{"id":57,"date":"2024-03-27T14:44:01","date_gmt":"2024-03-27T21:44:01","guid":{"rendered":"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/?page_id=57"},"modified":"2024-04-24T16:08:28","modified_gmt":"2024-04-24T23:08:28","slug":"pilot-projects","status":"publish","type":"page","link":"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/sample-page\/pilot-projects\/","title":{"rendered":"Pilot Projects"},"content":{"rendered":"\n\n\n\n\n  \n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--hero-primary horizontal-navigation\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--hero-primary\"\n    \n      >\n\n    \n  \n  <div class=\"inner-wrapper has-horizontal-nav\">\n\n          <div class=\"title-wrapper\">\n\n                  <div class=\"eyebrow-container\">\n                              \n<div class=\"f--field f--eyebrow\">\n\n    \n  <a href=\"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/\"  aria-label=\"Read more about Southern California Research Center for ALPD and Cirrhosis\">Southern California Research Center for ALPD and Cirrhosis<\/a>\n\n\n\n<\/div>\n                      <\/div>\n        \n                      \n<div class=\"f--field f--page-title has-stripe\">\n\n    \n  <h1>Pilot Projects<\/h1>\n\n\n<\/div>\n        \n              <\/div>\n    \n              \n<div class=\"f--field f--link eyebrow-link\">\n\n    \n    \n  \n<a\n  class=\"link \"\n  href=\"https:\/\/www.keckmedicine.org\/find-a-doctor\/\"\n  target=\"_blank\"  aria-label=\"Read&#x20;more&#x20;about&#x20;Are&#x20;You&#x20;a&#x20;Patient&#x3F;\">\n        Are You a Patient?\n    <\/a>\n\n\n<\/div>\n    \n    \n      \n              <div class=\"horizontal-nav\">\n                      <div class=\"horizontal-menu-container\">\n              <button class=\"expand-menu\">\n                                  In This Section\n                                <svg class=\"menu\" version=\"1.1\" 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aria-label=\"Display Submenu for Education\">\n        <svg height=\"35\" viewBox=\"0 0 35 35\" width=\"35\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n          <path d=\"m17.5 20.2142857 6.2142857-6.2142857 1.2857143 1.2857143-7.5 7.5-7.5-7.5 1.2857143-1.2857143z\" fill=\"#000\" fill-rule=\"evenodd\"\/>\n        <\/svg>\n      <\/button>\n    <\/div>\n  \n      <div class=\"submenus-wrapper\">\n      <div class=\"submenus-wrapper-inner\">\n        <ul class=\"submenu\" aria-hidden=\"true\">\n                      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-52\">\n      <a href=\"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/education\/information-for-the-public\/\" >Information for the Public<\/a>\n  \n  \n<\/li>\n                  <\/ul>\n      <\/div>\n    <\/div>\n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-23\">\n      <a href=\"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/news-publications\/\" >News &#038; Publications<\/a>\n  \n  \n<\/li>\n\n    \n      <li class=\" menu-item menu-item-type-post_type menu-item-object-page menu-item-24\">\n      <a href=\"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/support-us\/\" >Support Us<\/a>\n  \n  \n<\/li>\n\n    \n      <\/ul><!-- m--menu -->\n<\/nav>\n\n            <\/div>\n                  <\/div>\n        <\/div>\n\n\n  <\/div><\/div>\n\n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <h1 style=\"text-align: center;\">Pilot Projects<\/h1>\n<p>The Center plans to fund pilot projects for the 2024 grant year, each with direct cost support of $35,000 plus chargeback-free services from the Animal Core and Morphology Core (worth up to $7k). This funding will be supported in part by the matching cost-share of Keck School of Medicine at USC. The project period is from January 1 to December 31, with opportunity for renewal application.<\/p>\n<p>If you are interested in applying for pilot project funding,\u00a0please click on <a href=\"https:\/\/keck.usc.edu\/alpd-and-cirrhosis-research-center\/sample-page\/how-to-apply\/\">how to apply<\/a>.<\/p>\n<p>Please direct questions to <strong>Dr. Hidekazu Tsukamoto<\/strong> at <a href=\"mailto:htsukamo@med.usc.edu\" target=\"_blank\" rel=\"noopener\">htsukamo@med.usc.edu<\/a><\/p>\n<hr \/>\n<p style=\"text-align: center;\"><strong>Applications for 2024 are now CLOSED<\/strong><\/p>\n<p>If you would like more information for the 2025 funding cycle, please Please contact James Lee at <a href=\"mailto:James.Lee3@med.usc.edu\">James.Lee3@med.usc.edu<\/a> for any inquiries.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n\n\n\n    \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--stacking-cards \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--stacking-cards\"\n    \n      >\n\n    \n  <div class=\"outer-wrapper\">\n    <div class=\"inner-wrapper\">\n            <div class=\"header-container\">\n                      \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          The following 5 pilot projects were funded in 2023\n      <\/h2>\n\n\n<\/div>\n        \n              <\/div>\n      \n                <div class=\"cards-container\">\n              \n                  <div class=\"card\">\n\n                      <div class=\"title-description\">\n\n                          \n                                                            \n<div class=\"f--field f--description\">\n\n    \n  <p><strong>Cynthia Hsu, M.D. (UCSD)<br \/>\n<\/strong>\u201cEffect of gut microbial ethanol production on alcohol use disorder and AALD\u201d<\/p>\n<p><strong>Brian P. Lee, M.D. (USC)<br \/>\n<\/strong>\u201cAlcohol-Associated Hepatitis Bridge Clinic (ABC) at a Safety-Net Hospital\u201d<\/p>\n<p><strong>Raquel Weber, Ph.D. (UCSD)<br \/>\n<\/strong>\u201cThe role of Act1 in the pathogenesis of AALD\u201d<\/p>\n<p><strong>Zhiping\u00a0Lu, Ph.D. (USC)<br \/>\n<\/strong>\u201cThe role of a snoRNA-tRNA network in alcoholic liver diseases\u201d<\/p>\n<p><strong>Stanley Ng, Ph.D. (UCI)<br \/>\n<\/strong>\u201cMulti-omic profiling of individual liver tissue clones in both alcoholic and non-alcoholic steatohepatitis\u201d<\/p>\n\n\n\n<\/div>\n                          \n                      <\/div>\n\n\n                      \n                  <\/div>\n\n              \n          <\/div>\n      \n      \n    <\/div>\n\n  <\/div>\n\n\n\n\n\n  <\/div><\/div>\n\n\n\n\n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text white\"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <h2 style=\"text-align: center;\">How to Apply<\/h2>\n<p>The Center plans to fund pilot projects for the 2024 grant year, each with direct cost support of $35,000 plus chargeback-free services from the Animal Core and Morphology Core (worth up to $7k). This funding will be supported in part by the matching cost-share of Keck School of Medicine at USC. The project period is from January 1 to December 31, with opportunity for renewal application.