Faculty

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Woojin An, PhD
Associate Professor of Biochemistry & Molecular Medicine
Medicine
NRT 6507 1450 Biggy Street Health Sciences Campus Los Angeles
+1 323 442 4398

Overview

Dr. An is Assistant Professor of Biochemistry and Molecular Biology at the USC Norris Comprehensive Cancer Center and the Keck School of Medicine. Through molecular modeling of genes, he is researching how malignant cells grow in an effort to find ways of slowing and halting the disease. He received his Ph.D. in biochemistry in 1998 from Oregon State University (Corvallis, OR) and did postdoctoral research until 2004 at The Rockefeller University (New York, NY), then joined the staff at USC. Besides his 2005 RCDA award from STOP CANCER, in 2006 Dr. An received a grant from the Margaret E. Early Medical Research Trust to fund his work on histones. In 2008 he received a grant from the National Institute of General Medical Sciences, also for his work on histones. And in 2009 the Department of Defense funded his inquiry into the regulation of estrogen receptor-mediated transcription.

Publications

A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 Aug 19; 291(34):17536-46. View in: PubMed

MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19. View in: PubMed

Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83. View in: PubMed

Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions. Sci Rep. 2015; 5:14558. View in: PubMed

Linker histone H1. 2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015; 5:16714. View in: PubMed

Linker Histone H1. 2 Cooperates with Cul4A and PAF1 to Drive H4K31 Ubiquitylation-Mediated Transactivation. Cell Rep. 2013 Dec 26; 5(6):1690-703. View in: PubMed

VprBP Has Intrinsic Kinase Activity Targeting Histone H2A and Represses Gene Transcription. Mol Cell. 2013 Nov 7; 52(3):459-67. View in: PubMed

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. Nucleic Acids Res. 2013 Sep; 41(16):7656-72. View in: PubMed

Biological implications and regulatory mechanisms of long-range chromosomal interactions. J Biol Chem. 2013 Aug 2; 288(31):22369-77. View in: PubMed

Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell. 2013 Jul 3; 13(1):36-47. View in: PubMed

Cell-penetrating H4 tail peptides potentiate p53-mediated transactivation via inhibition of G9a and HDAC1. Oncogene. 2013 May 16; 32(20):2510-20. View in: PubMed

The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells. Sci Rep. 2013; 3:1588. View in: PubMed

The histone variant MacroH2A regulates Ca(2+) influx through TRPC3 and TRPC6 channels. Oncogenesis. 2013; 2:e77. View in: PubMed

Gene dysregulation by histone variant H2A. Z in bladder cancer. Epigenetics Chromatin. 2013; 6(1):34. View in: PubMed

Functional interplay between p53 acetylation and H1. 2 phosphorylation in p53-regulated transcription. Oncogene. 2012 Sep 27; 31(39):4290-301. View in: PubMed

An essential role of variant histone h3. 3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012 Sep; 8(9):e1002938. View in: PubMed

p53 Requires an Intact C-Terminal Domain for DNA Binding and Transactivation. J Mol Biol. 2012 Feb 3; 415(5):843-54. View in: PubMed

Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail. Mol Cell Biol. 2012 Feb; 32(4):783-96. View in: PubMed

Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing. Nucleic Acids Res. 2011 Nov 1; 39(21):9167-80. View in: PubMed

Histone variant H3. 3 stimulates HSP70 transcription through cooperation with HP1? . Nucleic Acids Res. 2011 Oct; 39(19):8329-41. View in: PubMed

Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011; 18(12):1358-65. View in: PubMed

Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Res. 2011 Jan; 39(1):104-18. View in: PubMed

Cooperative action of TIP48 and TIP49 in H2A. Z exchange catalyzed by acetylation of nucleosomal H2A. Nucleic Acids Res. 2009 Oct; 37(18):5993-6007. View in: PubMed

Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription. J Biol Chem. 2009 Jul 24; 284(30):19867-77. View in: PubMed

30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol. 2008 Sep 12; 381(4):816-25. View in: PubMed

CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell. 2008 Aug 22; 31(4):510-9. View in: PubMed

FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008 Apr 11; 30(1):86-97. View in: PubMed

Isolation and characterization of a novel H1. 2 complex that acts as a repressor of p53-mediated transcription. J Biol Chem. 2008 Apr 4; 283(14):9113-26. View in: PubMed

Purification and characterization of cellular proteins associated with histone H4 tails. J Biol Chem. 2007 Jul 20; 282(29):21024-31. View in: PubMed

Isolation and characterization of proteins associated with histone H3 tails in vivo. J Biol Chem. 2007 May 25; 282(21):15476-83. View in: PubMed

Histone acetylation and methylation: combinatorial players for transcriptional regulation. Subcell Biochem. 2007; 41:351-69. View in: PubMed

Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol. 2006 Feb; 26(3):1156-64. View in: PubMed

SWI/SNF remodeling and p300-dependent transcription of histone variant H2ABbd nucleosomal arrays. EMBO J. 2004 Oct 1; 23(19):3815-24. View in: PubMed

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004 Jun 11; 117(6):735-48. View in: PubMed

Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol. 2004 Apr; 11(4):308-15. View in: PubMed

Reconstitution and transcriptional analysis of chromatin in vitro. Methods Enzymol. 2004; 377:460-74. View in: PubMed

mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell. 2003 Aug; 12(2):475-87. View in: PubMed

Direct association of p300 with unmodified H3 and H4 N termini modulates p300-dependent acetylation and transcription of nucleosomal templates. J Biol Chem. 2003 Jan 17; 278(3):1504-10. View in: PubMed

Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. Mol Cell. 2002 Apr; 9(4):811-21. View in: PubMed

SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem. 2002 Feb 15; 277(7):5498-505. View in: PubMed

Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300. Mol Cell. 2000 Sep; 6(3):551-61. View in: PubMed

The site of binding of linker histone to the nucleosome does not depend upon the amino termini of core histones. Biochimie. 1999 Jul; 81(7):727-32. View in: PubMed

The non-histone chromatin protein HMG1 protects linker DNA on the side opposite to that protected by linker histones. J Biol Chem. 1998 Oct 9; 273(41):26289-91. View in: PubMed

Linker histone protection of chromatosomes reconstituted on 5S rDNA from Xenopus borealis:a reinvestigation. Nucleic Acids Res. 1998 Sep 1; 26(17):4042-6. View in: PubMed

Linker histone protects linker DNA on only one side of the core particle and in a sequence-dependent manner. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3396-401. View in: PubMed

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