Faculty

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Uttam Kumar Sinha, MD
Medical Director of Head and Neck Surgery of the Keck Medical Center of USC
Associate Professor of Otolaryngology-Head and Neck Surgery
Watt Family Endowed Chair for Head and Neck Cancers
Otolaryngology
CHP 204M 1540 Alcazar Street Off Campus Los Angeles
+1 323 442 5579

Overview

Dr. Uttam K. Sinha graduated with distinction from the Calcutta University, India in 1985. He was invited by the House Ear Institute and University of Southern California where he started his research career in molecular biology of neuroscience and cancer. He then finished residency in Otolaryngology-Head and Neck Surgery at USC. He continued to peruse academic career and completed a clinical fellowship in Microvascular and Plastic and Reconstructive Surgery in Mount Sinai Hospital, New York. He then went to Leon, France to complete a clinical fellowship in laryngology. Subsequently, he joined the faculty of the Department of Otolaryngology-Head and Neck Surgery at USC. Because of his academic achievements, leadership, teaching and research, he became Chief and Residency Program Director for the department. His major areas of research are head and neck cancer, thyroid cancer, plastic and reconstructive surgery, trauma, and speech and swallowing. By using nanotechnology, Dr. Sinha and his team are able to detect cancer cell in the saliva and serum. He is also studying the mechanism of metastasis. Dysphagia (difficulty in swallowing) is a common symptom following head and neck cancer therapy. Dr. Sinha and his team introduced a novel treatment called neuromuscular electrical stimulation (NMES) for rehabilitation of swallowing using a new “platform” technology called BION. He received multiple federal and foundation grants. His dedication to patient care and research made him world authority in head and neck diseases. To further the research endeavors, Dr. Sinha has established collaboration with multiple national and international institutes from England, France, India, China and Mexico. Three years ago Dr. Sinha launched a Patient Survivorship Program (http://hncsupport.org). The Support Group is actively involved in patient education and promoting awareness about head and neck cancer.

Awards

Alpha Omega Alpha (Gamma Chapter) as an Outstanding Resident

House Ear Institute: Rupley Fellowship, 1986

Calcutta University: Annual Scholarship for Academic Merit, 1977

Calcutta University: Gold Medal for highest marks in General Surgery, 1977

Government of India: National Scholarship for Academic Merit, 1973

Publications

Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review. Curr Opin Otolaryngol Head Neck Surg. 2017 Apr; 25(2):133-141. View in: PubMed

Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review. Curr Opin Otolaryngol Head Neck Surg. 2017 Jan 18. View in: PubMed

Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies. Int J Otolaryngol. 2017; 2017:8362874. View in: PubMed

Overcoming radioresistance in head and neck squamous cell carcinoma. Oral Oncol. 2016 Dec; 63:44-51. View in: PubMed

Erratum to "The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma" [Oral Oncol. 61 (2016) 27-30]. Oral Oncol. 2016 Nov; 62:e5. View in: PubMed

Erratum to "The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma" [Oral Oncol. 61 (2016) 27-30]. Oral Oncol. 2016 Oct 31. View in: PubMed

The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma. Oral Oncol. 2016 Oct; 61:27-30. View in: PubMed

Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-?1/MyoD homeostasis in head and neck cancer. J Surg Oncol. 2016 Jul; 114(1):27-31. View in: PubMed

Device Life of Two Generations of Provox Voice Prostheses. Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):501-7. View in: PubMed

ABCLOVE: Voice therapy outcomes for patients with head and neck cancer. Head Neck. 2016 Apr; 38 Suppl 1:E1810-3. View in: PubMed

The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers (Basel). 2016 Feb 19; 8(2). View in: PubMed

The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers (Basel). 2016; 8(2). View in: PubMed

Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2015 Aug; 141(8):723-7. View in: PubMed

Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2015 Aug 1; 141(8):723-7. View in: PubMed

Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer—review of current data. Oral Oncol. 2015 Jan; 51(1):12-5. View in: PubMed

Defining the localization and molecular characteristic of minor salivary gland label-retaining cells. Stem Cells. 2014 Aug; 32(8):2267-77. View in: PubMed