<\/p>\n<p>Information on applications for 2024 has been announced. Please contact James Lee at James.Lee3@med.usc.edu for any inquiries.<\/p>\n<h2 style=\"text-align: center;\">Eligibility<\/h2>\n<ol>\n<li><b>Junior faculty investigators (or senior postdocs in transition to junior faculty) <\/b>without funding, who wish to develop independent research programs in the Center\u2019s priority areas: how alcohol and risk factors sensitize the liver and pancreas for diseases; basic or translational research on development of new therapeutic and preventive modalities for cirrhosis, liver or pancreatic cancer;<\/li>\n<li><b>Investigators from other fields<\/b>, who are interested in expanding research to alcoholic liver and pancreatic diseases (ALPD) and cirrhosis;<\/li>\n<li><b>Investigators who aim to develop new collaborative research <\/b>on common and comparative mechanisms in both ALPD or new system biology projects on crosstalk among liver, pancreas, intestine, adipose, and brain within the context of alcohol effects.<\/li>\n<\/ol>\n<h2 style=\"text-align: center;\">LOI Instructions<\/h2>\n<p>Include:<\/p>\n<ol>\n<li>Proposed project title<\/li>\n<li>Your eligibility (see above)<\/li>\n<li>Project\u2019s central hypothesis<\/li>\n<li>Brief description of specific aims<\/li>\n<\/ol>\n<p>E-mail LOI to:<\/p>\n<p><strong>Hide Tsukamoto, D.V.M., Ph.D., FAASLD:<\/strong><br \/>\n<em>Director<\/em><br \/>\nE-mail: <a href=\"mailto:htsukamo@med.usc.edu\"><u>htsukamo@med.usc.edu<\/u><\/a><\/p>\n<p>Southern California Research Center for Alcoholic Liver and Pancreatic Diseases<br \/>\n<strong>Keck School of Medicine of USC<\/strong><br \/>\n1333 San Pablo Street, MMR-402,<br \/>\nLos Angeles, CA 90033<\/p>\n<p>LOI submissions will be evaluated by the Pilot Project Committee. Applicants with approved LOIs are invited to submit a full proposal by October per application instructions to be e-mailed.<\/p>\n<p>Please direct questions to <b>Dr. <\/b><b>Hidekazu<\/b><b> Tsukamoto <\/b>at <a href=\"mailto:htsukamo@med.usc.edu\"><u>htsukamo@med.usc.edu<\/u><\/a>.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n\n\n\n\n\n\n                                                \n  \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--accordions \"\n\n  \n   aria-label=\"Content Accordions\"\n  \n  \n  \n  \n  >\n  <div class=\"c--component c--accordions\"\n    \n      >\n\n    \n      <div class=\"header-container\">\n\n                  \n<div class=\"f--field f--section-title\">\n\n    \n  <h2>\n          Past Recipients\n      <\/h2>\n\n\n<\/div>\n      \n      \n    <\/div>\n  \n      <ul>\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-1--USAd_WQ8m\" aria-controls=\"section-1-1--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2022<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-1--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-1--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><b>Arpan Patel, M.D., Ph.D. (UCLA)<br \/>\n<\/b>\u201cPatient Navigation for Hospitalized Patients with Alcohol-Associated Liver Diseases: A Feasibility Pilot Study\u201d<\/p>\n<p><b>Brian Lee, M.D. (USC)<br \/>\n<\/b>\u201cAssessing Feasibility to Conduct Clinical-Translational Research in an Alcohol-Associated Hepatitis Bridge Clinic (ABC) at a Safety-Net Hospital\u201d<\/p>\n<p><b>Ram <\/b><b>Subramanyan<\/b><b>, M.D., Ph.D. (USC)<br \/>\n<\/b>\u201cAlcohol Inhibits Notch Signaling during Fetal Heart Development by Disrupting Gamma secretase Activity\u201d<\/p>\n<p><b>Zhiping<\/b><b> Lu, Ph.D. (USC)<br \/>\n<\/b>\u201cThe role of a snoRNA-tRNA network in alcoholic liver diseases\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-2--USAd_WQ8m\" aria-controls=\"section-1-2--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2021<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-2--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-2--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><b>Cholsoon<\/b><b> Jang, Ph.D. (UCI)<br \/>\n<\/b>\u201cElucidating synergistic impact of fructose and alcohol on cirrhosis and hepatocellular carcinoma\u201d<\/p>\n<p><b>Ram <\/b><b>Subramanyan<\/b><b>, M.D., Ph.D. (USC)<br \/>\n<\/b>\u201cModerate Prenatal Alcohol Exposure Impacts Notch Signaling and Outflow Tract Maturation in the Developing Heart\u201d<\/p>\n<p><b>Zhaoyang<\/b><b> Fan, Ph.D. (USC)<br \/>\n<\/b>\u201cMultiparametric MR mapping in short-term management of alcoholic hepatitis\u201d<\/p>\n<p><b>Arpan Patel, M.D., Ph.D. (UCLA)<br \/>\n<\/b>\u201cPatient Navigation for Hospitalized Patients with Alcohol-Associated Liver Diseases: A Feasibility Pilot Study\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-3--USAd_WQ8m\" aria-controls=\"section-1-3--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2020<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-3--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-3--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Debanjan Dhar, Ph.D. (UCSD)<\/strong><br \/>\n\u201cSynergism of Mitochondrial Damage and NLRP3 Activation in Obesity and Alcohol-Facilitated HCC Development\u201d<\/p>\n<p><strong>Ana Cristina Llorente Izquierdo, Ph.D. (UCSD)<\/strong><br \/>\n\u201cIntestinal stem-cell proliferation and differentiation in