Faculty 2017-09-07T10:35:44+00:00

Faculty

Yang Chai, DMD, PhD, DDS

Professor and Associate Dean, Research and Director, Center For Craniofacial Molecular Biology

Biomedical Engineering
CSA 148
Health Sciences Campus
Los Angeles

+1 323 442 3480
ychai@usc.edu


Overview

Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

Publications

An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. Biosens Bioelectron. 2017 Dec 15; 98:317-324. View in: PubMed

Ultrahigh mobility and efficient charge injection in monolayer organic thin-film transistors on boron nitride. Sci Adv. 2017 Sep; 3(9):e1701186. View in: PubMed

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 Jul 15; 144(14):2560-2569. View in: PubMed

Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 Jun 20; 7(1):3876. View in: PubMed

Enhanced Photocatalytic Activity of WS2 Film by Laser Drilling to Produce Porous WS2/WO3 Heterostructure. Sci Rep. 2017 Jun 09; 7(1):3125. View in: PubMed

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 Jun 02. View in: PubMed

Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 Mar 01; 26(5):860-872. View in: PubMed

Cellular and molecular mechanisms of tooth root development. Development. 2017 Feb 01; 144(3):374-384. View in: PubMed

Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 Jan 09. View in: PubMed

The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression. Mediators Inflamm. 2017; 2017:4024672. View in: PubMed

Novel electrochemiluminescence of perylene derivative and its application to mercury ion detection based on a dual amplification strategy. Biosens Bioelectron. 2016 Dec 15; 86:720-7. View in: PubMed

Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury. Stem Cells Dev. 2016 Dec 01; 25(23):1801-1807. View in: PubMed

Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15; 143(22):4115-4126. View in: PubMed

Nonstoichiometric acid-base reaction as reliable synthetic route to highly stable CH3NH3PbI3 perovskite film. Nat Commun. 2016 Nov 15; 7:13503. View in: PubMed

Sutures possess strong regenerative capacity for calvarial bone injury. Stem Cells Dev. 2016 Oct 20. View in: PubMed

Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Sep 22. View in: PubMed

Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9. Genesis. 2016 Sep; 54(9):490-6. View in: PubMed

The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. View in: PubMed

Neuropilin-1highCD4?CD25? Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm. 2016; 2016:7132158. View in: PubMed

Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol. 2016; 7:67. View in: PubMed

Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep. 2015 Nov 18; 5:16725. View in: PubMed

Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01; 142(21):3734-45. View in: PubMed

Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 1; 142(21):3734-45. View in: PubMed

Stem Cells in Teeth and Craniofacial Bones. J Dent Res. 2015 Nov; 94(11):1495-501. View in: PubMed

An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 01; 142(19):3374-82. View in: PubMed

An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 1; 142(19):3374-82. View in: PubMed

BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell. 2015 Apr 20; 33(2):125-35. View in: PubMed

Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun. 2015 Apr 17; 459(4):706-12. View in: PubMed

Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15; 400(2):180-90. View in: PubMed

The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr; 17(4):386-96. View in: PubMed

Different requirements for Wnt signaling in tongue myogenic subpopulations. J Dent Res. 2015 Mar; 94(3):421-9. View in: PubMed

Enzyme-free electrochemical immunosensor based on host-guest nanonets catalyzing amplification for procalcitonin detection. ACS Appl Mater Interfaces. 2015 Feb 25; 7(7):4127-34. View in: PubMed

New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal Chem. 2015 Feb 03; 87(3):1669-75. View in: PubMed

New type of redox nanoprobe: c60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal Chem. 2015 Feb 3; 87(3):1669-75. View in: PubMed

A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015; 10(12):e0145018. View in: PubMed

Mandible and Tongue Development. Curr Top Dev Biol. 2015; 115:31-58. View in: PubMed

Preface. Curr Top Dev Biol. 2015; 115:xix-xxi. View in: PubMed

A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep; 42(9):637-44. View in: PubMed

ALK5-Mediated Transforming Growth Factor ß Signaling in Neural Crest Cells Controls Craniofacial Muscle Development via Tissue-Tissue Interactions. Mol Cell Biol. 2014 Aug 15; 34(16):3120-31. View in: PubMed

ALK5-mediated transforming growth factor ß signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol. 2014 Aug; 34(16):3120-31. View in: PubMed

Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. View in: PubMed

Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6; 14(2):160-73. View in: PubMed

TGFß regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb; 141(4):909-17. View in: PubMed

