Back to Index
Zhang-Xu Liu, MD, PhD
Assistant Professor of Research Medicine
HMR 803 Health Sciences Campus Los Angeles
+1 323 442 3233


Dr. Liu's research interests include fucnation of liver NK and NKT cells, liver immunology and diseases, innate immunity in drug-induced hepatotoxicity, and immunity in alcoholic hepatitis. He is currently an Associate Editor of World Journal of Gastroenterology.

Dr. Liu earned his medical degree from Chongqing Medical University. He then went on to complete his master's degree at Sichuan University West China Medical School, followed by a PhD from Tohoku University School of Medicine.


Japanese Government (Mobusho): Fellowship, 1992-1997

Japanese Society of Gastroenterology: Award, 1997

American Digestive Health Foundation: Travel Award, 1999


Dara L, Liu ZX, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. View in: PubMed

Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. View in: PubMed

Wen SL, Gao JH, Yang WJ, Lu YY, Tong H, Huang ZY, Liu ZX, Tang CW. Celecoxib attenuates hepatic cirrhosis through inhibition of epithelial-to-mesenchymal transition of hepatocytes. J Gastroenterol Hepatol. 2014 Nov; 29(11):1932-42. View in: PubMed

Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. View in: PubMed

Gao JH, Wen SL, Yang WJ, Lu YY, Tong H, Huang ZY, Liu ZX, Tang CW. Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. PLoS One. 2013; 8(7):e69309. View in: PubMed

Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. View in: PubMed

Kaplowitz N, Shinohara M, Liu ZX, Han D. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. View in: PubMed

Liu ZX, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. View in: PubMed

Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. View in: PubMed

Liu ZX, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. View in: PubMed

Liu ZX, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. View in: PubMed

Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 2004 May; 126(5):1387-99. View in: PubMed

Arai K, Liu ZX, Lane T, Dennert G. IP-10 and Mig facilitate accumulation of T cells in the virus-infected liver. Cell Immunol. 2002 Sep; 219(1):48-56. View in: PubMed

Liu ZX, Kaplowitz N. Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. View in: PubMed

Liu ZX, Nishida H, He JW, Lai MM, Feng N, Dennert G. Hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity. J Virol. 2002 Feb; 76(3):990-7. View in: PubMed

Powered bySC CTSI