alcoholic liver disease\u201d<\/p>\n<p><strong>Bangyan Stiles, Ph.D. (USC)<\/strong><br \/>\n\u201cInhibiting NR3B function in alcohol induced liver steatosis\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-4--USAd_WQ8m\" aria-controls=\"section-1-4--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2019<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-4--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-4--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Honit Piplani, Ph.D. (Cedars-Sinai)<\/strong><br \/>\n\u201cParkin-dependent mitophagy attenuates the severity of alcoholic pancreatitis\u201d<\/p>\n<p><strong>Ana Cristina Llorente Izquierdo, Ph.D. (UCSD)<\/strong><br \/>\n\u201cIntestinal stem-cell proliferation and differentiation in alcoholic liver disease\u201d<\/p>\n<p><strong>Marc Liesa-Roig, Ph.D. (UCLA)<\/strong><br \/>\n\u201cThe role of the heme-related antioxidant transporter ABCB10 in alcoholic liver disease\u201d<\/p>\n<p><strong>Natalia Shalbueva, Ph.D. (UCLA)<\/strong><br \/>\n\u201cMitochondrial fragmentation in pancreatitis\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-5--USAd_WQ8m\" aria-controls=\"section-1-5--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2018<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-5--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-5--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Ana Cristina Llorente Izquierdo, Ph.D. (UCSD)<\/strong><br \/>\n\u201cIntestinal stem-cell proliferation and differentiation in alcoholic liver disease\u201d<\/p>\n<p><strong>Honit Piplani, Ph.D.\u00a0(Cedars-Sinai Medical Center)<\/strong><br \/>\n\u201cParkin-dependent mitophagy attenuates the severity of alcoholic pancreatitis\u201d<\/p>\n<p><strong>Shabnam Shalapour, Ph.D. (UCSD)<\/strong><br \/>\n\u201cRole of IgA+ and CD8+ T cells in alcoholic steatohepatitis progression to cancer\u201d<\/p>\n<p><strong>Raymond Wu, Ph.D. (USC)<\/strong><br \/>\n\u201cFate tracing of CD133+ cells in alcoholic liver injury and cancer transformation\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-6--USAd_WQ8m\" aria-controls=\"section-1-6--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2017<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-6--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-6--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Kinji Asahina, Ph.D. (USC)<\/strong><br \/>\n\u201cIdentification and genesis of tumor-initiating stem cells-like cells in alcoholic-promoted PDAC\u201d<\/p>\n<p><strong>Shabnam Shalapour, Ph.D. (UCSD)<\/strong><br \/>\n\u201cInvolvement of fatty liver and fibrosis in the development of NASH\/ASH-induced HCC by inducing localized immunosuppression\u201d<\/p>\n<p><strong>Hsin-Yuan Su, Ph.D. (Cedars-Sinai Medical Center)<\/strong><br \/>\n\u201cPancreatic stellate cells play a dual role in chronic pancreatitis\u201d<\/p>\n<p><strong>Jun Xu, Ph.D. (UCSD)<\/strong><br \/>\n\u201cThe inflammatory liver-brain axis during chronic alcohol consumption\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-7--USAd_WQ8m\" aria-controls=\"section-1-7--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2016<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-7--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-7--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Selma Masri, Ph.D. (UCI)<\/strong><br \/>\n\u201cInvestigating the role of alcohol as a zeitgeber on the gut and liver circadian\u201d<\/p>\n<p><strong>Shabnam Shalapour, Ph.D. (UCSD)<\/strong><br \/>\n\u201cRole of IgA-producing plasmocytes in development of ASH, NASH and HCC\u201d<\/p>\n<p><strong>Jun Xu, Ph.D. (UCSD)<\/strong><br \/>\n\u201cIL-17 SIGNALING REGULATES ALCOHOL-RELATED CHANGES OF LIVER-BRAIN AXIS\u201d<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-8--USAd_WQ8m\" aria-controls=\"section-1-8--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2015<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-8--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-8--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Paolo Sassone-Corsi, Ph.D. (UCI)<\/strong><br \/>\n\u201cTranscriptional and Epigenetic Reprogramming of the Circadian Clock by Alcohol\u201d<\/p>\n<p><strong>Gen-Sheng Feng, Ph.D. (UCSD)<\/strong><br \/>\n\u201cDissecting Shp2-regulated signals in alcoholic liver disorders\u201d<br \/>\nThe long term goal of this project is to dissect and decipher the putative role in alcoholic liver diseases (ALD) of signaling molecules that are known to be involved in the molecular pathogenesis of non-alcoholic liver diseases (NALD) and liver cancer development.<\/p>\n<p><strong>Keane Lai, M.D. (USC)<\/strong><br \/>\n\u201cThe role of stearoyl-CoA desaturase in tumor-initiating stem-like cells\u201d<br \/>\nEmerging evidence identifies stearoyl-CoA desaturase (SCD) as a mediator of stemness in tumor-initiating stem-like cells (TICs). This research is directed to understanding the mechanism by which SCD induces stemness in hepatic TICs.<\/p>\n<p><strong>Karsten Zengler, Ph.D. (UCSD)<\/strong><br \/>\n\u201cThe role of the microbiome in alcoholic liver disease\u201d<br \/>\nTo determine the cause of dysbiosis and bacterial overgrowth and to identify gene products and metabolites from the gut microbiome that lead to alcoholic liver disease, we propose to study the effect of acetate on intestinal microorganisms. We will furthermore determine the transcriptional response of the microbiome to perturbation.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-9--USAd_WQ8m\" aria-controls=\"section-1-9--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2014<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-9--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-9--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Akiko Eguchi, Ph.D. (UCSD)<br \/>\n<\/strong>\u201cNovel biomarkers and therapeutic targets focusing on extracellular vesicles in alcoholic liver disease\u201d<br \/>\nWe recently revealed that damaged hepatocytes release extracellular vesicles (EVs) in vitro and in a Non-alcoholic steatohepatitis (NASH) murine model. We will research whether EVs are released from damaged hepatocytes during alcohol exposure. Furthermore, we will investigate whether EVs activate HSCs and Kupffer cells, resulting in the progression of ALD.