Faculty

Peter Danenberg, PhD
Peter Danenberg, PhD
Professor of Biochemistry & Molecular Medicine
Medicine
BMT B11G 1333 San Pablo Street Health Sciences Campus Los Angeles
Dr. Danenberg received a B.S. degree in chemistry from the Case Institute of Technology (now Case-Western Reserve University) and a Ph.D. from the University of California at Santa Barbara. He did postdoctoral work in the laboratory of Charles Heidelberger at the University of Wisconsin's McArdle Laboratory for Cancer Research. The initial phase of Dr. Danenberg's research career involved studies on the mechanisms of action of cancer drugs, with particular emphasis on the interaction of the fluorinated pyrimidines with the enzyme thymidylate synthase. This work ultimately gave rise to the still widely-used drug combination of 5-fluorourcil and folinic acid. His subsequent research was directed at identifying tumor biomarkers that would predict response to anti-cancer agents with the aim of promoting the concept of personalized medicine in cancer. Positive results from these studies, together with a procedure that Dr. Danenberg patented for isolating intact mRNA from paraffin-embedded tissues, formed the basis for the founding of the biotech-diagnostic company Response Genetics, Inc.

American Cancer Society: Faculty Research Award, 1979-1984

Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types Biochem Biophys Res Commun. 2018 Jun 07; 500(3):621-625. . View in PubMed

Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types Biochem Biophys Res Commun. 2018 06 07; 500(3):621-625. . View in PubMed

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action Crit Rev Oncol Hematol. 2016 Oct; 106:118-31. . View in PubMed

Efficiency of fluorodeoxyglucose positron emission tomography/computed tomography to predict prognosis in breast cancer patients received neoadjuvant chemotherapy Springerplus. 2015; 4:817. . View in PubMed

EGFR, FLT1 and heparanase as markers identifying patients at risk of short survival in cholangiocarcinoma PLoS One. 2013; 8(5):e64186. . View in PubMed

Glutathione S-transferase PI (GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and prognosis of NSCLC Lung Cancer. 2012 Oct; 78(1):87-91. . View in PubMed

Gene expression of the mismatch repair gene MSH2 in primary colorectal cancer Tumour Biol. 2011 Oct; 32(5):977-83. . View in PubMed

Biomarkers for cetuximab-based neoadjuvant radiochemotherapy in locally advanced rectal cancer Clin Cancer Res. 2011 May 15; 17(10):3469-77. . View in PubMed

Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancer J Thorac Oncol. 2010 Dec; 5(12):1933-8. . View in PubMed

Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases Cancer Chemother Pharmacol. 2010 Apr; 65(5):825-31. . View in PubMed

A three-gene signature for outcome in soft tissue sarcoma Clin Cancer Res. 2009 Aug 15; 15(16):5191-8. . View in PubMed

Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells Prostate. 2009 Jan 01; 69(1):12-23. . View in PubMed

Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jan; 107(1):81-91. . View in PubMed

High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1 Cancer Chemother Pharmacol. 2008 Dec; 63(1):85-9. . View in PubMed

Both beta-actin and GAPDH are useful reference genes for normalization of quantitative RT-PCR in human FFPE tissue samples of prostate cancer Prostate. 2008 Oct 01; 68(14):1555-60. . View in PubMed

High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF J Gastrointest Surg. 2008 Oct; 12(10):1674-81; discussion 1681-2. . View in PubMed

Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer BMC Cancer. 2008 Jul 25; 8:210. . View in PubMed

High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF Neoplasia. 2008 Jul; 10(7):674-9. . View in PubMed

Adenocarcinoma developing in de novo Barrett's mucosa in the remnant esophagus after esophagectomy: clinical and molecular assessment Dis Esophagus. 2008; 21(3):E6-8. . View in PubMed

DPD is a molecular determinant of capecitabine efficacy in colorectal cancer Int J Oncol. 2007 Aug; 31(2):413-8. . View in PubMed

Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells Oncol Rep. 2007 May; 17(5):1201-5. . View in PubMed

ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine Ann Oncol. 2006 Dec; 17(12):1818-25. . View in PubMed

Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer Clin Colorectal Cancer. 2006 Nov; 6(4):305-11. . View in PubMed

Epidermal growth factor receptor and epidermal growth factor receptor variant III gene expression in metastatic colorectal cancer Clin Colorectal Cancer. 2006 Sep; 6(3):214-8. . View in PubMed

Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2 Int J Cancer. 2006 Aug 15; 119(4):765-70. . View in PubMed

5-fluorouracil-related gene expression levels in primary colorectal cancer and corresponding liver metastasis Int J Cancer. 2006 Aug 01; 119(3):522-6. . View in PubMed

Genistein-induced neuroendocrine differentiation of prostate cancer cells Prostate. 2006 Aug 01; 66(11):1136-43. . View in PubMed

