman M, Verhoeff NP, Wolf U, Chow TW. Trajectories of Behavioural Disturbances Across Dementia Types. Can J Neurol Sci. 2015 Nov; 42(6):389-94. View in: PubMed
Ting WK, Fischer CE, Millikin CP, Ismail Z, Chow TW, Schweizer TA. Grey matter atrophy in mild cognitive impairment / early Alzheimer disease associated with delusions: a voxel-based morphometry study. Curr Alzheimer Res. 2015; 12(2):165-72. View in: PubMed
Farb NA, Grady CL, Strother S, Tang-Wai DF, Masellis M, Black S, Freedman M, Pollock BG, Campbell KL, Hasher L, Chow TW. Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation. Cortex. 2013 Jul-Aug; 49(7):1856-73. View in: PubMed
Chow TW, Alobaidy AA. Incorporating new diagnostic schemas, genetics, and proteinopathy into the evaluation of frontotemporal degeneration. Continuum (Minneap Minn). 2013 Apr; 19(2 Dementia):438-56. View in: PubMed
Shnall A, Agate A, Grinberg A, Huijbregts M, Nguyen MQ, Chow TW. Development of supportive services for frontotemporal dementias through community engagement. Int Rev Psychiatry. 2013 Apr; 25(2):246-52. View in: PubMed
Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88. View in: PubMed
Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. View in: PubMed
Chow TW, Fridhandler JD, Binns MA, Lee A, Merrilees J, Rosen HJ, Ketelle R, Miller BL. Trajectories of behavioral disturbance in dementia. J Alzheimers Dis. 2012; 31(1):143-9. View in: PubMed
Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011 Sep; 134(Pt 9):2456-77. View in: PubMed
Chow TW, Pio FJ, Rockwood K. An international needs assessment of caregivers for frontotemporal dementia. Can J Neurol Sci. 2011 Sep; 38(5):753-7. View in: PubMed
Spreng RN, Rosen HJ, Strother S, Chow TW, Diehl-Schmid J, Freedman M, Graff-Radford NR, Hodges JR, Lipton AM, Mendez MF, Morelli SA, Black SE, Miller BL, Levine B. Occupation attributes relate to location of atrophy in frontotemporal lobar degeneration. Neuropsychologia. 2010 Oct; 48(12):3634-41. View in: PubMed
Links KA, Chow TW, Binns M, Freedman M, Stuss DT, Scott CJ, Ramirez J, Black SE. Apathy is not associated with basal ganglia atrophy in frontotemporal dementia. Am J Geriatr Psychiatry. 2009 Sep; 17(9):819-21. View in: PubMed
Chow TW, Binns MA, Cummings JL, Lam I, Black SE, Miller BL, Freedman M, Stuss DT, van Reekum R. Apathy symptom profile and behavioral associations in frontotemporal dementia vs dementia of Alzheimer type. Arch Neurol. 2009 Jul; 66(7):888-93. View in: PubMed
Chow TW, Binder C, Smyth S, Cohen S, Robillard A. 100 years after Alzheimer: contemporary neurology practice assessment of referrals for dementia. Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan; 23(6):516-27. View in: PubMed
Chow TW, Binns MA, Freedman M, Stuss DT, Ramirez J, Scott CJ, Black S. Overlap in frontotemporal atrophy between normal aging and patients with frontotemporal dementias. Alzheimer Dis Assoc Disord. 2008 Oct-Dec; 22(4):327-35. View in: PubMed
Feldman HH, Jacova C, Robillard A, Garcia A, Chow T, Borrie M, Schipper HM, Blair M, Kertesz A, Chertkow H. Diagnosis and treatment of dementia: 2. Diagnosis. CMAJ. 2008 Mar 25; 178(7):825-36. View in: PubMed
