Faculty

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Wendy Gilmore, PhD
Associate Professor of Research Neurology
Neurology
MCH B-4 Health Sciences Campus Los Angeles
+1 323 442 1054

Overview

Dr. Gilmore completed her Ph.D. training in Veterinary Anatomy at Texas A&M University in 1982, specializing in unique interactions between the brain and the immune system that affect reproductive function. She was recruited to USC as a postdoctoral fellow in 1982 to study the effect of hormones and neuropeptides in models of multiple sclerosis, with a focus on measurements of clinical and pathological disease activities. She was appointed as Assistant Professor of Neurology in 1989 and subsequently promoted to Associate Professor of Neurology and Cell and Neurobiology.

In her early years as a faculty member, Dr. Gilmore expanded her research projects to include the study of the influence of hormones and pregnancy on immune function in patients with MS. Currently active research projects in her laboratory are focused on developing a better understanding of the balance between healthy and pathological immune mechanisms in MS, and how new and approved disease modifying drugs for MS alter this balance. In addition, new projects involve early stage testing of a new drug that has potential to promote neuroprotection and repair of neurological damage in MS.

Dr. Gilmore has received funding from the National Institutes of Health, the National Multiple Sclerosis Society, the Nancy Davis Foundation, the USC Zumberge Foundation and the USC Medical Faculty Women’s Association Research Fund. She is a member of several professional organizations, has served on review panels for the National Institutes of Health (NIH) and the National Multiple Sclerosis Society (NMSS) and is the Research Advocate on the Board of Trustees of the Southern California & Nevada Chapter of the NMSS.

Publications

Successive pregnancies in multiple sclerosis. Neurology. 2016 Jul 27. View in: PubMed

In vitro assessment of the direct effect of laquinimod on basic functions of human neural stem cells and oligodendrocyte progenitor cells. J Neurol Sci. 2014 Nov 15; 346(1-2):66-74. View in: PubMed

Assessment of changes in immune measures of multiple sclerosis patients treated with laquinimod. J Neuroimmunol. 2013 Oct 15; 263(1-2):108-15. View in: PubMed

The dual role of CXCL8 in human CNS stem cell function: Multipotent neural stem cell death and oligodendrocyte progenitor cell chemotaxis. Glia. 2011 Dec; 59(12):1864-78. View in: PubMed

17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss. Neurobiol Dis. 2010 Aug; 39(2):127-37. View in: PubMed

Cuprizone induces similar demyelination in male and female C57BL/6 mice and results in disruption of the estrous cycle. J Neurosci Res. 2010 Feb 1; 88(2):391-402. View in: PubMed

SJL mice exposed to cuprizone intoxication reveal strain and gender pattern differences in demyelination. Brain Pathol. 2009 Jul; 19(3):467-79. View in: PubMed

Vaccines for multiple sclerosis: progress to date. CNS Drugs. 2008; 22(3):175-98. View in: PubMed

Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion. J Leukoc Biol. 2007 May; 81(5):1205-12. View in: PubMed

The risk of relapses in multiple sclerosis during systemic infections. Neurology. 2006 Aug 22; 67(4):652-9. View in: PubMed

A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine. J Immunol. 2005 Nov 15; 175(10):6733-40. View in: PubMed

T cell expansion is regulated by activated Gr-1+ splenocytes. Cell Immunol. 2005 May; 235(1):39-45. View in: PubMed

Increased CXCL8 (IL-8) expression in Multiple Sclerosis. J Neuroimmunol. 2004 Oct; 155(1-2):161-71. View in: PubMed

Preliminary studies of cytokine secretion patterns associated with pregnancy in MS patients. J Neurol Sci. 2004 Sep 15; 224(1-2):69-76. View in: PubMed

Resistance to glucocorticoid-induced apoptosis in PLP peptide-specific T cell clones from patients with progressive MS. J Neuroimmunol. 2000 Sep 22; 109(2):197-210. View in: PubMed

Macrophage-derived nitric oxide inhibits the proliferation of activated T helper cells and is induced during antigenic stimulation of resting T cells. Cell Immunol. 2000 Jan 10; 199(1):43-9. View in: PubMed

Guillain-Barré syndrome, pregnancy, and the puerperium. Epidemiology. 1998 Nov; 9(6):588-90. View in: PubMed

Steroid hormone regulation of cytokine secretion by proteolipid protein-specific CD4+ T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol. 1998 Oct 1; 161(7):3365-74. View in: PubMed

Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol. 1997 Jan 1; 158(1):446-51. View in: PubMed

Defective post-thymic tolerance mechanisms during the chronic progressive stage of multiple sclerosis. Nat Med. 1996 Dec; 2(12):1354-60. View in: PubMed

Neuropathogenicity of mouse hepatitis virus JHM isolates differing in hemagglutinin-esterase protein expression. J Neurovirol. 1995 Dec; 1(5-6):330-9. View in: PubMed

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J Immunol. 1995 Mar 15; 154(6):2959-68. View in: PubMed

Effect of persistent mouse hepatitis virus infection on MHC class I expression in murine astrocytes. J Neurosci Res. 1995 Jan 1; 40(1):10-21. View in: PubMed

Coronavirus induction of class I major histocompatibility complex expression in murine astrocytes is virus strain specific. J Exp Med. 1994 Sep 1; 180(3):1013-23. View in: PubMed

Sequential infection of glial cells by the murine hepatitis virus JHM strain (MHV-4) leads to a characteristic distribution of demyelination. Lab Invest. 1992 Jun; 66(6):744-54. View in: PubMed

The enhancement of polyclonal T cell proliferation by beta-endorphin. Brain Res Bull. 1990 May; 24(5):687-92. View in: PubMed

The role of opioid peptides in immunomodulation. Ann N Y Acad Sci. 1990; 597:252-63. View in: PubMed

Evidence for a subpopulation of antigen-presenting cells specific for the induction of the delayed-type hypersensitivity response. Cell Immunol. 1989 Mar; 119(1):171-81. View in: PubMed

Antigenic assessment of coronaviruses isolated from patients with multiple sclerosis. Arch Neurol. 1988 Jun; 45(6):629-33. View in: PubMed

The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: evidence for G protein involvement in signal transduction. Cell Immunol. 1988 May; 113(2):235-50. View in: PubMed

Characterization of the structural proteins of the murine coronavirus strain A59 using monoclonal antibodies. Proc Soc Exp Biol Med. 1987 Jun; 185(2):177-86. View in: PubMed

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