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Uttam Kumar Sinha, MD
Associate Professor of Otolaryngology Head and Neck Surgery
Watt Family Endowed Chair For Head and Neck Cancers
Head and Neck Cancer Clinical Services Program Coordinator
CHP 204M 1540 Alcazar Street Off Campus Los Angeles
+1 323 226 7315


Dr. Uttam K. Sinha graduated with distinction from the Calcutta University, India in 1985. He was invited by the House Ear Institute and University of Southern California where he started his research career in molecular biology of neuroscience and cancer. He then finished residency in Otolaryngology-Head and Neck Surgery at USC. He continued to peruse academic career and completed a clinical fellowship in Microvascular and Plastic and Reconstructive Surgery in Mount Sinai Hospital, New York. He then went to Leon, France to complete a clinical fellowship in laryngology. Subsequently, he joined the faculty of the Department of Otolaryngology-Head and Neck Surgery at USC. Because of his academic achievements, leadership, teaching and research, he became Chief and Residency Program Director for the department. His major areas of research are head and neck cancer, thyroid cancer, plastic and reconstructive surgery, trauma, and speech and swallowing. By using nanotechnology, Dr. Sinha and his team are able to detect cancer cell in the saliva and serum. He is also studying the mechanism of metastasis. Dysphagia (difficulty in swallowing) is a common symptom following head and neck cancer therapy. Dr. Sinha and his team introduced a novel treatment called neuromuscular electrical stimulation (NMES) for rehabilitation of swallowing using a new “platform” technology called BION. He received multiple federal and foundation grants. His dedication to patient care and research made him world authority in head and neck diseases. To further the research endeavors, Dr. Sinha has established collaboration with multiple national and international institutes from England, France, India, China and Mexico. Three years ago Dr. Sinha launched a Patient Survivorship Program (http://hncsupport.org). The Support Group is actively involved in patient education and promoting awareness about head and neck cancer.


Alpha Omega Alpha (Gamma Chapter) as an Outstanding Resident

House Ear Institute: Rupley Fellowship, 1986

Calcutta University: Gold Medal for highest marks in General Surgery, 1977

Calcutta University: Annual Scholarship for Academic Merit, 1977

Government of India: National Scholarship for Academic Merit, 1973


Low GM, Thylur DS, N Yamamoto V, Sinha UK. The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma. Oral Oncol. 2016 Oct; 61:27-30. View in: PubMed

Peng G, Masood K, Gantz O, Sinha U. Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-?1/MyoD homeostasis in head and neck cancer. J Surg Oncol. 2016 Jul; 114(1):27-31. View in: PubMed

Thylur DS, Villegas BC, Fisher LM, Sinha UK, Kokot N. Device Life of Two Generations of Provox Voice Prostheses. Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):501-7. View in: PubMed

Ouyoung LM, Swanson MS, Villegas BC, Damodar D, Kokot N, Sinha UK. ABCLOVE: Voice therapy outcomes for patients with head and neck cancer. Head Neck. 2016 Apr; 38 Suppl 1:E1810-3. View in: PubMed

Swanson MS, Kokot N, Sinha UK. The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers (Basel). 2016; 8(2). View in: PubMed

Swanson MS, Hudson RL, Bhandari N, Sinha UK, Maceri DR, Kokot N. Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2015 Aug 1; 141(8):723-7. View in: PubMed

Swanson MS, Sinha UK. Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer—review of current data. Oral Oncol. 2015 Jan; 51(1):12-5. View in: PubMed

Zhang H, Boddupally K, Kandyba E, Kobielak K, Chen Y, Zu S, Krishnan R, Sinha U, Kobielak A. Defining the localization and molecular characteristic of minor salivary gland label-retaining cells. Stem Cells. 2014 Aug; 32(8):2267-77. View in: PubMed

Mazhar K, Gunawardana M, Webster P, Hochstim C, Koempel J, Kokot N, Sinha U, Rice D, Baum M. Bacterial biofilms and increased bacterial counts are associated with airway stenosis. Otolaryngol Head Neck Surg. 2014 May; 150(5):834-40. View in: PubMed

Kokot N, Mazhar K, Reder LS, Peng GL, Sinha UK. Use of the supraclavicular artery island flap for reconstruction of cervicofacial defects. Otolaryngol Head Neck Surg. 2014 Feb; 150(2):222-8. View in: PubMed

Swanson MS, Sinha UK. Diagnosis and management of merkel cell carcinoma of the head and neck: current trends and controversies. Cancers (Basel). 2014; 6(3):1256-66. View in: PubMed

Zu Y, Narayanan SS, Kim YC, Nayak K, Bronson-Lowe C, Villegas B, Ouyoung M, Sinha UK. Evaluation of swallow function after tongue cancer treatment using real-time magnetic resonance imaging: a pilot study. JAMA Otolaryngol Head Neck Surg. 2013 Dec 1; 139(12):1312-9. View in: PubMed

Kokot N, Mazhar K, Reder LS, Peng GL, Sinha UK. The supraclavicular artery island flap in head and neck reconstruction: applications and limitations. JAMA Otolaryngol Head Neck Surg. 2013 Nov 1; 139(11):1247-55. View in: PubMed

Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, Gutkind JS. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. View in: PubMed

Cervenka B, Villegas B, Sinha U. Solitary fibrous tumor of the postcricoid region: a case report and literature review. Case Rep Otolaryngol. 2013; 2013:908327. View in: PubMed

Reinstadler DR, Sinha UK. Uncommon cutaneous neoplasms of the head and neck. Facial Plast Surg Clin North Am. 2012 Nov; 20(4):483-91. View in: PubMed

