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Ulf P Flodby, PhD
Associate Professor of Research Medicine
HMR 911 Health Sciences Campus Los Angeles
+1 323 442 1106


Dr. Flodby's research interests include development of transgenic mouse and rat models for lung research, lung injury and repair of alveolar epithelium, lung stem/progenitor cells, lung ion transport and alveolar epithelial tight junction regulation.

Dr. Flodby earned his medical degree from Karolinska Institute in Stockholm, then went on to complete a fellowship at the University of Utah, Department of Human Genetics.


Wenner-Gren Foundations: Postdoctoral Stipend Award, 1996-1998

Wenner-Gren Foundations: Repatriation Stipend, 1998-2000

Swedish Cancer Society: Graduate Student Grant Award, 1996


Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. View in: PubMed

Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z. Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1; 307(7):L524-36. View in: PubMed

Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X. TRIM72 is required for effective repair of alveolar epithelial cell wounding. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L449-59. View in: PubMed

Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. View in: PubMed

Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK. Dynamic involvement of ATG5 in cellular stress responses. Cell Death Dis. 2014; 5:e1478. View in: PubMed

Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct; 92(10):911-7. View in: PubMed

Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. Interactions Between ß-Catenin and Transforming Growth Factor-ß Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP). J Biol Chem. 2012 Mar 2; 287(10):7026-38. View in: PubMed

Demaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z. Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. View in: PubMed

MacFarlane AJ, Anderson DD, Flodby P, Perry CA, Allen RH, Stabler SP, Stover PJ. Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. J Biol Chem. 2011 Dec 23; 286(51):44015-22. View in: PubMed

Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. View in: PubMed

Flodby, P. , Borok, Z. , Crandall, E. D. , and Kim, K. J. Current Topics in Membranes. In: Claudins, Editor: A. S. L. Yu). Chapter 8. Claudins and barrier function of the lung. 2010; Volume 65:177-194. View in: PubMed

MacFarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem. 2008 Sep 19; 283(38):25846-53. View in: PubMed

Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z. Rat aquaporin-5 4. 3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. View in: PubMed

Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z. Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. View in: PubMed

Westerberg R, Tvrdik P, Undén AB, Månsson JE, Norlén L, Jakobsson A, Holleran WH, Elias PM, Asadi A, Flodby P, Toftgård R, Capecchi MR, Jacobsson A. Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem. 2004 Feb 13; 279(7):5621-9. View in: PubMed

Antonson P, Schuster GU, Wang L, Rozell B, Holter E, Flodby P, Treuter E, Holmgren L, Gustafsson JA. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol. 2003 Feb; 23(4):1260-8. View in: PubMed

Flodby P, Teglund S, Gustafsson JA. Knockout mice and steroid receptor research. Methods Mol Biol. 2001; 176:201-26. View in: PubMed

Gaufo GO, Flodby P, Capecchi MR. Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways. Development. 2000 Dec; 127(24):5343-54. View in: PubMed

Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos KG. Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996 Oct 4; 271(40):24753-60. View in: PubMed

Flodby P, Liao DZ, Blanck A, Xanthopoulos KG, Hällström IP. Expression of the liver-enriched transcription factors C/EBP alpha, C/EBP beta, HNF-1, and HNF-4 in preneoplastic nodules and hepatocellular carcinoma in rat liver. Mol Carcinog. 1995 Feb; 12(2):103-9. View in: PubMed

Bongertz V, Jansson M, Flodby P, Morgado MG, Galvão-Castro B, Wigzell H. Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil. Braz J Med Biol Res. 1994 May; 27(5):1225-36. View in: PubMed

Flodby P, Antonson P, Barlow C, Blanck A, Porsch-Hällström I, Xanthopoulos KG. Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats. Exp Cell Res. 1993 Sep; 208(1):248-56. View in: PubMed

Legraverend C, Antonson P, Flodby P, Xanthopoulos KG. High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors. Nucleic Acids Res. 1993 Apr 25; 21(8):1735-42. View in: PubMed

Bolmstedt A, Hemming A, Flodby P, Berntsson P, Travis B, Lin JP, Ledbetter J, Tsu T, Wigzell H, Hu SL, et al. Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteins. J Gen Virol. 1991 Jun; 72 ( Pt 6):1269-77. View in: PubMed

Nygren, P-Å. , Flodby, P. , Andersson, R. , Wigzell, H. , and Uhlén, M. In vivo stabilization of a human recombinant CD4 derivative by fusion to a serum-albumin-binding receptor. In: Modern Approaches to Vaccine Development (eds. : R. M. Chanock, et al. ) - volume 91 of Vaccines. New York, NY: Cold Spring Harbor Laboratory Press, pp. 363-368. 1991. View in: PubMed

Gidlund M, Sydow M, Stenbeck A, Flodby P, Fossum H, Matsuda S, Lundin K, Wigzell H, Lind P. Production and characterization of a fragment containing the HIV-gp120 binding region of CD4 using a bovine papilloma virus (BPV) vector. Arch Virol. 1990; 113(3-4):209-19. View in: PubMed

Hemming A, Bolmstedt A, Flodby P, Lundberg L, Gidlund M, Wigzell H, Olofsson S. Cystein 402 of HIV gp 120 is essential for CD4-binding and resistance of gp 120 to intracellular degradation. Arch Virol. 1989; 109(3-4):269-76. View in: PubMed

Rekosh D, Nygren A, Flodby P, Hammarskjöld ML, Wigzell H. Coexpression of human immunodeficiency virus envelope proteins and tat from a single simian virus 40 late replacement vector. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):334-8. View in: PubMed

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