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William DePaolo, PhD
Assistant Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
NRT 5503 1450 Biggy Street Health Sciences Campus Los Angeles
+1 323 442 7981


Okazaki S, Loupakis F, Stintzing S, Cao S, Zhang W, Yang D, Ning Y, Sunakawa Y, Stremitzer S, Matsusaka S, Berger MD, Parekh A, West JD, Miyamoto Y, Suenaga M, Schirripa M, Cremolini C, Falcone A, Heinemann V, DePaolo RW, Lenz HJ. Clinical significance of <i>TLR1</i> I602S polymorphism for patients with metastatic colorectal cancer treated with FOLFIRI plus bevacizumab. Mol Cancer Ther. 2016 May 11. View in: PubMed

Kamdar K, Khakpour S, Chen J, Leone V, Brulc J, Mangatu T, Antonopoulos DA, Chang EB, Kahn SA, Kirschner BS, Young G, DePaolo RW. Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease. Cell Host Microbe. 2016 Jan 13; 19(1):21-31. View in: PubMed

Nguyen V, Pearson K, Kim JH, Kamdar K, DePaolo RW. Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance. PLoS One. 2015; 10(3):e0118875. View in: PubMed

Sugiura Y, Kamdar K, Khakpour S, Young G, Karpus WJ, DePaolo RW. TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. Mucosal Immunol. 2013 Nov; 6(6):1101-9. View in: PubMed

Kamdar K, Nguyen V, DePaolo RW. Toll-like receptor signaling and regulation of intestinal immunity. Virulence. 2013 Apr 1; 4(3):207-12. View in: PubMed

Michail S, Bultron G, Depaolo RW. Genetic variants associated with Crohn's disease. Appl Clin Genet. 2013; 6:25-32. View in: PubMed

Depaolo RW, Kamdar K, Khakpour S, Sugiura Y, Wang W, Jabri B. A specific role for TLR1 in protective TH17 immunity during mucosal infection. J Exp Med. 2012 Jul 30; 209(8):1437-44. View in: PubMed

DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011 Mar 10; 471(7337):220-4. View in: PubMed

Depaolo RW, Tang F, Kim I, Han M, Levin N, Ciletti N, Lin A, Anderson D, Schneewind O, Jabri B. Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis. Cell Host Microbe. 2008 Oct 16; 4(4):350-61. View in: PubMed

DeBord KL, Anderson DM, Marketon MM, Overheim KA, DePaolo RW, Ciletti NA, Jabri B, Schneewind O. Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infect Immun. 2006 Aug; 74(8):4910-4. View in: PubMed

Marketon MM, DePaolo RW, DeBord KL, Jabri B, Schneewind O. Plague bacteria target immune cells during infection. Science. 2005 Sep 9; 309(5741):1739-41. View in: PubMed

Overheim KA, Depaolo RW, Debord KL, Morrin EM, Anderson DM, Green NM, Brubaker RR, Jabri B, Schneewind O. LcrV plague vaccine with altered immunomodulatory properties. Infect Immun. 2005 Aug; 73(8):5152-9. View in: PubMed

DePaolo RW, Rollins BJ, Kuziel W, Karpus WJ. CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance. J Immunol. 2003 Oct 1; 171(7):3560-7. View in: PubMed

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