Cao C, Chen Y, Masood R, Sinha UK, Kobielak A. a-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis. Mol Cancer Res. 2012 Jul; 10(7):892-903. View in: PubMed

Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. View in: PubMed

Masood R, Roy I, Zu S, Hochstim C, Yong KT, Law WC, Ding H, Sinha UK, Prasad PN. Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer. Integr Biol (Camb). 2012 Feb 1; 4(2):132-41. View in: PubMed

Yavrouian EJ, Sinha UK. Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma. ISRN Surg. 2012; 2012:715743. View in: PubMed

Russell SM, Lechner MG, Gong L, Megiel C, Liebertz DJ, Masood R, Correa AJ, Han J, Puri RK, Sinha UK, Epstein AL. USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011 Sep; 47(9):810-7. View in: PubMed

O'Dell K, Sinha U. Osteoradionecrosis. Oral Maxillofac Surg Clin North Am. 2011 Aug; 23(3):455-64. View in: PubMed

Korostoff A, Reder L, Masood R, Sinha UK. The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. Oral Oncol. 2011 Apr; 47(4):282-7. View in: PubMed

Sinha UK, Schorn VJ, Hochstim C, Chinn SB, Zhu S, Masood R. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck. 2011 Feb; 33(2):178-88. View in: PubMed

Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 1; 109(4):818-27. View in: PubMed

Liebertz DJ, Lechner MG, Masood R, Sinha UK, Han J, Puri RK, Correa AJ, Epstein AL. Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2010; 2:5. View in: PubMed

Goodman M, Liu L, Ward K, Zhang J, Almon L, Su G, Berglund L, Chen A, Sinha UK, Young JL. Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. Cancer. 2009 Sep 1; 115(17):4010-20. View in: PubMed

Verma SP, Sinha UK. Use of an oral sensory feedback device in the management of jaw-opening dystonia. Otolaryngol Head Neck Surg. 2009 Jul; 141(1):142-3. View in: PubMed

Yavrouian EJ, Sinha UK, Rice DH, Salam MT, Gill PS, Masood R. The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. View in: PubMed

Zazzali JL, Marshall GN, Shetty V, Yamashita DD, Sinha UK, Rayburn NR. Provider perceptions of patient psychosocial needs after orofacial injury. J Oral Maxillofac Surg. 2007 Aug; 65(8):1584-9. View in: PubMed

Sinha UK, Mazhar K, Chinn SB, Dhillon VK, Liu L, Masood R, Rice DH, Gill PS. The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. View in: PubMed

Masood R, Kumar SR, Sinha UK, Crowe DL, Krasnoperov V, Reddy RK, Zozulya S, Singh J, Xia G, Broek D, Schönthal AH, Gill PS. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. Int J Cancer. 2006 Sep 15; 119(6):1236-48. View in: PubMed

Young PA, Sinha U, Rice DH, Stucker F. Circles of prominence: a new theory on facial aesthetics. Arch Facial Plast Surg. 2006 Jul-Aug; 8(4):263-7. View in: PubMed

Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT. Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 2006 Apr 10; 24(11):1754-60. View in: PubMed

Crowe DL, Sinha UK. p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines. Head Neck. 2006 Jan; 28(1):15-23. View in: PubMed

Bumm K, Grizzi F, Franceschini B, Koch M, Iro H, Wurm J, Ceva-Grimaldi G, Dimmler A, Cobos E, Dioguardi N, Sinha UK, Kast WM, Chiriva-Internati M. Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma. Hum Pathol. 2005 Dec; 36(12):1289-93. View in: PubMed

Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. View in: PubMed

St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, Jordan R, Wolinsky L, Park NH, Liu H, Abemayor E, Wong DT. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. View in: PubMed

Sinha UK, Young P, Hurvitz K, Crockett DM. Functional outcomes following palatal reconstruction with a folded radial forearm free flap. Ear Nose Throat J. 2004 Jan; 83(1):45-8. View in: PubMed

Sinha UK, Kundra A, Scalia P, Smith DL, Parsa B, Masood R, Gill PS. Expression of EphB4 in head and neck squamous cell carcinoma. Ear Nose Throat J. 2003 Nov; 82(11):866, 869-70, 887. View in: PubMed

Sinha UK, Rhee J, Alcaraz N, Urken ML. Pressure-Specifying Sensory Device: quantitative sensory measurement in the oral cavity and oropharynx of normal adults. Ear Nose Throat J. 2003 Sep; 82(9):682-4, 687-90. View in: PubMed

Nguyen DC, Parsa B, Close A, Magnusson B, Crowe DL, Sinha UK. Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas. Int J Oncol. 2003 Jun; 22(6):1285-90. View in: PubMed

Sinha UK, Gallagher LA. Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa. Laryngoscope. 2003 Feb; 113(2):228-36. View in: PubMed

Sinha UK, Saadat D, Doherty CM, Rice DH. Use of AlloDerm implant to prevent frey syndrome after parotidectomy. Arch Facial Plast Surg. 2003 Jan-Feb; 5(1):109-12. View in: PubMed

Sinha UK, Johnson TE, Crockett D, Vadapalli S, Gruen P. Three-layer reconstruction for large defects of the anterior skull base. Laryngoscope. 2002 Mar; 112(3):424-7. View in: PubMed

Sinha UK, Shih C, Chang K, Rice DH. Use of AlloDerm for coverage of radial forearm free flap donor site. Laryngoscope. 2002 Feb; 112(2):230-4. View in: PubMed

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