Diagnosis and management of merkel cell carcinoma of the head and neck: current trends and controversies. Cancers (Basel). 2014 Jun 27; 6(3):1256-66. View in: PubMed

Bacterial biofilms and increased bacterial counts are associated with airway stenosis. Otolaryngol Head Neck Surg. 2014 May; 150(5):834-40. View in: PubMed

Use of the supraclavicular artery island flap for reconstruction of cervicofacial defects. Otolaryngol Head Neck Surg. 2014 Feb; 150(2):222-8. View in: PubMed

Diagnosis and management of merkel cell carcinoma of the head and neck: current trends and controversies. Cancers (Basel). 2014; 6(3):1256-66. View in: PubMed

Evaluation of swallow function after tongue cancer treatment using real-time magnetic resonance imaging: a pilot study. JAMA Otolaryngol Head Neck Surg. 2013 Dec 1; 139(12):1312-9. View in: PubMed

Evaluation of swallow function after tongue cancer treatment using real-time magnetic resonance imaging: a pilot study. JAMA Otolaryngol Head Neck Surg. 2013 Dec; 139(12):1312-9. View in: PubMed

The supraclavicular artery island flap in head and neck reconstruction: applications and limitations. JAMA Otolaryngol Head Neck Surg. 2013 Nov 1; 139(11):1247-55. View in: PubMed

The supraclavicular artery island flap in head and neck reconstruction: applications and limitations. JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11):1247-55. View in: PubMed

A novel orthotopic mouse model of head and neck cancer and lymph node metastasis. Oncogenesis. 2013 Sep 09; 2:e68. View in: PubMed

Transoral robotic resection of oropharyngeal synovial sarcoma in a pediatric patient. Int J Pediatr Otorhinolaryngol. 2013 Jun; 77(6):1042-4. View in: PubMed

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. View in: PubMed

Solitary fibrous tumor of the postcricoid region: a case report and literature review. Case Rep Otolaryngol. 2013; 2013:908327. View in: PubMed

A novel orthotopic mouse model of head and neck cancer and lymph node metastasis. Oncogenesis. 2013; 2:e68. View in: PubMed

Uncommon cutaneous neoplasms of the head and neck. Facial Plast Surg Clin North Am. 2012 Nov; 20(4):483-91. View in: PubMed

a-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis. Mol Cancer Res. 2012 Jul; 10(7):892-903. View in: PubMed

Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. View in: PubMed

Predictive value of bedside clinical signs and symptoms in early diagnosis of deep vein thrombosis in acutely ill medical patients with special reference to deep vein thrombosis prophylaxis. J Indian Med Assoc. 2012 Apr; 110(4):218-23. View in: PubMed

Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer. Integr Biol (Camb). 2012 Feb 1; 4(2):132-41. View in: PubMed

Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer. Integr Biol (Camb). 2012 Feb; 4(2):132-41. View in: PubMed

Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma. ISRN Surg. 2012; 2012:715743. View in: PubMed

USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011 Sep; 47(9):810-7. View in: PubMed

Osteoradionecrosis. Oral Maxillofac Surg Clin North Am. 2011 Aug; 23(3):455-64. View in: PubMed

The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. Oral Oncol. 2011 Apr; 47(4):282-7. View in: PubMed

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck. 2011 Feb; 33(2):178-88. View in: PubMed

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. View in: PubMed

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 1; 109(4):818-27. View in: PubMed

Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2010 Feb 22; 2:5. View in: PubMed

Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2010; 2:5. View in: PubMed

Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. Cancer. 2009 Sep 1; 115(17):4010-20. View in: PubMed

Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. Cancer. 2009 Sep 01; 115(17):4010-20. View in: PubMed

Use of an oral sensory feedback device in the management of jaw-opening dystonia. Otolaryngol Head Neck Surg. 2009 Jul; 141(1):142-3. View in: PubMed

The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. View in: PubMed

Efficient multilevel brain tumor segmentation with integrated bayesian model classification. IEEE Trans Med Imaging. 2008 May; 27(5):629-40. View in: PubMed

Provider perceptions of patient psychosocial needs after orofacial injury. J Oral Maxillofac Surg. 2007 Aug; 65(8):1584-9. View in: PubMed

