Thank you for your interest in volunteering for one of the University of Southern California Alzheimer’s Therapeutic Research Institute (USC ATRI) coordinated studies.
To participate, please find a trial that is right for you (or someone you love) and contact a clinical site near you. Each of our studies have different eligibility criteria. While not everyone can join a trial, you can always become an advocate by sharing the trials with someone you know who might be able to participate.
To watch an informational video about why your participation in clinical trials is so important, click here.
We appreciate your support as we seek to prevent and treat Alzheimer’s disease.
Active Studies – Recruiting
If you are 50 years of age or older, you can monitor your own cognitive health by participating in the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is designed to identify people who may have an increased risk for developing Alzheimer’s disease, using the latest technology to monitor their cognitive performance through regular online memory testing. Volunteers of the APT Webstudy participate at their convenience, anywhere they have access to the internet. APT Webstudy participants benefit by:
- Having their cognitive health assessed over time;
- Being on the ‘fast track’ for relevant clinical trials to prevent Alzheimer’s;
- Making an invaluable contribution to advancing Alzheimer’s research, perhaps helping those in the research field find the first Alzheimer’s survivor; and
- Helping ensure that future generations do not experience Alzheimer’s and its difficult challenges.
The APT Webstudy is being conducted by the University of Southern California Alzheimer’s Therapeutic Research Institute (USC ATRI), funded by the National Institute on Aging (NIA), and is non-interventional.
To participate in the APT Webstudy or to learn more, please visit www.aptwebstudy.org. Those identified from the APT Webstudy to have a potential increased risk for memory loss will be referred to participating TRC-PAD (below) site locations. You do not have to participate in the TRC-PAD in-person study to participate in the online APT Webstudy. Participants have the option of participating in either English or Spanish.
The LEADS study – or the Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS) explores the development of early-onset Alzheimer’s disease and how it compares to the more common late-onset Alzheimer’s disease. Better understanding of this form of the disease may ultimately lead to more effective treatments. LEADS is a 2-year observational study designed to enroll 500 participants. Researchers are also recruiting cognitively normal volunteers for a 1-year comparison.
The purpose of the Memory Improvement Through Nicotine Dosing (MIND) study is to determine whether daily transdermal nicotine (patch) will have a positive effect on early memory impairment in participants diagnosed with Mild Cognitive Impairment (MCI). We are looking for healthy, non-smoking adults, age 55+.
Those identified to have a potential increased risk for memory loss caused by Alzheimer’s disease, will be referred from the APT Webstudy (above) to the Trial Ready Cohort for the Prevention of Alzheimer’s Dementia (TRC-PAD) in-person study. The purpose of TRC-PAD is to find as many people as possible (also called a “cohort”) who are interested in participating in clinical trials aimed at discovering treatments that will reduce the risk of developing Alzheimer’s dementia. TRC-PAD will help researchers enroll participants into these trials quickly to allow new treatments to be discovered as soon as possible. Participants do not have to participate in the TRC-PAD study in order to participate in the online APT Webstudy.
TRC-PAD is being conducted by the University of Southern California Alzheimer’s Therapeutic Research Institute (USC ATRI), funded by the National Institute on Aging (NIA), and is non-interventional.
To get involved with the TRC-PAD in-person study, please register and participate in the APT Webstudy first at www.aptwebstudy.org. Those identified from the APT Webstudy to have a potential increased risk for memory loss will be referred to participating TRC-PAD site locations.
Enrolling in 2021
Cognition Theraputics CT1812
NIA grant number: R01AG065248
CT Number: TBD
Background: Alzheimer’s disease is characterized by the accumulation of a substance called amyloid (or Aβ) in the brain. The most toxic forms of amyloid are small aggregates of amyloid peptide called oligomers.
This study will investigate whether CT1812, a novel and promising therapeutic candidate can halt or slow the process of Alzheimer’s disease.
CT1812 is a small-molecule drug that has been shown to pass into the brain in high concentrations where it binds to a specific set of proteins on synapses called the sigma-2 receptor complex. The sigma-2 receptor responds to and regulates damage to cells, like that inflicted on neurons by Aβ oligomers during Alzheimer’s disease. When CT1812 is bound to the sigma-2 receptor, previous studies have shown that toxic Aβ oligomers are removed from synapses and are unable to bind again. This mechanism is unique among Alzheimer’s therapeutics in development and may offer an indirect means of addressing the toxic insult of Aβ oligomers, potentially protecting against the damage to and destruction of synapses that is characteristic of neurodegenerative diseases such as Alzheimer’s disease.
Randomized Clinical Trial: In 2021 a nationwide randomized controlled clinical trial will enroll approximately 540 individuals from Alzheimer’s Clinical Trial Consortium (ACTC) sites and sites from other partnering institutions. Participants aged 55 to 85 with mild cognitive impairment (MCI) due to Alzheimer’s disease or mild Alzheimer’s disease (MMSE 20-30) who have elevated Aβ (as measured by PET or CSF) will be sought. Participants will be randomized to receive CT1812 or placebo for 18 months. In addition to a battery of cognitive measures, the study will use a variety of biomarkers to evaluatetarget engagement and assess changes in neurodegeneration and disease progression. This study will leverage the centralized resources, shared expertise, and experienced trial sites of the ACTC to investigate the potential of CT1812 to preserve cognitive function for individuals with early Alzheimer’s disease.
Active Studies – Not Yet Recruiting
AHEAD 3-45 combines two studies with distinct participant groups but with common screening and recruitment to increase efficiency. More details on each study can be found on the study website.
We anticipate enrollment for AHEAD 3-45 to begin in the first half of 2020. One way to take steps toward participating in AHEAD 3-45, is to enroll in the Alzheimer Prevention Trials (APT) Webstudy today. The APT Webstudy aims to identify participants who may be good future candidates for AHEAD 3-45. Information on how to register for the APT Webstudy can be found above.
Learn more: https://www.a3a45.org/.
Trial-Ready Cohort- Down Syndrome (TRC-DS)
Active Studies – Not Recruiting
For more information, click here.
Studies – Completed
“We call the condition of memory impairment alone amnestic Mild Cognitive Impairment (aMCI),” says Dr. Ronald Petersen, director of the NIA-funded Mayo Alzheimer’s Disease Research Center. “Researchers are particularly interested in the brain changes and memory loss of aMCI, because more people with this condition go on to develop AD than do people without it. We don’t yet know for sure whether aMCI is a separate condition or a transitional stage between normal aging and AD.”
Studies – Closed
Elevations of liver enzymes, which were serious in nature, were observed in some study participants who received the Janssen BACE inhibitor, atabecestat. After a thorough evaluation of all available liver safety data from their studies, Janssen concluded that the benefit-risk ratio was no longer favorable to continue development of atabecestat for people who have late-onset preclinical stage Alzheimer’s disease.