<\/p>\n<p><strong>Keane Lai, M.D. (USC)<\/strong><br \/>\n&#8220;The role of stearoyl-CoA desaturase (SCD) in tumor-initiating stem-like cells (TICs) from alcohol-HCV induced HCC&#8221;<br \/>\nEmerging evidence identifies stearoyl-CoA desaturase (SCD) as a mediator of stemness in tumor-initiating stem-like cells (TICs).\u00a0We propose that SCD is induced by \u03b2-catenin and SCD activity is required for sustained activation of \u03b2-catenin in TICs.<\/p>\n<p><strong>Ramachandran Murali, Ph.D. (Cedars-Sinai Medical Center)<\/strong><br \/>\n\u201cDecoy receptors in alcohol and tobacco mediated pancreas pathology\u201d<br \/>\nThis proposal seeks to understand the role of decoy receptors in pancreatic cancer due to smoking and<br \/>\nchronic alcohol abuse. We hyothesize that the decoy receptors are tumor survival factors.\u00a0In this proposal, the expression of death\u00a0receptors and decoy receptors will be documented by immunohistochemisty (IHC) and western blot analysis;\u00a0pancreatic tissue of K-Ras mutant mouse model treated with and without smoking compound and alcohol,\u00a0and human pancreatic tissues will be utilized.<\/p>\n<p><strong>Karsten Zengler, Ph.D. (UCSD)<\/strong><br \/>\n\u201cThe role of the microbiome in alcoholic liver disease\u201d<br \/>\nAlcoholic liver disease is dependent on gut-derived bacterial products. It has been demonstrated that alcoholic liver disease is associated with changes in the intestinal microflora with both qualitative (dysbiosis) and quantitative (intestinal bacterial overgrowth) differences. We propose to reveal these key microorganisms and to determine factors that are responsible to initiate dysbiosis in an animal model.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-10--USAd_WQ8m\" aria-controls=\"section-1-10--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2013<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-10--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-10--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Akiko Eguchi, Ph.D. (UCSD)<br \/>\n<\/strong>\u201cBid-dependent mitochondrial dysfunction and cell death in alcoholic liver disease\u201d<br \/>\nWe will research whether Bid activation in hepatocyte essential for mitochondrial dysfunction, whether suppression of Bid protects against hepatic steatosis and liver damage in ALD and whether Bid inhibition will be an effective approach for treatment of steatohepatitis and fibrosis in ALD. Furthermore, we investigate the communication of cell death between parenchymal and non-parenchymal cells in ALD. These results will reveal the contribution of mitochondrial dysfuction in cell death and propose the new thepapuetic approach.<\/p>\n<p><strong>Douglas E. Feldman, Ph.D. (USC)<br \/>\n<\/strong>\u201cGenetic dissection of the mitochondrial UPR in liver tumor-initiating stem cells\u201d<br \/>\nEmerging evidence indicates that impaired mitochondrial function plays a key role in alcoholic liver disease, liver steatosis and onset of hepatocellular carcinoma. The experimental aims set forth in this proposal address the mechanisms underlying oncogenesis by alcohol-induced mitochondrial dysfunction. These aims are well aligned with the funding program&#8217;s long term goals of mechanisms of alcohol-induced liver injury.<\/p>\n<p><strong>EekJoong Park, Ph.D. (UCSD)<br \/>\n<\/strong>\u201cNOD2 inhibits alcohol-induced liver damage through activation of autophagy\u201d<br \/>\nAlcoholic liver disease (ALD) is characterized by severe liver inflammation, steatosis and fibrosis, triggered by the endotoxin, lipopolysacchride (LPS), systemically entering into the liver. This project will demonstrate how NOD2, a pattern recognition receptor, prevents ALD development and will present a new therapeutic target for the treatment of ALD.<\/p>\n<p><strong>Jun Xu, Ph.D., M.D. (USC)<br \/>\n<\/strong>\u201cMetabolomics Core of the Southern Calif. Research Center for ALPD and Cirrhosis\u201d<br \/>\nAlcoholic liver disease (ALD) affects over 2 million people in the U.S. After decade effort in research of therapeutic targets, we still don&#8217;t have effective treatment when ALD progresses to the late stage of cirrhosis except liver transplantation. Therefore, new research approaches such as Metabolomics should be sought by the Center because many manifestations of ALD spectra reflect metabolic disturbance in the liver.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-11--USAd_WQ8m\" aria-controls=\"section-1-11--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2012<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-11--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-11--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>EekJoong Park, Ph.D. (UCSD)<br \/>\n<\/strong>\u201cNOD2 inhibits alcohol-induced liver damage through activation of autophagy\u201d<br \/>\nThis project will present a new mechanism by which NOD2 prevents TLR4-mediated ALD through activation of autophagy. Targeting these signaling events through TLR4-NOD2-mTOR-autophagy may lead to new therapies for the prevention of ALD.<\/p>\n<p><strong>Takeshi Saito, M.D., Ph.D. (USC)<br \/>\n<\/strong>\u201cETOH mediated deregulation of hepatic innate immunity that support HCV\u201d<br \/>\nThis proposed study is designed to investigate our central hypothesis &#8220;Alcohol metabolism in the hepatocytes establishes a platform for efficient HCV replication and deregulate antiviral innate immunity, resulting in the acceleration of liver fibrosis and refractory to antiviral therapy&#8221;<\/p>\n<p><strong>Jun Xu, Ph.D., M.D. (USC)<br \/>\n<\/strong>\u201cMetabolomic Core for Southern California Research Center for ALPD and Cirrhosis\u201d<br \/>\nAlcoholic liver disease and alcoholic pancreatitis are major life-style diseases in the United States. The proposed metabolomic studies will advance our understanding of pathogenesis and disease progress of the diseases, which would lead to development of early diagnostic markers and therapeutic targets.