Development of highly polymorphic simple sequence repeat markers using genome-wide microsatellite variant analysis in Foxtail millet [Setaria italica (L. ) P. Beauv]. BMC Genomics. 2014 Jan 28; 15:78. View in: PubMed

Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal Chem. 2014 Jan 21; 86(2):1053-60. View in: PubMed

Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 01; 23(1):182-93. View in: PubMed

Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 1; 23(1):182-93. View in: PubMed

Development of highly polymorphic simple sequence repeat markers using genome-wide microsatellite variant analysis in Foxtail millet [Setaria italica (L. ) P. Beauv]. BMC Genomics. 2014; 15(1):78. View in: PubMed

Noncanonical transforming growth factor ß (TGFß) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11; 288(41):29760-70. View in: PubMed

Supersandwich-type electrochemiluminescenct aptasensor based on Ru(phen)3(2+) functionalized hollow gold nanoparticles as signal-amplifying tags. Biosens Bioelectron. 2013 Sep 15; 47:524-9. View in: PubMed

CTGF mediates Smad-dependent transforming growth factor ß signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013 Sep; 33(17):3482-93. View in: PubMed

A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet (Setaria italica). Nat Genet. 2013 Aug; 45(8):957-61. View in: PubMed

Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron. 2013 Jul 15; 45:189-94. View in: PubMed

Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12; 288(15):10440-50. View in: PubMed

Smad4-Irf6 genetic interaction and TGFß-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar; 140(6):1220-30. View in: PubMed

Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One. 2013; 8(4):e61653. View in: PubMed

Molecular regulatory mechanism of tooth root development. Int J Oral Sci. 2012 Dec; 4(4):177-81. View in: PubMed

Molecular and cellular regulatory mechanisms of tongue myogenesis. J Dent Res. 2012 Jun; 91(6):528-35. View in: PubMed

A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May; 139(9):1640-50. View in: PubMed

A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May; 40(5):433-6, 438-9. View in: PubMed

Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar 1; 122(3):873-85. View in: PubMed

Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar; 122(3):873-85. View in: PubMed

Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20; 287(4):2353-63. View in: PubMed

Novel electrochemical catalysis as signal amplified strategy for label-free detection of neuron-specific enolase. Biosens Bioelectron. 2012 Jan 15; 31(1):399-405. View in: PubMed

Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012; 16:60-70. View in: PubMed

The mechanism of TGF-ß signaling during palate development. Oral Dis. 2011 Nov; 17(8):733-44. View in: PubMed

Highly conducting gold nanoparticles-graphene nanohybrid films for ultrasensitive detection of carcinoembryonic antigen. Talanta. 2011 Jul 15; 85(1):130-5. View in: PubMed

The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. View in: PubMed

Glucose oxidase and ferrocene labels immobilized at Au/TiO2 nanocomposites with high load amount and activity for sensitive immunoelectrochemical measurement of ProGRP biomarker. Biosens Bioelectron. 2011 May 15; 26(9):3838-44. View in: PubMed

Alk5-mediated transforming growth factor ß signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol. 2011 May; 31(10):2079-89. View in: PubMed

SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May; 138(10):1977-89. View in: PubMed

Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May; 39(5):321-4. View in: PubMed

Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 01; 347(1):109-21. View in: PubMed

Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1; 347(1):109-21. View in: PubMed

Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov; 48(11):645-55. View in: PubMed

Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov; 28(11):2027-40. View in: PubMed

Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2010 May; 25(5):1167-78. View in: PubMed

TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010 May 1; 341(1):186-95. View in: PubMed

TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010 May 01; 341(1):186-95. View in: PubMed

Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15; 184(8):4295-306. View in: PubMed

Towards a molecular understanding of cleft palate. Beijing Da Xue Xue Bao. 2010 Feb 18; 42(1):9-13. View in: PubMed

Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem. 2010 Feb 12; 285(7):4975-82. View in: PubMed

TGF-ß signalling and tooth development. Chin J Dent Res. 2010; 13(1):7-15. View in: PubMed

Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec; 136(24):4225-33. View in: PubMed

Fate of HERS during tooth root development. Dev Biol. 2009 Oct 01; 334(1):22-30. View in: PubMed

Fate of HERS during tooth root development. Dev Biol. 2009 Oct 1; 334(1):22-30. View in: PubMed

Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):343-50. View in: PubMed

Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability. BMC Plant Biol. 2009 May 29; 9:63. View in: PubMed

Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. Stem Cells. 2009 Apr; 27(4):866-77. View in: PubMed

