Dr. Natarajan's major areas of research interest include cancer biology, functional genomic screens, drug discovery, biologics development and targeted therapy. His current research involves performing a functional genetic screen, combining bar-coded lentiviral shRNA library with HT-sequencing to identify modulators of TLR5 signaling. This study identified several candidates which differentially affect NF-kB activation by IL1, TNF and flagellin.
Dr. Natarajan earned his Masters in Biotechnology at The Indian Institute of Technology. He then went on to complete his PhD in Bioechemistry, followed by three research fellowships; the first at The Weizmann Institute of Science, the second at Harvard Medical School, and the third at The Council of Scientific and Industrial Research.
India: National Merit Scholarship, 1989-1992
India: National Scholarship from Department of Biotechnology, 1992-1994
Natarajan V, Komarov AP, Ippolito T, Bonneau K, Chenchik AA, Gudkov AV. Peptides genetically selected for NF-?B activation cooperate with oncogene Ras and model carcinogenic role of inflammation. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):E474-83. View in: PubMed
Mannava S, Moparthy KC, Wheeler LJ, Natarajan V, Zucker SN, Fink EE, Im M, Flanagan S, Burhans WC, Zeitouni NC, Shewach DS, Mathews CK, Nikiforov MA. Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence. Am J Pathol. 2013 Jan; 182(1):142-51. View in: PubMed
Berman AE, Leontieva OV, Natarajan V, McCubrey JA, Demidenko ZN, Nikiforov MA. Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget. 2012 Dec; 3(12):1522-32. View in: PubMed
Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13314-8. View in: PubMed
Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17; 335(6070):859-64. View in: PubMed
Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74. View in: PubMed
Kasher R, Gayer B, Kulik T, Somjen D, Venkatesh N, Fridkin M, Katchalski-Katzir E, Kohen F. Design, synthesis, and evaluation of peptides with estrogen-like activity. Biopolymers. 2004; 76(5):404-20. View in: PubMed
Im SH, Kim SH, Azam T, Venkatesh N, Dinarello CA, Fuchs S, Souroujon MC. Rat interleukin-18 binding protein: cloning, expression, and characterization. J Interferon Cytokine Res. 2002 Mar; 22(3):321-8. View in: PubMed
Venkatesh N, Zaltsman Y, Somjen D, Gayer B, Boopathi E, Kasher R, Kulik T, Katchalski-Katzir E, Kohen F. A synthetic peptide with estrogen-like activity derived from a phage-display peptide library. Peptides. 2002 Mar; 23(3):573-80. View in: PubMed