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-12--USAd_WQ8m\" aria-controls=\"section-1-12--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2011<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-12--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-12--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Jun Xu, M.D., Ph.D. (USC) <\/strong><br \/>\n&#8220;Notch signaling in Nos2 activation and steatohepatitis by obesity and alcohol&#8221;<br \/>\nThis proposal is aimed to study the role of notch signaling in proinflammatory (M1) activation of hepatic macrophage and its effect on steatohepatitis caused by obesity and alcohol feeding in mice. The causal link between glucose metabolism and M1 activation (Nos2 expression) will also be sought both in vitro and in vivo.<\/p>\n<p><strong>Michael Karin, Ph.D. (UCSD) <\/strong><br \/>\n&#8220;IKK in alcoholic pancreatitis&#8221;<br \/>\nThis project aims to investigate the role of IKK* and IKK*, the two catalytic subunits of IKK complex, in the pathogenesis of alcoholic pancreatitis development. We will determine whether loss of IKK* sensitizes mice to alcoholic pancreatitis. We will investigate the role of defective autophagy in this pathology and will examine how ethanol feeding affects IKK signaling in vivo, using mutant mice with pancreatic-specific deletions of IKK* or IKK*.<\/p>\n<p><strong>EekJoong Park, Ph.D. (UCSD) <\/strong><br \/>\n&#8220;NOD2 inhibits alcohol-induced liver damage through suppression of mTOR signaling&#8221;<br \/>\nAlcoholic liver disease (ALD) is well-characterized to be associated with steatosis, inflammation (steatohepatitis), fibrosis, cirrhosis and in some case hepatocellular carcinoma. Toll-like receptor-4 (TLR4) is a major molecule to regulate this alcohol-induced inflammation and liver diseases. Interestingly, a recent study shows that TLR4 activation is inhibited by nucleotide-binding oligomerization domain containing 2 (NOD2), another pattern recognition receptor, in intestinal epithelial cells. Therefore, my project will investigate whether NOD2 activation can prevent TLR4-induced ALD including hepatosteatosis and fibrogenesis.<\/p>\n<p><strong>Takeshi Saito, M.D., Ph.D. (USC) <\/strong><br \/>\n&#8220;ETOH mediated deregulation of hepatic innate immunity that support HCV&#8221;<br \/>\nThis study is designed to investigate the pathogenesis of immune deregulation caused by the combination of HCV and alcoholic liver diseases (ALDs). This proposal also aims to investigate the link between innate immune deregulation and the progression of liver fibrosis through the understanding of inflammasomes formation by viral hepatitis and ALDs.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-13--USAd_WQ8m\" aria-controls=\"section-1-13--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2010<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-13--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-13--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Kinji Asahina, Ph.D. (USC) <\/strong><br \/>\n&#8220;Hepatic stellate cell precursors in developing and fibrotic livers&#8221;<br \/>\nThe study proposes to determine cell lineages of mesenchymal progenitor cells in developing livers and to isolate different liver mesenchymal cell types from adult livers.<\/p>\n<p><strong>Jingzhen (Jenny) Yuan, Ph.D. (UCLA) <\/strong><br \/>\n&#8220;The role of protein kinase D in cell death in alcoholic pancreatitis&#8221;<br \/>\nThis project is designed to investigate the potential role for a novel PKD1 signaling pathway in mediating alcohol abuse-induced necrosis in pancreatitis and to define the mitochondria-dependent and independent mechanisms by which PKD1 regulates alcohol-caused pancreatitis.<\/p>\n<p><strong>Michael Karin, Ph.D. (UCSD) <\/strong><br \/>\n&#8220;IKK in alcoholic pancreatitis&#8221;<br \/>\nThis study is to investigate the role of IKKa and IKK\u03b2, the two catalytic subunits of IKK complex, in alcoholic pancreatitis development. Mutant mice with pancreatic-specific deletion of IKK\u03b1 or IKK\u03b2 will be used to determine whether and how the loss of IKK\u03b1 could sensitize alcoholic pancreatitis by enhanced defective autophagy and how ethanol feeding affects IKK\u03b2\/NFkB signaling in vivo.<\/p>\n<p><strong>Fawzia Bardag-Gorce, Ph.D. (UCLA) <\/strong><br \/>\n&#8220;Non toxic low dose of proteasome inhibitor reduces oxidative stress&#8221;<br \/>\nThis pilot study investigates the attenuation of ethanol-induced oxidative stress by using proteasome inhibitor treatment. It also investigates the beneficial effects of proteasome inhibitor treatment in reducing the ethanol-induced steatosis.<\/p>\n<p><strong>Bernd Schnabl, M.D. (UCSD) <\/strong><br \/>\n&#8220;Early bacterial translocation as mechanism for alcohol-induced liver fibrosis progression&#8221;<br \/>\nThe major goal is to investigate bacterial translocation and it&#8217;s relevance to liver injury in an animal model of intragastric alcohol feeding. In addition, quantitative and qualitative changes in the enteric microbiome are assessed.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-14--USAd_WQ8m\" aria-controls=\"section-1-14--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2009<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-14--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-14--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Kinji Asahina, Ph.D. (USC) <\/strong><br \/>\n\u201cHepatic stellate cell precursors in developing and regenerating livers\u201d<br \/>\nThis project pursues to isolate and characterize different mesenchymal cell types in developing livers, to test differentiation potential of submesothelial cells, and to determine whether capsular fibroblasts express the markers of submesothelial cells in adult liver.