Emerging opportunities for the next generation of dental implants? Dent Today. Emerging opportunities for the next generation of dental implants? Dent Today. 2009 Mar; 28(3):98-9. View in: PubMed

Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27; 323(5918):1232-4. View in: PubMed

Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS One. 2009; 4(5):e5438. View in: PubMed

Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability. BMC Plant Biol. 2009; 9:63. View in: PubMed

TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol. 2008 Sep 15; 321(2):303-9. View in: PubMed

Fabrication of an iodide-selective electrode based on phthalocyaninatotitanium(IV) oxide and the selective determination of iodide in actual samples. Anal Bioanal Chem. 2008 Sep; 392(1-2):297-303. View in: PubMed

Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008 Aug 22; 283(34):23139-49. View in: PubMed

Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2. 1 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. View in: PubMed

Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell. 2008 Aug; 15(2):322-9. View in: PubMed

TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 01; 320(1):19-29. View in: PubMed

TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 1; 320(1):19-29. View in: PubMed

The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn. 2008 Jun; 237(6):1604-13. View in: PubMed

Epithelial fibroblast growth factor receptor 1 regulates enamel formation. J Dent Res. 2008 Mar; 87(3):238-43. View in: PubMed

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008 Jan 30; 3(1):e1516. View in: PubMed

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008; 3(1):e1516. View in: PubMed

Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 01; 312(1):435-47. View in: PubMed

Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1; 312(1):435-47. View in: PubMed

TGF-beta signaling and aplasia cutis congenita: proposed animal model. J Calif Dent Assoc. 2007 Dec; 35(12):865-9. View in: PubMed

TGF-beta mediated Msx2 expression controls occipital somites-derived caudal region of skull development. Dev Biol. 2007 Oct 1; 310(1):140-53. View in: PubMed

TGF-beta mediated Msx2 expression controls occipital somites-derived caudal region of skull development. Dev Biol. 2007 Oct 01; 310(1):140-53. View in: PubMed

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct; 124(9-10):729-45. View in: PubMed

Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn. 2007 Aug; 236(8):2245-57. View in: PubMed

Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev. 2007 Jul; 124(6):409-15. View in: PubMed

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007 May 01; 305(1):90-102. View in: PubMed

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007 May 1; 305(1):90-102. View in: PubMed

The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 01; 303(1):391-404. View in: PubMed

The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 1; 303(1):391-404. View in: PubMed

Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev Biol. 2006 Sep 01; 297(1):238-48. View in: PubMed

Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev Biol. 2006 Sep 1; 297(1):238-48. View in: PubMed

Recent advances in craniofacial morphogenesis. Dev Dyn. 2006 Sep; 235(9):2353-75. View in: PubMed

Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol. 2006 Aug 15; 296(2):298-314. View in: PubMed

An in vitro model for characterizing the post-migratory cranial neural crest cells of the first branchial arch. Dev Dyn. 2006 May; 235(5):1433-40. View in: PubMed

Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 2006 Jan 15; 289(2):420-9. View in: PubMed

TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006 Jan; 133(2):371-81. View in: PubMed

Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. J Invest Dermatol. 2005 Dec; 125(6):1302-9. View in: PubMed

Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov; 132(22):4937-50. View in: PubMed

Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev. 2005 Sep-Oct; 7(5):440-57. View in: PubMed

LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol. 2005 Feb 01; 278(1):130-43. View in: PubMed

Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol. 2005 Feb 01; 278(1):193-202. View in: PubMed

LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol. 2005 Feb 1; 278(1):130-43. View in: PubMed

Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol. 2005 Feb 1; 278(1):193-202. View in: PubMed

A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 2005 Jan; 3(1):e11. View in: PubMed

PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis. Dev Dyn. 2005 Jan; 232(1):75-84. View in: PubMed

Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development. 2003 Nov; 130(21):5269-80. View in: PubMed

Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 01; 261(1):183-96. View in: PubMed

Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 1; 261(1):183-96. View in: PubMed

TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn. 2003 Jul; 227(3):387-94. View in: PubMed

Prospects for tooth regeneration in the 21st century: a perspective. Microsc Res Tech. 2003 Apr 01; 60(5):469-79. View in: PubMed

Timing of odontogenic neural crest cell migration and tooth-forming capability in mice. Dev Dyn. 2003 Apr; 226(4):713-8. View in: PubMed

Prospects for tooth regeneration in the 21st century: a perspective. Microsc Res Tech. 2003 Apr 1; 60(5):469-79. View in: PubMed

