Faculty

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Tim J. Triche
Postdoctoral Scholar Research Associate
Medicine
NOR 3513 Health Sciences Campus Los Angeles
+1 323 442 8072

Overview

Dr. Triche applies mathematical and statistical techniques to model the development of progenitor cells in normal growth and aging, in immune function, and cancers of the blood. The increasingly prominent role of immunotherapy in controlling cancers, as well as the balance between a robust immune function and debilitating autoimmune disorders, both highlight the importance of this process. Dr. Triche draws upon years of experience with the massive Cancer Genome Atlas and TARGET pediatric cancer projects as a starting point for these models. However, neither development nor disease is a static process. Close collaborations with physician-scientists and mathematical biologists allow the fine details of the models to be filled in with primary experimental evidence. Retrospective verification in well-characterized pediatric and adult cohorts allows the lab to justify prospective testing in randomized clinical trials, moving the predictions of the models from basic research to patient care.

From a population health perspective, the patients served today by USC physicians are perhaps the best ethnic and demographic representation of patients across the United States 20 years from now. By improving the precision and relevance of models in these patients, the expected benefit of adjustments to the standard of care can be calibrated. In this way, the real-world impact of basic advances in treatment can be quantified. Delivering the right therapies to the right cells at the right point in time can maximize the benefits and limit the toxicity (both systemic and financial) to patients and their families. But a related question, less common but equally important, must also be answered: "By how much?"

Publications

Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015 Jan 29; 517(7536):576-82. View in: PubMed

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013 May 30; 368(22):2059-74. View in: PubMed

Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015 Jan 29; 517(7536):576-82. View in: PubMed

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013 May 30; 368(22):2059-74. View in: PubMed

Li WL, Buckley J, Sanchez-Lara PA, Maglinte DT, Viduetsky L, Tatarinova TV, Aparicio JG, Kim JW, Au M, Ostrow D, Lee TC, O'Gorman M, Judkins A, Cobrinik D, Triche TJ. A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families. J Mol Diagn. 2016 Jul; 18(4):480-93. View in: PubMed

Gopalakrishnan R, Matta H, Tolani B, Triche T, Chaudhary PM. Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors. Oncogene. 2015 Jun 29. View in: PubMed

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med. 2015 Jun 25; 372(26):2481-98. View in: PubMed

Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014 Sep 11; 513(7517):202-9. View in: PubMed

Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014 Jul 31; 511(7511):543-50. View in: PubMed

Lay FD, Triche TJ, Tsai YC, Su SF, Martin SE, Daneshmand S, Skinner EC, Liang G, Chihara Y, Jones PA. Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Res. 2014 Apr; 24(4):545-53. View in: PubMed

Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014 Mar 20; 507(7492):315-22. View in: PubMed

Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014; 5:3365. View in: PubMed

Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013 Jul 4; 499(7456):43-9. View in: PubMed

Triche TJ, Weisenberger DJ, Van Den Berg D, Laird PW, Siegmund KD. Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res. 2013 Apr; 41(7):e90. View in: PubMed

Comprehensive molecular portraits of human breast tumours. Nature. 2012 Oct 4; 490(7418):61-70. View in: PubMed

Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27; 489(7417):519-25. View in: PubMed

Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012 Jul 19; 487(7407):330-7. View in: PubMed

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 30; 474(7353):609-15. View in: PubMed

Lewinger JP, Conti DV, Baurley JW, Triche TJ, Thomas DC. Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. Genet Epidemiol. 2007 Dec; 31(8):871-82. View in: PubMed

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