<\/p>\n<p><strong>Ekihiro Seki, M.D., Ph.D. (UCSD) <\/strong><br \/>\n\u201cTLR4 regulates the activation of hepatic stellate cells and Kupffer cells in alcoholic liver fibrosis\u201d<br \/>\nThis study is receiving the second year of pilot project support from the Center and examines the role of TLR4, the receptor for endotoxin, on hepatic stellate cells and Kupffer cells in the pathogenesis of alcoholic liver disease by using genetic chimeric mice in which TLR4 expression on these two cell types is manipulated by transplantation of bone marrow cells. The study further examines TLR4-inducible gene expression in hepatic stellate cells in alcoholic liver disease.<\/p>\n<p><strong>Jingzhen (Jenny) Yuan, Ph.D. (UCLA) <\/strong><br \/>\n\u201cThe role of protein kinase D1 in alcohol-induced pancreatitis\u201d<br \/>\nThis study is to investigate whether the novel protein kinase PKD1 is a key downstream participant in the PKC signal transduction pathways mediating regulatory effects of ethanol on the activation of proinflammatory transcription factors and cell death pathways.<\/p>\n<p><strong>Bernd Schnabl, M.D. (UCSD) <\/strong><br \/>\n\u201cEarly bacterial translocation as mechanism for alcohol-induced liver fibrosis progression\u201d<br \/>\nThis project aims to assess the enteric microbiota and bacterial translocation to the systemic circulation in the early course of alcohol-induced liver injury and fibrosis, and to define a mechanism by which alcohol causes intestinal bacterial overgrowth.<\/p>\n<p><strong>Hyeongnam (Joe) Jeong (USC) <\/strong><br \/>\n\u201cIdentification of novel transforming genes in hepatocellular carcinoma (HCC)\u201d<br \/>\nThe main purpose of this study is to identify specific transforming genes relating to HCC development through the use of a lentiviral cDNA expression library screen. A novelty of this approach is the use of immortalized liver progenitor (oval) cells as our targets for liver screening, as compelling evidence has identified oval cells as the cell-of-origin for HCC.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-15--USAd_WQ8m\" aria-controls=\"section-1-15--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2008<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-15--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-15--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Ekihiro Seki, M.D., Ph.D. (UCSD)<\/strong><br \/>\n\u201cThe role of TLR4 in the activation of the hepatic stellate cells and Kupffer cells in alcoholic-induced fibrosis\u201d<br \/>\nThis study examines the role of TLR4, the receptor for endotoxin, on hepatic stellate cells and Kupffer cells in the pathogenesis of alcoholic liver disease by using genetic chimeric mice in which TLR4 expression on these two cell types is manipulated by transplantation of bone marrow cells.<\/p>\n<p><strong>Shuping Zhong, Ph.D. (USC)<\/strong><br \/>\n\u201cHow does alcohol affect machinery and activity of RNA pol III transcription?\u201d<br \/>\nThis study is receiving the second year of pilot project support from the Center and is defining the role of RNA polymerase III transcription as a priming mechanism of alcohol-induced liver tumor formation.<\/p>\n<p><strong>Tatiana Kisseleva, Ph.D. (UCSD)<\/strong><br \/>\n\u201cCharacterization of the role of fibrocytes in alcoholic liver disease\u201d<br \/>\nThis study investigates the origin, fate, and role of bone marrow-derived \u201cfibrocytes\u201d in the pathogenesis of alcoholic liver disease by utilizing innovative genetic mouse models and bone marrow transplantation technique.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-16--USAd_WQ8m\" aria-controls=\"section-1-16--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2007<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-16--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-16--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>David Adelson, Ph.D. (VA\/UCLA)<\/strong><br \/>\n&#8220;Neural mechanisms potentiating CCK-induced pancreatitis in ethanol-fed rats&#8221;<br \/>\nThe proposed study will use an in vivo urethane-anesthetized rat preparation to record impulse activity from splanchnic primary afferent neurons (SPANs) innervating the pancreas, in order to test the hypothesis that pancreatic SPANs in ethanol-fed rats are hyperresponsive, relative to pancreatic SPANs in normally-fed rats, to stimuli that induce acute pancreatitis. The mechanisms responsible for this SPAN hyperresponsiveness will also be investigated.<\/p>\n<p><strong>Vijay Kalra, Ph.D. (USC)<\/strong><br \/>\n&#8220;Dynamics of gene expression and inflammation in liver sinusoidal endothelial cell&#8221;<br \/>\nThe study proposes to study the effect of ethanol on the expression of cytochemokines (MCP-1, IL-8, MIP-1b, TNF-a, and IL-1b) , chemokine receptors (CCR2 and CCR5) and adhesion molecules (ICAM-1,VCAM-1 and E-selectin) in liver sinusoidal endothelial cells by RNase protection assay (RPA) using custom made RPA panel of probes<\/p>\n<p><strong>Keigo<\/strong> <strong>Machida, Ph.D. (USC)<\/strong><br \/>\n&#8220;The role of TLR4 for oncogenic potential by HCV, alcohol, and diabetes&#8221;<br \/>\nThis project investigates the mechanisms underlying synergistically increased risk of developing liver cancer in HCV core or NS5A transgenic mice exposed to alcohol or high cholesterol\/fat diet.<\/p>\n<p><strong>Shuping<\/strong> <strong>Zhong, Ph.D. (USC)<\/strong><br \/>\n&#8220;Mechanism of alcohol-induced liver cancer&#8221;<br \/>\nThe study investigates whether alcohol affects RNA pol III transcription to uncover the mechanism of alcohol-associated human cancers<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-17--USAd_WQ8m\" aria-controls=\"section-1-17--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2006<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-17--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-17--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Mamoru Ishii, Ph.D. (USC)<br \/>\n<\/strong>&#8220;Transcriptional regialtion of Msx2 gene by alcohol and its importance in alscohol liver diseases&#8221;<br \/>\nThis study is aimed at determining whether FGF10 is involved in the proliferation and differentiation of liver progenitor cells from the budding foregut endoderm and whether FGF10 is involved in the regenerative process of the liver in response to injury and that this process is impaired during chronic exposure to alcohol.