Faculty

Raymond D Mosteller, PhD
Raymond D Mosteller, PhD
Associate Professor of Biochemistry & Molecular Medicine;Director of The Computer Curriculum, Educational Affairs
Medicine
BMT B11 E 1333 San Pablo Street Health Sciences Campus Los Angeles
CURRENT RESEARCH INTERESTS:
Dr. Mosteller's research interests are in the area of guanine nucleotide binding proteins (G-proteins) including the Ras proteins (e.g. k-ras) from eucaryotic organisms including yeast (Saccharomyces cerevisiae) and humans. His most recent research has involved studies of the interactions of G-proteins with other regulatory molecules in the cell such as the guanine nucleotide exchange factor (GNEF) and Vav. He is also interested in the membrane phosphoinositides, PIP2 and PIP3, and the PI-3-kinase signalling pathway.

PREVIOUS RESEARCH INTERESTS:
His previous research interests include the following: regulation of expression of the tryptophan operon in Escherichia coli; interaction of the alpha and beta subunits of tryptophan synthase from Escherichia coli; protein metabolism and turnover in Escherichia coli; interaction of transducin protein with rhodopsin in photoreceptor cells; the mechanism of protein synthesis in vitro on polyribosomes from rabbit reticulocytes.

EDUCATION AND TRAINING:
Dr. Mosteller received his B.A. and Ph.D. degrees from the University of Texas in Austin. As an undergraduate, he was elected into the Phi Eta Sigma and Phi Beta Kappa honor societies. His Ph.D. work was with Dr. Boyd Hardesty studying protein synthesis in vitro on polyribosomes from rabbit reticulocytes. He completed his postdoctoral studies at Stanford University working with Dr. Charles Yanofsky on the regulation of expression of the tryptophan operon in Escherichia coli. Dr. Mosteller also spent a one year sabbatical with Dr. Melvin Simon at the California Institute of Technology (Caltech) studying the interaction of the protein transducin with rhodopsin in photoreceptor cells. After his sabbatical, Dr. Mosteller collaborated for 10 years with Dr. Daniel Broek in the USC Norris Comprehensive Cancer Center studying various aspects of Ras and G-protein regulation in yeast (Saccharomyces cerevisiae) and humans.
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