The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. View in: PubMed

EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. Int J Cancer. 2006 Sep 15; 119(6):1236-48. View in: PubMed

Circles of prominence: a new theory on facial aesthetics. Arch Facial Plast Surg. 2006 Jul-Aug; 8(4):263-7. View in: PubMed

Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 2006 Apr 10; 24(11):1754-60. View in: PubMed

p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines. Head Neck. 2006 Jan; 28(1):15-23. View in: PubMed

Analysis of the brain-stem white-matter tracts with diffusion tensor imaging. Neuroradiology. 2005 Dec; 47(12):895-902. View in: PubMed

Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma. Hum Pathol. 2005 Dec; 36(12):1289-93. View in: PubMed

Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. View in: PubMed

Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. View in: PubMed

Relationships between stem cells and cancer stem cells. Histol Histopathol. 2004 Apr; 19(2):505-9. View in: PubMed

Relationships between stem cells and cancer stem cells. Histol Histopathol. 2004 04; 19(2):505-9. View in: PubMed

Quantitative assessment of parallel acquisition techniques in diffusion tensor imaging at 3. 0 Tesla. Conf Proc IEEE Eng Med Biol Soc. 2004; 2:1072-5. View in: PubMed

Functional outcomes following palatal reconstruction with a folded radial forearm free flap. Ear Nose Throat J. 2004 Jan; 83(1):45-8. View in: PubMed

Expression of EphB4 in head and neck squamous cell carcinoma. Ear Nose Throat J. 2003 Nov; 82(11):866, 869-70, 887. View in: PubMed

Pressure-Specifying Sensory Device: quantitative sensory measurement in the oral cavity and oropharynx of normal adults. Ear Nose Throat J. 2003 Sep; 82(9):682-4, 687-90. View in: PubMed

Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas. Int J Oncol. 2003 Jun; 22(6):1285-90. View in: PubMed

Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa. Laryngoscope. 2003 Feb; 113(2):228-36. View in: PubMed

Use of AlloDerm implant to prevent frey syndrome after parotidectomy. Arch Facial Plast Surg. 2003 Jan-Feb; 5(1):109-12. View in: PubMed

Three-layer reconstruction for large defects of the anterior skull base. Laryngoscope. 2002 Mar; 112(3):424-7. View in: PubMed

Use of AlloDerm for coverage of radial forearm free flap donor site. Laryngoscope. 2002 Feb; 112(2):230-4. View in: PubMed

Molecular pathology of head and neck cancer. Histol Histopathol. 2002; 17(3):909-14. View in: PubMed

Reconstruction of pharyngeal defects using AlloDerm and sternocleidomastoid muscle flap. Laryngoscope. 2001 Nov; 111(11 Pt 1):1910-6. View in: PubMed

Frontotemporal reconstruction with hydroxyapatite cement and the radial forearm free flap. Arch Facial Plast Surg. 2001 Oct-Dec; 3(4):271-6. View in: PubMed

Image content extraction: application to MR images of the brain. Radiographics. 2001 Mar-Apr; 21(2):535-47. View in: PubMed

Office myringoplasty with alloderm. Laryngoscope. 2001 Jan; 111(1):181-4. View in: PubMed

Disease specific intelligent pre-fetch and hanging protocol for diagnostic neuroradiology workstations. Proc AMIA Symp. 2001; 468-72. View in: PubMed

Structure localization in brain images: application to relevant image selection. Proc AMIA Symp. 2001; 622-6. View in: PubMed

Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J Neurooncol. 2000 Dec; 50(3):215-26. View in: PubMed

Interactive software for generation and visualization of structured findings in radiology reports. AJR Am J Roentgenol. 2000 Sep; 175(3):609-12. View in: PubMed

Teleradiology as a foundation for an enterprise-wide health care delivery system. Radiographics. 2000 Jul-Aug; 20(4):1137-50. View in: PubMed

Improving the quality of care through routine teleradiology consultation. Acad Radiol. 2000 Mar; 7(3):149-55. View in: PubMed