<\/p>\n<p><strong>Daryl Davies, Ph.D. (USC)<br \/>\n<\/strong>&#8220;The action of ehtanol on human peptide transporter activity&#8221;<br \/>\nThis study examined alcohol-induced inhibition of human di- and tri-peptide transporter (hPepT1) activity as a possible pathophysiological mechanism of known reduction of micronutrient uptake by intestine of alcoholics.<\/p>\n<p><strong>Vijay Kalra, Ph.D. (USC)<br \/>\n<\/strong>&#8220;Dynamics of gene expression and inflammation in liver sinusoidal endothelial cell&#8221;<br \/>\nThe study proposes to study the effect of ethanol on the expression of cytochemokines (MCP-1, IL-8, MIP-1b, TNF-a, and IL-1b) , chemokine receptors (CCR2 and CCR5) and adhesion molecules (ICAM-1,VCAM-1 and E-selectin) in liver sinusoidal endothelial cells by RNase protection assay (RPA) using custom made RPA panel of probes<\/p>\n<p><strong>Keigo<\/strong> <strong>Machida, Ph.D. (USC)<\/strong><br \/>\n&#8220;The role of TLR4 for oncogenic potential by HCV, alcohol, and diabetes&#8221;<br \/>\nThis project investigates the mechanisms underlying synergistically increased risk of developing liver cancer in HCV core or NS5A transgenic mice exposed to alcohol or high cholesterol\/fat diet.<\/p>\n<p><strong>Xiao-Ming Ou, Ph.D. (USC)<br \/>\n<\/strong>&#8220;Alcohol liver injury mediated by monoamine oxidase B&#8221;<br \/>\nThis pilot study investigates the effects of alcohol on transcription of monoamine oxidaseB gene as a potential mechanism of alcohol-induced toxicity<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-18--USAd_WQ8m\" aria-controls=\"section-1-18--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2005<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-18--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-18--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Woojin<\/strong> <strong>An, Ph.D. (USC)<br \/>\n<\/strong>&#8220;Role of Ethanol-induced histone mark for p53 function&#8221;<br \/>\nThis study aims to investigate whether p53-dependent induction of apoptosis of ethanol-damaged hepatocytes functionally correlate with histone acetylation and methylation to manipulate and utilize the chromatin structure<\/p>\n<p><strong>Mamoru Ishii, Ph.D. (USC)<\/strong><br \/>\n&#8220;Transactional regialtion of Msx2 gene by alcohol and its importance in alcoholic liver diseases&#8221;.<br \/>\nThis study aims to test whether Msx gene expression in HSC are crucial to molecular regulation of liver regeneration, and whether alcohol impairs liver regeneration via its inhibitory effects on Msx genes<\/p>\n<p><strong>Henry Lin, M.D. (USC)<br \/>\n<\/strong>&#8220;Endotoxemia and Liver Injury in Alcohol Liver Disease &#8221;<br \/>\nThis study aims to determine whether small intestinal bacterial overgrowth has a cause and effect relationship with endotoxemia and liver injury<\/p>\n<p><strong>Kasper Wang, M.D. (USC\/CHLA)<br \/>\n<\/strong>&#8220;Role of FGF 10 in liver organogenesis and regeneration&#8221;<br \/>\nThis study will determine whether FGF10 is involved in the proliferation and differentiation of biliary epithelium from the budding foregut endoderm., and whether FGF10 is involved in the regenerative process of the liver in response to injury and that this process is impaired during chronic exposure to alcohol<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-19--USAd_WQ8m\" aria-controls=\"section-1-19--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2004<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-19--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-19--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Yuan-Ping Han, Ph.D. (USC)<\/strong><br \/>\n&#8220;MMP-9 in the myofibroblastic activation of HSC&#8221;<br \/>\nThis study seeks to further understand the molecular pathways whereby IL-1a regulates matrix melloproteinase expression and activation, and the specific function of the MMPs in liver fibrosis.<\/p>\n<p><strong>Ite<\/strong> <strong>Laird-Offringa, Ph.D. (USC)<\/strong><br \/>\n&#8220;HuR-regulation of TNF alpha in alcoholic liver disease&#8221;<br \/>\nThis study will examine whether methylation of HuR by CARM1 is increased in Kupffer cells from alcohol-treated liver, and whether that contributes to the increased TNFa levels observed in these cells following inflammatory stimuli.<\/p>\n<p><strong>Jian<\/strong> <strong>-Min Yuan, M.D. (USC)<\/strong><br \/>\n&#8220;Pilot study of risk factors for alcoholic liver disease in Los Angeles&#8221;<br \/>\nThis study seeks to assess the association between self-reported alcohol consumption and the risk of ALD; to determine the modifying roles of obesity, cigarette smoking, and dietary intake of antioxidants, fat and iron in the alcohol-ALD association; and to determine the modifying role of acetaminophen on the alcohol-ALD association.<\/p>\n<p><strong>Aurelia Lugea , Ph.D. (UCLA)<\/strong><br \/>\n&#8220;Plasminogen system and alcohol-induced pancreatic fibrosis&#8221;<br \/>\nThis project seeks to clarify the underlying mechanisms mediating alcohol-induced alterations in the PIg system and how these changes lead to fibrosis in the pancreas.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-20--USAd_WQ8m\" aria-controls=\"section-1-20--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2003<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-20--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-20--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Yuan-Ping Han, Ph.D. (USC)<\/strong><br \/>\nExamined the mechanistic pathway for the induction and activation of matrix metallo-proteinases in liver damage induced by alcohol over dosage.<\/p>\n<p><strong>Joseph Reeve, Ph.D. (UCLA)<\/strong><br \/>\nDetermined the specific phosphorylation sites of PKC isoforms.