An in vivo platform for translational drug development in pancreatic cancer Clin Cancer Res. 2006 Aug 01; 12(15):4652-61. . View in PubMed

Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus Am J Gastroenterol. 2006 Jul; 101(7):1458-66. . View in PubMed

DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value Clin Lung Cancer. 2006 Jul; 8(1):39-44. . View in PubMed

Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer Clin Cancer Res. 2006 May 15; 12(10):3078-84. . View in PubMed

Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer Clin Colorectal Cancer. 2006 Jan; 5(5):344-9. . View in PubMed

Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus Dis Esophagus. 2006; 19(4):260-6. . View in PubMed

Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma Surgery. 2005 Nov; 138(5):924-31. . View in PubMed

High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer Clin Cancer Res. 2005 Mar 15; 11(6):2215-21. . View in PubMed

Downregulation of TS, DPD, ERCC1, GST-Pi, EGFR, and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal cancer J Am Coll Surg. 2005 Mar; 200(3):336-44. . View in PubMed

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis Carcinogenesis. 2005 Mar; 26(3):525-30. . View in PubMed

A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma Clin Colorectal Cancer. 2005 Mar; 4(6):390-5. . View in PubMed

Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer Prostate Cancer Prostatic Dis. 2005; 8(3):260-5. . View in PubMed

Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus Arch Surg. 2004 Jul; 139(7):712-6; discussion 716-7. . View in PubMed

A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus Oncogene. 2004 Jun 10; 23(27):4780-8. . View in PubMed

High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer Clin Cancer Res. 2004 Jun 01; 10(11):3794-9. . View in PubMed

A longterm follow-up study of thymidylate synthase as a predictor for survival of patients with liver tumours receiving hepatic arterial infusion chemotherapy Eur J Surg Oncol. 2004 May; 30(4):407-13. . View in PubMed

HER-2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumors Int J Cancer. 2004 Feb 10; 108(4):540-8. . View in PubMed

Differential SPARC mRNA expression in Barrett's oesophagus Br J Cancer. 2003 Oct 20; 89(8):1508-12. . View in PubMed

Association between Cyclooxygenase expression and colorectal adenoma characteristics Cancer Res. 2003 Jul 15; 63(14):3891-3. . View in PubMed

Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity Jpn J Cancer Res. 2002 Nov; 93(11):1221-9. . View in PubMed

Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma J Gastrointest Surg. 2002 May-Jun; 6(3):359-67. . View in PubMed

Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells Anticancer Drugs. 2002 Mar; 13(3):259-70. . View in PubMed

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression Clin Cancer Res. 2001 Dec; 7(12):4096-101. . View in PubMed

ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy J Clin Oncol. 2001 Dec 01; 19(23):4298-304. . View in PubMed

Increased c-myb mRNA expression in Barrett's esophagus and Barrett's-associated adenocarcinoma J Surg Res. 2001 Aug; 99(2):301-6. . View in PubMed

Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival Clin Cancer Res. 2001 Jul; 7(7):1850-5. . View in PubMed

Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival Oncogene. 2001 Jun 14; 20(27):3528-32. . View in PubMed

Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors Clin Cancer Res. 2001 May; 7(5):1313-9. . View in PubMed

[Molecular markers as basis for chemotherapy? ]. Chirurg. 2000 Dec; 71(12):1433-9.. View in PubMed

Expression of metastases-associated genes in cervical cancers resected in the proliferative and secretory phases of the menstrual cycle Clin Cancer Res. 2000 Dec; 6(12):4653-7. . View in PubMed

Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma J Natl Cancer Inst. 2000 Nov 15; 92(22):1805-11. . View in PubMed

Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma Cancer Res. 2000 Sep 15; 60(18):5021-6. . View in PubMed

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase Clin Cancer Res. 2000 Apr; 6(4):1322-7. . View in PubMed

Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials Am J Gastroenterol. 1999 Aug; 94(8):2313-5. . View in PubMed

Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes Cancer Res. 1999 Jul 15; 59(14):3505-11. . View in PubMed

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression Cancer Res. 1999 May 15; 59(10):2302-6. . View in PubMed

Concurrent paclitaxel and radiation therapy for breast cancer Semin Radiat Oncol. 1999 Apr; 9(2 Suppl 1):34-42. . View in PubMed

High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil Clin Cancer Res. 1998 Oct; 4(10):2371-6. . View in PubMed

Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA Clin Cancer Res. 1998 Sep; 4(9):2229-36. . View in PubMed

Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells Anticancer Res. 1998 Jul-Aug; 18(4A):2327-38. . View in PubMed

Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma J Clin Oncol. 1998 Apr; 16(4):1465-9. . View in PubMed

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy J Clin Oncol. 1998 Jan; 16(1):309-16. . View in PubMed

[Expression of p16 and p16 beta in squamous epithelial carcinomas and adenocarcinomas of the esophagus: differences in regulation dependent on kind of tumor and histology] Langenbecks Arch Chir Suppl Kongressbd. 1998; 115(Suppl I):491-4. . View in PubMed