Evaluation of SNOMED3. 5 in representing concepts in chest radiology reports: integration of a SNOMED mapper with a radiology reporting workstation. Proc AMIA Symp. 2000; 799-803. View in: PubMed

Endoscopic surgical management of sphenoid sinus disease. Laryngoscope. 1999 Oct; 109(10):1601-6. View in: PubMed

Surgery of the salivary glands. Otolaryngol Clin North Am. 1999 Oct; 32(5):887-906. View in: PubMed

Inverse correlation between choline magnetic resonance spectroscopy signal intensity and the apparent diffusion coefficient in human glioma. Magn Reson Med. 1999 Jan; 41(1):2-7. View in: PubMed

Case-based explanation of non-case-based learning methods. Proc AMIA Symp. 1999; 212-5. View in: PubMed

Initial experiences with building a health care infrastructure based on Java and object-oriented database technology. Proc AMIA Symp. 1999; 515-9. View in: PubMed

Process models for telehealth: an industrial approach to quality management of distant medical practice. Proc AMIA Symp. 1999; 545-9. View in: PubMed

Managing the emergency airway in Le Fort fractures. J Craniomaxillofac Trauma. 1998; 4(4):38-43. View in: PubMed

Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Arch Otolaryngol Head Neck Surg. 1998 Jan; 124(1):46-55. View in: PubMed

Intraoperative mapping of sensate flaps. Electrophysiologic techniques and neurosomal boundaries. Arch Otolaryngol Head Neck Surg. 1997 Aug; 123(8):823-9. View in: PubMed

Use of a mechanical microvascular anastomotic device in head and neck free tissue transfer. Arch Otolaryngol Head Neck Surg. 1996 May; 122(5):529-32. View in: PubMed

Temporal bone findings in Alzheimer's disease. Laryngoscope. 1996 Jan; 106(1 Pt 1):1-5. View in: PubMed

Sensory recovery in noninnervated free flaps for head and neck reconstruction. Laryngoscope. 1995 Dec; 105(12 Pt 1):1290-3. View in: PubMed

Safety of thyroidectomy in residency: a review of 186 consecutive cases. Laryngoscope. 1995 Nov; 105(11):1173-5. View in: PubMed

Dynamic properties of the posterior cricoarytenoid muscle. Ann Otol Rhinol Laryngol. 1994 Dec; 103(12):937-44. View in: PubMed

MR imaging signal response to sustained stimulation in human visual cortex. J Magn Reson Imaging. 1994 Jul-Aug; 4(4):537-43. View in: PubMed

Abnormal neuritic architecture identified by Di-I in Pick's disease. J Neuropathol Exp Neurol. 1993 Jul; 52(4):411-8. View in: PubMed

Auditory system degeneration in Alzheimer's disease. Neurology. 1993 Apr; 43(4):779-85. View in: PubMed

Magnetic resonance image synthesis from analytic solutions of spin-echo and radio frequency-spoiled gradient-echo images. Invest Radiol. 1992 Oct; 27(10):856-64. View in: PubMed

Radionecrosis secondary to interstitial brachytherapy: correlation of magnetic resonance imaging and histopathology. Neurosurgery. 1992 Aug; 31(2):336-43. View in: PubMed

A PACS-based interactive teaching module for radiologic sciences. AJR Am J Roentgenol. 1992 Jul; 159(1):199-205. View in: PubMed

Anatomical relationships of the cochlear nuclei and the pontobulbar body: possible significance for neuroprosthesis placement. Laryngoscope. 1987 Sep; 97(9):1009-11. View in: PubMed

Computer-aided three-dimensional reconstruction of the cochlear nerve root. Arch Otolaryngol Head Neck Surg. 1987 Jun; 113(6):651-5. View in: PubMed

Fractures of the upper-third of the tibial shaft. Int Surg. 1983 Jul-Sep; 68(3):267-70. View in: PubMed

Drop metastasis from sinonasal undifferentiated carcinoma: clinical implications. Spine (Phila Pa 1976). 2001 Jul 01; 26(13):1486-91. View in: PubMed

Drop metastasis from sinonasal undifferentiated carcinoma: clinical implications. Spine (Phila Pa 1976). 2001 Jul 1; 26(13):1486-91. View in: PubMed

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