<\/p>\n<p><strong>Bruce Runyon, M.D. ( Rancho Los Amigos Medical <\/strong><br \/>\nCompared the use of corticosteroids versus pentoxifylline in the treatment of patients with severe alcoholic hepatitis.<\/p>\n<p><strong>Aurelia, Lugea Ph.D. (UCLA)<\/strong><br \/>\nExamined the effect of ethanol and its metabolites, acetaldehyde and FAEEs, on components of the plasminogen activating system in rat pancreas.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-21--USAd_WQ8m\" aria-controls=\"section-1-21--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2002<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-21--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-21--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Gunther<\/strong> <strong>Dennert,, Ph.D. (USC)<\/strong><br \/>\nExamined the effects of alcohol in a small animal model on lymphocyte immunity in the liver.<\/p>\n<p><strong>Chih<\/strong> <strong>-Lin Hsieh, Ph.D. (USC)<\/strong><br \/>\nDissected how ethanol causes chromosome breaks and to examine the sites of methylation change in rats treated with ethanol for short-term and long-term periods.<\/p>\n<p><strong>Bruce Runyon, M.D. ( Rancho Los Amigos Medical Center)<\/strong><br \/>\nCompared the use of corticosteroids versus pentoxifylline in the treatment of patients with severe alcoholic hepatitis.<\/p>\n<p><strong>Zhiquin<\/strong> <strong>Tan, M.D., Ph.D. (USC)<\/strong><br \/>\nExamined the effect of alcohol on viral infection in T-lymphocytes and to develop a therapeutic target to block HIV-1 infection.<\/p>\n<p><strong>Yvonne Wan, Ph.D. (Harbor-UCLA)<\/strong><br \/>\nDetermined the impact of interfering retinoid signaling at the receptor level on alcoholic liver disease.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-22--USAd_WQ8m\" aria-controls=\"section-1-22--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2001<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-22--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-22--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Laurie DeLeve, M.D., Ph.D. (USC)<\/strong><br \/>\nExamined the changes in the specialized features of liver endothelial cells which are thought to be an initiating factor in alcoholic cirrhosis.<\/p>\n<p><strong>Gunther<\/strong> <strong>Dennert, Ph.D. (USC)<\/strong><br \/>\nExamined the effects of alcohol in a small animal model on lymphocyte immunity in the liver.<\/p>\n<p><strong>Ilya<\/strong> <strong>Gukovsky, Ph.D. (VA\/UCLA)<\/strong><br \/>\nDeveloped an animal model for investigating chronic pancreatitis resulting from ethanol intake.<\/p>\n<p><strong>Xuan<\/strong> <strong>Liu, D.D.S., Ph.D. (Charles R. Drew University)<\/strong><br \/>\nExamined the effect of alcohol on viral infection in T-lymphocytes and to develop a therapeutic target to block HIV-1 infection.<\/p>\n<p><strong>Vincent Wu, Ph.D. (VA\/UCLA)<\/strong><br \/>\nExamined the molecular mechanisms underlying alcohol-mediated sensitization of CCK actions on pancreatic acinar cells.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-23--USAd_WQ8m\" aria-controls=\"section-1-23--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">2000<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-23--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-23--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Laurie DeLeve, M.D., Ph.D. (USC)<\/strong><br \/>\nExamined the changes in the specialized features of liver endothelial cells which are thought to be an initiating factor in alcoholic cirrhosis.<\/p>\n<p><strong>Anna Gukovskaya, Ph.D. (VA\/UCLA)<\/strong><br \/>\nExamined the mechanisms of ethanol toxicity to pancreas that mediate alcoholic pancreatitis.<\/p>\n<p><strong>Ilya Gukovsky, Ph.D. (VA\/UCLA)<\/strong><br \/>\nThe goal of the project was to develop a model of chronic alcohol-induced pancreatitis that can be used for further investigations into the mechanisms underlying the disorder.<\/p>\n<p><strong>Shelly Lu, M.D. (USC)<\/strong><br \/>\nExamined how changes in methionine metabolism contribute to the pathogenesis of liver injury.<\/p>\n<p><strong>Steven Y. Sussman, Ph.D. &amp; Clyde W. Dent, Ph.D. (USC)<\/strong><br \/>\nResearched hospital discharge data in Los Angeles County to determine what groups have high prevalence of alcoholic liver and pancreatic disease.<\/p>\n<p><strong>Hal Yee, M.D., Ph.D. (UCLA)<\/strong><br \/>\nExamined how alcoholic hepatitis, a consequence of acute and massive alcohol ingestion, results in internal bleeding and severe fluid retention.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n              <li>\n          <button type=\"button\" class=\"accordion-trigger \" id=\"heading-1-24--USAd_WQ8m\" aria-controls=\"section-1-24--USAd_WQ8m\" aria-expanded=\"false\" aria-disabled=\"false\">\n                          <span class=\"item-title\">1999<\/span>\n            \n                      <\/button>\n\n          <div id=\"section-1-24--USAd_WQ8m\" role=\"region\" aria-labelledby=\"heading-1-24--USAd_WQ8m\" class=\"accordion-panel\">\n\n                            \n    \n\n\n\n\n\n\n<div\n  class=\"cc--component-container cc--rich-text \"\n\n  \n  \n  \n  \n  \n  \n  >\n  <div class=\"c--component c--rich-text\"\n    \n      >\n\n    \n  <div class=\"inner-wrapper\">\n        \n<div class=\"f--field f--wysiwyg\">\n\n    \n  <p><strong>Anna Gukovskaya, Ph.D. (VA\/UCLA) <\/strong><br \/>\nExamined the mechanisms of ethanol toxicity to pancreas that mediate alcoholic pancreatitis.<\/p>\n<p><strong>Michael Lai, M.D. (USC) <\/strong>Examined the molecular mechanism of enhanced hepatotoxicity which occurs when alcoholic liver disease and hepatitis C virus infection are simultaneously present.<\/p>\n\n\n\n<\/div>\n  <\/div>\n\n\n  <\/div><\/div>\n            \n                      <\/div>\n        <\/li>\n\n          <\/ul>\n  \n\n  <\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":2,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":true,"footnotes":""},"class_list":["post-57","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - 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