BIOC 515: Molecular Basis of Disease

This course seeks to address the interface between basic science and medicine. The course will explore the experimental logic used to unravel the mechanism of disease development, identify and validate therapeutic targets and design therapeutic approaches. The modeling approaches that will be studied utilize cell culture and model organisms including mice, C. elegans and zebra fish. Therapeutic interventions will include small molecules, RNA, peptides, stem cells and personalized medicine. Upon successful completion of this course, students should be able to build hypotheses, design experimental strategies that will facilitate greater understanding of the mechanisms underlying the disease process and develop rational therapeutic approaches. The course will enable improved understanding of current literature pertaining to disease-based research.