High frequency of simultaneous loss of p16 and p16beta gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach Oncogene. 1997 Sep 18; 15(12):1481-8. . View in PubMed

Increased photosensitivity in HL60 cells expressing wild-type p53 Photochem Photobiol. 1997 Aug; 66(2):265-70. . View in PubMed

Identification of mutations by RNA conformational polymorphism "bar code" analysis Genomics. 1995 Nov 01; 30(1):120-2. . View in PubMed

Gene amplification and multidrug resistance induced by the phosphatase-inhibitory tumor promoter, okadaic acid Carcinogenesis. 1995 Mar; 16(3):637-41. . View in PubMed

Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing J Biol Chem. 1994 Dec 16; 269(50):31962-8. . View in PubMed

Effect of 5-fluoro- and 5-bromouracil substitution on the translation of human thymidylate synthase mRNA J Biol Chem. 1994 Jun 10; 269(23):16269-75. . View in PubMed

Detection of clonal T-cell populations in gastrointestinal lymphomas by analysis of cRNA conformational polymorphisms of rearranged T-cell-receptor-gamma genes Br J Haematol. 1994 Feb; 86(2):316-21. . View in PubMed

Differential S100 beta expression in choroidal and skin melanomas: quantitation by the polymerase chain reaction Invest Ophthalmol Vis Sci. 1993 Nov; 34(12):3366-75. . View in PubMed

Conformational polymorphisms of cRNA of T-cell-receptor genes as a clone-specific molecular marker for cutaneous lymphoma J Invest Dermatol. 1993 Oct; 101(4):514-6. . View in PubMed

Analyses of p53 gene mutations in primary human bladder cancer Oncol Res. 1993; 5(6-7):245-9. . View in PubMed

Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s) Nucleic Acids Res. 1992 Feb 11; 20(3):573-9. . View in PubMed

Inactivation of Tetrahymena rRNA self-splicing by cis-platin proceeds through dissociable complexes Nucleic Acids Res. 1991 Jun 11; 19(11):3123-8. . View in PubMed

Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA Cancer Res. 1990 Mar 15; 50(6):1757-63. . View in PubMed

Deoxyuridylate effects on thymidylate synthase-5-fluorodeoxyuridylate-folate ternary complex formation Biochem Pharmacol. 1989 Sep 15; 38(18):2985-93. . View in PubMed

Characterization of the mode of binding of substrates to the active site of Tetrahymena self-splicing RNA using 5-fluorouracil-substituted mini-exons Biochemistry. 1989 Aug 08; 28(16):6779-85. . View in PubMed

Activity of thymidylate synthetase and its inhibition by 5-fluorouracil in highly enzyme-overproducing cells resistant to 10-propargyl-5,8-dideazafolate Mol Pharmacol. 1989 Aug; 36(2):219-23. . View in PubMed

Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells Cancer Chemother Pharmacol. 1988; 22(1):58-62. . View in PubMed

Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate J Biol Chem. 1985 Sep 15; 260(20):10996-1000. . View in PubMed

Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo Mol Pharmacol. 1985 Feb; 27(2):302-7. . View in PubMed

Deoxyribonucleoside-induced selective modulation of cytotoxicity and mutagenesis Basic Life Sci. 1985; 31:313-34. . View in PubMed

Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized Biochem Biophys Res Commun. 1984 Jul 18; 122(1):439-45. . View in PubMed

Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides J Biol Chem. 1983 Apr 10; 258(7):4130-6. . View in PubMed

Induction of mutations by 5-fluorodeoxyuridine: a mechanism of self-potentiated drug resistance? Biochem Biophys Res Commun. 1983 Jan 27; 110(2):573-7.. View in PubMed

Fluorinated pyrimidines and their nucleosides Adv Enzymol Relat Areas Mol Biol. 1983; 54:58-119. . View in PubMed

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase Biochem Pharmacol. 1981 Feb 01; 30(3):247-57. . View in PubMed

Fluorinated pyrimidines as tight-binding inhibitors of thymidylate synthetase Pharmacol Ther. 1981; 13(1):69-90. . View in PubMed

Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexesEvidence for large conformational changes during catalysis. Biochemistry. 1980 Sep 02; 19(18):4244-51. . View in PubMed

Evidence for a sequential interaction of the subunits of thymidylate synthetase J Biol Chem. 1979 Jun 10; 254(11):4345-8. . View in PubMed

Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism Biochemistry. 1978 Sep 19; 17(19):4018-24. . View in PubMed

Inhibition of hexokinase by multisubstrate analogs Biochim Biophys Acta. 1977 Feb 09; 480(2):351-6. . View in PubMed

Growth inhibition of cells in cultures and of vaccinia virus infected HeLa cells by derivatives of trifluorothymidine Chemotherapy. 1976; 22(3-4):221-31. . View in PubMed

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