Developmental expression of Smad1-7 suggests critical function of TGF-beta/BMP signaling in regulating epithelial-mesenchymal interaction during tooth morphogenesis. Int J Dev Biol. 2003 Feb; 47(1):31-9. View in: PubMed

TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells. Crit Rev Oral Biol Med. 2003; 14(2):78-88. View in: PubMed

Developmental patterning of the circumvallate papilla. Int J Dev Biol. 2002 Aug; 46(5):755-63. View in: PubMed

Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development. Dev Dyn. 2002 May; 224(1):69-78. View in: PubMed

Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002; 170(2-3):83-98. View in: PubMed

Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem. 2001 Nov 23; 276(47):44163-72. View in: PubMed

Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev Biol. 2001 Aug 01; 236(1):181-94. View in: PubMed

Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev Biol. 2001 Aug 1; 236(1):181-94. View in: PubMed

Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet. 2000 May; 25(1):110-4. View in: PubMed

Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis. Mech Dev. 2000 May; 93(1-2):71-81. View in: PubMed

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 2000 Apr; 127(8):1671-9. View in: PubMed

Nerve growth factor (NGF) supports tooth morphogenesis in mouse first branchial arch explants. Dev Dyn. 1999 Nov; 216(3):299-310. View in: PubMed

Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants. Mech Dev. 1999 Aug; 86(1-2):63-74. View in: PubMed

PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro. Dev Dyn. 1998 Dec; 213(4):500-11. View in: PubMed

A mouse mandibular culture model permits the study of neural crest cell migration and tooth development. Int J Dev Biol. 1998 Jan; 42(1):87-94. View in: PubMed

Problem-based learning at the University of Southern California School of Dentistry. J Dent Educ. 1997 May; 61(5):417-25. View in: PubMed

Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo. Dev Dyn. 1997 Apr; 208(4):526-35. View in: PubMed

Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Dev Biol. 1994 Mar; 162(1):85-103. View in: PubMed

Parenchymal cell proliferation and mechanisms for maintenance of granular duct and acinar cell populations in adult male mouse submandibular gland. Anat Rec. 1993 Mar; 235(3):475-85. View in: PubMed

Proliferative and structural differences between male and female mouse submandibular glands. Anat Rec. 1993 Feb; 235(2):303-11. View in: PubMed

DNA synthesis and development strategies with possible consequences on sexual dimorphism in adult mouse submandibular glands. Crit Rev Oral Biol Med. 1993; 4(3-4):511-6. View in: PubMed

Gene expression, signal transduction and tissue-specific biomineralization during mammalian tooth development. Crit Rev Eukaryot Gene Expr. 1992; 2(4):315-29. View in: PubMed

Three-dimensional localization of DNA synthesis in secretory elements of adult female mouse submandibular gland. Adv Dent Res. 1990 Jun; 4:34-44. View in: PubMed

Three-dimensional reconstruction of adult female mouse submandibular gland secretory structures. Anat Rec. 1990 Apr; 226(4):489-500. View in: PubMed

Appearance of acinar-cell-specific mucin in prenatal mouse submandibular glands. Differentiation. 1989 May; 40(2):93-8. View in: PubMed

Three-dimensional movement analysis of lateral pterygoid electromyographic activity during mastication in the rat. Arch Oral Biol. 1988; 33(9):635-40. View in: PubMed

Awards

NIDCR, NIH: Chair of the Board of Scientific Counselors, 2013

Craniofacial Biology Research Award: IADR Distinguished Scientist Award, 2011

Journal of Bone and Mineral Research: Editorial Board, 2010-2014

American Association for the Advancement of Sciences (AAAS) Elected Fellow

NIH: NIH MERIT Award, 2010

NIDCR, NIH: Member of the Board of Scientific Counselors, 2008-2012

JBMR: Editorial Board DEVELOPMENTAL BIOLOGY, 2007-2014

University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 2007

The Chinese Journal of Dental Research: Editorial Board, 2006-2014

Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration

Regular member of SBDD study section CSR NIH

Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration

NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK

University of Southern California: Award of Excellence in Teaching, 2001-2003

University of Southern California: Annual Excellence in Teaching Award, 1997

University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 1997

Special Recognition by the Dean for outstanding service and contribution to the University of Southe

OKU Scholarship award for outstanding academic performance

University of Southern California, School of Dentistry: Annual Teaching Award, 1995

University of Southern California, (GPA 4.0): PHI KAPPA PHI, All-University Honor Society, 1991

University of Southern California: Certificate for Outstanding Academic Achievement, 1990