Krawczyk DC, Morrison RG, Viskontas I, Holyoak KJ, Chow TW, Mendez MF, Miller BL, Knowlton BJ. Distraction during relational reasoning: the role of prefrontal cortex in interference control. Neuropsychologia. 2008; 46(7):2020-32. View in: PubMed
Chow TW, Izenberg A, Binns MA, Freedman M, Stuss DT, Scott CJ, Ramirez J, Black SE. Magnetic resonance imaging in frontotemporal dementia shows subcortical atrophy. Dement Geriatr Cogn Disord. 2008; 26(1):79-88. View in: PubMed
Grinberg A, Lagunoff J, Phillips D, Stern B, Goodman M, Chow T. Multidisciplinary design and implementation of a day program specialized for the frontotemporal dementias. Am J Alzheimers Dis Other Demen. 2007 Dec-2008 Jan; 22(6):499-506. View in: PubMed
Rascovsky K, Hodges JR, Kipps CM, Johnson JK, Seeley WW, Mendez MF, Knopman D, Kertesz A, Mesulam M, Salmon DP, Galasko D, Chow TW, Decarli C, Hillis A, Josephs K, Kramer JH, Weintraub S, Grossman M, Gorno-Tempini ML, Miller BM. Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions. Alzheimer Dis Assoc Disord. 2007 Oct-Dec; 21(4):S14-8. View in: PubMed
Chow TW, Hynan LS, Lipton AM. MMSE scores decline at a greater rate in frontotemporal degeneration than in AD. Dement Geriatr Cogn Disord. 2006; 22(3):194-9. View in: PubMed
Chow TW. Treatment approaches to symptoms associated with frontotemporal degeneration. Curr Psychiatry Rep. 2005 Oct; 7(5):376-80. View in: PubMed
Johnson JK, Diehl J, Mendez MF, Neuhaus J, Shapira JS, Forman M, Chute DJ, Roberson ED, Pace-Savitsky C, Neumann M, Chow TW, Rosen HJ, Forstl H, Kurz A, Miller BL. Frontotemporal lobar degeneration: demographic characteristics of 353 patients. Arch Neurol. 2005 Jun; 62(6):925-30. View in: PubMed
Chow TW, Hodges JR, Dawson KE, Miller BL, Smith V, Mendez MF, Lipton AM. Referral patterns for syndromes associated with frontotemporal lobar degeneration. Alzheimer Dis Assoc Disord. 2005 Jan-Mar; 19(1):17-9. View in: PubMed
Waltz JA, Knowlton BJ, Holyoak KJ, Boone KB, Back-Madruga C, McPherson S, Masterman D, Chow T, Cummings JL, Miller BL. Relational integration and executive function in Alzheimer's disease. Neuropsychology. 2004 Apr; 18(2):296-305. View in: PubMed
Morrison RG, Krawczyk DC, Holyoak KJ, Hummel JE, Chow TW, Miller BL, Knowlton BJ. A neurocomputational model of analogical reasoning and its breakdown in frontotemporal lobar degeneration. J Cogn Neurosci. 2004 Mar; 16(2):260-71. View in: PubMed
Sobrido MJ, Miller BL, Havlioglu N, Zhukareva V, Jiang Z, Nasreddine ZS, Lee VM, Chow TW, Wilhelmsen KC, Cummings JL, Wu JY, Geschwind DH. Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia. Arch Neurol. 2003 May; 60(5):698-702. View in: PubMed
Chow TW. Frontotemporal dementias: clinical features and management. Semin Clin Neuropsychiatry. 2003 Jan; 8(1):58-70. View in: PubMed
Chow TW, Mendez MF. Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration. Am J Alzheimers Dis Other Demen. 2002 Sep-Oct; 17(5):267-72. View in: PubMed
Chow TW, Miller BL, Boone K, Mishkin F, Cummings JL. Frontotemporal dementia classification and neuropsychiatry. Neurologist. 2002 Jul; 8(4):263-9. View in: PubMed
Chow TW, MacLean CH. Quality indicators for dementia in vulnerable community-dwelling and hospitalized elders. Ann Intern Med. 2001 Oct 16; 135(8 Pt 2):668-76. View in: PubMed